1 searching for good matches in protein sequences

... time while reading - Define the information in which part of the text after skimming then scan to locate the exact information students need The information may be ordered basing on the letter ... underlined: “People are driving more cars, burning (2)………… fuel, using more water, eating more food, making more garbage, and producing more things in factories than ever before.” Then they will find ... People are driving more cars, burning (2)………… fuel, using more water, eating more food, making more garbage, and producing more things in factories than ever before Life is becoming difficult

Ngày tải lên: 22/10/2019, 13:52

... ions near cysteine or histidine can be attributed largely to the DNA binding proteins, such as zinc-finger proteins that utilize CYS/HIS to coordinate the binding to Zn2+ions, and Zn2+in turn stabilizes ... information regarding how the ions are co-ordinated in each specific site by the neighboring amino acids For example, MetalPDB extracts the metal ion binding sites from experimentally determined ... geometry of metal sites in proteins, revealing how ions with similar chemical properties can be discriminated by the finely tuned binding sites [14] In this work, we pro-vide an innovative approach

Ngày tải lên: 25/11/2020, 15:25

... BMP in repairing damage induced by interleukin-1 (IL-1) was investigated Ad-BMP-2 was injected intra-articularly into murine knee joints, which were isolated 3, 7, and 21 days after injection for ... differences in safranin O staining intensity between BMP-2-exposed cartilage and controls were observed by mere visual investigation Therefore, the safranin O staining intensity was scored in patellar ... imaging system There was a significant (30%) increase in safranin O staining intensity in the patella on day 7 When the data of all time points were pooled, a significant increase in safranin

Ngày tải lên: 09/08/2014, 10:21

... assay for identification of HIV-1 IN inhibitors that are effective against ASV IN We were also interested in evaluating the utility of the flu-orescent assay for determining IC50 values for integrase ... obtained with Mg++ as cofactor In this case, optima for ASV IN were in the range of pH 8–8.5 for both processing and joining, whereas the optima for HIV-1 IN were substantially lower, pH 7 for ... solution assay for integrase joining activity Figure 2 Moderate-throughput solution assay for integrase joining activity Panel A Principles of a solution assay to measure integrase joining activity

Ngày tải lên: 10/08/2014, 05:21

... role of adiponectin in cancer etiology is not yet fully understood Although adiponectin may provide indirect protection against carcinogenesis by affecting insulin sensitivity and inflammatory states, ... results in Trang 7inhibition of cell proliferation The adiponectin receptor exists in 2 isoforms: adiponectin receptor 1 (AdipoR1), which is abundantly expressed in skeletal muscle, and adiponectin ... and informed consent was obtained from each patient before enrollment in this study All resected primary tumors and regional lymph nodes were histologically evaluated by H&E staining according

Ngày tải lên: 10/08/2014, 10:21

... recorded from individual cells We previouslyhypothesized that this ongoing spontaneous bursting activity may interfere with inducing plasticity and main-taining changes [29] Therefore, in addition ... at all In short, no interesting changes could be attributed to the induction sequences in any of the exper-iments in Series II (As an aside, extending the response window to 10–160 ms (as in [26]) ... electrodes in one-hour windows before and after an induction sequence, as well as the number of spikes in those bursts Very strong stimuli were used as induction sequences in these experiments In most

Ngày tải lên: 11/08/2014, 08:20

... of sequence similarity to proteins in the Uniprot100 data-base The remaining 18,716 unigenes are candidates for encoding Brassica-specific proteins or non-coding RNAs In the absence of genomic ... The remaining two originate from positions within gene clusters (one of protein kinase-encoding genes and the other of oxidoreductase-encoding genes) Discussion We assembled unigenes using 810,254 ... by searching against NCBI Uniprot100 using a cut-off of 1E-5 A total of 72,148 sequences were annotated Incorporation of assemblies into the Brassica genome sequence annotation As partners in

Ngày tải lên: 12/08/2014, 03:20

... selective advantages of maintaining optimal protein function [3,4] These conflicting forces are perhaps most manifest within the env gene that encodes the HIV envelope proteins The HIV envelope is ... distinct but addi-tive roles in HIV infection and pathogenesis [15] While gp120 mediates entry via CD4 and co-receptor binding, gp41 is essential for post receptor binding events includ-ing viral ... circulat-ing recombinant forms The presence of potential recom-bination breakpoints in these datasets was first determined using the GARD method [40] The distribu-tion of detected breakpoints was

Ngày tải lên: 12/08/2014, 04:21

... No increase in PTHrP mRNA or protein occurred with PHA stimulation of PBMCs In contrast, HTLV-1 infection markedly up-regulated PTHrP mRNA expression com-pared to uninfected PBMCs In PBMCs infected ... specific for the PTHrP N-terminal region (amino acids 1 to 40) and mid-region (amino acids 57 to 80) Enzyme Linked Immunosorbant Assays p19 Gag protein in the culture supernatant was measured using ... compared to uninfected PBMCs at day 0 As shown in fig-ure 2B PTHrP protein was detectable in the conditioned medium 1 week following co-culture with HTLV-1 pro-ducer cells and peak PTHrP protein expression

Ngày tải lên: 13/08/2014, 05:20

... [27], but lack protein interaction motifs for the phosphofurin acidic cluster sorting protein (PACS) sorting adaptor (E4A4) or SH3 domains (AxxA), and are deficient in modulating MHC class I ... Nef-mediated increase in CD4+ T lymphocyte death identified the C-terminal di-leucine motif and the interaction site for the NAKC signalosome as two distinct protein interaction sites involved in this ... activity in HIV-infected HLAC Figure 4 Molecular determinants for Nef's activity in HIV-infected HLAC HLACs were infected with 3 ng p24 of wt HIV-1, Δnef HIV-1 or HIV-1 encoding for the indicated

Ngày tải lên: 13/08/2014, 05:21

... sufficient N atoms for reaction, resulting in the formation of In droplets (see Fig 1-9) [47] In droplets interrupt the continuity of the InN material and can form short circuits in electronic devices ... of InN nanoislands grown on planar GaN (a) for 40 min after InGaN surface treatment – Sample C1, (b) directly without InGaN for 20 min – Sample A2, and (c) directly without InGaN for 60 min – ... responsible for etching InN during growth and further lowering growth rates [24] In one study, the V/III ratio was adjusted by reducing ammonia flow rates, resulting in the growth rate improving from

Ngày tải lên: 09/09/2015, 11:06

... 5.4 Maintainability scoring for facade ……… 135 5.5 Maintainability scoring for wet area ……… 137 5.6 Maintainability scoring for roof ……… 139 5.7 Maintainability scoring for sanitary-plumbing system ... 5.8 Maintainability scoring for HVAC system.……… 144 5.9 Maintainability scoring for elevators ……… 146 5.10 Maintainability scoring for electrical system ……… 149 5.11 Maintainability scoring for ... Grading for construction of slope in floor ……… … 315 C.3.10 Grading for installation of waterproofing ……… … 315 C.3.11 Grading for installation of finishes (tiles) ……… 316 C.3.12 Grading for installation

Ngày tải lên: 14/09/2015, 08:23

... recent performance of the financial sector are encouraging many firms to become bolder, which is reflected in the key findings of the research Key findings include the following: Financial institutions’ ... across business lines Risk reporting Managing real-time (or intra-day) risk Instilling a culture of risk more broadly in the organisation Collecting, standardising and storing data Using human ... and casualty insurers will suffer from weak demand in sluggish developed economies in the coming years, following outright declines in global business volumes in 2008-09 Emerging insurance markets

Ngày tải lên: 06/12/2015, 23:16

... products by reviewing & improving business linkages 3 Strengthen products by reviewing & improving business linkages 4 Continually improve products based on feedback 4 Continually improve ... products by reviewing and improving business linkages • Forward linkages – Identify opportunities and / or gaps – Develop forums – Complement existing linkages with new ones • Backward linkages – Solidify ... Villages and tourism in Vietnam 2 Developing market links & marketing responsibly product-3 Ensuring product quality, innovation & product-3 Ensuring product quality, innovation &

Ngày tải lên: 07/05/2016, 12:37

... requirements in Principles A and B for acting in the public interest at all times, achieving good governance in the public sector also requires: C Defining outcomes in terms of sustainable economic, ... processes and information it needs to monitor value for money effectively, including using benchmarking information from other entities for financial and service quality comparisons D2 Planning interventions ... of robust processes, including systems for:  capturing, processing, analyzing, and reporting the required information;  integrating financial management; and  establishing effective project

Ngày tải lên: 10/12/2016, 22:55

... • Financing channel: defined as the source of financing and how the financing is channeled (see Section 1.07.5); • Financing instrument: defined as the specific delivering method of financing ... 4SUBSIDY INCENTIVES HIRING FINANCE POOL FINANCING FINANCING 1.07.1.2 Analytical Framework for Support Mechanism of PV in Rural Areas The wide range of existing support mechanisms for PV in rural ... in financing rural renewable energy because of the high risk and low profit associated with these loans Financial institutions are not always interested in giving or opening lines of credit for

Ngày tải lên: 30/12/2017, 12:55

... reality of interdisciplinary integrated teaching in English 3 The sollutions 3.1 Principles of integration 3.2 Methods of implementation when integrating interdisciplinary knowledge in the lesson ... allphenomena and things Integration is a way of thinking in which links are sought, so integration makes true learning happen (Clark, 2002) Thus, with thedefinition of learning as a way of finding relationships ... starting point for understanding different integratedapproaches:-    Multidisciplinary Integration -    Interdisciplinary Integration -    Transdisciplinary Integration(2) In this intative experience

Ngày tải lên: 08/08/2019, 14:11

... A C-terminal 4· methionine tag was introduced into the nascent chains to increase the labelling efficiency The nascent chain corresponding to the authentic preprotein comprised 101 amino acids, ... sophisticated N-terminal extensions, containing multipurpose functional information A signal peptide can be divided into three distinct domains; the N-, H-, and C-domains [5,6] The N-domain interacts with ... nascent chain; ?, unknown cross-linking adducts; *, cross-linking adducts with E coli L23; d, cross-linking adducts with E coli Ffh; s, cross-linking adducts with B subtilis Ffh; n, cross-linking adducts...

Ngày tải lên: 16/03/2014, 22:20

... by observing, folding, measuring and inducing - The instructional materials greatly assisted the lessons, and supported students in exploring and discovering new information - Low-cost instructional ... as a means to innovation In the lesson study teachers played a central role in deciding on the innovation in teaching and learning They were the ones to implement the innovations in their actual ... leave much room for creative thinking The idea of using open-ended problems to improve school mathematics teaching, to develop and foster methods for teaching problem-solving and thinking skills,...

Ngày tải lên: 13/08/2015, 10:21

... Many factors form (or block formation of) protein complexes that contact the RNA polymerase directly, increasing or decreasing its affinity for binding to a gene’s promoter and initiating transcription ... by RNA polymerase In Figure A, the repressor protein (R) binds to the regular binding site and blocks transcription In Figure B, the repressor protein can not bind to the binding site due to some ... matching of bases by finding an optimal alignment 13 CHAPTER BACKGROUND Sequence similarity forms the basis to find interesting features in long genomic sequences Similar substrings between sequences...

Ngày tải lên: 03/10/2015, 21:58