— inflammation metabolism tissue repair and overtraining

... sirtuins in metabolism and DNA repair, and further touch on their roles in cancer mainly by affecting genome integrity and cancer-associated metabolism. Sirtuins in metabolism Glucose metabolism ... nucleotide-excision repair (NER), homologous recombination (HR) and non-homologous end joining (NHEJ) [75] BER and NER are two repair pathways preferentially for single-strand breaks (SSB) and repair the ... mainly regarding DNA repair and energy metabolism, and further discuss the implication of sirtuins in cancer specifically by regulating genome integrity and cancer-related metabolism. Keywords:

Ngày tải lên: 04/12/2022, 16:10

... temperatures), important metabolic and physiologic plant processes are interrupted As a consequence, protein aggregation and denaturalization in chloroplasts and mitochondria, destruction of membrane ... anatomical alterations and decreased intracellular energy availability or increased energy consumption due to repair synthesis The cell responses to stress include changes in cell cycle and division, ... where water is limited These adjustments depend on the severity and duration of drought, as well as the development phase and morphology and anatomy of plants The cellular response includes the action

Ngày tải lên: 22/06/2014, 03:20

... pp 3-20, ISSN 0305-7364 Vinit-Dunand, F.; Epron, D.; Alaoui-Sosse, B & Badot, P.M (2002) Effects of copper on growth and on photosynthesis of mature and expanding leaves in cucumber plant ... Review of Plant Physiology and Plant Molecular Biology, Vol 49, pp 697–725, ISSN 1040-2519 Trang 43 Oxygen Metabolism in Chloroplast Boris Ivanov, Marina Kozuleva and Maria Mubarakshina Institute ... apolar media this lifetime is higher, 12 μs in ethanol and 24 μs in benzene, and in the heavy water the lifetime increases almost twentyfold and reaches 68 μs (Krasnovsky, 1998) The chloroplast

Ngày tải lên: 22/06/2014, 03:20

... fungus Candida albicans Proc Natl Acad Sci USA, Vol 103, pp 726–731 Phillips, A.J., Sudbery, I & Ramsdale, M (2003) Apoptosis induced by environmental stresses and amphotericin B in Candida ... structural and functional changes induced by acetic acid in the yeasts Zygosaccharomyces bailii and Saccharomyces cerevisiae Cytometry, Vol 31, pp 307-313 Ramsdale, M (2006) Programmed Cell Death and ... bailii in synthetic and complex media Appl Environ Microbiol, Vol 67, pp 2123-2128 Rodrigues, F., Ludovico, P & Leão, C (2005) Sugar Metabolism in Yeasts: an Overview of Aerobic and Anaerobic

Ngày tải lên: 22/06/2014, 03:20

... inflammation, and focal degeneration of the upper respiratory tract The tracheas, bronchi, and lungs exhibited acute inflammation with epithelial degeneration, acute bronchial inflammation, and ... (morphology and size) and route of intake 2.1 Chemical form Uranium is a heavy metal that forms compounds and complexes of different varieties and solubilities The chemical action of all isotopes and ... Herein, we reviewed the toxicological data in vivo and in vitro on both natural and depleted uranium and renewed efforts to understand the intracellular metabolism of this heavy toxic metal The reader

Ngày tải lên: 22/06/2014, 03:20

... cancer, mesothelioma, bladder cancer Tan and Kelsey, 2009; Paul and Dey, 2008; Gehrke, Gandhirajan and Kreuzer, 2009 GSK-3β colorectal cancer Ge and Wang, 2010 Table 3 The common proteins ... β-catenin and activation of Wnt target genes It was hypothesized that FZD9 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or ... interaction to it, and it prevents TCF7L1/TCF3 from binding to DNA The DNA replication licensing factor proteins (MCM5 and MCM6) have interaction with each other and MCM5 also binds to MDFI and β-catenin,

Ngày tải lên: 22/06/2014, 03:20

... pathway and human cancer”, Oncol Rep., Vol 14, Issue 6, pp 1583-8 Katoh M and Katoh, M., 2003, “ Identification and characterization of human PRICKLE1 and PRICKLE2 genes as well as mouse Prickle1 and ... homologous to Drosophila tissue polarity gene prickle”, Int J Mol Med, Vol 11,pp 249-256 Klaus, A., and Birchmeier, W., 2008, “Wnt signaling and its impact on development and cancer”, Nat Rev Cancer, ... S and Dey, A., 2008, “Wnt Signaling and Cancer Development: Therapeutic Implication”, Neoplasma, Vol 55, pp 165-176 Trang 3Peifer,M and Polakis ,P., 2000,” Wnt signaling in oncogenesis and embryogenesis-a

Ngày tải lên: 22/06/2014, 03:20

... incorporation into patellar and tibial carti-lage was assessed The carticarti-lage of the patella and the tibia was isolated 3, 7, and 21 days after viral injection and incu-bated with 35SO42- ... com-promised cartilage repair Moreover, BMP-2 clearly elevated degradation of aggrecan, mediated by MMPs and ADAMTS Thus, BMP activity appears to be involved in cartilage repair and the replacement ... participated in the design and coordi-nation, and helped to draft the manuscript WvdB participated in study design and revision of the final manuscript All authors read and approved the final manuscript

Ngày tải lên: 09/08/2014, 10:21

... [1,5,7,29] and car-Proportional reduction in integral dose to normal tissues Figure 3 Proportional reduction in integral dose to normal tissues Table 2: Mean radiation dose to normal tissues Thyroid ... reduction in radiation dose to normal tissues delivered with past, current and potential future treatment, and to model the associated reduction in sec-ondary breast and lung cancer risk While the motivation ... within female breast and male lung tissue to the excess relative risk of secondary can-cer Figure 4 Estimated contribution of different doses within female breast and male lung tissue to the excess

Ngày tải lên: 09/08/2014, 10:21

... endocrine (BRENDA [6,7] gland), alimentary (BRENDA viscus), and nervous tissues that provide for a wide diversity in expression profiles In addition, muscle and fat depots from adult and juvenile steers ... the tissue libraries and characteristics of tags generated from them is found in Additional file 1 The tag data are broken out by tissue, classified according to the BRENDA tissue ontology, and ... juvenile and adult animals, and cluster C includes all 13 tissues of the ‘nervous tissue’ class These results indicate the validity of using transcript abundance to determine relatedness of tissues

Ngày tải lên: 09/08/2014, 22:23

... the heart and bone tissue BStoecker contributed to the analyses of bone microarchitecture DB contributed con-tributed to the analyses of the heart and bone tissue All authors have read and approved ... the tissue level In the present study, the LPS-induced TNF-α expression in vas-cular and bone tissue was down-regulated with IF These observations suggest the IF may aid in the resolution of inflammation ... [48] at the tissue level thus averting the det-rimental consequences of inflammation-induced bone loss and vascular changes that can lead to cardiovascular diseases Numerous pre-clinical and clinical

Ngày tải lên: 11/08/2014, 08:21

... region initiated expression of GUS and DIR1:GUS in seedlings, roots and floral tissues and in all living cells including the veins and mesophyll cells of untreated and mock-inoculated leaves This ... 6 and 12 hpi, stained and scored for GUS activity Similar results were obtained at both 6 and 12 hpi, therefore just the 12 hpi data is pre-sented in Figure 3B and 3C Mock-inoculated leaves and ... and mock-inoculated leaves in the vasculature and mesophyll cells in both the DIR1pro: GUS-11 and DIR1pro:DIR1-GUS-29 lines In contrast, less intense GUS staining was observed in inoculated and

Ngày tải lên: 11/08/2014, 11:21

... from tissues representing various tissue types (leaves, roots, stems, and floral meristems), growth stages (young seedlings, juve-nile vegetative stage, and early reproductive stages), and abiotic ... root than in other tissues such as leaf and flower [12] The genes associated with clusters E and G are mainly expressed in actively dividing (young seedling and floral meristem) tissues Products ... including providing feed and fodder for millions of dairy and beef cattle, horses, sheep, and countless wild animals [5] Turf grass production for use in golf courses and lawns is a multi-billion

Ngày tải lên: 12/08/2014, 05:20

... incubating tissues with DAB, and counted per section Preparation of primary astrocytes and microglia Media and antibiotics were purchased from Invitrogen (Carlsbad, CA, USA) Cell cultureware and Petri-dishes ... cord tissue sections The injured spinal cord tissue sections were collected at day (A,B), day 7(C,D), and day 14(E,F) after SCI, and then subjected to immunofluorescence for b-actin (red) The tissues ... brief, tissue sections were warmed and dehydrated in PBS Proteinase K was applied to the tissues followed by 3% H2O2 in methanol Terminal deoxynucleotidyl transferase (TdT) was added to the tissues...

Ngày tải lên: 10/08/2014, 05:21

... adapted from the candidate s published review: Chen CZC and Raghunath M Focus on collagen: in vitro systems to study fibrogenesis and antifibrosis —state of the art Fibrogenesis Tissue Repair 2009, ... 15 2.3 Understanding the last mile of the fibrotic pathway 16 2.4 Fibrogenesis in vitro—constraints and options 18 2.4.1 Biosynthetic issues—getting collagen made and deposited in ... Martinez s help, patience and guidance with the animal studies Special thanks to my husband and collaborator, Dr Andrew Krishna Ekaputra, who kept me smiling when times were tough, and generously shared...

Ngày tải lên: 10/09/2015, 15:52

... curves and data were normalized to the copy number of 18S RNA Expression of ACMSD isoforms in E coli pGEM-ACMSD I and pGEM-ACMSD II were digested with XhoI and Bpu1102I and cloned into pET-15b and ... swiss-pdbviewer and visual molecular dynamics [49] Acknowledgements We thank G Magni and S Ruggieri for helpful comments and suggestions and T Begley (Department of Chemistry and Chemical Biology, ... Escherichia coli and Pichia pastoris ACMSD I and II cDNAs were subcloned into pET15b and pET32b E coli expression vectors, providing the recombinant proteins with a N-terminal His6-tag, and a thioredoxin-tag,...

Ngày tải lên: 19/02/2014, 02:20

... ligand affinity between Y7 and Y2 may prove very useful for studies of ligand–receptor interactions and 3D modeling, and we have previously been able to utilize differences between chicken and ... radioligand This radioligand had iodinated tyrosines at positions 21 and 27 and a specific activity of 4000 CiÆmmol)1 Saturation experiments were carried out with serial dilutions of radioligand, and ... the tissue distribution and phylogeny of the chicken Y6 and Y7 receptors and performed the initial pharmacological characterization of the latter It is clear, from these studies, that the Y6 and...

Ngày tải lên: 19/02/2014, 07:20

... EAC and S180 cells, mice muscle, sarcoma tissue and the kidney of normal and sarcoma-bearing mice Mitochondria from EAC and S180 cells were prepared according to Moreadith and Fiskum [47] and ... in EAC and S180 cells and in sarcoma tissue indicates that the upregulated proteins are entirely tumor-cell specific On the other hand, the influx and efflux rate of creatine in both EAC and S180 ... as well as in creatine metabolism On the other hand, a high expression of GAMT had been found in the liver and pancreas and other tissues, such as the testes, epididymis and ovary, whereas the...

Ngày tải lên: 07/03/2014, 04:20

... well as repair and services However, this campaign only focussed on employers and employees in the repair and maintenance sector In particular:      Automotive body, paint and interior repair ... automotive repair and maintenance (general repair) Electrical Services (electrical services) Motor Vehicle Clutch & Brake Repair Service (clutch and brake) Radiator, Muffler & Exhaust Repair (radiator/muffler/exhaust) ... paint and interior repairs sector was the second highest, from which we received 0.72% of complaints Table 1: Complaints table Industry categories Auto electrical repair Body, paint and interior repairs...

Ngày tải lên: 16/03/2014, 12:20

... NUTRITION AND METABOLISM Nutrition and Health Adrianne Bendich, PhD, FACN, Series Editor For other titles published in this series, go to www.springer.com/series/7659 NUTRITION AND METABOLISM ... chapters Nutrition and Metabolism: Underlying Mechanisms and Clinical Consequences, edited by Christos S Mantzoros, MD is a very welcome addition to the Nutrition and Health Series and fully exemplifies ... up-to-date and authoritative review of the major scientific and clinical aspects of the overlapping areas between nutrition and metabolism I am indebted to all my colleagues, most of them scientists and...

Ngày tải lên: 22/03/2014, 19:20