2— monitoring the central nervous system

... by the time of the emergence of the Plathelminthes in the evolutionary history The eye of the planarian is one of the most ancestral and primitive types of visual systems in animals and is 950 ... cloning the planarian cytochrome b561 cDNA [40] The cytochrome b561 gene product was specifically expressed in the planarian nervous system [40], suggesting that the AsA-related electron transfer system, ... used in the present study The broad white bar and the two flanking small white bars represent the coding region and the noncoding regions of the planarian PHM cDNA, respectively; whereas the two...

Ngày tải lên: 30/03/2014, 15:20

... that the lack of CCR5 does not protect from MS, but rather it may predispose to the chronic course of the disease [69] This would further imply that in view of the redundancy in the chemokine system, ... disability in young adults in the Western world It is a chronic inflammatory disease, characterized by the appearance of focal demyelinated plaques within the central nervous system (CNS) [1] Essential ... protection from MS, and the lack of effect of CCL3 deficiency in mice [67] illustrates redundancy in the chemokine system Although some of the data on the role of CCR5 in the pathogenesis of MS...

Ngày tải lên: 19/06/2014, 22:20

... Identifying the location of these receptors in the central nervous system (CNS), the function of pathways that incorporate them, and the behavioral and physiological changes induced by their interaction ... and the cortex, between the discrete regions of the thalamus and the hypothalamus, and between the basal ganglia and the association regions of the cerebral cortex The thalamic nuclei and the ... in the Central Nervous System The capacity to integrate information from a variety of external and internal sources epitomizes the cardinal role of the CNS, namely to optimize the needs of the...

Ngày tải lên: 12/07/2014, 20:21

... Abnormal CT scans of the brain in asymptomatic children with acute lymphocytic leukemia after prophylactic treatment of the central nervous system with radiation and intrathecal chemotherapy N Engl ... support to boost the immune system, and either no craniospinal radiation or focused radiation to the tumor bed The increased risk of neurotoxicity associated with very high doses of chemotherapy is ... are planned that further reduce the dose of craniospinal radiation to 1,800 cGy, virtually no attention has been paid to the possible contribution of the chemotherapy to the cognitive decline...

Ngày tải lên: 06/08/2014, 18:21

... chemotherapy or if they represent a combination of the response to chemotherapy and, for example, physiological changes caused by the body’s reaction to the presence of a tumor In addition, the ... seen in the CC of the control; (b) in the CC from a 5-FU-treated animal, the cellular density in the CC has decreased markedly (e,f) The expression of MBP seen in control animals (e) (the fiber-like ... contribute to the effects of chemotherapy on cognition The ability of irradiation to the CNS to suppress the generation of new neurons in the hippocampus has been suggested to be relevant to the understanding...

Ngày tải lên: 06/08/2014, 18:21

... also found that the agents caused increased cell death and decreased cell division in the subventricular zone, the dentate gyrus of the hippocampus and the corpus callosum in mice These effects ... injury due to cancer treatment The knowledge gained from this and other studies will guide the development of translational clinical research to protect the nervous system from injury, to better ... hippocampus and the corpus callosum), primarily in progenitor cells and oligodendrocytes To determine whether these findings resulted in functional impairment, they investigated the auditory brainstem...

Ngày tải lên: 06/08/2014, 18:21

... disease of the central nervous system Proc Natl Acad Sci U.S.A 1995, 92, 5312-5316 Johnson, G.C., Fales, W.H., Maddox, C.W and RamosVara, J.A Evaluation of laboratory test for confirming the diagnosis ... Magnification A and B, ×66 C and D, ×132 Immunohistochmical study of nitric oxide synthase in the central nervous system of goat Enhanced expression of nNOS and iNOS in L monocytogenes-infected brain ... positive-staining bacteria were found in the neuronal processes Both nNOS and iNOS immunoreactivity were found in a proportion of the neurons in the brainstem and the staining pattern was similar to...

Ngày tải lên: 07/08/2014, 14:23

... wrote the initial draft WY drew the pictures WZ revised the draft SL described the MRI features GL provided the pathological diagnosis TJ was the surgeon and gave the final approval of the version ... Angiitis of the Central Nervous System: a Case Report and Review CNS Spectrums 2008, 13:209-213 Page of 10 Ozawa T, Sasaki O, Sorimachi T, Tanaka R: Primary angiitis of the central nervous system: ... angiitis of the central nervous system: serial MRI of brain and spinal cord Neuroradiology 2001, 43:599-607 14 Moore PM: Diagnosis and management of isolated angiitis of the central nervous system...

Ngày tải lên: 09/08/2014, 02:20

... known that the nanoparticles will interact with the proteins present in the biological system, i.e the material surrounding the nanoparticles are proteins present in the nervous system of the cockroach ... Begley DJ: Delivery of therapeutic agents to the central nervous system: The problems and the possibilities Pharmacology & Therapeutics 2004, 104:29-45 29 Vinson SB: The role of the foreign surface ... model system We study the effects and interactions of negatively charged gold nanoparticles (nAuNPs) with the cockroaches CNS in vivo The authors refer to the nervous system as the brain and the...

Ngày tải lên: 11/08/2014, 00:22

... the neurons The research group detected the significant presence of H2S in the brain homogenate preparation of CBS-/- mice (Shibuya et al., 2009) Kimura further observed that 3-MST acts together ... (Sparatore et al., 2011) These findings highlight the potential therapeutic benefit of H2S in PD which can be achieved either by the administration of exogenous H2S or the modulation of endogenous ... for the dementia (WHO) The DSM-IV-TR, 28       also classifies the DAT as early onset (65 years or below) and late onset (65 years or above) (APA) The DM-IV-TR further categorizes DAT of the...

Ngày tải lên: 09/09/2015, 08:17

... sodium butyrate therapy 96 4.4 Discussion 115 Chapter Concusion 126 Chapter References 131 VIII SUMMARY The structural and functional complicity of the central nervous system (CNS) and the unavailability ... functional therapeutic effects to ameliorate the diseases The most ideal human gene therapy is the perfect combination of these three components to generate a safe and effective way for the delivery ... in central nervous system (CNS) Chapter Introduction In the past decades, more than 400 clinical gene therapy studies have been evaluated, yet only a few have been directed to diseases of the nervous...

Ngày tải lên: 12/09/2015, 10:15

... SUMMARY The studies presented in this thesis focused on development and modification of baculovirus-based vectors in order to achieve improved gene delivery to the Central Nervous System There ... functions of the therapeutic genes 1.1.2 Non-viral and Viral Gene Delivery Systems Depending on the usage of vectors, there are two main types of gene delivery systems: non-viral and viral systems ... within the cell is reverse transcribed into double-stranded DNA which can then integrate randomly into the host cell genome The use of retrovirus vectors for gene delivery to the nervous system...

Ngày tải lên: 14/09/2015, 11:28

... SUMMARY Gene therapy is a promising approach for the treatment of neurological disorders in the central nervous system (CNS) Because of the complex structure and high vulnerability of the CNS, it ... specificity of the therapeutic gene is primarily determined by the activity of the promoter at the transcriptional level, and the duration of the transgene expression can also be influenced by the selection ... cells in the nervous system, carrying out the fundamental tasks of receiving, conducting and transmitting signals Therapeutic protection of these cells is one of the main goals of gene therapy...

Ngày tải lên: 16/09/2015, 08:30

... onto the cover glass beside the sticky tape, with the help of a second blunt needle The embryo was not lifted above the surface of the dissecting medium, as this caused dispersion of the tissue The ... of the model organism, Drosophila melanogaster, is also given Chapter introduces the concepts and theory of FCS as well as the experimental setup of this instrument The calibration of the FCS system ... equal to the mean value Therefore, the standard deviation (σ) is equal to the square root of the mean value Although it is important to minimize the number of molecules 10 occupying the focal...

Ngày tải lên: 12/10/2015, 17:36

... at the back of the head These proteins can potentially be a mixture of neurotoxins (which attack the nervous system) , hemotoxins (which attack the circulatory system) , cytotoxins and many other ... India The skin is either olive-green, tan, or black and it has faint, pale yellow cross bands down the length of the body The underbelly is cream or pale yellow, and the scales are smooth The head ... in the CNS, it is not clear whether their localization shown to be necessary in the physiological function (Chiappinelli, 1991) However, there is no direct evidence for their transport across the...

Ngày tải lên: 16/10/2015, 15:35

... is the connection between the cerebrum and the rest of the nervous system, with one exception The rest of the brain, the spinal cord, and the PNS all send information to the cerebrum through the ... regions, is the central component of the sympathetic division of the autonomic nervous system Some of the largest neurons of the spinal cord are the multipolar motor neurons in the anterior horn The ... 9/20 The Central Nervous System Brain Stem The midbrain and hindbrain (composed of the pons and the medulla) are collectively referred to as the brain stem ([link]) The structure emerges from the...

Ngày tải lên: 25/08/2016, 13:53

... individuals with other CNS cancer These relative survival estimates show the distinct difference between the two types of cancer even though they both affect the central nervous system; therefore, brain ... Cancer Institute NOS, Not Otherwise Specified 210 SEER Survival Monograph Chapter 25 Cancer of the Brain and Nervous System Table 25.7: Cancer of the Other Central Nervous System: Distributions and ... Institute 211 SEER Survival Monograph Chapter 25 Cancer of the Brain and Nervous System Table 25.9: Cancer of the Other Central Nervous System Cancer: 1-, 2-, 3-, 5-, 8-, & 10-Year Relative Survival...

Ngày tải lên: 22/03/2014, 17:20

... pre-date the current treatment era and therefore changes in accompanying systemic therapy, supportive care or improved delivery methods may have either reduced the morbidity from cranial radiotherapy ... = 15) The majority of children initially assessed on the WPPSI-R scale moved on to the WISC-III scale at their year or year test points (as they entered the 6-16 age range) Changes in the assessment ... in the case of the former, but much higher in the case of the latter Analysis of the IQ scores in our control group suggests the presence of a practice effect Out of 132 controls tested at the...

Ngày tải lên: 10/08/2014, 21:23

... In the present case, the given time interval represents the time between the first presentation and the detection of the intraspinal metastases as the primary site of the tumor; in this case, the ... in the literature, the choice of treatment of MCC brain metastases will depend, as in many other types of brain metastases, on the number of metastases, systemic spread of the disease and the ... Time since the detection of the primary tumor 0-4 years (50%

Ngày tải lên: 11/08/2014, 03:20

... structures of the zebrafish central and/or peripheral nervous system Additional data file 28 includes Tables J-L, listing the miRNAs analyzed, the family/cluster they belong to and the mismatch LNA probe ... providingthe the zebrafishbrain miR-153a usedfiguresinthe zebrafishnucleic miR-138 testother inthedpf information acid miR-137 expressionininthezebrafish brain about miR-135cexpressionthespecificity ... miR-219 expression in the diencephalon at the level of the post-optic commissure (poc) of the larval and adult brain In the larval brain (a), miR-219 is widely expressed in the ventral (VT) and...

Ngày tải lên: 14/08/2014, 08:20