Nghiên cứu nhằm mô tả các thể lâm sàng theo Y học cổ truyền trên bệnh nhân ung thư vú giai đoạn I, II, IIIA đang điều trị phác đồ AC tại bệnh viện K từ tháng 10/2010 đến tháng 8/2011 và đánh giá tác dụng hỗ trợ điều trị của bài thuốc cổ phương “Thập toàn đại bổ” trên bệnh nhân ung thư vú giai đoạn I, II,IIIA đang điều trị phác đồ AC thuộc thể khí huyết lưỡng hư,... Mời các bạn cùng tham khảo.
Trang 1! " # $% & $' () *+ ,
- .+ " */ $ *0 1 2 34
") " # $% "5 )
6789:;<*=>;;?@AB6789:;CD>EFGHBIJ:;<;7IK:6H
1LMNOPQMNR7S5TQU3VWXNYZ[QO\]67S5TQ 5YOQ^N]_`NOabbcde]f]dOghibjSNYdOkl6O\]]mdV`noNdV^NpMNONOiN`NYdOWPqYQrQsl[NtUtt
tusrNYsQo`dVvwOf]sxu4d[QpMNOPQMNRdydOfNY12z OfNY8z fdf]|}NYO~dV
sQo`dVv]rpSQdO`]]mwOWNY3OwdlSNs[Qpm dV^NpMNONOiN`NYdOWPqYQrQsl[NtUtttusrNYsQo`dV wOf]sxu4dO`T]dOgOO`n{dhWNYOWLMNONOiNdOgOO`n{dhWNYOWYQrQsl[Nt
O[]ONf]O]OQ{b dhM]rlNOdZT]dNONcNU]OfNNUr]Oen]rNOb NYOQ^N]_`dOwON]NYOr
dONY^9w2U2 ZT]dNOp`xNNcNdOwONNOWNYOcNY]NYOrdONY^9w2U2 ZT]dNOO[ p[]O]`U7kblYhlpQNdNYu3Uu3]rNOb NYOQ^N]_`dOwON]NYOrdONY^9w2U2 ZT]
dNOdV^NdON]r]eOrQNObO`NOWOcNY]LSQdO`]3OwdlSNs[Qpm]df]|}NYsQo`dVvO~dVhSb
YQebbTdjsT]dNO]rwOf]sxu4dV^NpMNONOiN`NYdOWPqYQrQsl[NtUttUttu
;K:6;CB; >¡¢;K>;£B¤¥F;7¦>;§@¥:¡¨F¤©
Zv r]Oh Q ^NOMª3V N3Ov3O`3V rNYUROlr6O\]4m
d `noNUd V WXNYZ[QO\]67S5TQ
«brQ h ªd V rNYd V rN82¬YbrQ h ]lb
®
"° 3± "#
²³´®µ¶·®¸¹®º»®º¼½¾®¿³´®µ¶·®Ă¶Â®Đ¾Ê³®³¶Ôµ®Ơ®
öƯ®³Ì®³¶¾Ỉ¿®³·ĨÍ®µỊ̳®µ¶Ê®´¾Ĩ¾®Íͳ´®³¶·®Ơ®
ξϵ®ÐÑÒÓ®µÔ®ºÏ®µÕ®¸¼³´®Í¶¾ÊÒ®Ö×Ø®µÔ®ºÏ®Í¶Êµ®
Ù¼®¿³´®µ¶·®ÚÛÜÝ®²³´®µ¶·®¸¹®Þ·ßÍ®ă¿Ñ³®³¾ÏÒ®
º»®Đϳ¶®µ¼»³®µ¶â³®³Ì³®¸¾Ïͮ޾Ỉ¿®µỊ®º»®êô®Ă¶ơ¾®
¶ßĂ®´¾ÌÑ®Íưͮö·ì³´®Ă¶ưĂ®µ½¾®Í¶ỉ®ĩĂ¶í¿®
µ¶¿ịµì®µ½¾®¸í³´®ĩî½®µỊ®¸»®Íưͮö·ì³´®Ă¶ưĂ®
Þ¾Ỉ¿®µ®¼»³®µ¶â³®ĩ¶ïѮͶԵӳð¾®ÊµÓê¾³¶®¶ñÍì®
ÚÖÜÝòỊ̳®ºâҮ껳´Ó®Đϳ¶®³¶â³®êÑ¿®ó¶¾®Þ¾Ỉ¿®µđ
¶ïѮͶԵ®¸Ĩ¾®ÍưͮöưÍ®Þô®Íï®õ³µ¶ỊÑÍöͺ¾³÷®
³¶·®õø®ĩù¼î¼Ị¿Đ¾Í¾³Ó®øöͺ¼Ă¶¼êöÑÒ¾Ù÷ìÓúø®
ĩúĂ¾Ị¿Đ¾Í¾³Ó®øöͺ¼Ă¶¼êöÑÒ¾Ù÷ìÓ®ûõø®ĩ×®ü®
ûº¼¿Ị¼¿ỊÑ;º®®ù¼î¼Ị¿Đ¾Í¾³Ó®øöͺ¼Ă¶¼êöÑÒ¾Ù÷ì®
ý®µ¶·þ³´®´ÿĂ®ÍưÍ®µỊÏ¿®Í¶0³´®ó¶1³´®Ò¼³´®
Ò¿ơ³®³¶·®Đ¿ô³®³1³Ó®³1³Ó®Í¶ư³®2³®º»Ò®Í¶¼®
Đϳ¶®³¶â³®ó¶1³´®³¶Ì³´®Òϵ®Ò3¾Óó¶ï®Í¶đ¿Ó®Đ3®
ÙƠ®Þ¾Ỉ¿®µỊ®Ò»®Í4³®5³¶®¶·Ơ³´®µĨ¾®µÔ®ºÏ®ÞưĂ®
0³´®Þ¾Ỉ¿®µ®6ÜÝòỊ̳®µ¶Ê®´¾Ĩ¾®Þ7®Í﮳¶¾Ỉ¿®Í1³´®
µ³¶®³´¶¾Ì³®Í0¿®³¶9Ò®µ8Ò®ỊÑ®´¾5¾®Ă¶ưĂ®µÍ¶® ÍôÍ®Þ ®Þ5Ò®Đ5¼®ÍưͮͶ ®êơ®ê¾³¶®º âÒ® 껳´®¸»®Íị³®ºâҮ껳´®ÍÑ®Đϳ¶®³¶â³®¿³´®µ¶·®
¸¹®ó¶¾®Þ¾Ỉ¿®µỊ®¶ïѮͶԵÓÞô³´®µ¶þ¾®Í﮵¶ ®µ2³´® Í·þ³´®ó¶5®³2³´®Ò¾³®ÙđͶ®ÍÑ®Í쮵¶ ®¸»®
³â³´®ÍѼ®Í¶Ôµ®º·ß³´®êơ³´®ÚÜÝ®ø﮶Ѿ®î¿®
³¶®µỊ¼³´®¸¾Ïͮ޾Ỉ¿®µỊ®¶ỉ®µỊß®º»® ö·ì³´®Ă¶ưĂ®µỊ®º¾Ï¿®µÍ¶®ÍôÍ®ĩÍÔö®´¶Ă®µö® î·ì³´Ó®ÍÔö®´¶Ă®µÊ®Đ»¼®´ơÍì®Í¶¼®óʵ®ă¿5®ó¶5® ă¿Ñ³®³¶·³´®Í4³®´ầ®ỊÑ®ÍưÍ®Đ¾Ê³®Í¶0³´®³´¿ö®
¶¾ Ò®³¶·®³¶¾Ò®µí³´ý®¸»®Ă¶·ì³´®Ă¶ưĂ®ê¾³¶®
µ®º¾Ï¿®ĩÙí³´®ÍưÍ®µ¶¿ơÍ®Í﮳´¿ô³®´ơÍ®Þð³´®
¸ịµÓ¶ôÍ®¸ịµÓó¶¼ư³´®¸ịµýì®ÖÜÝò¶ịĂ®µ¼»³®Þ½¾® Đ®º»®Òðµ®µỊ¼³´®Íưͮл¾®µ¶¿ơͮͮö·ì³´®Þ7® Þ·ßÍ®µ¶Ñ®óÊ®¸»®Ă¶ưµ®¶¿ö®Þ ®Þ¾Ỉ¿®µỊ®Í¶0³´®
®¶¿öʵ®º·³´®¶·®Òѳ´®º½¾®óʵ®ă¿5®µơµ®Ú×ÜÝ Ð¶·³´®³¶Ì³´®³´¶¾Ì³®Í0¿®ó¶¼Ñ®¶ñÍ®Þ ®Þư³¶®
´¾ư®µưÍ®ÙƯ³´®Þ¾Ỉ¿®µỊ ®¶¿öʵ®¶·®µỊ̳®
ºâҮ껳´®¸»®µ¶ôÍ®³´¶¾ÏÒ®¸í³®Í4³®ỊÔµµ®ÞÿÍ® Đ¾Ïµ®Þư³¶®´¾ư®µưÍ®ÙƯ³´®¶ỉ®µỊ߮޾Ỉ¿®µỊ®ÍÑ®ÍưÍ® Đ»¾®µ¶¿ơÍ®µỊ̳®Đϳ¶®³¶â³®¿³´®µ¶·®¸¹®Þѳ´®
Trang 2!"#"&'(")&*#")&+(" +,)"#&-)"& ./0"12"3456"
)&7/8"#9 "# :/"&;/&"#&-)"& ./" "#; "#$</"3= "
&( ">?)"#<!@"
A0"B9"#C")D)"#&E"FG>"H;/8"#&IJ"K"&L)")M"
#!5 /"#$</"N./&"/&G/"!/8"#&+"37"8 ( " JO/"P6
P"6PQ" (/8" !"#$"R&D)" S"Q/#&$()5)F /I"#O "
N./&"3 ./"T"#U"AVWXVAV" :/"YWXVAA0"
X0"ZD/&"8 D"#D)"[?/8"&\"#," !"#")]("N; "
#&!^)")M"R&+_/8"`a&4R"#J;/" O "NMb"</"N./&"
/&G/"!/8"#&+"37"8 ( " JO/"P6"PP"PPQ" (/8" !"
#"R&D)" S"Qc"#&!d)"#&E"e&f"&!5:#"+g/8"&+0"
qhrstuvwxyzrv{y|}x
~; "#&!^)")M"R&+_/8"a&4R"#J;/" O "NM@"
&G/"HG>"AV86"~O)&"F/&"AX86"~O)&"#!4#"AX86"
c&f)&")(>"#&CJ"86"Ả!5</"e&!/8"Y86"Z+_/8"
!5"AX86"a&?)" %("AX86"~O)&"#&+,)"AX86"
c&f)&"&J;/8"e"Y86"&?)"!:"X80"cD)"3%"&!^)"
+,)"N;J")&:" O#"# <!")&!/" +,)" E/"1 .#"
(>"P10"a&!^)" +,)"[/8"[+= "[O/8"#&(/8"
#&!^)" H)" N/8" >D5" #$()#J$" &/8"
T5!/8HIJ"Ắ;/"!^)"HC/"!*#"/Ế>"XVV0
hivtyz
ỚỚ ¡ằỚỚẳ
a&IJ"K"&L)"& ./" O @
Ắ"c&/" JD/"D)" %/&"F;"ẵ/8"#&+"37"[-("
3;J"FG>"H;/86"8 C "R&ặ!"N./&0"c&/" JD/"8 ( "
JO/"P6"PP"PPQ"#&IJ"aM")&Ỡ)"R&ớ/8")&^/8"!/8"
#&+"!^)"#:"ẵPcc"XVVX0"
Ắ"Z+,)" !"#$"&'(")&*#"FÙ/" Ù!"R&D)" S"
Qc"H(!" !"#"R&ặ!"#&!4#"ờ(#I5"" ,#0
Ắa&E"#O/8")&!/8")ớ/"#^#"ở"Vỡ"/&"#&IJ"
#&(/8" E>"T($/JŨHe56)&Ỡ)"/Ế/8"#]5")ớ/"#^#6 )&Ỡ)"/Ế/8"8(/6"&4/")ớ/"#^#0
a&IJ"K"&L)")M"#$!5 /@"~./&"/&G/"#&!d)""
#&E@"T&f"&!5:#"F+g/8"&+6"c(/"e&f"!*#"e:#6
& .#" d)"!/"e:#"ợ0
ỚỪổỬ³Í¡ằỚỚẳ
Ắ"T&9/8" ]"# <!")&!/")&L/"3 "8 ( " JO/" N./&6")&Ì"H^"#J;/"#O/86")&Ỡ)"/Ế/8"#]5"+_/8" 3;"8(/"#&4/0"
Ắẵ/8"#&+"37"[ ")Ế/6"D "R&D#6 " !"#"&'(" )&*#6&Jộ)" !"#"&'(")&*#"R&D)" S"e&D)0"
Ắ"~Ỉ"[Ĩ" !"#$"&Jộ)"e&9/8"[/8"#&!^)" /8& </")Ỡ!""/8;5"F</"#:R0"T&9/8"F;>" Ù5" ]" )D)"Ó#"/8& .>"#&IJ"5<!")Ù!"/8& </")Ỡ!0" ửhrữyzÒrỎÒ
¾ựầựỚÁỲÂÁấỚẩ@"8& </")Ỡ!">9"
#C"# :/")Ỡ!6"#&ẫ"/8& .>"FG>"H;/8"/8ặ!"/& </" )'" ^ ")&Ỡ/80"
¾ựậựđẻÉÊẹỉV"N./&"/&G/0"
c9/8"#&Ỡ)"/A"ễ"/X"ễ"ịX
AẮ " ỹW Ư"ờ"A"ẮờWX"
a$J/8" '@"X
AẮ " ỹWễ"A6Ủ0"
ờ@"aồ"F." DR"Ỡ/86")'" +,)"#U"/8& </")Ỡ!"
#+=)"e&JC/8"ốXỡ"ốXỡ"F;"#ồ"F." DR"Ỡ/8"#J;/" Nd"#$J/8"/8& </")Ỡ!")]("HHI$>(/"#$</"" N./&"/&G/"!/8"#&+"37"8 ( " JO/"P3;"P" !"#% NM"#,"N/8"R&D)" S"Qc0
[@"T&JC/8"H( ".)&">J/8">!^/"F;"V6A0" 1= ")D)"8 D"#$"#$</6")g">ặ!"#f/&" +,)"" /"ễ"ỉV"N./&"/&G/0"
¾ự¾ựđÔỚỲÁỚỏỚ
~+=)"A@"c&/" JD/"D)" %/&"#&IJ"K"&L)"
& ./" O 6K"&L)")M"#!5 /0"
~+=)"X@"c& ("/&'>"
Ắc&L/" +,)"AAỦ"N./&"/&G/" ]"#<!")&!/" /8& </")Ỡ!")&J">?)"#<!"A0"
Ắ"YV"N./&"/&G/"#&E"e&f"&!5:#"F+g/8"&+"
+,)" D/&"H^"#&Ỡ"#-6")& ("F;>"X"/&'>"
ơ"4ÈừứÚÈũưÝ@"ỉV"N./&"/&G/")'"H^"#&Ỡ"#-"
FẺ6" !"#$"R&D)" S"Qc"" ,#6">\ " ,#")D)&" /&(!"XA"/8;5@"""
ß" JJ$!N ) /"V>8W>X6"#$!5 /"#à/&">O)&" /8;5"A0"
ß"c5)FJR&JHR&(> [I"VV>8W>X6"#$!5 /"
#/&">O)&"/8;5"A0"
Trang 35!"# $%!&'$()*+ ,- /01 0120 34 56
718 79 31:0;<=>? 7+
B C1D3 <E FG 01H 7I0J
B K1?63 0L1=I0 38? ?60L M <N7; OP= <N7
QM 0LRS 7T 0LRS 718 U <V0 0LRS 718 QW 3XY
31? Z[ 14Y 31\7J ]=>? ^HN0L 0LRS Q 71Y0L _U
7`=1?63 <a 5b3 5:0c;31=Y U ^d0;OP=d0 Q 7`=
Qe-O^;?60L 5Y? Z1=f0 U- g1`7J
hijiklmnkqrkstmpqskuvrk
K1wx y0L g120 <z <z3 7{01 3XY |=/g 1z=
?0L 71H |xY Z[ Q}}~ ĂeJ
 ]2O 5R0L+ ?E0 00; 00; ÊY 31yS; 31D0
f0;Ô0L 743J
 GƠ0 ^2O 5R0L+ 30L 7183 OD? _56 ^HN0L
1E0L 3d?; 31 3d?; 7=Ư? 3d?; 1wOxL^x.=0cJ
=01 14Y OD? _FK;F]K;?@w;3@wY7=0=0cJ
hiikÀmstkmksmktpkokrk
 7y 3D3 71Ư ^2O 5R0L ?0L 71H ` 71wx S
1Ả3 3 7?S>0J
 ĐD01 L=D 7D3 Ô0L <=>? 7@ 1P 7@N 3XY R=
71?63 710L Ã?Y =V0 <= 3D3 7@/? 3180L <z3
701 7@I0 ^2O 5R0L R 3Ơ0 ^2O 5R0L; 5x 5D01 L=Y e 014O 0L 7w57ă
ÁâđêôơẶưôẪàẬK1wx g1HÈ0L g1Dg 7160L
ZI S 5=01 1Ả3 _C QẺJ-cJ
ẼâÉ°ẨẸẨỀỂỂẸÉẨỄỂẾảàẬKT 71D0L Q-·e-Q- <V0 71D0L W·e-QQJ
ÌâỈãÍỊảẾỂẸÉẨỄỂẾảà
½L1=I0 38? <HN3 7193 1=/0 5Y? Z1=<HN3 1z= <E0L Đx <83 7@x0L ½L1=I0 38? ¾ 5=01 1Ả3 _Òáạc K@Hằ0L Đ= 1Ả3 ¾ |R ½z= g1I
?S/7J ½L1=I0 38? 31Ê 01O 020L 3Yx 583 Z1ẳw 31x /01 0120; Z10L OY0L ^= \7 Z[
7D3 1=0Rx Z1D3J
Âạ/01 0120 <HN3 710L 70 <dS <X > 3D3
7D3 Ô0L <=>? 7;D3 Ô0L Z10L Ox0L O?60
34 71Ư Lẵg 3XY 71?63 R 79 0L?S/0 71YO L=Y
Rx 0L1=I0 38?J ½V? <6= 7HN0L 0L1=I0 38? ./01 =ắ0 =V0 0ẵ0L 71IO 71ặ 31`0L 7= 0LT0L 0L1=I0 38? 7I0 <6=HN0L R Dg Ô0L g1HÈ0L g1Dg <=>? 7AZ1D3J
ầẩ ẫấ
ậâèôẪẻẪỂÉỂÉẽỂẾéỀÐẹÉềôẽểẶễỂẸẹÉếÍệÉỨẾẾìẹỉàệĩỂ
Ẻ~Jeí
eQJWí
Q-J}í
K1Ư ị1{ 1?SV7 ^HÝ0L 1H K1Ư GY0 Z1{ ?\7 ZV7 K1Ư 01=/7 <z3 ?Þ0 ZV7
òẨềàỊỏậâèôẪẻẪỂÉỂÉẽỂẾéỀÐẹÉềôẽểẶễỂẸẹÉếÍệÉỨẾẾìẹỉàệĩỂ
K@x0L U 71Ư ^2O 5R0L;1Ư Z1{1?SV7HÝ0L 1H 31=VO 7õ ^/ /01 0120 3Yx 01\7Ẻ~;eícJ
óâèôẪẸẨỀẨỊÍãỂẻẪỂÉẹÉếÍệÉỨẾÉẨẪỂỊãẨỉÍỂẸÐẹÉềôẽểẶễỂẸẾéỀệÉỨẾẾìẹỉàệĩỂ K@x0L U 71Ư ^2O 5R0L 7õ ^/ /01 0120 L=Y=<x0 Ò31=VO <Y 56;õ ^/ 3D3 L=Y=<x0 3XY 3y U 71Ư
^2O 5R0L 71wx S 1Ả3 3 7?S>0 7HÈ0L <HÈ0L 01Y?;g ọ -;-Mc.y0L QcJ
Trang 4!"#$
%&'&()*+
,-.#/&-$
#0&' (1+0*+$
& 2+ 34
; <=$ <>?@$ >$ A?A$ =$ =$ <>$ <=?<$
BC=?=@$
;G$ <=$ <>?@$ H$ <<?@$ I$ H=?E$ <A$ <I?H$
&J,KL 7M#/$
$
NO#/PQR,2/ !"#S2#&
TQU4VW#/ X(+YZ&[+Y\4] SM +&(84+&^#/_( S *# 6 L3+78+Y 2(4&`#/ 34+'#& +Ya#,KL 7M#/
NO#/bQN *# 6 L3+78+Y 2(4&`#/ 34+'#&+Ya#,KL 7M#/
&cL
N(d##^#e#fg ^#ge#fg h 4&O)ge#fg &U#i#e#fg jW#/+c4e#fg
cg %&^#/g cg %&^#/g cg %&^#/g cg %&^#/g cg %&^#/g
klmnCqrlstqC
x34+'#&
yCqlmnCqrlstqCopuCzs{uC|}CvlsClvCvloCzCGC C sC|luoClvC| qCzsC?CooC|}uC olpqrCzoC|qlCrC}CClmCol|CrsnC}C}|CoC|qlCqq?ColqCq?CColC|lvClqComCC qrlC|lqrCt?CvCwC=?=@ ¡CzoC|qlCuqCqqC|lvClqCql¢qrClqrComCCqrlC|lqrCt?C
vB=?=@ £oC|qlC}¤qrC|moCr¥vC¦CoClsCqlmn£C
§QU4VW#/ X(+YZ&[+Y\4] SM +&(84+&^#/_( S *# 6 L3+78+Y 2(4&`#/ 34+'#& +Ya#4¨#,KL 7M#/
NO#/§QN *# 6 L3+78+Y 2(4&`#/ 34+'#&+Ya#4¨#,KL 7M#/
&cL
"S"4&
4©(e #f
"&ªL!«
/, !S #e #f
"+ J(
4©(e #f
i#/Yª
e #f
i#/
4Yª + # #
e #f
i#/¬
e #f
i#/¨
e #f
c %&^
#/ c %&^#/ c
%&^#
/ c
%&^#
/ c
%&^#
/ c
%&^#
/ c
%&^# /
klmnC olpqrC >=C >=C >AC <HC <C HFC <=C H=C >C HEC >@C <@C >DC <IC klmnCkC <=C H=C <@C <@C =C I=C DC HIC >C HEC <@C >@C <@C <@?@C
vC wC=?=@C wC=?=@C BC=?=@C BC=?=@C BC=?=@C wC=?=@C wC=?=@C x34
+#&
Trang 5!"#$ !%"&'! ()*+ ,- / "0 10(" (2*+ "0 34$5%.51&!6 ,7!% 89:+ 8;: (<= ,">? "@! (# A
!%"B= ,"C!% D' E? F G+GHI6 ,- / "0 ,&J* (2*+ ,7!% *K4 $L* M ,">? "@! !"N!% D"O!% (# A !%"B= ,"C!% D' E? P G+GHIQ:- / ,7!% (K4=,&!&! D"O!% (# RS D"L( 1&/,%&T= U !"#$Q
VW XY Z[
:"45 1\!% ?"]! ^_ ^_( ,`!" (<= 3&/? "_&
*!% ,"N 35= Da bccd eUf+ 1*g! !O! h ,K/*
(")!% ^_( ,`!" (<= ^Ni!% ,&'* "#= %]j !'!
!"&k* 1>, l& ("5 1/!" !"]! (m!% !"N "&/*
n*\ ^&k* ,K :K&/* (")!% !hj $=!% ,`!" (">,
("< n*=!+\&^k* M (L( ^l,"#= (">, 5!% (\
"=& !"#$ 1/!" !"]!+ !"#$ !%"&'! ()* ,">?
"@! R5 pq& !"#$ (")!% !"N!% ("N= (# A
!%"B= ,"C!% D'Q
rO! h ,K/* (")!% ,"Ni!% %s? D"& ^&k* ,K
?"L( ^g 8t ph ^Nl( D"C!% ("u ,C, D"& vw!%
,"*C( !%"&'! ()*Q x= ("\j h ,K/* (")!% `,
%s? D"& vw!% ?"L( ^g 8t+ $s( vw pyj !"#$
!%"&'! ()* ^Nl( D"C!% ("u K>, ,C, R5 pq&
!"#$ (")!%Q tL( 1/!" !"]! ^&k* ,Ko "#=
(">, *O! (# 1&J* "&/! ("L! 7!+ ,- / ^_(
,!" !hj M !"#$ !%"&'! ()* %&\$ "@! !"#$
(")!%Qz{!% ,#( h ^_( ,!" v5 "#= (">,h$
!%|!% ?"L, ,K&J! !=!% O!%+ %s? M bGG}
1/!" !"]! ^&k* ,Ko ?"L( ^g 8t+ ,"Ni!% %s?
M ^l, "#= (">, ,") U ,KM ^&Q :K'! ]$ Rh!%+
1/!" !"]! ,"Ni!% $~( 0&#( ,| ^l, "5s(
!"N!% R=* ^# ,#( 0& K{!% 2! U+ M !"#$
vw!% ,"*C( !%"&'! ()* "&u$ ,">j 1/!" !"]!
K{!% ,#( 2! UQ
:"45 !%"&'! ()* (<= %&L5 RN :O! &u!
r&!" E:K*!% vNl( Nl( A "~(I+ ,K5!% ,"h!"
?"2! 1h& ,"*C( :"y? ,5h! ^0& 1 (# K>, !"&k*
po ,"*C( (# ,L( v{!% ,7!% (Ni!% $&! vo("
!"N :"{( ^o= ,7!% (Ni!% (")( !7!% (<= ,u
1h5 j$?"5 :+" ( ^j 1h&u,; U+7!% (=5
"&/* %&L (<= !,4K4K5!6 N@!% n*j ,7!%
(Ni!% $&! vo(" ^s( "&/* ph D"O!% ^s( "&/*6
0(" !" h$,7!% ("RC ,"S( 1h5 (<= ?"=%5
(j,4 M ("*_,60(" ,*y,^ ^Nl( (")!% $&!"
,'! ,"S( !%"&/$ (@ ,L( v{!% )( ("u ,u 1h5
*!% ,"N ,"S( n*\!Q *= ^# ,7!% (Ni!% R)(
^k D"L!% (<= (@ ,"J ^g!% ,"i& h$ %&\$ (L( ,L( v{!% ?"{ (<= "#= (">, !"N !O!+ 1*g!
!O!+ K{!% ,#(+ ("L! 7!Q u, "l? pq& 0(" ,"Nl( (# ,L( v{!% )( ("u ,*!% D"* ,"2! D&!"+
=! ,"2!+ %&\$ ^=* 1/!" !"]! R %&\$ ^Nl( ,2! RC ph (Ni!% ^_ (<= (L( (@! ^=*+ (">, Nl!% (*_( RC!% ^Nl( (\& ,"&/!+ 7! *C!% ,C,
"@! edfQ 3#= (">, (# ,L( v{!% h$ %&\$ ,"J ,`(" D"C& *+ !%7! ("s! RS ?"L, ,KJ! D"C& *+ ,&'* v&/,(L( ,u 1h5 *!% ,"N v&(7! !"N!% 1\! ,"]!
!# (m!% %]j ^_( pq& (L( ,u 1h5 1!" ,"Ni!% (<= (@ ,"J+^s( 1&/,h !"T!% ,u 1h5 (# ,C( ^_
?"]! ("&= !"=!" !"N "g!% (2*+10(" (2*+J* (2* efQ
_( ,`!" "0 10(" (2*+ "0 31+ "0 ,&J* (2*
^Nl( D"C!% ("u (# A !%"B= ,"C!% D' M !"#$ vw!% ,"*C( !%"&'! ()*Q tm!% ,"45 !%"&'! ()* (<= ,L( %&\ :O! &u! r&!"+ !% R]$ (# ,L( v{!% ,7!% (Ni!% (")( !7!% ,05 $L* (<= ,<j N@!% E'$ vNq&v= !Nq( !% R]$ ("5 ," ,">j ,7!% RC Nl!% "g!% (2* ph "4$5%.5 1&!I6 35h!% Da h$ ,7!% ,!% RC 10(" (2* ,5!% $L*+ &!,4K4K5!+ ," ( ^j ,u 1h5 10(" (2* ^= !"]! ,K*!% ,`!" ph ^0& ,"S( 1h5 ,7!% (Ni!% D"\ !7!% v&/, D"*!+ ,7!% RC Nl!%
"g!% (2*+"4$5%.51&! ("*_,"S( !%"&/$+h$
%&\$ ,L( v{!% (<= ?"#!% 0 ,K'! ,u 1h5 10(" (2* $L* !%50&p&ph ,u 1h5 %C( M !"T!% ("*_, 1o %&\$ ,u 1h5 $L* v5 ?"#!% 0+ 1\5 p/ ,u 1h5 %=! ph ,"y! ," 1o %]j ,! ,"N@!% 1!%
^_( ,C ,'! ,"S( !%"&/$6N@!% n*j h$ ,7!%
"g!% (2*+ 10(" (2* ph "4$5%.51&! ^C& pq& 1/!" !"]! ,"&u* $L* ph ^s( 1&/, h !"T!% 1/!" !"]! R=* 0 ,K ph "#= ,K :"{( ^o= ," (
Trang 6!"#$!"%&'()"#*+",-./"#0()"1*23"24.",-."
()+*5"65/"#0()"37()"24."68"39,+):+15(";"
23.<#"#35=.",-."#>?("#3@2"()35A,B"C*23"#>.D#"
E" &F2"()35?("2G."2H"#-2"IJ()":8,"#0()"
1*23"24.";"(3K()"1A(3"(3L("3*"1*23"24."I+"
3HM"#>":5A."3+O2"%*"#>"QR"6D!"#-2"IJ()"2S5"
#35A("2-2"23T"UV",-."2$M"(3H,"()35?("2G.">W#"
>X">A#P C85"#3.V2"()35?("2G."2H"6N"Y+8()"Z["6\5"
#-2"IJ()"#3]2" !"#="18+"U5(3"#>&;()"68"#-5"
U5(3/"1S+"6A")M("68"#3D("#3^")L!"#_("#3&'()"
1`()" <2"#V"#>?("#3@2"()35A,B"aM,"#3S+"2H"
#-2"IJ()"1S+"6A")M(/"8,")5S,"bcd"#?("23.<#"
2H",9(")M("2M+"#>?("#3@2"()35A,B"C*23":5(3"
2H"#-2"IJ()"M("#34(/"3*" &e()"3.!=#/"1S+"6A"
)M("fghP"di"2-2"#-2"IJ()"#>?(/"#j":A"#0()",9("
bkd/"bcd"2$M"(3H,"()35?("2G."#3Wl"3'(">W#"
(35m."U+"6\5"(3H,"23G()P"
no " pqr s
tP"d>+()"2-2"#3u":L,"U8()"2$M".()"#3&"6]/"
235=,"#j":A"2M+"(3W#"#39+"l3L(":+*5"2$M"!"3v2"
2_"#>.!m(":8"#3u"Z3w"3.!=#":&x()"3&"yz{/g|}/
#3.<2")5M5" +*("~68"I5"20("t"Ă"3*23"(-23P"
{P"d3.V2"2H"#-2"IJ()" 5m."#>"3Â"#>F":8,"
)5S," <2"#(3"2$M"l3-2" 7"ba"23+"1A(3"(3L("
.()"#3&"6]")5M5" +*("~~"~b"?(":L,"U8()"68"
2D(":L,"U8()"y2H""()3ÊM"#3V()"Z?"6\5"
l"Ô"Ơ/Ơ}P
rƯÀ
a3]()"#5"%5("23L("#38(3"2S,"'("CM(")5-,"
V2"68"2-2" 7()"()35Al"#*5"1A(3"65A(""Y8"
<5/"Z3+M""3v2"a_"#>.!m(" E"#*+" 5m."Z5A(" )5]l" x"#+()".-"#(3"#3@2"35A(" m"#85P
oÃăÁâđêô ơẶÃê"ưẶ
ẨÃẪà ẬÈẺẺẺẼPÉdR(3"3R(3"1A(3".()"#3&";" Q5A#"M,"(0,"{ƠƠƠP2°ẸỀỂỄỂả·ÌẾ·5ãÍỊỀ½ Q5A("#3()"#5("#3&"65A(""3v2"d>.()"&'()/" t¾"Ă{zP
ÈoÃăÁâẬÈẺẺÒẼP"CA(3".()"#3&" 6]P"4ỂáạằẳẾẵắ·5ỂặỀầ6á4ẩỈầ{ẫ"Ăz¾/"{{¾"Ă {/"g"ĂấP
ậoèơơ ẻrđẻơẽẪéÐđẹềểễ ẽếểè"
ẬệệệẼo"Ứ.:#29(#9>"l3MU9"~~"U#.I!"+ì"2Ml925# M15(9"5("lM2:5M%9:"Ă">9ì>M2#+>!",9#MU#52"1>9M#" 2M(29>Pỉ3ĩỈ·í·Ềịĩ/ấẫĂấ¾P
ÒoÃểẹơèorđÝẽễo ẽếểèẬÈẺẺÈẼP Þ+%+>.1525("M(I"lM2:5M%9:"69>U.U"I+%+>.1525(" M(I"2!2:+l3+Ul3M,5I9"MU"ì5U#"Ă":5(9"239,+Ă
#39>Ml!"5(",9#MU#M#52""1>9MU#"2M(29>ò"d39" ỏ.>+l9M("õ>)M(5óM#5+("ì+>"ọ9U9M>23"M(3" d>9M,9(#"+ì"aM(29>"tƠ¾zt"Ứ.:#29(#9>"ồ3MU9"
~"d>5M:Pỉ3ĩỈ·í·Ềịĩ/ÈẺẬÒẼđttấ"Ăt{tP" ổoÃêỗôê"ẬÈẺẺẺẼP"ố-(3")5-"#-2" IJ()"(L()"2M+"#3u"#>*()"2$M"185"#3.V2"d3Dl"
#+8(" *5"1_";"()&e5"2H"#._5Pc.D("60("#3*2"Uộ"
!"3v2/"ố*5"3v2""Y8"<5P
éểễ
Ð ẢĐờởĐỡĐớợÐẢÐỡ ĐÐ é Đợ nÐợÐẢÐờĐợợÐéÐợ ÐéùĐ
ợÐợÐÐỡ Ðợ
"
d39"+1ủ92#569U"+ì"39"U#.I!"ð9>9"#+"I9U2>519"#39"#MI5#+(M:"2:5(52M:"2:MUU5ì2M#5+(U"+ì"39"U#M)9"~
~"~~b"1>9MU#"2M(29>"lM#59(#U"ð3+"M>9"#>9M#9I"1!"ba"#39>Ml!"M#"#39""3+Ul5#M:"ì>+,"tƠũ{ƠtƠ"#+"
ẫũ{Ơtt"M(I"96M:.M#9"#39"5,lM2#"+ì"úd3Ml"#+M("IM5"1+ụ">9,9I!"+("#39"U.ll+>#69"#>9M#,9(#"ì+>"
Trang 7!"#$%&&%&(%)*$" !%+",+$*%-"!.$,! %/01%"*$%!$"!$2%)3%(4%!0$*"-35%60$%*$ 78! % 01/$2%!0"!%0$% -*1-1*!1,%19%:;0.%073$!%871,#%07<% %0.#0$ !%=>?5@AB'%91881/$2%)3%:4",%C0.%7"!%C$!<%=?D5EAB%",2% :F0.$!%21+%7",%C$!<%=DG5HAB5%60$%-*1-1*!1,%19%!0$% !"#$%&&%-"!.$,! %/01%0"I$%D%J%K%#",#8.1, % L$!" !" % %0.#0$ !5%()17!%!0$%*$27+!.1,%19%+8.,.+"8%!1M.+.!$ '%!0$%I1L.!$2%!1M.+.!3'%",1*$M."%
!1M.+.!3'%2."**0$"%!1M.+.!3%"*$%81/$*%0",%+1,!*188#*17-%",2%0"I$% !"! !.+"883% #,.9+",!%-%N%G5GOBP
!0$%,"7 $"%!1M.+.!3% %81/%)7!%%21$ %,1!%0"I$% !"! !.+"883% #,.9+",!%-%Q%G5GOBP"81-$+."%!1M.+.!3% % 1++7**$2%.,%)1!0%!0$%#*17- 5%()17!% 7)+8.,.+"8%!1M.+.!$ '%!0$%*$27+$2%8$7C1+3!$'%0$L1#81).,P%.,J +*$" $2%(R6'%(S6%"*$%81/$*%!0",%+1,!*18%#*17-%",2%0"I$% !"! !.+"883% #,.9+",!%=-%N%G5GOBP%!0$% ,$-0*1!1M.+.!3%/" %,1!%*$+1*2$2%.,%)1!0%19%!0$%#*17- 5%&,%+1,+87 1,'%:60"-%!1",%2".%)1<%*$L$23%
*$27+$2% 1L$%19%0$%(4%!0$*"-3T %!1M.+.!$ %1,% !"#$%&&%&(%)*$" !%+",+$*%-"!.$,! 5%
UVWXYZ[\]^ZV_\`a_baVZcadVefa_gdVZ_hWcid_h`Y_b[_fjYklZVeV[W
.../ c
%&^# /
klmnC olpqrC >=C >=C > ;AC <HC <C HFC <=C H=C >C HEC >@C <@C >DC <IC klmnCkC <=C