10 treatment of hepatocellular carcinoma and liver metastases

... injury, fi-brosis, and HCC, and it likely represents an important target for the treatment of liver fibrosis and/or HCC [13] The activation of NF-κB drives transcription of hundreds of genes with ... Department of Nursing, Chang Gung University of Science and Technology, Taoyuan, Taiwan Full list of author information is available at the end of the article Trang 2Hepatocellular carcinoma (HCC) ... endoplasmic reticulum stress, and cell death via apoptosis RA190 blocks proteasomal degradation of IκBα and consequent release of NF-κB into the nuclei of HCC cells Treatment of mice bearing an orthotopic

Ngày tải lên: 30/05/2020, 21:33

... AccessTranscriptome analysis of paired primary colorectal carcinoma and liver metastases reveals fusion transcripts and similar gene expression profiles in primary carcinoma and liver metastases Ja-Rang ... concordance of gene expres-sion in the primary carcinoma and liver metastases Functional enrichment analysis of differentially expressed genes The common 1895 DEGs in primary carcinoma and liver metastases, ... primary carcinoma; LM, liver metastases; NL, normal liver Trang 5Transcriptome sequencing and mapping Five sets of quadruple-matched tissues (primary carcin-omas, liver metastases, normal colon, and

Ngày tải lên: 20/09/2020, 15:07

... Identification of PLVAP as a therapeutic target for HCC To identify genes specifically expressed in HCC and not in non-tumorous liver tissue, we compared the gene ex-pression profiles of 18 pairs of HCC and ... non-tumorous liver tissue A: Differential expression of the PLVAP gene according to microarrays of 18 pairs of HCC and adjacent non-tumorous liver tissue PN: paired non-tumorous liver; PHCC: ... associated with radiation-induced injury to liver, lung and gastrointestinal tract [8-10] HCC patients with liver cirrhosis and impaired liver function are often pre-cluded from treatment using cytotoxic

Ngày tải lên: 30/09/2020, 14:52

... slug and snail in primary tumors and their corresponding metastases A) The number of the lesions with different staining intensity of HNF4alpha, Slug and Snail in the primary tumors and its metastases ... that of E-cadherin in the metastases, and the expression of Snail and Slug in the metastases was significantly reduced compared with the primaries In addition, it was showed that the expression of ... expression of MET marks in primary tumors and their corresponding metastases suggested the occurrence of MET in the metastases A) The number of the lesions with different staining intensity of the

Ngày tải lên: 05/11/2020, 06:12

... normal human liver tissues and human liver tissues with hepatocellular carcinoma This workflow was then applied to differential analysis of the N-glycoproteome of HCC and normal human liver tis-sues ... and the quantification accuracy This workflow was further applied to the differential analysis of N-glycoproteome of normal human liver tissue and that with hepatocellular carcinoma A total of ... Trang 1Differential analysis of N-glycoproteome between hepatocellular carcinoma and normal human liver tissues by combination of multiple protease digestion and solid phase based labeling

Ngày tải lên: 02/11/2022, 09:30

... silencing of VEGF and KSP by siRNA cocktail inhibits proliferation and induces apoptosis of hepatocellular carcinoma Hep3B cells Chung Chinh Doan1,2*, Long Thanh Le2, Son Nghia Hoang2, Si Minh Do1and ... Conclusion: Silencing of VEGF and KSP plays a key role in inhibiting cell proliferation, migration, invasion and inducing apoptosis of Hep3B cells Simultaneous silencing of VEGF and KSP using siRNA ... cocktail, Proliferation, Apoptosis, Hepatocellular carcinoma Background Primary liver cancer, hepatoblastoma (HB) and hepatocel-lular carcinoma (HCC), is one of the most common solid tumors, ranking

Ngày tải lên: 16/12/2017, 11:28

... of hepatocellular carcinoma 1.2.1.Clinical symptoms The clinical symptoms of HCC are often present in late stage of the disease because of good functional balance of liver 1.2.2 Marker of ... level of HCC cells was often divided into 4 different levels: high and medium , low and non-differentiated levels basing on ratio of nucleus/cytoplasm 1.2.5 Diagnostic criteria of hepatocellular carcinoma ... cases and the mortality of HCC, acount for 15.4% and 21.5% (19.568 cases) of total of cancer, respectively Therefore, nowadays, the trend of HCC have been increasing according to the time and this

Ngày tải lên: 08/01/2020, 16:26

... expression of CK7, CK8, CK18, and SALL4 affect the OS and DFS of HCC patients, but without statistical significance (Figure 3) The expression of CK7, CK19, CK8 and CK18 may affect the OS and DFS of ICC ... second leading cause of cancer-related deaths in Taiwan and the third leading cause of cancer-related deaths worldwide [1] Hepatocellular carcinoma (HCC) and intra-hepatic cholangiocarcinoma (ICC), ... interval falling between the date of surgery and the date of tumor recurrence or the date of the most recent follow-up with no proof of tumor recurrence At the time of the previous visit for regular

Ngày tải lên: 15/01/2020, 02:18

... activation energy, Q-value of 0.25 and a threshold of 5000 counts) Dynamic exclusion was applied to a repeat count of 1 and an exclusion time of 30 sec Database Searching and System Biology Analysis ... expression profile of and demonstrate the role of HSP70 in HepG2 cell in response to TNFα treatment Figure 5 Involvement of HSP70 in TNFα-promoted cell migration and TNFα-suppressed apoptosis of HepG2 ... analysis and comparison of the human hepatocyte and hepatoma cell line HepG2 proteomes Journal of proteomics 2016; 136: 234-47 16 Aitken A Post-translational modification of 14-3-3 isoforms and

Ngày tải lên: 15/01/2020, 17:08

... necrosis and CR, 30–99% necrosis and PR, < 30% necrosis and SD, the accuracy of mRECIST to assess tumor response was 63.6%, with 6 lesions (9.1%) of underestimation and 18 lesions (27.3%) of overestimation ... Association For The Study Of The Liver; European Organisation For Research And Treatment Of Cancer EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma J Hepatol 2012;56(4): ... European Association for the Study of the Liver; European Association for the Study of the Liver EASL clinical practice guidelines: management of hepatocellular carcinoma J Hepatol 2018;69(1):182

Ngày tải lên: 17/06/2020, 19:01

... that abnormal expression of GABPA is associated with tumor development and progression However, the function and clinicopathological significance of GABPA in hepatocellular carcinoma (HCC) remain ... HCC progression and metastasis, and is a potential therapeutic target in HCC Keywords: Hepatocellular carcinoma, GABPA, Prognosis, Metastasis, E-cadherin Background Hepatocellular carcinoma (HCC), ... contributors 1 Department of Hepatobiliary Surgery, ZhongShan Hospital Xiamen University, Xiamen, China 2 Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma (Xiamen

Ngày tải lên: 06/08/2020, 07:19

... Foundation of China. RZ is funded by Research Cooperation Project of Guangdong Province. KL and EX are scholars of Science and Technology Planning Project of Guangdong Province. Availability of data and ... outlined using red and blue circles, respectively At the beginning of image fusion, the Fig 2 (A-1) and (B-1): CT images of the models (A-2) and (B-2): US-CT image fusion of the area of ablation (left ... The shape, height, and gradient of the phantom model were tested at 1 h, 6 h, and 12 h after construction of the model The structure of the phantom model and the position of the marks were checked

Ngày tải lên: 20/09/2020, 01:13

... equal volume (1 mm3), and transplanted into the left lobe of the liver of 24 nude mice to establish orthotopic xenograft models, as previ-ously described [20] Preparation of liver samples Each week ... contrast, and the liver boundaries were obscure At 15 keV, when the distance was increased to 1 m, the progressive branching of the liver vessels was visible, and the tiny vessels at the outer edge of ... projection imaging of HCCLM3 liver xenografts at weeks 1 to 4 1w-b and 2w-b are magnified images of the boxed regions in 1w-a and 2w-a, respectively The red arrows indicate the margins of the tumor,

Ngày tải lên: 20/09/2020, 01:16

... MO, FIA and MAM participated in the design of the study and conceived of the study, and participated in its design and coordination and helped to finalize the manuscript All authors read and approved ... effects of seven novel compounds labeled as 1 –7 (concentration of 50 μM and 10 μM), on Huh7 and MCF7 cell lines b Molecular structure and cytotoxic activity with IC 50 values of DAAD2 on 10 HCC and ... etiology of hepatocellular carcinoma and consequences for treatment Oncologist 2010;15:14 –22. 10 Lachenmayer A, Alsinet C, Chang CY, Llovet JM Molecular approaches to treatment of hepatocellular carcinoma

Ngày tải lên: 20/09/2020, 18:47

... pathology (XCY and DYG) The final diagnosis of biphenotypic primary liver carcinoma (both types of tumor intermixed) depended on a combination of H and E stain findings [19] and proof of both hepa-tocellular ... of both hepatocellular carcinoma and cholangiocarcinoma phenotypes in hepatocellular carcinoma and cholangiocarcinoma components in combined hepatocellular and cholangiocarcinoma Med Mol Morphol. ... M Clinical and pathological features of Allen's type C classification of resected combined hepatocellular and cholangiocarcinoma: a comparative study with hepatocellular carcinoma and cholangiocellular

Ngày tải lên: 21/09/2020, 01:58

... [14] and prostate cancer cells [15], bladder cancer [16] and retinoblastoma [17], promotes apoptosis of colorectal and gastric adenocarcinoma cancer [18, 19], represses migration and invasion of ... programs, miRanda and TargetS-can Our analysis revealed that FOS and Met were two potential targets of miR-449a The 3’-UTR of FOS and Met mRNA contains a complementarysite for the seed region of miR-449a ... expression of FOS and Met in HCC tissues We further examined the mRNA expression of FOS and Met in 77 cases of HCC tissues A significant inverse correlation between the levels of miR-449a and mRNA

Ngày tải lên: 22/09/2020, 23:52

... candidate for the treatment of HCC Keywords: Incarvine C, ROCK, Vasculogenic mimicry, Hepatocellular carcinoma Background Hepatocellular carcinoma (HCC) is the sixth most com-mon malignancy and ... survival, and invasion and metastasis in clinical trials [8–10] The initial morphologic and molecular characterization of tumor VM cells revealed co-expression of endothelial and tumor markers and ... fasudil, inhibitors of ROCK, caused loss of actin stress fibers and focal adhesion complexes [31] We found that treatment of MHCC97H cells with IVC decreased the level of p-MYPT-1 and distributed

Ngày tải lên: 23/09/2020, 00:10

... wzxia66@126.com Institute of Basic Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250062, China Trang 2target and better understanding of the molecular mecha-nisms ... Natural Science Foundation of China [81303077,81971088]; The Project of Medicine Science and Technology Development of Shandong [2017WS268]; Natural Science Foundation of Shandong Province [ZR2018LH012, ... cells/well and cultured for 24, 48, and 72 h respectively Then, 20μL of 5 mg/mL MTT solution (Sigma, USA) was added and incubated for 4 h 150μL of dimethyl Trang 3sulfoxide (DMSO) was added and the

Ngày tải lên: 28/09/2020, 09:44

... hepatocellu-lar carcinoma, and blockade of EGF receptor activity halt the development and progression of HCC [35-37] Thus, overexpression of EGF might be an important step toward development of liver cancer ... between EGF +61A/G and HCC was present both in healthy controls and in patients with chronic liver diseases, indi-cating the role of EGF +61A/G in the risk of HCC, re-gardless of type of controls Moreover, ... polymorphism and HCC risk s.e of: logOR s.e of: logOR −0.5 0 0.5 1 1.5 −0.5 0 0.5 A B Figure 3 Begg ’s funnel plot of the Egger’s test for publication bias of EGF +61A/G polymorphism and HCC risk

Ngày tải lên: 29/09/2020, 16:09

... analysis of the migration of serum starved QGY-7703 and PLC cells treated with vehicle and α2M* (e) Transwell analysis of the effect of antibody blocking on the invasion of serum starved QGY-7703 and ... Association of cell surface GRP78 with α2M* facilitated the invasion and metastasis of HCC (a-b) Transwell analysis of the invasion of serum starved QGY-7703 and PLC cells treated with vehicle and α2M* ... samples Association of cell surface GRP78 withα2M* promotes the invasion and metastasis of HCC in hepatocellular carcinoma cell lines QGY-7703 and PLC by stimulating the transloca-tion of GRP78 from

Ngày tải lên: 30/09/2020, 10:56