A series of 4-methyl carbapenems having structural similarity to ME1036 showed potent activities against MRSA and PRSP, as well as against the gram-negative organism ampicillin-resista[r]
Trang 1KHÁNG SINH -LACTAMIN ( -LACTAM)
Azetidin = β-lactamin
Trang 3CÁC THUỐC CHÍNH
Penicillin: (PENAM)
penicillin G; penicillin V methicillin; oxacillin
ampicillin; amoxicillin;
carbenicillin; ticarcillin
Chất ức chế -lactamase: (OXAPENAM)
acid clavulanic
CARBAPENEM: imipenem
N
S O
N
O O
N O
Trang 4CÁC THUỐC CHÍNH
Cephalosporin (CEPHEM)
Thế hệ I : cephalexin; cephalothin
Thế hệ II: cefoxitin; cefaclor Thế hệ III: cefotaxime; cefoperazone; ceftriaxone Thế hệ IV : cefepime
Thế hệ V: ceftobiprole MONOBACTAM : aztreonam
N O
S
NH O
Trang 5CƠ CHẾ KHÁNG KHUẨN
Trang 6ME1036 ME1036 (CP5609; developed by Meiji Seika, licensed
by Forest) is a broad-spectrum carbapenem that binds
with a high affinity to PBP 2a of MRSA (IC50 0.13 to 0.73
g/ml) and that exhibits potent in vitro inhibitory
activity against MRSA
A series of 4-methyl carbapenems having structural similarity
to ME1036 showed potent activities against MRSA and PRSP, as
well as against the gram-negative organism ampicillin-resistant,
-lactamase-negative Haemophilus influenzae
N HO
O
CO2H S
HN
NH
Imipenem
Trang 7PZ-601 (Razupenem) PZ-601 (formerly known as SMP-
601; licensed from Dainippon Sumitomo Pharma Co., Ltd.,
Osaka, Japan) is a new carbapenem currently being developed
by Protez Pharmaceuticals (now Novartis) that has
demonstrated a high degree of potency against MRSA
N HO
O
S
HN
NH
Imipenem