... 5B) Owing to the lower steric limitations of the side chain of the Ala than of the Leu, water may occupy the space Furthermore, the side chain of His140, which is coordinated to the T3 copper, ... loses its chloride ionand probably also the T2 copper, as the B-value of the T2 copper was rather high On the basis of the anoma-lous signal, the estimated occupancy of the T2 copper was about ... folding of the protein during the post-translational processing, and thereby the function of the mature laccase Our structural analysis of wild-type MaL indicated that the last four amino acids of the
Ngày tải lên: 16/03/2014, 00:20
... essential role of fatty acids and lipids in cell growth and differentiation, and the occurrence of a different type (type I) of fatty acid biosynthetic pathway in the human host from that of the malaria ... estimated on the basis of the linear regression of the fraction number of the molecular mass markers cytochrome c (CyC), carbonic anhydrase (CA), and BSA From the calibration curve of the sucrose ... between the two states [24,25] These two states have been iden-tified as the major and the minor forms of the holo-ACP structure, on the basis of their percentage contri-butions (65% and 35%,
Ngày tải lên: 16/03/2014, 10:20
Báo cáo khoa học: Conformational properties of bacterial DnaK and yeast mitochondrial Hsp70 Role of the divergent C-terminal a-helical subdomain pdf
... that of DnaK The twofold reduction of the KSV values estimated for mtHsp70 both in the absence and the presence of ATP (Table 2) supports the existence of differences in the Trp environment of ... [42], thermal unfolding of DnaK gave rise to three endotherms at 43.5, 57.5 and 74C The first and second endotherms have been assigned to the unfolding of the N-terminal ATPase domain and the C-terminal ... regarding both the number and position of their amide I compo-nents (Fig 4A; for the sake of simplicity, only spectra of KCCC are shown) Furthermore, decomposition of the amide I band into its
Ngày tải lên: 16/03/2014, 22:20
Transforming the Face of Health Professions Through Cultural and Linguistic Competence Education: The Role of the HRSA Centers of Excellence potx
... “Transforming the Face of Health Professions Through Cultural & Linguistic Competence Education: The Role of the HRSA Centers of Excellence,” is one result of the efforts of HRSA and the COEs The publication ... Transforming the Face of Health Professions through Cultural and Linguistic Competence: The Role of the Centers of Excellence, was developed by a panel of experts, the Expert Team, brought together ... overview of the content of these chapters follows: Chapter 1: Cultural and Linguistic Competence and the Centers of Excellence provides an overview of the COE legislative mandates, a brief history of
Ngày tải lên: 22/03/2014, 15:20
WORKING PAPER NO. 218 THE ZERO-INTEREST-RATE BOUND AND THE ROLE OF THE EXCHANGE RATE FOR MONETARY POLICY IN JAPAN potx
... the variability of the real rate depending onthe level of the nominal equilibrium rate of interest The downward bias in the variability ofthe real rate accounts for the reduced effectiveness of ... Prasad (1997) studied the effect of an appreciation Orphanides and Wieland (1998) provided a first study of the effect of the zero bound on the distributions of output and inflation in the U.S economy ... particular the size of the shocks to the economy, the propagation ofthose shocks throughout the economy (i.e the degree of persistence exhibited by importantendogenous variables), the level of the equilibrium
Ngày tải lên: 22/03/2014, 23:20
Báo cáo khoa học: Autophosphorylation of heme-regulated eukaryotic initiation factor 2a kinase and the role of the modification in catalysis doc
... to explore the role of autophosphorylation of the HRI protein in the intramolecular protein–protein interac-tion (between the NTD and KD) and catalysis upon heme binding Identification of autophosphorylated ... identify other phosphorylation sites in HRI and to establish the contribution of the autophosphorylation process to heme sensing and catalysis The results obtained should aid the clarifica-tion of the ... examined the catalytic activities of dephos-phorylated HRI, and compared the catalytic and heme-sensing properties of phosphorylated and dephosphorylated HRIs The effects of heme on the kinase
Ngày tải lên: 28/03/2014, 23:20
INVESTIGATING DIVERSITY IN THE BANKING SECTOR IN EUROPE: THE PERFORMANCE AND ROLE OF SAVINGS BANKS pdf
... objective and standard of assessment is the impact that they have on the lives of their clients; and the other one is profitability Ultimately and over the long term, impact and effectiveness are the ... why these types of banks were needed and why they had the specific feature of being not-for-profit institutions This may offer a possible first answer to the question of whether these types of ... scope of their operations The pitfalls of the policy were first criticised by McKinnon (1973) and Shaw (1973) in two influential books Their critique was one of the building blocks of the policy of
Ngày tải lên: 29/03/2014, 07:20
Báo cáo khoa học: Role of the plasma membrane leaflets in drug uptake and multidrug resistance ppt
... cytoplasmic leaflet of the membrane to the aqueous medium rather than to the extracellular leaflet [12,13] The question remains as to whether the release of drugs from the cytoplasmic leaflet of the plasma ... addition of the TMRM. Trang 4presence of CCCP reflects the total cellular uptake ofTMRM, the time course of the quenching was com-pared with the time course of TMRM uptake into the cells The time ... elapsed from the addition of the dye and k is the reaction constant; a and c represent the extent of the secondary fluorescence drop and the fluorescence remaining after both phases of fluorescence
Ngày tải lên: 29/03/2014, 08:20
Vietnam’s Competitiveness and the Role of the Private Sector potx
... oversight of these companies and their spending is limitedand largely reactive • The costs of slow progress on privatization are high for Vietnam’s competitiveness – Retards entry of new private ... Conditions Demand Conditions Availability of suppliersand supporting industries Sophistication of local customers andneeds – e.g., strict quality, safety, and environmental standards • Many ... 18, 2008, 3pm Vietnam’s Competitiveness and the Role of the Private Sector 2 Copyright 2007 © Professor Michael E Porter 20081201 – PACE strategy.ppt The Need For An Economic Strategy • Vietnam
Ngày tải lên: 30/03/2014, 02:20
Báo cáo khoa học: Role of the surface charges D72 and K8 in the function and structural stability of the cytochrome c6 from Nostoc sp. PCC 7119 potx
... residues K8 and D72 are located near the crossing region of the helices, and the Nx atom of K8 is found at a distance of 6.2 A˚ from the nearest side-chain oxy-gen of D72 Taking the functionally and ... Gibbs energy of unfolding than the mutants, with the exception of D72A at pH 4 and 3, and of the double mutants D72A⁄ K8D and Table 3 Thermal unfolding transition of wild-type cyt c6and its mutant ... together with their best fits, for the thermal unfolding of wild-type cyt c6, and for the mutants D72K and D72A⁄ K8D at pH 5.0 are shown in Fig 3A as typical examples The effect of pH on thermal
Ngày tải lên: 30/03/2014, 20:20
aggarwal and conroy-price discovery in initial public offerings and the role of the lead underwriter
... between the opening price on day 1 and the offer price; offer-to-close return is the percentage difference between the closing price on day 1 and the offer The mean and median number of comanagers and ... quoting and trading the stock We use unique quote data with the identity of the market maker to examine the quoting behavior of the lead underwriter during the preopening period; the behavior of other ... herein are those of the authors and do not necessarily ref lect the views of the Commission or the authors’ colleagues upon the staff of the Commission. 1 See Aggarwal and Rivoli ~1990! and Ritter
Ngày tải lên: 23/04/2014, 16:09
Báo cáo hóa học: " Fall prevention and vitamin D in the elderly: an overview of the key role of the non-bone effects" docx
... data in the study and takes responsibility for the integrity of the data and the accuracy of the data analyses Study concept and design: CA and OB Acquisition of data: CA and OB Analysis and interpretation ... demands of gravity, the when the center of gravity exerts a reaction force to the ground equal and opposite to the force of gravity in the vertical plane situated in the middle of the support base ... [35] Selection of these strategies depends, apart from the nature of the disturbance, on the subject’s state of attention and pre-vious experience [31,36] Maintenance of posture and balance during
Ngày tải lên: 19/06/2014, 08:20
Tài liệu A Compilation of the Messages and Papers of the President pdf
... chairs of the President of the Senate and of the Speaker of the House of Representatives be shrouded in black during the residue of the session, and that the President pro tempore of the Senate, the ... statement of the condition of the public defenses, of all the preparations and means of defense, and of the actual and authorized strength of the Army on the 1st of January, 1829, and the 1st of January, ... the proclamation of the King of Great Britain of the 7th of October, 1763, as the southern boundary of the Province of Quebec, making in all 239 miles of the height of land In the course of these...
Ngày tải lên: 18/02/2014, 08:20
Compilation of the Messages and Papers of the Presidents pdf
... Compilation of the Messages and Papers of the Presidents 46 hundred and eighteen (118) west; thence northerly to the northeast corner of said township; thence westerly to the southeast corner of the ... of May, A.D 1902, and of the Independence of the Compilation of the Messages and Papers of the Presidents 47 United States the one hundred and twenty-sixth [SEAL.] THEODORE ROOSEVELT By the President: ... day of November, A.D 1901, and of the Independence of the United States the one hundred and twenty-sixth THEODORE ROOSEVELT By the President: JOHN HAY, Secretary of State BY THE PRESIDENT OF THE...
Ngày tải lên: 07/03/2014, 01:20
Compilation of the Messages and Papers of the Presidents doc
... to the state of war in that island and the condition of the people there, appears to leave it to the discretion of the President to direct the scope of the information to be so reported and the ... who thereupon yielded up to the representative of the Government of the United States the sovereignty and public property of the Hawaiian Islands Compilation of the Messages and Papers of the Presidents ... for the recognition of the independence of the people of Cuba, demanding that the Government of Spain relinquish its authority and government in the island of Cuba and to withdraw its land and...
Ngày tải lên: 08/03/2014, 00:20
A Compilation of the Messages and Papers of the Presidents doc
... of the United States_: A Compilation of the Messages and Papers of the Presidents 26 I communicate, for the information of Congress, the report of the Director of the Mint of the operations of ... Compilation of the Messages and Papers of the Presidents 33 I communicate to the House of Representatives the report[43] of the Secretary of State on the subject of their resolution of the 6th of December ... expedient Their first meeting was with the Cherokees The extract from the speech of our commissioners and the answers of the Cherokee chiefs will show the caution of the former and the temper of the...
Ngày tải lên: 08/03/2014, 00:20
A Compilation of the Messages and Papers of the Presidents Section 2 pot
... for the accommodation of Congress and of the President and of the public offices of the Government have made a report of the state of the buildings designed for those purposes in the city of Washington, ... ADAMS A Compilation of the Messages and Papers of the Presidents 21 ADDRESS OF THE SENATE TO JOHN ADAMS, PRESIDENT OF THE UNITED STATES THE PRESIDENT OF THE UNITED STATES SIR: The communications ... Congress a report of the Secretary of State, with a copy of an act of the legislature of the State of Kentucky consenting to the ratification of the amendment of the Constitution of the United States...
Ngày tải lên: 17/03/2014, 02:20
Báo cáo khoa học: Mycobacterium tuberculosis ClpC1 Characterization and role of the N-terminal domain in its function ppt
... interest to understand the mode of action of these proteins in M tuberculosis In this study, we functionally characterized the ClpC1 protein of M tuberculosis, and investigated the role of its N-terminal ... 1) These proteins were further characterized to compare their biochemical properties and functions The enzymatic activity of the three proteins was assayed at different pH values ClpC1 and the ... which increased with the addition of Mg2+, Mn2+ and Ca2+ (Fig 5) The optimum concentration of these metal ions was found to be 10 mm (Fig 5) The addition of sodium chloride and potassium chloride,...
Ngày tải lên: 23/03/2014, 06:20
A Compilation of the Messages and Papers of the Presidents Section 3 (of 3) of Volume 8: Grover Cleveland, First Term. pptx
... day of April, 1885, and of the Independence of the United States of America the one hundred and ninth GROVER CLEVELAND By the President: T.F BAYARD, Secretary of State BY THE PRESIDENT OF THE ... day of April, 1885, and of the Independence of the United States of America the one hundred and ninth GROVER CLEVELAND By the President: T.F BAYARD, Secretary of State BY THE PRESIDENT OF THE ... swords, and the colors of the Battalion of Engineers, of the several regiments, and of the United States Corps of Cadets will be put in mourning for the period of six months The date and hour of the...
Ngày tải lên: 31/03/2014, 11:20
Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx
... cloned into pGEX-4T-2 The KIND domains of Spir-2 and PTPN13 were generated by RT-PCR and inserted into pEGFP-C1 and pGEX-4T-2 The N- and C-terminal regions of the v-KIND KIND2 and the MAP2 CD were ... proteins of these subregions (Fig S1C) and 1654 Fig Of all members of the KIND family of proteins, only KIND2 binds to MAP2 Pull-down assay (PD) of the endogenous MAP2 from cerebellar lysates of P21 ... Discussion The present study revealed the structural and functional determinants of the protein–protein interaction between v-KIND and MAP2 (i.e the MAP2-binding core module in v-KIND and the v-KIND-binding...
Ngày tải lên: 14/02/2014, 19:20