Bài viết Hiệu quả điều trị trúng đích trên bệnh nhân ung thư phổi không tế bào nhỏ giai đoạn muộn có và không có đột biến gen EGFR trình bày: Liệu pháp điều trị trúng đích là một liệu pháp điều trị mới, đã được chứng minh có hiệu quả cho bệnh ung thư phổi không tế bào nhỏ, đặc biệt trên nhóm bệnh nhân có đột biến gen EGFR,.... Mời các bạn cùng tham khảo.
Trang 11 234356789
!" # $ %& %' # % ( )
* + ,- . (/0 1 2 #0 34
5 6/ ,- 5 #4 ( 7 78%
9:;<=3>=?@ABCD=6E=,?F=?AB
CD=:;?G=?AB#H#I=?JKBL?@=?6M=A
2NOPQRSTU6VW56X4YUZ2NOPQRSTU6VW5[\]^_\T`4RVW2\TW\
aUbcd\edfUgchNihNjQRfkW\lX`YhlUbcd\edfUgchNi`mUZfnfOoWW\pQR`UQ\Wq\UbcrcsW\]tbQ\cQR
h\Od\uU[\vQRhwtX]Q\xZfyWtUbhhNzQQ\q` tbQ\Q\{QWqfYhtUwQR|Q}~4R\UzQWpcQ\` feQ\
RUehlbfedpQRh]XQtY9 mUlUbcd\edfUgchNihNjQRfkW\\^UQ\q` tbQ\Q\{QcQRh\Od\uU[\vQR
hwtX]Q\xRU^Uf]TQ`cYQWq X[\vQRWqfYhtUwQR|Q}~ XfeQ\RUeh\PURU^QQRtbQ\[\vQRhUwQ
hQ9_ Xh\PURU^QQRh]XQtY9^clUbcd\edfUgchNihNjQRfkW\Q\q` tbQ\Q\{QcQRh\O d\uU[\vQRhwtX]Q\xRU^Uf]TQ`cYQWq X[\vQRWqfYhtU \Od\uU [\vQRhwtX]Q\xRU^Uf]TQfOoWfUgchNifkW\tQR|Nl]hUQUteWfiQ\fYhtUwQ}~tQR[h\ch
RUsUhNQ\hR|Q XW]NdU]Q~\UQ\QWeWfedpQRfUgchN \eQR~\UQ\Q X]eQ\_ XW^WeWQ\q` tbQ\whrcsQR\UzQWpc[\vQRR\UQ\QfOoWhNOPQR\odQX] fedpQR\]XQh]XQ^ch\eQR\]yW1h\eQRfUgchNifkW\3qc\OmQRRUs` Q\q` fYhtUwQ }~9 ] mUQ\q` fYhtUwQ}~93qWsUh\UbQWqQR\^h\QR[zWs_ XQ\q` fYhtUwQ}~9}Nl]hUQUtRUjd[]XUQRtbQ\Q\{QcQRh\Od\uU[\vQRhwtX]Q\xRU^Uf]TQ
`cYQWqfYhtUwQR|Q}~
?¡¢£:=9¤?¥¦?§> ?¨=9¤©ª@«=?¬®¯¤ª>©=9°=78%B²:¦?F¦®>³:¤CGC´=9®µ¶?
Si ^W\·l U zQ\b¸2N ¹Q{Q\eQ\Z2N cQRh {`4R\U zQWpc
~|Q_N ]h |U QZ2N OPQRSTU\VW56X4YU
}`^U l ¸ ^Q[\^Q\8`º»^\]] W]`
#¾ 6¿ #$
ĂÂĐÊÔÊƠƯÌÔỈĨÍÊÔỈỊÌÊÔÍÎÏÔÐÂÑÂÔÒÌÔỈÓÂÔÔÂĐỈÔ
ÕƠÖÌÔ×ÊÐÔỈÎØỖÎÚÂÔÛÌÔÛỊÓÂÔ×ÊÐÔỈÎØỖÎÚỘÂÏÊÔ
ÊÎÝỈÔÒÌÔÞßÔỈăÔÛĐÔỈâÔÒỊÊÐÔÞƠỊÔÊÎÝỈÔđêôÔơưìÔỉĩÂÔ
ÛÍÊÔí×ƠÊÔÐÂịƠÔÒÂĐÞÔÎìỈÔỈÎ×ĩÞÔÛíÔÒÌÔ×ÊÐÔỈÎØÔ
ÙÎÚÂÔîïÔîØðÞÔÛÌÖÔñíÊÐÔỈòôÔÊÐÌƯÔÞÌÊÐÔÊÎÂó×Ô
ÞôÔÞÎÏỖÎõÊÔỈâÔÞöƠÔí×íÔỈĨÊÎỖÎíỈÔñÂÊÎÌỖÎíỈÔ
ỈøÊÔ×ÊÐÔỈÎØỖÎÚÂÔîØðÞÔỈÖÔĨƠÔđùôÔúưìûüÔýþüÿÔ
ÞíÞÔỈĨØ0ÊÐÔÎðÙÔ×ÊÐÔỈÎØỖÎÚÂÔÛÌÔỈÎøÔ1Î2ÊÐÔỈÏÔ
ÜÌỊÔÊÎòÌÔÞ3ÊÔÛÓÂÔÛÌÔỈÎøÔỈÏỘÌỊÔÊÎòìÔ4ÎíÞÔÒÑÂÔ
ÞíÞÔ1ÎĩÂÔ×Ôî5ÞÔ1ÎíÞÌÔîÏÊÔÊƠƯÌÔÒ6ÊÔĨÝỈÔ1ÎßỖÎíỈÔ
ÎÂĐÊÔñÑÖÔ1ÎĩÂÔ×ÊÐÔỈÎØỖÎÚÂÌÔÎ7×ÔÎÏỈÔÞíÞÔ
ỈØ0ÊÐÔÎðÙÔ1ÎÂỖÎíỈÔÎÂĐÊÔîïÔĨôÂÔÒÌỊÔÐÂƠÂÔîỊÓÊÔ
ỈÏÊÔỈĨøÊÔÎỊ5ÞÔ8ÂÔÞ9Êì ÝỈÔÊÎÂó×Ô
ỈÏÊỘÔỈĨỊÊÐÔÞíÞỖÎØôÊÐÔỈÎÞÔîÂó×ÔỈĨÔÊÎØÔ ÙÎ6×ÔỈÎ×ỈÌÎßƠÔỈÔÒÌÔÓÔỈÌăÔÛĐÔñĩÊÐÔỈỊÌÊÔỈÎøÔ ñƠ×ÔÔÊ9ÖÔÞöƠỘĐÊÎÔÊÎõÊÔ×ÊÐÔỈÎØỖÎÚÂÔÒ6ÊÔ
ĨÝỈÔÎÝÙÌÔÞÎÔÝÙÔÔêÿÔđêưìÍĨỊÊÐÔÊÎịÊÐÔÊ9ÖÔ Ð7ÊÔîõƯÌÔƯÔÎÞÔîïỖÎíỈÔÎÂĐÊÔîØðÞÔÊÎÂó×ÔîÞÎÔ ÙÎõÊÔỈâỘĐÊÎÔÎÞÔỈÂóÖÔ::7Í7::ÐÔỈĨỊÊÐÔ×ÊÐÔỈÎØÔ ÙÎÚÂÌÔỈÎìÞÔîƯÔñÔĨƠÔî0ÂÔÞöƠÔÊÎịÊÐÔ8ØðÞÔ ÙÎÖỒÑÂÔÐÂìÙÔÞÔÞÎÏÔÎỊÓỈÔîÊÐÔÞöƠÔÞÎìÊÐÌÔ 1ỊÔ8ÌÂÔÎ0ÂÔÐÂƠÊÔñĩÊÐÔÒÌÔÊõÊÐÔÞƠỊÔÞÎÝỈỔðÊÐÔ ñĩÊÐÔÞöƠÔÊÐØ0ÂỘĐÊÎìÔßÔÛÌÔÞÎÝỈÔÞÔÞÎÏÔÎỊÓỈÔ
ỈÊÎÔỈƯĨỊñÂÊÔ1ÂÊƠñÔÍ4ñÔÞöƠÔỈÎÔỈÎøÔỨ×ÔỈĩÔ ÙÎíỈÔỈĨøÊỘÂø×Ồ2Ô ÌÔÙÂ8ĨÖƠÛÔÐĨỊ!ỈÎÔ
"ƠÞỈỊĨÔĨÞÙỈỊĨÔÐ#ÖÔÐ"ÂÊÂÜÔÒÌÔĨÛỊỈÂÊÂÜÌÔ îØðÞÔÐÂÔÌÔÛĐ×ỖÎíÙÔîÂó×ÔỈÔìÊÐÔîÞÎìÔÕÎÂó×Ô ÊÐÎÂÍÊÔÞ×ÔîïÔÞÎÊÐỒÂÊÎỒĩÂÔÍÊÔí×ƠÊÔÞÎ5ỈÔ ÞÎ$ÔÐÂịƠÔîỈỘÂÏÊÔÐÊÔ ÔÒÑÂỒÞÔîÔîíÙÔ ÊÐÔỈÎ×ĩÞÔÞöƠÔ1ÎĩÂÔ×ÔỈĨỊÊÐÔÛÂĐ×ỖÎíÙÔîÂó×ÔỈĨ
ỈìÊÐÔîÞÎìÔ4ÎỊ%ÊÐÔêüÔýÔúüÿỘĐÊÎÔÊÎõÊÔ×ÊÐÔ
Trang 2234356789 8
!"#$!%&'(!)!*+,!'-!./!01!*$)'!2!34,'!
56!7!85!.9:!(3'!;<=>?!@A.!01!*$)'!'+B!CD!
/:!'E'!"F,3$'!;<=>!./!A$!GH.!CI'!JK$!
LM.!0$NL!F!0P.Q!R,!0/!*S'!'T'!L'(! !
"#$!%&'(!)!*+,!'-!C:'(!01!*$)'!(3'!
;<=>! U'(!0A"!V'(!M!JK$!LM.!0$NL!F 0P.!WXY?!ZLB!'$E'Q!I$![$S!\:C!. :!./!
'$NL!'($E'!.VL!JN!$SL!]L^!.9:!G$SL!"A"!
0$NL!!_'(!0P.!E'!*S'!'T'!L'(! !"#$!
%&'(!)!*+,!'-!($:$!0,I'!CL1'?!`,!0/Q!0N!
+$!'($E'!.VL!0 a.!H.!$S'!JK$!Cb.!ELc! 5?!dA'!($A!e!GS!0A"!V'(!,+'!*1!fg>>h! JK$!0$NL!F!0P.!2!:$!'/C!*S'!'T'!L'(!
!"#$!%&'(!)!*+,!'-!($:$!0,I'!CL1'!./!
J+!%&'(!./!01!*$)'!(3'!;<=>?! 8?!dA'!($A!U$!($:'!iM'(!*S'!%&'(!)'!
j'!fk=lh!J+!U$!($:'!iM'(!,+'!*1!fglh!i:L!
0$NL!F!0P.!2!'/C!*S'!'T'!L'(! !"#$!
%&'(!)!*+,!'-!($:$!0,I'!CL1'!./!J+!%&'(!
./!01!*$)'!(3'!;<=>?!
mnopqrsptu
vmwxyz{y|}wx~|$)'!.VLQ!C&!^!
G,I!F U'(!a"Q!./!3,!R$!R.!U$!($:'!
iM'(!EC?! mnxz|}
6!*S'!'T'!L'(! !"#$!%&'(!)!*+,!
'-!($:$!0,I'![!0 a.!0$NL!F!*'(!
I$!*S'!J$E'!:,!J+!*S'!k#$!ZFL'(!
'(Q!*S'!J$S'!!ZFL'(! '(Q!*S'!J$S'!
L!\(O!J+!*S'!J$S'!I.!:$?!S'!'T'!
0 a.!.'!0,A'!4A.!0O'!RH:!J+,!%)!]L^!C&!
*S'!.!J+!%&'(!C.!L'(! !'+,!%A.?!
@A.!CL!C&!L'(! !"#$!0_.!F,'(!":F:$'Q!
0 a.!G+C!4 !'($SC!¡C!01!*$)'!(3'!;<=>!
I$!FL'(!TC!'($E'!.VL!<3'!7!kF,3$'Q!
ZF U'(!dI$!.!¢!+!\1$?
£mw¤|}¥w¦¥
ZL!§"!.A.!&'(!'!JN!GTC!i+'(!J+!.§'!
GTC!i+'(¨.9:!*S'!'T'c!'!I'(!,+'!T'Q!
SL!.V'(!GTC!i+'(Q!%P.! K.!LQ!I.Q!.A.!
#'! '(!R$!.©'!RH:!FE'!%AC!GTC!i+'(Q! A.!4 !'($SC!.§'!GTC!i+'(!J+!¡'!^'!.?!
ª$!*S'!'T'!i«!0 a.!3,!R$!R.!F,'(! iLM!U$!($:'!0$NL!Q*!0¬L!!G_.!)"!'§'! 0$NL!!0P.!.,!0)'!%$!®!J,'(Q!C¯!3,!R$!
,°.!%)!_.!'($E'!.VL?!
$SL!"A"!0$NL!F!F_'(!0P.!(±C!R a.! ¯!!5XC(J$E'Q!R²'(!0 U'(!LM'(!5! J$E''(+BQ!E'!b.!Cª$!'(+B!.,!0)'!%$!*S'! 'T'!./!R¯L!$SL!$)'!Fj'!*S'Q!4L¯!$S'! 01.!P'!%&'(!.¯"!'§'!0 a.Q!4$'!F:!%-$! '($E'!.VL!,°.!®!J,'(?!
S'!'T'!0 a.!.$:!+'!8!'/C!3,!
'!FI'(!01!*$)'!(3'!;<=>c!'/C!./!01!
*$)'!f;<=>!f³hh!J+!'/C!%&'(!./!01!*$)'!
f;<=>!fh?d1!*$)'!(3'!;<=>!0 a.!4A.!0O'!
*'(!%´!L§!($^$!F'!H!(3'!J+!%´!L§! l.,F"$,'!µ>l!JK$!01!'IB!G¬'!G a!G+!¶·!
W¸Y!J+!5·!W¹Y!J+!01!0°.!$SL!G+!5·!.,!.^!8!
%´!L§?
ZF,'(!]LA!'!3,!R$!0$NL!Q*S'!'T'! i«!0 a.c!
dA'!($A!0A"!V'(!,+'!FI'(!fRH:!FE'!! '§'!0O'!.9:!*A.!i´!0$NL!F!3,!.º!iM!
:F',i%B!i:L!!¶!A'(Q!¸!A'(!f*^'(!5h? dA"!V'(!,+'!FI'(!0 a.!0A'!($A!+'!8! CV.c!#'!0O'©'(!f.º!iM!:F',i%B!($! '(LBE'!,°.!©'(!GE'!i:L!U$!($:'!0$NL!hJ+! ($^C!f.º!iM!:F',i%B!($^C!i:L!U$!($:'! 0$NL!h
dA'!($A!0A"!V'(!H.!j!3,!EL!.L'!
>;@lZ!W6Y!i:L!¶!J+!¸!A'(!f*^'(!8h?Ze!GS! 0A"!V'(!,+'!*1!fg>>Q!gJ3F:GG!>3i",'i3!
>:3h!0 a.!P'!*'(!#'(!.9:!e!GS!0A"!V'(!
,+'!,+'!f@>h!J+!e!GS!0A"!V'(!C1!"¬'!
fk>h?
<$!'§'!U$!($:'!iM'(!*S'!%&'(!$)'!
j'!fk=lQ!kF,(F3ii$J37=F33!lLFJ$J:GhA'(hc
Trang 31 234356178
!"#$%"!&"'()"!*+,"-./-"#*0%"!1"#3).").4"#+-"
5.*"6-.")7"89%".*6%"!*+-"!1:-;"6-."-.<-"!="
>4-?">@"9!"5A"-?%BC-"-.<-"-D4;")7"!.E-?"!*-"
)%F*")G-?"!4-?"!HI-?".J,"K9!".L4"8M*".4N)"
5+!".()"-?.*C-")O%P"
Q.*"-./-"!.I*"?*R-"SF-?"!.CK"!4D-"T"UVWX" V>L1R''"W%1>*>R'Y"U!.Z-?YX" !"#$%"!&"'()"!*+," -./-"#*0%"!1"#3).").4"#+-"5.*"6-."-.<-"!="
>4-?;")7"!.E-?"!-")%F*")G-?"!4-?"!HI-?".J," K9!".L4"8M*".4N)"5+!".()"-?.*C-")O%P"
[\]^_`ab]c^dbefg]ehi]^ecjfkclmnoph]fqmrs
z{{| }.E-?")7"!6%").O-?"1M"1D-?")~R"6-.;"5.Ă"--?".4Â!"#T-?"KÂ-.
{| }.Ă"--?".4Â!"#T-?"@-."!.HI-?;"*6%").O-?"6-."!F*".*:%
Ê{| }.Ă"--?".4Â!"#T-?"@-."!.HI-?"-.H-?",.Ă*")F"? -?P"Ô7"KN!")~R"!6%").O-?"6-. Ơ{| }.E-?")7"5.Ă"--?".4Â!"#T-?"@-."!.HI-?".4N)"'DK">*6)"-.H-?")-"!Ư",.)">"!F*"
!.*:%"#HJ)
{| Ô$-")7"SƯ"?*(,"#À")$-"!.*+!">D"#HJ)").K"S7)"B"!+
{| Ô$-")7"SƯ"!J"?*(,"19!"-">D"#HJ)").K"S7)"B"!+"!.HI-?"%BC-
{| }.E-?"!Ư",.)">"!F*".*:%;")$-")7"SƯ"!J"?*(,"'C-"!)">D"#HJ)").K"S7)"#N)"*C!
{| *6!"?*HI-?;"-K">*6-"-.H-?").HR")7"-?%B")"!=">4-?
{| 6-."-N-?").K"S7)"#N)"*6!""6-.">*6-
z{| Ả9,".F*
{| =">4-?
[\]^Đ`dÃkcÃ]xb]c^dbxbw]^eckectcjfăÁâđêôơ
cẶ]^mnxb]c^db
dÃkcÃ]xb]c^dbxbw]^eckect
[ư]cxb
w]^cfg]
efg]ăơ
[ư]cxbw]^
uyecẨ]ăơ
[ư]c]^Ẫ]^
eà]ehdt]âẬơ
[ư]ceà]ehdt]
Ậơ
ÈHI-?"53-."'-"
-.9!")~R"5.F*"%"!C-""
Ô".4N)"ẺẼÉ"-?Ư)
}.F*"%"#3)."
*+-"K9!
Q*ĂK"°"{|"S4"
>*"H)"#*0%"!
Q*ĂK"Ẹ"{|"
.4N)"!-?""
Ẹ"{|
-?"°"{|"S4"
>*"H)"#*0%"!
ỀỂ-?"#T").9!").Ễ"
#*:K"%-?"!.H"UÔẾảY
1">0"@-."
!.HI-?
}.E-?"!-?"U-.H-?").HR"!">0"
-?HÀ-?"@-."!.HI-?Y *+,"!)"!-?
·-"!.H-?""
!.O",.Z!
*+-"K9!"
.4D-"!4D-
Ể-"!Â*"8R*"8Ì-?"-.H-?"5.E-?"%9!"
.*6-"!.CK"!·-"!.H-?"K*
Ỉ%9!".*6-"!.CK" KT!".4N)"-.*0%"
!·-"!.H-?"K*
Trang 4234356789
!"#$"%&#'()#*+#,)#-./0#.10#23& #45&$#
6 7&$#6 86#9%6:%&#;<="=>?)@#A 80#4"B2#*C#
2 !"#$"%&#'()#*+#,)#0D%#080#& EF#GH#-./0#
6 I #45&$#2=G2#J$#>%&A#*1"#6#K#LMLN#-./0#
O=F#:+#0E#P#&$ Q%#2 R&$#AS?# TUV WXYZ[\]^Z YX_`a$ "S�bc#2cI&#
2 D#-de#-D#080#&$ceSf0#-gJ#-b0#2>J&$#
&$ "S�bc#e# h0#-./0#ij"#-k&$#-gJ#-b0#
2J&$#&$ "S�bc#e#G"& #>.!&$#lg"# h0#m#i+#
aj"#6 S#nceB2?
opqrs
t#2 8&$#LuvwLxx#-y 8&$#LzvwLx{#-|#
0E#2}&$#0j&$#~L#4B& #& It#Lz#4B& #*"B&#
2 %#F|"Sc#0 c� h&#Fc#-./0#& &#
*+J#&$ "S�bc?#l0#-"F#0D%#080#4B& #& I&# -./0#2& #4+e#2J&$#4&$#{?#E#{#4B& #& I&# -./0#O80#-& #0E#-j2#4"y&#$=&#(#2>J&$#
A R"#c#*+#zz#4B& #& I&#A &$#0E#-j2#4"y&#$=&#
&+e#4&$#z?#lj#2c}"#2>c&$#4 & #0 c&$#:+#
wM##xwMw?##:B# 6# 7&#&%F##0#w#
& EF#0E#*+#A &$#0E#-j2#4"y&#(?#9 &$# 2# cR0# J0#-|#&$.&$# 2# cR0##xL#&F#
0 "yF#2#:B#0%J# 7&##0#w#& EF#0E#:H#nJ#-%# GR#080#4B& #& I&#-|#0%J#2c}"?#<#4B& # h0#
A R"#c#0D%#22#0#4B& #& I&#-Cc#:+#ng&$#c&$#
2 #4"c#F#2cey&?
Z[oTYW] ¡¢Z[Y£¤¥_¦Z§\Z[\]^ZYX_
TYW]¨ \_Z[©Zª«¬¨ \® ¯°±©©Zª³¨² \® ¯°±©©Zªµµ¨´
_¶]#&F¨ wM##xwMw¨ #¨ #
]·]§¸Z\#&#¹¨
##a%F¨ zN#NMw¹¨ xu#NwM~¹¨ w#NuMx¹¨
##a¨ {N#z{M~¹¨ x#zMw¹¨ x~#zLMu¹¨
]ºZ¡»\¼§§\_½Y&#¹¨
##i2¨ wN#{xM{¹¨ ~#wwMw¹¨ x#{~M¹¨
##9 &$# 2# J0# -|#
&$.&$##xL#&F¨ NN#~M¹¨ w~#M~¹¨ w#xMz¹¨
¾¿ÀÁÂZ\\ÃY#&#¹¨
##%>0"&JF#2cey&¨ ~L#xLL¹¨ {#xLL¹¨ zz#xLL¹¨
##%>0"&JF#2y#4+J#:1&¨ L¨ L¨ L¨
#:B#-j2#4"y&#$=&#(#2>J&$#Äcd #&$ "S�bc#:+#zN¹#{v~LM#2>J&$#-E#0 D#eyc#:+#-j2# 4"y&#ÅÆ#-j2#4"y&#OE%#-Jg&#-"&# & #A &$#:+F#:B0 #A c&$#n0 #F|##=OJ&#xu#0 "yF#NNM¹#
*+#-j2#4"y&#-"F#Å~N~##=OJ&#wx#0 "yF#{~Mu¹?#a$J+"#>%#0Ç 82# "B&#Fj2#GR#-j2#4"y�E#
&$ Q%#A 80#*1"##:B#2 6# 7&#& #-j2#4"y&#-"F#xu)##=OJ&#x~#wM~¹#*+#-j2#4"y&#OE%#-Jg&#
A &$#-"&# & ##=OJ&#xu#wM~¹?#9 &$#6 82# "B>.!&$# /6#&+J#F%&$#-j2#4"y&#$Ie#A 8&$#
9ÈG#4&$#z?
Trang 5
!"#$%&'() *+,-.!/-0'12&!"3!456
7!/'89!"-0'12&! 4*:!-0'12&! ;<=>?!"@!">A2CD
EFGHIJKLHefgHhijLHklmLnHhJoLHlpLl _` _U[\HQabVYS
EqJHrsJHhtuHvLnHGlwxHGlobHLnlJyLHxvzH
klmLnHnlJHLl{LHh|}xHG~|LnHl}uHLiHhtuH
vLnHliLHGiLHgzH[HGltLnHlixH\HGltLnHhJzH
GHh xlHfHezHl|sLnHnJHGHHhtuHvLnHGiLH
IFHPPHHLlfHhFGHIJKLHMNOPHQRHiHrsJH
LlfHhFGHIJKLHMNOPHQZSHPPHgzHW[HGltLnH
rHW\HGltLnHHLlfHhFGHIJKLHMNOPHQZSHLH
|}GHH[[b[[YHrHaWYHiHrsJHLlfHhFGHIJKLH
MNOPHQRHHaXYHrHXYHQILnHXSHzHLlJyLbH
wHxlyLlHxlHLHklmLnHxfHHLnlgHGlqLnHkyH
:92-+!"
;)'/+!" ;)'/+!"
456BDLHH[\S 456BLHHTTS 456BDLHHaWS 456BDLHHaWS
P _aU[\HQ[[b[[YS UTTHQaXYS WTUaWHQaWYS W_UaWHQXYS
d _XU[\HQT_b\cYS _TUTTHQ[_bVaYS _TUaWHQcWYS _TUaWHQcWYS
W`U[\HQaXYS _`UTTHQT[b_VYS WaUaWHQ_WYS WXUaWHQaXYS
PPHHPHZHP
H
_aU[\HQ[[b[[YS UTTHQaXYS TUaWHQaWYS _UaWHQXYS PPHH_b[[¡H`XY¢HWb\_H£Hab_a PPHHT¡H`XY¢HR_bTV\H£H_Tbc[
QPHhtuHvLnHliLHGiL¡HPHhtuHvLnHFGHulL¡Hd HILlH¤LHhLl¡H HILlHGKLHGoL¡HPPH htuHvLnHGiLHIFS
HxHaHGlJHhJoHgzHhJzHGHLyzHGyLHQ[HGltLnH PPHH_b[[¡H`XY¢Wb\_HRab_aHrH\HGltLnHPPH
HT¡H`XY¢HR_bT`HRH_Tbc[SH¥yLHxjLlHhfbHnlJH Ll{LHxtxHhtuHvLnHGiLHG~jLnHx¦gHILlHLl§LH xliHGl¨Hxl©HqHªg~Li«kH¤LHhLlUG¬LnHgzHW[H
GltLnHrHW\HGltLnHhJzHG~HHLlfHhFGHIJKLH MNOPHQZSHLH|}GHH\`bTTYHrHVWYHiHrsJH LlfHhFGHIJKLHMNOPHQRHHXabacYHrHTWYbH xliHGl¨HxlJzHl|sLnHxJHGlJLHGiLHG~jLnHrH xHL¬LnHGqGHlLHHLlfHxfHhFGHIJKLHMNOPHQZS
!"®$¯=°,+,-+!"'/±,'/²B/3:64;D
Trang 6234356789
!"#$%&'(')(*+ !,- ,/0 !1,23-'245678/ -95:;<
=
>-0?)(*+ !=
CDE1F<GHIJIKLM= CDE1N<GHIJIOOM= CDE1F<GHIJIPQM= CDE1N<GHIJIPQM= RHISTHUVWXHY= PZVKLIGL[\OO]M= PKVOOIGZP\P^]M= _LVPQIG`Q]M= Q`VPQIGOQ]M=
abcd= VKLIGKQ\ZL]M= P_VOOIGO^\PK]M= QOVPQIGPQ]M= _PVPQIGLQ]M=
efbIghbIUibIYbjHIkfHYIWUld\ImnIkoImcbIUbpHImnIqIHYUrjIWUfHYIslItImcIuvwIgxIywItIHUndISzWI {b|HI}av~IGMHYIgTIuvwItIHUndISzWI{b|HI}av~IGMIkIghbIHUndISzWI{b|HI}av~IGMHIWI
xI^\ZIWUHYIgxIO\PZIWUHYIGIJIQ\Q_ZMHYIWo\IHYIgTIywItIHUndISzWI{b|HI}av~IGMIkIghbI HUndISzWI{b|HI}av~IIMHIWIxI_KIWUHYIgxI`IWUHYIGIJIQ\QO_MI{cHYI^M
!#2?!?8 56 !D@.@ 2 & 2 2
/A != 2 CDE1F<= 2 CDE1N<= = uvwIGUHYMI
IHIJI`QMI ^\Z= O\PZ=
~IJIP\P_IG[Z]IJ_\_^IIO\_`M
IJIQ\Q_Z=
ywIGUHYMI
~IJI_\LKIG[Z]IJI_\QLI P\^LM
IJIQ\QO_=
?A)#?A)78*%8 N 3?3/,22?& ,2?!?8 56 !,2¡ ,- ¢1@<
.,2?!?8 56 !& 2:2£ !,?¤ ,/? 1D@<'¥8 2 & 2 2 '.:2£ !'
)¢,?¤ !3 CDE
Trang 7
!" #$
%&'()*+,)-&./(0)123)4(0)-1.)3156)718(0)
-9):;<)(1=)716)>.2?)31@-)16A()>B)C)06D6)><E()
-9()FD)GHIJHKLM)(0./6):A(1)718(0)?N()71O)
(P(0)31Q4)-14R-M?N()SA4)31@3)1TD)-)?5)>6V()
79-)123)1D6)-14W?)G3SD-6(4X)Y;)Z<?[-DF[SL)>B)
>E-)>9()\-](^)?_D)16A4)`4O)>6a4)-&)Yb6)-c)SA)
dW(0)e)(PX)S;)ff,)Y;)g)(PX)S;)ee,)hijk
%&<(0):W6)?O(1)>TM[&S<-6(6:)Y;)0[l6(6:)>B)?1<)
-1mn)16A4)`4O)Y.2-)o6)d<)Yb6)1TD)?1m-)&4na()
-1W(0)>p?):6A-)-&'()(1TX):A(1)(1q()?T)>o-)
:69()0[()rstuv)w6A4)`4O)(;n)>B)>.2?)?1x(0)
X6(1)`4D)(16a4)31q()-y?1)1z6)?x4)Y;)-1{)
(016AX)SqX)d;(0)he+|)eejv)}016'()?x4)(;n)
-1[<)Z~6)+):A(1)(1q()4(0)-1.)3156)718(0)-9)
:;<)(1=)06D6)><E()X4o()-E6)K6A-)}DX)>.2?)
>6a4)-&)>y?1):(0)[&S<-6(6:M)-&<(0)>T)?T)f)
:A(1)(1q()?T)>o-):69()rstu)(1En)?OX)Yb6)
%HdM)?1<)?@?)79-)`4O))31)123)Yb6)?@?):@<)
?@<)-.b?)-'()-19)06b6v
@3)x(0)?_D)(0./6):A(1)>W6)Yb6)A4)31@3)
>6a4)-U& (0)>y?1)>.2?)-1[<)Z~6)<(0))-1@(0M)
0zX)>@3)x(0)-1?)-1V)G-1[<)urH%L)Y;)>@3)
x(0)-<;()-E(0)G1[<)?1)dW)D&(<ld76L}016'()
?x4)016)(1R()>.2?)F4)1.b(0)06OX)-c)SA)>@3)
x(0)-<;():o)uu)C)(1TX)>o-):69()rstu)G)
d<)Yb6)(1TX)>o-):69()rstu)GL)uu)dD4)+f)
-1@(0)Y;)+)-1@(0)C)(1TX)>o-):69()rstu)GL)
S]()S.2-)S;)ffMff,)Y;)g+,)d<)Yb6)(1TX)>o-)
:69()rstu)G)S;)g,)Y;),v)%4n)(16'(M)d)
?1'(1)SA?1)(;n)718(0)?T))(01D)-1W(0)7')?T)
-1V)Z<):A(1)>B)Y;<)06D6)><E()?4W6M7y?1)-1.b?)
71W6)4)>B)Sb()Y;)?1<)Z6)?P()('()-c)SA)>@3)x(0)
1<;()-<;()Y;)Xo-)31]()718(0)?D<)Y;)718(0)
Y.2-)-&o6)&~)&A-)C)(1TX)?T)>o-):69()G:O(0)Lv
16)F-)>@3)x(0)-<;()-&E(0M)-c)SA)5()>U(1J-P(0)
?1)dW)D&(<ld76)C)(1TX)>o-):69()rstu)GL)
>a4)?D<)1()(1TX)718(0)>o-):69()C)?O)-1/6)
>6VX)f)-1@(0)Y;))-1@(0)G-c)SA)S]()S.2-)S;)
iM,)Y;)+,)d<)Yb6)gMg*,)Y;)+,L)?1<)
-1mn)(1TX):A(1)(1q()?T)>o-):69()>.2?)
1.C(0)S26))d)?O6)16A()-<;()-E(0)(16a4)1() (1TX)718(0)>o-):69(v)
W6)Yb6)-1/6)06D()dW(0)-1'XM)?T)d)?O6)
-16A()?T))(01D)-1W(0)7')C)?O)t)Y;))C) (1TX)>o-):69()rstu)GLv)%&4(0)YU)t)C) (1TX)>o-):69()rstu)GL)d<)Yb6)(1TX)>o-):69() rstu)G)S]()S.2-)S;)*M)-1@(0)Y;)Mg)-1@(0)
G3))+M+eL|)-&4(0)YU))C)(1TX)>o-):69() rstu)GL)d<)Yb6)(1TX)>o-):69()rstu)))]()
S.2-)S;)ef)-1@(0)Y;))-1@(0)G3))+M+eLv)9-)
`4O)(;n)?1<)-1mn)d)16A()Z6A()?_D)>o-):69() 0[()rstu)06 3)7<)Z;6)-1/6)06D()dW(0)?1<) (1TX):A(1)(1q()Z(0)S6A4)31@3)>6a4)-) (0)
>y?1M)1<;()-<;()31)123)Yb6)79-)`4O)?_D)-1{) (016AX)sI)hegjv)%4n)(16'(M)-&4(0)YU)t) Y;))-&<(0)(016'()?x4)>a4)(0()1()-&<(0)
-1{)(016AX)Is)GS]()S.2-)S;)*M)-1@(0)Y;) ef)-1@(0)d<)Yb6)eMe)-1@(0)Y;)feMf)-1@(0LMZ)
-'4)?14()?1()XQ4)>a4)S;)4(0)-1.)3156) 718(0)-9):;<)(1=)06D6)><E()HHIJHKv)}04n'() (1q()?T)S)Z<)(016'()?x4)?1.D)31q()>U(1)SA4) 31@3)>6a4)-&)-& (0)>y?1):.b?)e)1<p?):.b?)gM)
-<(0)716)1{)(016AX)Is)?1)?1()31@?)>z) [&S<-6(6:):.b?)e)-&'():A(1)(1q()718(0)1 -)
-14W?)S@M)YW()S;)>W6)-.2(0)(1En)?OX)Yb6)S6A4) 31@3)>6a4)-&)-& (0)>y?1)1(v)qn)S;)Ym()>a)
?1.D)06O6)`4n9-)>.2?)?_D)(016'()?x4)d<) d@(1)16A4)`4O)S6A4)31@3)>6a4)-&)-& (0)>y?1) :.b?)e)1<p?):.b?)g)-'()1D6)(1TX):A(1)(1q() 4(0)-1.)3156)718(0)-9):;<)(1=)06D6)><E()?4W6)
?T)Y;)718(0)?T)>o-):69()0[()rstuv)%4n) (16'(M)Z<)-1?)-9)>6a4)-)4(0)-1.)(T6)?14(0)Y;) 4(0)-1.)3156)718(0)-9):;<)(1=)(T6)&6'(0)-E6) K6A-)}DX)?N()(16a4)-&D(1)?B6M)(1m-)S;)>x(0)
-.b?)Xo-)S6A4)31@3)>6a4)-&)-& (0)>y?1)XD(0)
SE6)16A4)`4O)(1.(0)?N()Xb6)XM)Xo-):o)31R() :A(1)(1q()YQ()31O6)?1U4)0@(1)(p(0)76(1)-9)716)
-1[<)>456)S6A4)31@3)>6a4)-&)(;nM)('()Y6A?)SD)
?1():A(1)(1q()?1<)?@?)(016'()?x4)>@(1)06@)
SA4)31@3)>6a4)-&)-& (0)>y?1)?N()&m-)71T)71P(v)
%&<(0)-.(0)SD6)0](M)716)S6A4)31@3)>6a4)-&
Trang 8234356789
!"#$%&'($'()$*"#$(+$,(-.$/(0"#$1$23)$"(4$
,(-$2.1"$(5"$"67$8.$9.:$;7<=$"#(.>"$'?*$'@$
(A$,(B$.A"$%A$#.C.$D*E1$FG"$%H$>"$FI.$JK$
L+M"#$<N*$LI"$(5"=$%A$'()$'B'$/1$D*C$'@$O$
"#(P7$(5"$FH$<Q$(K"#$/>$F3$%+7$ 7$%+M'$
'B'$/1$L*R"$'(&"($SB'$'()$T"#$"(@<$2:"($
"(U"$*"#$(+$,(-.$/(0"#$1$23)$"(4$V%W$2.1"X /(0"#$%W$2.1"$YZ[\=$(!$(*K'X/(0"#$(!$
(*K'=$#.7.$%)8"$JI<X<*W"=$%.H*$$%&'($2+I'$
^X2+I'$_``` bcdefg
h*E$'(+7$SB'$%]"($%+M'$Ji$'C.$(.:"$j$L:$
%B,$?"#$)3"$2W$J7*$k$F3$l$(B"#$%.H*$
"(+"#$%.H*$$%&'($2m"#$n L).".2$%o$/p)$q3.$
%+M'$(r.$#.7"$JK"#$2:"($/(0"#$.1"$A"$F3$
(r.$#.7"$JK"#$(><$)3"$2W$s$"(@<$2:"($
"(U"$*"#$(+$,(-.$/(0"#$1$23)$"(4$#.7.$%)8"$
<*W"$'@$%W$2.1"$#n"$YZ[\`$
ftuvwx yz
;#(.>"$'?*$%+M'$({$M$/."($,(&$2s.$|H$3.$ 'G,$"(3$"+I'$};#(.>"$'?*$SB'$%]"($%W$2.1"$
#n"$D*E1$%]"($&"($%B,$?"#$(*K'$)"#$%.H*$
$*"#$(+$%8.$i'$B"#$F3$*"#$(+$,(-.~
;(@<$"#(.>"$'?*$U"$Ă"#$'C<$5"$Ji$#.!,$
%$'Â7$'B'$'B"$2W$F3$%"#$"#(.:,$8.$h *"#$
U<$;#(.>"$'?*$Zn"$ÊÔ )n."$F3$2W$<0"$Ơ@7$
J."($Êh +r"#$|8.$(Ă'$$Ơ3$;W.$'Ư"#$"(+$'B'$
2B'$J$8.$/()7$"#$2+I*$2:"($F.:"$Ơ6*$
;#(]=$À8'($7.=$$h *"#$+5"#$F3$2:"($F.:"$
7)$,(-.$h *"#$+5"#`$
f d
cẢxĐÃăÁẢâĐđêôơc
ZL)27L$'7"'n $J7.J.'J`$3Ặ3ưẨẪàẬÈ3ẺẼẨÉ$°
đêơlẸ$ÊẸỀ`$
êcỂỄẾzảỂ·zảfÌỈzảãzfÌ
ãÍuỂỊyzảb½Ể¾ảỄÒâázỂđêôạơc
hằ"($(ằ"($ẳ$F)"#$q)$*"#$(+$8.$Ơ3$;W.$F3$
h(B.$;#*E>"=$_ỀỀẵ$Ê_ỀỀắ`$2ặầẪẩẫ2ẩấẨậ2ẼẨ
5èẻẽẪÉ$é=$ẵỀ$ÊẵÐ`$
ạcẹâã ẹỂxẢề ểẹễă
uzzể đêôôếơcệ$7"JL7.)"7L$F.nỨ$)ì$(n$
<)Ln'*L7 $,7()#n"nJ.J$)ì$L*"#$'7"'n `È 2ẩỉẬưẪĩẨẪỉẺÉê=$k_í$ÊkÐk`$
écuềâỄịãfễăđêôôêơc Ý<)/."#$<)Ln'*L7 $q7<7#n$."$2 )"'(.7L$ n,.(nL.*<`$ĩẨẪỉậàẨàÉê=$í_Ẹắ$ÊíkỀl`$ Þcã uĐẢb đêôôÞơc$Y,.qn <7L$
# )Ứ($ì7') $ n'n,) $<*7.)"J=$J<7LL
<)Ln'*Ln$/."7Jn$."(.2.) J=$7"q$")"ÊJ<7LL'nLL
L*"#$'7"'n ò$'* n"$/")ỨLnq#n$7"q$ì** n$
q.n'.)"J`$È3ẺẼẨĩẨẪỉẺ=êạđơ_ẵẵl$Ê_ẵlắ`$
°cểzỏỂẢcÃczăểzuẢĐcđêôô°ơcệ$
ÀL))qÊÀ7Jnq$hnJ$ì) $Y,.qn <7L$Z )Ứ($[7'Ê
) $\n'n,) $*7.)"J$."$*"#$õ7"'n `$3ẺẼẨ 3ưẨẪàẬóàọ`=êkắíẵ$Êkắíí`$
ếcÁồ ồ duâ zăịããổ đêôôơc
ỨỨỨ`D.7#n"`')<$
ỗcỂẢềềẢcịỄvổẹccẢâĐđêôôôơc
;nỨ$#*.qnL."nJ$)$nF7L*7n$(n$ nJ,)"Jn$)$
n7<n"$"$J)L.q$*<) J`$Y* ),n7"$ố #7".ộ7Ê
)"$ì) $\nJn7 '($7"q$h n7<n"$)ì$õ7"'n =
;7.)"7L$õ7"'n $ờ"J.*n$)ì$(n$".nq$Ý7nJ=$
;7.)"7L$õ7"'n $ờ"J.*n$)ì$õ7"7q7`$È4ưởẺ 3ưẨẪàẬẨọở=ớê=$_Ềẵ$Ê_^l`$
ớcẹvỂuĐẢợuzảâãzểÃẢĐzu ùủĐđêôôêơc$õ)<,7 J)"$)ì$ì)* $'(n<)(n Ê 7,E$n#.<n"J$ì) $7qF7"'nq$")"ÊJ<7LL'nLL*"#$ '7"'n `4ðẨậẺÈũàú=$ạé°Ẹ_$ÊẸắ`$
ôcãổcẹcỄcfcỂãzảỏềẢâẹc
ẢâĐđêôôớơcZnì.".2$) $õ7 2),L7."ÊÔ7'L.7SnL$ "$Ô*L<)"7 E$ệqn")'7 '.")<7`$4ðẨậÈũàú=$ ạ°đôơẸÐí$ÊẸẵắ`$
cuâềỄăãxuãuâẹâẢịẢẢâ
Đ đêôôơc Znì.".2$Fn J*J$'.J,L7."$,L*J$ q)'n7SnL$."$,7.n"J$Ứ.($")"ÊJ<7LL$'nLL$L*"#$ '7"'n $(7 2)* "#$<*7.)"J$)ì$(n$n,.qn <7L$
# )Ứ($ì7') $ n'n,) $VụừhốZkÐỀẵaò$ệ"$ ),n"$L72nL=$ 7"q)<.ộnq$,(7Jn$k$7L`$ửưẨẪàở ĩẨẪỉẺ=$^_^$Ê^_ắ`$
Trang 9
!"#$$%!&!'(#$)*!%+#,- /!
12345678940:;2<90=>?72@05A0B?@5C737D02@53905?0
E7C;0F2?D5G@2C7302340:2H@72I9@030G2C793C<0E;50
JKLL#MN
0
>2?Y9C940C;9?2GZ07<02309AA9HC7[9069C;540A5?092C693C05A0353\<62@@H9@@]3Y0H23H9?0_`FaFbc d5E9[9?e0C;90?9<G53<90E2<049653<C?2C94053@Z0730Bfg1\6]C2C940_`FaF0G2C793C<c0hDi9HC7[9<5A0
C;90<C]4Z0E9?90C502<<9<<0C;905[9?2@@0?9<G53<90?2C90^h11b0A5?0C;90C2?Y9C940C;9?2GZ0730Bfg10\ 6]C2C94023403530Bfg10\6]C2C94024[23H940_`FaF0G2C793C<e0jb0F56G2?73Y0C;90G?5Y?9<<7[9\A990
<]?[7[2@0^:g`b02340C;905[9?2@@0<]?[7[2@0^h`b02AC9?0C;90C2?Y9C940C;9?2GZ05A0C;9<90CE50Y?5]G<05A0 G2C793C<c0kl0Y9A737D05?09?@5C737D0\0C?92C940<C2Y90==mn=o0_`FaF0G2C793C<0E9?90<9@9HC940A5?0C;7<0
<C]4Zp0=493C7Z06]C2C7530DZ0<9q]93H73Y02340`H5?G753<0r1s`0C9H;37q]9<p0hD<9?[90C;90?9<G53<90 5A0C;90C2?Y9C940C?92C693C02AC9?0t02340u0653C;<p0H56G2?90C;90:g`02340h`05A0C;90<]DY?5]G<c0350 H56G@9C90?9<G53<90E2<05D<9?[9402AC9?0t02340u0653C;<05A0C2?Y9C940C?92C693Cc0h110C934<0C50 49H?92<907303530Bfg10\06]C2C940Y?5]G0H56G2?940E7C;0Bfg10\06]C2C940Y?5]Gc0>;9?90E2<020
<C2C7<C7H2@@Z0<7Y37AH23C076G?5[9693C0730D5C;0:g`02340h`05A0Bfg10\06]C2C940Y?5]Gc0f9A737D05?0 9?@5C737D0H230G?5@53Y0C;90<]?[7[2@05A0;9024[23H940_`FaF0G2C793C<0;2?D5?73Y0Bfg106]C2C753<c0 v%NwxMyz{$x$zL#,,|%,,K$)|#$|%M}OPRLK+#+~x$}#M)%+%y+%M#N
E9?9039[9?05?0@7Y;C0A5?69?0<659?<0E7C;0 24[23H940 @]3Y0 24935H2?H735620 Framf0 tllu0>?72@c4 .e00\c0