1. Trang chủ
  2. » Thể loại khác

Nghiên cứu xác định đột biến gen RB1 và phát hiện người lành mang gen bệnh u nguyên bào võng mạc

8 46 0

Đang tải... (xem toàn văn)

THÔNG TIN TÀI LIỆU

Thông tin cơ bản

Định dạng
Số trang 8
Dung lượng 627,18 KB

Các công cụ chuyển đổi và chỉnh sửa cho tài liệu này

Nội dung

Bài viết xác định đột biến gen RB1 và phát hiện người lành mang gen bệnh u nguyên bào võng mạc thông qua nghiên cứu trên 20 bệnh nhân và các thành viên gia đình của bệnh nhân.

Trang 1

    !  " # $ % &#' ()   *

+,  -) / % #*   #)0 (1 

234(54/46'7234896:46'7

6;<2=4>(?4'76;<@4>(54A7234(54B6C46'

60DEFGHIJKLMN34O2PKQ RSGLTKSGUVW0DXGHEYGH ZGHX[\G]O^T_GH`JNaO]SGLbKX[cGadGW\GGLKe`fVNWLgWLEFGHHh[G\Gb^iPW]KjGHkGDkWK ]alfW 68mR69QOHkGinGHTlKDopXlGWMGHW^GHTKSNLqGLWLOGLNrXWsNTObX[WNLtNGuGHGLvG Nw`xGLfxGHHKsy`VWNnWLgGLqGWLr[iEzN{|KSNyLxWLKSGiPW]KjGHkGmR6WD\G]SGLGLhGXGHX[\G ]O^T_GH`JNHKsyNL}Gi^xGf~`]SGLigiKcXW]SGL€yWLFKGHuGGHl]KjGNLtGHNL^W‚QOWcGic igyLxWLKSGGHEFKOGL`lGHHkG]SGLNL^NxNWLOGLTK\GHKliqGLTONL}Gi^xGWE~NfKGLGLƒ`HKw`W

aS`VN]SGL{2HLK\GNtXiEzNWL…NLKSGT~K`†NW\X‡ˆxNiGLiPW]KjGHkGmR6W\G]SGLGLhGXGHX[\G ]O^T_GH`JN{‰LxWLKSGGHEFKOGL`lGHHkG]SGLW\GNxNWLOGLTK\GHKliqGL]SGLGLhG{Š…lNLMG 7 ]SGLGLhGTONxNWLOGLTK\GHKliqGL8]‹Q`ŒQlGLQNLQk`9Nl]SGLGLhGiEzNNL}Gi^xG`VN]SGLX GHX[\G]O^T_GH`JNŽWLXvWHKwKqGLW…HkGiEzNxyb†GHig‘xNiGLiPW]KjGWD\GHkGmR6{jWpXw NL^WLr[i’yLxWLKSG “ 78”7•9]SGLGLhGNniPW]KjGHkGmR6Q^GHinyLxWLKSGiEzN iPW]KjG`~K

`rWGXNak^WKbW\Gk‘^G67TOk‘^G yLxWLKSG–“ 8—˜•9GHEFK]‹TO˜“ 8 GHEFK`ŒaOGHEFKOGL

`lGHHkG]SGLQ–“678–7•9OGHEFKOGL`lGHHkG]SGL{

™š6›Cœ4>894žŸ› ¡4><;¢7>£4&#'7¤¥¦ž§¨4>£474>©ª§Ÿ46<¬4>>£4

I l NL­  \G LS‡0D ®G |hG ¯GLQ0D EFGH IJK  LMN 3 4O 2PK

°`lK a TlGlGL]K ^NLk`±H`lK a N^`

2HO[ GLvG‡  67“ 76“ 76

2HO[ iEzN NLry W LXvG‡  “ 7 “ 76

  ³ (´ µ

¶·¸¹º»¼¸·½¾¿·Ă¸¹·ĐÊÔ·Ơ¾·½Ư¸Ì·ỈĨ·ÍỊº»Ì¸

Ở¸·Í¼¸·¸ÌĨÎĐ·ÏÐÔ·ÍÌÑ·ÍÌÒÓ¸¹·¹Ô»·¸¼¸·Ỉ¿·ÕÖÍ

½Ĩ׸·¹Ø¸·ỊØÍĨ¸¿½ƠÙÏÍ¿ĐÙ ÚÛ·ÜÝÞÛßă·Ơ¾·¹Ø¸

Õ⸹·ĂÙĨ·ÍỊđ·êºÙ¸·ÍỊô¸¹·ÍỊ¿¸¹·ĂĨƯÔ·Ìơ¸Ì·Í̾¸Ì

Ôưº·ÍỊìÔ·Ă¾·Ỉº»·ÍỊ·ÔÌỉÔ·¸ĩ¸¹·¸Ìí¸·ÔịĐ·ì¸Ì

Ï츹·¹Ĩìí·ĐÐÍ·Ôâ·ÍÌÑ·¸Ìơ¸·ÍÌư»·ÕÒîÔïÞƯ¸Ì

ÍÌÒÓ¸¹·ðị»·ỊÙ·ñ·ĐÖÍ·ĐÐÍ·òóÚôõößăðºưÍ·ÌĨƯ¸

Ï÷Đ·¸¹Ù»·Íø·¸Ìù¸¹·¸ĩĐ·Õúº·ÏÙº·ÏĨ¸Ìăͺ»

¸ÌĨ¼¸·½Ư¸Ì·Ôâ··ÌÑ·ðị»·ỊÙ·ñ·ÌÙĨ·½¼¸·ĐÐÍ·ûóÚ

üóöß·Ă¾·Ôâ·ÍÌÑ·Ỉý¸·Õ׸·Đþ·ƠđÙ·¸×º·ÿÌ0¸¹

ÕÒîÔ·ÔÌ1¸Õ¿ì¸·Ă¾·ÕĨ̺·ÍỊ·ÿ2í·ÍÌÓĨ3ÛÚü4ï

5Ì6¸¹·ÿ¼·Íø·ÔìÔ·¸¹ÌĨ¼¸·Ôỉº·ÍỊ¼¸·ÍÌ×·¹Ĩ÷Ĩă·Ôâ

ͼ¸·7õõ·Ơ¿ÊĨ·ÕÖÍ·½Ĩ׸·¹Ô»·½Ư¸Ìă·ÍỊ¿¸¹·Õâ·ÕÖÍ

½Ĩ׸·Ă0·¸¹Ì8Ù·ÔÌĨ×Đ·ÿÌ¿ị¸¹·9ûöă·ÕÖÍ·½Ĩ׸

ĐưÍ·Ì¿ÍÔ·ÍÌ¼Đ·Õ¿Ê¸·¹Ô»·ƠƯÔÌ·ÿ̺¸¹·Ỉ2ÔÌ ÿ̺¸¹·ÔÌĨ ·Ôđ¸·ƠÊĨ·Ơ¾·ÕÖÍ·½Ĩ׸ ÏÙĨ·¸¹Ì8Ù·Ă¾·ÕÖÍ·½Ĩ׸·Ơ¾Đ ị¸Ì·ÌÒñ¸¹·Í÷Ĩ êºì·ÍỊ¸Ì·ÔÐÍ·¸6Ĩ·ÏíƠĨÔĨ¸¹·ÔÌĨ×Đ·ÿÌ¿ị¸¹·ûõö

39Ú74ï · ĨƯÍ ·Ì¾¸¹·¸ĩĐ·Ôâ·ĐÖÍ·Ï6·ƠÒ

Ơ÷¸·ÍỊ·ÏĨ¸Ì·ỊÙ·½2·½Ư¸Ì·º·¸¹º»¼¸·½¾¿·Ă¸¹ ĐÊÔă·ÔìÔ·¸¹ÌĨ¼¸·Ôỉº·ÔÌ·»×º·Ííí·ÍỊº¸¹·Ă¾¿ ÕÍÔ ÕĨÑĐ·Ỉ2ÔÌ·ÍηÌôÔ·ÔÙ·½Ư¸Ìă·ÔÌÒÙ·Ôâ

¸¹ÌĨ¼¸·Ôỉº·¸¾¿·ÕÒîÔ·ÍĨ׸·Ì¾¸Ìñ·ĐỉÔ·ÕÖ íÌÔ¸·Í·3Ûõ4ï ĨƯÔ·íÌìÍ·ÌĨƯ¸·ÕÖÍ·½Ĩ׸·¹Ø¸ ÝÞ۷ͼ¸·½Ư¸Ì·¸ÌÔ¸·º·¸¹º»¼¸·½¾¿·Ă¸¹·ĐÊÔ

¹Ĩìí·ÔÌ1¸·Õ¿ì¸·Ï÷Đ·½Ư¸Ì·ÕÑ·ÕĨ̺·ÍỊ·½Ư¸Ì ÿ2í·ÍÌÓĨ·¸¹ĩ¸·¸¹øÙ·½Ĩ׸·ÔÌỉ¸¹·ÔÌ¿·ÍỊă·Ơ¾

Í̸·ÕÌ·ÕÑ·íÌìÍ·ÌĨƯ¸·¸¹ÒÓĨ·Ơ¾¸Ì·ĐÙ¸¹·¹Ø¸

½Ư¸Ì··ÔÌ¿·ÔìÔ·Í̾¸Ì·ĂĨ¼¸·¹ĨÙ·Õơ¸Ì·Ă¾·ÔÌ1¸ տ츷ÍÒ÷Ô·ÏĨ¸Ì·¸ÌĐ·¹ĨịĐ·Í·ƠƯ·ĐÐÔ·½Ư¸Ìï

¼¸·Ôỉº·ÕÒîÔ·ÍÌÔ·ÌĨƯ¸·Ă÷Ĩ·ĐÔ·ÍĨ¼º

Ûß·ìÔ·Õ2¸Ì·ÕÖÍ·½Ĩ׸·¹Ø¸·ÝÞ۷ͼ¸·½Ư¸Ì·¸ÌÔ¸ º·¸¹º»¼¸·½¾¿·Ă¸¹·ĐÊÔï·ûß·íÌìÍ·ÌĨƯ¸·¸¹ÒÓĨ

Trang 2

 !"#$!$%!&' !()*!+,+!(  !-.*!$.#

/0 !&' ! 1!2!$23*!&4!-5$!"6+7

 8 9:  ;< => ;? @

A89BCEFGH

IJK!&' ! 1!/LM+!+ N!/4,!O,+!/P

&' !2!$23*!&4!-5$!"6+!QR#!-4!1"

S$!-!TU(!V2W!$.W.!X Y2!&' !(6.!Z' !-.'

[\(!])2$L^$7

IJ_!(  !-.*!()4$!$.#!/0 !&#4!$`"!a_

&bc!"d!-!aK!# !+ P!%"!+e#!&' ! 17

f8gEhGHigji

klmnopqrstutvnwx!"!",2!(y !"6+

+ b$!/z$!&{$!|}]~7

2€t€tẮ‚ƒ„4…ƒ†nps‡ˆ‰ẮŠẮ‹}Œ~!(Ễ$

Sb/LM+!(,+ !+ U(!(Ž!",2!(4!X Ố!&{$

Q2$!QP+ !X %4I+ 4)4Ồ4)" I.S4#"3!‘J’‹

J“‹!a”7

•–ƒtp—ƒ˜3™wš›œ!/LM+!SŨ!Qž$!/Ÿ

T 2U+ !/6.!4!& !J¡!%O4!+e#!$%!œZa!-ằ

+,+!+ặX!"`.!/ặ+! '2!/LM+!( U(!TU!( %4

$ *!+ấ2!(Lằ+!/13!ầxẩ7

]  !X Ố!X W!ấ$!š›œ!‘ Ÿ!(+ !JKẽ”

$`"‹!aKẹ!/'"!Z2ỒỒ%)ếaK"[!QŒ]šc!Kc’ẽ!"`

O2z.!-!$LM+c!’ề!]#V!X43"%)#S%c!xẽ!}Œ~7

› 2!(0 ! '(!+e#!X W!ấ$!š›œ‹!ể“4›ễ’

X ệ(c!x“!+ 2!Tố!ầể“4›ễxK!$.13c!’’4›ễxK!$.13c

¡J4›ễ“’!$.13ẩc!¡J4›ễ’!X ệ(7!ZW4!V2W!"Y2!ồ

aK4›7

ổỗỠƠộờởƠỠịỰỨỰỠỪỬơộỠƠớỠịƯơÀ+,+!SW!X N"

š›œ!SÁ!/LM+!(.U!  !$.W.!() !(R!()R+!(.UX

(*!",3!~ZÂ!xaKK!Ã%%(.+!~#3Ả%)7!ĂU(!V2W

/LM+!( 2!( ẳX!-!OŨ!ẵ!&{$!X Ố!"È"!~ZÂ

šœÂÉ[][xaKKÊ~-#(!}#(#!›4%+(.4c!}Œ~ É%V2%+.$!~#3S.S!’7J!-!ZẺ~É]!+e#!Œ›ZÂ7 ])0 !(R!/LM+!S4!S, !()*!$1! $!$%‹ }Œ~!‘ŒÃÌKKểKKể7a”!-!"œŒ~!‘ŒšÌKKKxaJ7J”7 Í89ĨỳĐứÒGHgCÓGÒứÔ

Œ$ *!+ấ2!(21!( e!+ ặ(!+ Á!( %4!/64 /ấ+!$ *!+ấ2!()4$!ạ! ỷ+7!Z' ! 1!-

$.#!/0 !&' ! 1! 4!(4!(R!$23'!( #"

$.#!-4!$ *!+ấ2!-!+ừ!V23È!)ệ(!2.!T ử

$ *!+ấ2!T !T z$!/`$!ẵ!(.UX!(ž+!( #"

$.#7!Z' ! 1!-!$.#!/0 /LM+!( z$!&,4!-È TU(!V2W!OÙ(!$ '"!$%!( z$!V2#!&,+!SÚ!/.È2 (!/Ÿ!$.ệX!+ 4!+,+!&,+!SÚ!(L!-ỹ!Q.!()23È 4ặ+!R#!+ ỷ!X ,+!/`!/.È2!()!X ỵ! MX7!›,+ ( z$!(.!+,! 1cTU(!V2W!+ 2N/4, 4 (4!/LM+!/W"!&W4!&ậ!"ẳ(7Œ$ *!+ấ2/LM+ (U!  ! 4!(4!-0!"ž+/ậ+ !T 4#! ỷ+c

T z$!-0!"ž+/ậ+ !4!T ,+7

   Ýỡ ưà

A8ÝáDâÔãảjÒĐăGgữgÔáÒgĐĨCÒjÒẫèGH éảỳGÒêẻHéGìắA

ÉŨ!Qž$!+ặX!"`.!/ặ+! '2!+ 4!(4!& !J¡

%O4!$%!œZa!/Ÿ!T 23U+ !/6.!}Œ~!S#2!(,+ + U(!Ž!"Y2!",2!+e#!&' ! 17!Ăậ+ !( Lằ+ +e#!+,+!SW!X N"!š›œ!()4$!T 4W$!J’Kĩ

’’K!&X7ỉ0 !a!! 0 W !š›œ!/6.!Q.'

T 2U+ !/6.!%O4!đ!+e#!$%!œZa7 f8ÝáDâÔãảjÒĐăGgĐựDòCáGHéGìắA ÉW!X N"!š›œ!/LM+!$.W.!() !(R!$%!/Ÿ

X ,(! '!/ (!&.U7!ĂU(!V2W!+ 4!( ỹ3!/ó!X ,( .'!/LM+đễJK!‘“Kô”&' ! 1!2!$23*

&4!-5$!"6+!+ừ!/ (!&.U!$%!œZa7

Trang 3

 !"#$%&$'"()*+,-./#0$1234561+7

8899:;<=>?@ABCDEFBCG99:;<=>?@ABCH9G 9:;JKB@B@HBGLM9LNOPQO677JR STUVWXYVZ[\ZV]V^Z_VUZ`abVcY\VdZefVghiVUZXVjkl^V^ZmV^nV]Vop\qVjr^VZstXbVvV\wUbxy^ZVUZkz^ {||VodbVxZ}\qV^nVcY\VdZefVdZ~ĂV€Y\VdZefVghiVjYfVoY_V^Z_VdZY\VÂ\qVqsYsV[\ZVU‚VUTdVUZÊ_VjÔ

dZƠUVZst\Vj†UVosT\VjsÔfĂ

7"6 !Ư.ˆ‰-"2À/#‹#Œˆ$.61+7 ˆŽ%

‘’'“ ”23•ˆŽ3 ẢŒˆ$. —

#Œˆ$.

Đ

ˆ™/

Ã$

%-ˆœ*,"3

ižă Áâ_\Vđ ^Ăđă]êđăôơÊẶVưẨ

ẪdĂàÊ]ô{ẨuqẬcÈẺẼ ÉÊUÊu °Ẹ Ề\ỂuơsfVÊUVỂẶĂ]]Ế

iăđ Áâ_\Vđ ^Ăôảă·VÌVẨ

ẪdĂưudảảỈẼ ÉÊUÊu °Ẹ hZ_aVÊUVỂẶĂỄ]ôẾ

iăả Áâ_\V]| ^Ă]|đđã]|đ{VơÊẶVhư

ẪdĂưZuđ{žẨuqVẬcỈẺẼ ÉÊUÊu ÍÊỊ

iẺă Áâ_\V]đ h]đ]]ơÊẶư

ẪdĂhac{đăẸỂẶẬcỈ]½Ẽ ÉÊUÊu ÍÊỊ

ižả à\Uu_\V]đ qĂăẺ{ô½VẨVÌV·¾V^Ă]đđđã

ôẨVÌV· ÉÊUÊu °Ẹ is^ZUÊuVÊUVỂẶV]đẾ

iẺž Áâ_\V]ả ^Ă]ảžđưVÌVẨ

ẪdĂưauẺž]ỈẼ ÉÊUÊu °Ẹ ẨosơsVÊUVỂẶV]{Ế

iẺ½ Áâ_\V]ả ^Ă]ảžđưVÌVẨ

ẪdĂưauẺž]ỈẼ ÉÊUÊu °Ẹ ẨosơsVÊUVỂẶV]{Ế

iă| Áâ_\Vô] ^Ăô]đảơÊẶV

dĂẪẸỂẶă]{ÈẼ ÉÊUÊu °Ẹ

É_XơỂaÊuVÊUVỂẶĂ

Ễ]žẾ

ÒSVVV]VVVôVVVVđVVV{VVVžVVVẺVVVăVVVV½VVVảVVVẪáẼVVVẪãẼ

{||od

Trang 4

 !"#!"#$#%&'(&) *%+,-).%/ 04"12(&) *%34 0

56789:;8<=>87=?@8ABC=D78=EFG8HIJK8LMKNO8PFG=8G=QG8<R8AS78PE6G8TUG8VWXY8ZD<8AS78PE6G87\G PFG=8G=QG8P]>8T^_8`8PFG=8G=QG8<R8AS78PE6G87a>8_B8b678=c<8de_f8`8AS78PE6G8_?78_S78=>g<8G=Eh: G:<iU>7Ejf8X8AS78PE6G87[\G8EG7[>GY8kT=E\G8<l:8<mG8nD<AoG=8Apq<8J8AS78PE6G8_eE8_?78J8G:<iU>7E

7\G8Un>G8XK8rs8X8G:<iU>7Ej87\G8Un>G8X`f8<D<8AS78PE6G8Gs@8TQ@8iF<=8b=:GT8jo<=8_B8rs87a>8G\G8_B b678=c<8de_Y

<Y`tX8u LCYx<YUXJMw[`tXv`tJjUiTydz{O88Un>G8uw `

WFG=8G=QG8_B8d|8VW}t kTp~E8PG=87=p~GT

€‚ƒ„€‚…‚†‡…‡‰€‚ˆŠ†‹ŒŽ‘’“‚‚”•–—˜Œ™š

56789:;8TE;E8G=87›8TUG8VWX8<œ]8PFG=8G=QG8_B8d|8VW}t8<=>87=?@8PFG=8G=QG8<R8AS78PE6G8nR] J8G:<iU>7Ej8uw87aE8ro8`tX8rs8`tJ87\G87G=87›8<žkwf8AS78PE6G8nR]8J8G:<iU>7Ej8Gs@8jŸG8A6G87=]@

A E8b=:GT8jo<=8_Bf8s_87=]@A E8]<Ej8]_EG87=l8XJM87¡8xd>iU:<EGU87=sG=8w[TEGU8rs87a>8_B8b678=c< de_8d]:8{8<>j>G8b6876CY

¢„£¤ˆ¥¦…§¨ˆ’‡¤†‹ŒŽˆ‰©ˆ‚ª‚«‡©†‡‘§€‚’“‚‚”

u=sG=8rE\G8TE]8AG=8<œ]8G=¬GT8PFG=8G=QG8AB8C=D78=EFG87=?@8AS78PE6G8Apq<876G8=sG=8nD<8AoG=

7G=87aGT8_]GT8TUG8VWX87aE8<D<8ro8AS78PE6G8<=­8AE®_8AB8nD<AoG=8Apq<87\G8PFG=8G=QGY

…†ƒ„£¤ˆ¥¦…•‘††‹§¨ˆ’‡¤‘¯ˆ‚ª‚«‡©†‡‘§€‚’“‚‚”

£¤ˆ¥¦…

˜’“‚‚” °±’“‚‚” ‚ª‚«‡©†‡‘§€‚

5=µGT8_]GT8TUG8PFG= J JIXK ` `IH M MIXK

56789:;8<=>87=?@8AB8C=D78=EFG8{IH8Lt}NO8GTp~E8P|8rs8}IH8L{`NO8GTp~E8_·8is8GTp~E8sG=8_]GT TUG8PFG=f8{IXK8L{KNO8=sG=8rE\G8is8]G=f8<=ofU_8PFG=8G=QG8is8GTp~E8sG=8_]GT8TUG8PFG=Y

Trang 5

 !"#$%&'() *% +,-.%/+$012340+4- /,  56789:;<=

8>9?@A@BCDEFGEHIJ@KBJ@J@LJMN94IJ@AJ@FGAGIJ@OQFRJSN6T

UVWXYZ[X\][]XW^`aXWbX\c`XdefXghgXWai`aXj]k`X\]lXm_`aXno`aX`ap`XgaqXWarstXno`aX`ap`Xdeuv jiXnwXno`aX`ap`XmxZXyahWXa]o`Xmz{gXm|WXn]V`X}~Xa{yXWX€lX‚X`ZgƒcqW]}X„…XW†]Xj~XW^Xˆ‰uu‚Xji

ˆ‰uuˆXW^k`Xc€q`XˆXgŠlX\c`Xdef‹XŒoXYZ[XgŠlXm|WXn]V`X€lX‚X`ZgƒcqW]}X`isXƒiXbXWalsXmŽ]XaZ`\ }~gaX‘’Xn]V`XmŽ]Xl€]Wl]`XWa“Xf‚”XW•X–qƒcZ€]`cXWai`aX…^\]`cXjiXW†qX‘XVWXa—gX˜‹X™šXjiXc

\h]Xno`aX`ap`XƒiX`\z›]Xn_`aXWaz›`\’Xaœ`\XgXm|WXn]V`X\c`Xdef‹

e

Trang 6

     !"

#$%&'('%)(*+%',-.'/0%)'123'4-',$%&'56

7(*9%'4:%'46+%';<7'%&6=1'>?3'7&@'7&AB%)C'D&E

,6<%'F'78G'H1 /I6'7J%'>(K7'7&AB%)'):D'7L

MNMOPQQQRMNMSPQQQ'78.%)'>T'78G'UAV3'>6%&'8W

XMYZ'M[\P']'%)(*+%',-.'/0%)'123'3&^'U_%)

&-%)'7&_'&W6'>W('('`3'7a%&'F'&?3'123'/9'7J%

>(K7'b(K7'&6$%'3cW'3`3';&T6'('7.%)'E'1?7'MS\P

d&J%'4I%('%)(*+%',-.'/0%)'1233&^'e%&

&AF%)'M',+%'1?7P'f(*'%&6+%C('%)(*+%',-

/0%)'1237&@'g',+%'3&6<1';&.e%)'gORhOi

3`3'78AB%)'&VD'/I6'3`3'1_3'Uj';&`3'%&W(

5k%'U<%'1l'4mW'%<(';&n%)'UAV3'3&o%'U.`%

/-'U69('7';pD'7&B6Pq6$3'D&`7'&6$%'Uj7',6<%')H%

r#M'78+%',$%&'%&s%'('%)(*+%',-.'/0%)'123

>t'4-1'3u'>F'3&.'/6$3'78@%';&W6'3&o%'U.`%

7AI3'>6%&'3v%)'%&A'46$('D&`D'U69('78')H%C

Uw%)'7&B6')6xD'y(e%'4z'7T7'%&{%)'%)AB6'1W%)

)H%')s*',$%&'%&|1')6e1'7}'4$'1?3',$%&P

~<7'y(e'%)&6+%'3_('3&.'7&K*'SNgQ'€Qi

,$%&'%&s%'3‚'Uj7',6<%')H%'r#MP'f}'4$'Uj7',6<%

D&`7'&6$%'UAV3'UƒUAV3',`.'3`.'78.%)'3`3

%)&6+%'3_('7+%'7&<')6I6'5W.'Uj%)'7„'M…i'U<%

[gi'XhR…\C(*'%&6+%';<7'y(e'%)&6+%'3_('%-*

7Au%)'Uw%)'/I6';<7'y(e'%)&6+%'3_('7+%'MQgQ

,$%&'%&s%('%)(*+%',-.'/0%)'123726'3&s(

†(C'#?3'‡ˆ'/-'3&s('‰'€…i'XORMS\'&W*

7Au%)'7Š'%&A'7}'4$'Uj7',6<%'D&`7'&6$%'F'M…g

,$%&'%&s%('%)(*+%',-.'/0%)'123726'fs*

#W%'‹&W'hSi'XM…\P'f}'4$'Uj7',6<%'78.%)(

%)(*+%',-.'/0%)'1235W.'Uj%)'3‚'7&@'UAV3

)6e6'&a3&'4-'5.'7.%)'3`3'%)&6+%'3_('>„'5Œ%)

UW'52%)'3`3'D&Au%)'D&`D';&`3'%&W('/-'3

1k('%)&6+%'3_('b`3'Up%&'3`3'Uj7',6<%P'‡2%)

4AI6';6@1'>.`7'3&K7'AV%)'%)&6+%'3_('D&s%'7

3&s('†('Ž(8.DHW%'‡.4H3(4W8'H%H763>

(W46*'‹H7‘.8;Rއ‹';6<%'%)&p'%+%';<7

&VD'&W6'&.:3'%&69('&u%'3`3'D&Au%)'D&`D

;&`3'%&W('U@'7’%)'Uj'%&2*'D&`7'&6$%'3`3'Uj7

,6<%'r#MP'f&T%)';+'7L'3`3'%)&6+%'3_('78+%

7&<')6I6C'3‚'78+%'…QQ'4.26'Uj7',6<%')s*',$%&C

7.%)'U‚'Uj7',6<%'/n'%)&“W'3&6<1';&.e%)'€gi /-'Uj7',6<%'1K7'&.:3'7&+1'%(34H.765')s*'5p3&

;&(%)'5p3&'1ƒ'3&6<1';&.e%)'g[iC'%).-6'8W 3m%'):D'3`3'Uj7',6<%';&`3'%&A'Uj7',6<%'>W6

%)&“WC'Uj7',6<%'726'/p'78'3?7'%T6')H%'>D4636%)

4-1 e%&'&AF%)'7I6'y(`'78”%&'D&6+%'1ƒ')H% 3&6<1';&.e%)'gQiP'•`352%)'Uj7',6<%'Uƒ UAV3'D&`7'&6$%'7+%')H%'r#M'F'gQ',$%&'%&s% ('%)(*+%',-.'/0%)'123q6$7'‹W1 )w1–'Uj7 ,6<%'/n'%)&“WC'Uj7',6<%'1K7'1j7'&.:3'%&69(

%(34H.765C'Uj7',6<%'78+%'6%78.%'4-1 e%&'&AF%) U<%'y(`'78%&'3?7'%T6')H%P'‹).-6'8WC'%)&6+% 3_('3m%'b`3Up%&'UAV3'g'Uj7',6<%'1I6'1K7'g

%(34H.765'78+%'Hb.%'MQ'/-'M'%(34H.765'78+% Hb.%'MhC'3`3'Uj7',6<%'%-*')s*'4$3&';&(%)'5p3& 1ƒ'/-'72.'%+%'1ƒ';<7'&x3P

q9';<7'y(e'D&`7'&6$%'%)AB6'-%&'1W%)')H%

7+%',T'1—',$%&'%&s%C'%)&6+%'3_('D&`7'&6$% UAV3YNS'[Oi'%)AB6',T'/-'ONS'Yhi'%)AB6 1—'4-'%)AB6'-%&'1W%)')H%',$%&C'3m%'426'gOi

%)AB6',T'/-'h[i'%)AB6'1—';&n%)'D&e6'4

-%)AB6'1W%)')H%',$%&C';<7'y(e'%-*'3v%)

7Au%)'Uw%)'/I6'%)&6+%'3_('7AI3'Us*';&.e%) )J%'OQi',T'1—',$%&'%&s%'('%)(*+%',- /0%)'123';&n%)'D&e6'-'%)AB6'-%&'1W%)')H% ,$%&'XY\P'~<7'y(e'D&`7'&6$%'Uj7',6<%')H%'78+% 3`3'7&-%&'/6+%')6W'U”%&'W%&C'3&pC'H1'3&

7&K*C'YNMQ'YQi'78AB%)'&VD'4-'%)AB6'4-%& 1W%)')H%',$%&C';<7'y(e'%-*'3v%)'D&l'&VD /I6'y(*'4(˜7'56'78(*9%'3cW'1H%5H4'4-';&.e%) OQi'3`3'7&-%&'/6+%')6W'U”%&'>t'4-'%)AB6'-%& 1W%)')H%',$%&P‹&{%)';<7'y(e'7+%'3&.'7&K*C /6$3'`D'5Œ%)'y(*'78%&'b`3Up%&'Uj7',6<%')H%

7+%'7&-%&'/6+%')6W'U”%&',$%&'%&s%'>t')‚D D&J%'4-1'>`%)'7™'3u'3&<'56'78(*9%C'7L'U‚'&š

7V'3n%)'7`3'3&o%'U.`%'78AI3'>6%&'%&|1'1Œ3

Ua3&'%)’%'%)LW'/-')6e1'74$'1?3',$%&P

Trang 7

  ! "#

$%&'()*'+,-*./01*23145*6,-'*-'7-*89*:;)

6+<-*=>-*?@AB*)CD-=*:9*&'()*'+,-*:EF8*0*:;)

6+<-*GH+*GI)*-J8K>D)+L*)C

M-*>ND-*A1*OP*>ND-AQR*$%*&'()*'+,-*S/.*2TU45*-=EV+*6W*OP*U/

2SQ45*-=EV+*GX*89*:;)*6+<-*=>-*?@A*Y*)Z-=

)'(+*L[*'F&*)\B*S/A1*2S145*)'P-'*O+M-*89*:;)

6+<-*=>-R

"]^  _`a bc

$d*)P+:EF8*)'e8*'+,-*OH+*fe*'g*)CF*h+-'

&'i*8jk*:d*)P+*8I&*@;*l*)<*mn='+M-*8oJ*:p8

:+qG*K7G*fP-=B*8r-*K7G*fP-=*6,-'*J-=*)'E

Os-=*GZ8*OP*N(8*:[-'*t<J*)W*L+*Jtd-*6u-=*hv

)'Jr)*f+-'*'w8*&'7-*)\xR

y  " z {| }~

{€^|‚ƒc„…„†‡‚ˆ‰ŠŠ‹{ŒŽ

C6+)kK*C>)+-D6Kkf)DGk‘*’C>f>-)*f)k)Jf*k-L

“J)JC>*8'kKK>-=>f”•*C>O+>–—˜™š›œžŸ ¡ ™¢

£¤¢B¥B*AU¦§ASTR

{¨ƒ©ª‰^Š‚‡_«ƒ†Š‰†‰¬­®‚¯„€a‰†

{‚|©c^‰†®"ŒŽŽ°R*±>CGK+->*GJ)k)+D-f*+

-C>)+-DGk* &k)+>-)f‘* C>K>Ok-8>* )D* KD–”

&>->)Ck-8>*k-L*KD–”>N&C>ff+O+)t*GDK>8JKkC

6kf+fR²¤¢³œ´B¥‚TTA”TTTR

µ^_«ƒ€¶ ·‚ƒ©¶‰¸c‰_«¬|­‚ƒŠa^¹

€ƒº"‚|‰„Šƒº¶{‚„c»©€‹{ŒŽŽ¥R*¼>-”

f+)O>*GJK)f)>&*8K+-+8kK*GDK>8JKkC*f8C>>-+-=*D“

A.1*J-C>Kk)>L*+-L+O+LJkKf*–+)'*C>)+-D6Kkf)DGk

L>)>8)f*QS*-DO>K*GJ)k)+D-f*+-*)'>*?@A*=>->R

4š£²š¡™¡½¥B*USS”UT3R

¾„†¶„a"‚ „cc„¨^†„c‚ƒc„…„†‡

‰¬„€ŒŽŽ°R*•*8DG&C>'>-f+O>B*f>-f+)O>*k-L

>8D-DG+8kK*k&&CDk8'*“DC*)'>*L>)>8)+D-*D“

GJ)k)+D-f*+-*)'>*?@A*=>->*+-*C>)+-D6Kkf)DGkR

¿ĂÂĂ¡½ĐЂUAT”U0TR

¥­^‰¬a„†ˆ"ƒ«a„ccB*?@A*=>->*GJ)k”

)D-*+-*?>)+-D6Kkf)DGk*2A¦¦¦5R4š£™Â£š¡

¡¤ÂB¾B*0.Q”0 R

ʈ©¶«€ƒº­‚^ƒ…‰¶„c¯‚Ô«„c» ‚

€„†¸ˆ­‚„€€‰¯"ŒŽŽ°R*Ơ>)>8)+D-*D“ GDfk+8*?@A*GJ)k)+D-f*+-*“kG+K>f*–+)

C>)+-D6Kkf)DGkR4š£²š¡™¡½µŽ‚.30”.UAR Ư‡©»„cƒ ‚ƒ¶«^Š„‚ª©a^‰¬„€

ŒŽŽ¾RJ)&k)+>-)*8K+-+8*“DC*=>->)+8*8DJ-f>K+-= k-L*=>->*)>f)+-=*D“*C>)+-D6Kkf)DGkRÌ¡1¢œ

žÂỈ¤¢B°B*0U”Q1R Đ"ƒ«a„cc­ˆ‚¯†„cЬ¯‚ƒĨĨ^c»͂

ƒ†¶¬«‰a¸‰¯Œ°°ÊR*Ị'>*f&>8)CJG*D“*?@A

=>CG”K->*GJ)k)+D-f*+-*'>C>L+)kCt*C>)+-D6Kkf)D” GkRÌ£4š£¿ĂÂĂ¡½¥ĐB*¦31”¦3¦R

°{€ƒc¶ƒ‚®†„‹€‰‚|‰cÍcЉª"ÎĨ‰ª {‰¬„€ŽŽ¥ÏL>-)+8k)+D-*D“*0S*->–*8D-f)+ )J)+D-kK*?@A*=>->*GJ)k)+D-f*+-*¼&k-+f'B*ÐD”

KDG6+k-B*k-L*ÐJ6k-*C>)+-D6Kkf)DGk*&k)+>-)fR 4š£²š¡™¡½¥B*¦¦R

Ž»©‹Ñc»ÒcӂƒÓc»{c«©Ôc‚

«Õa«Ö|^c««Ò©ŒŽÊ5R*Ơ[8'*)×*'w8*J -=JtM-*6PD*Os-=*GZ8R0؟Ỉ ÙẤ œÛÂỈܚÝ  ÞỈ½ŽŒ¾

~c„Š^aԂƒ»»{‚ƒº‰€€ Œ°°µ ß>8'k-+fGf*D“*D-8D=>->f+f*+-*&k)+>-)f*–+)

“kG+KkK*C>)+-D6Kkf)DGkRăâ1™ÂỈĂâBÊЌ¥‚

¦U.”¦S3R

«ƒ‹ ͂„c»‚©¯‰¬„€

ŒŽŽđDff*D“*'>)>CDêt=Df+)t*k-L*GJ)k)+D-f

kC>*)'>*GkôDC*G>8'k-+fGf*D“*?@A*=>->*+-k8)+ Ok)+D-*+-*Ð'+->f>*–+)'*f&DCkL+8*C>)+-D6Kkf” )DGkR4š£²š¡™¡BŽŒ¥‚31.R

µˆ^_«¬‰†‡‚„cЉª„cЉ ‚«‰c‰¬

„€ŒŽŽµR*¼>-f+)O>*k-L*>““8+>-)*L>)>8)+D-*D“

?@A*=>->*GJ)k)+D-f*>-'k-8>f*8kC>*“DC

“kG+K>f*–+)'*C>)+-D6Kkf)DGkR Ì£4š£

¿ĂÂĂ¡½ƯB*0UQ”0S¦R

¾{¨^Š^~‚ c„†^‡‚‡‰ơ†^‚«„†^ơ|‰¬

„€ŽßJ)k)+D-kK*k-kKtf+f*D“*'>*?@A*=>-> +-*ßDCD88k-*&k)+>-)f*–+)'*C>)+-D6Kkf)DGkR²¤¢

³œ´½ƯB*QU3A”QU3TR

¥ ƒ©Š„‹‰† ‚„©¬«^‰† ¹ ^€„†¶

|‚"„©»Í{‚„»ư¶ ¹ ¯‰†«ƒ©‰¬‡‰¬„€

Trang 8

 !"#$%&'()*)+,-.)/,0())+-+1/2%(/0%+,3-45

3%+67/89:/&4363-%+,/;</=>?@$/6+A/BC?DEF

6GHIGJKJLM"N:OP5QRQF

ST#UVWXYZ[Y\NV]^Y_`YVbcdNeV[YfN

UXZgYVaZNeZbgV[ZaaehNZ``VfNiZbYZ[Y

hNj[d``bYe T"F/C4363-%+67/,0())+-+1/%2

3*)/89:/1)+)/-+/k367-6+/'63-)+3,/l-3*/()3-+%5

;76,3%&6/().)67,/::/+%.)7/&4363-%+,Fm6GH

nopoJqrSL/QROF

Ss#eVgtV_eNuZVbeNh`vYb_cbhNwYWxy

bZzyec[VaZ_UZ`Va {"FD')03(4&/%2/89:

1)+)/&4363-%+,/6+A/7%,,/%2/*)3)(%|<1%,-3</-+

C)}-06+/'63-)+3,/l-3*/()3-+%;76,3%&6~/-A)+3-5

063-%+/%2/,-}/+%.)7/&4363-%+,F3Kpo€‚ƒHK€„q

!L/OP5OOF S{#uVaVW…b†NUd[VgZ‡NYaˆZ[`cfN fZ[[ZY[c†Z`Va !"#=)3)03-%+/%2/1)(&7-+)

&4363-%+,/-+/6(1)+3-+)/()3-+%;76,3%&6/'65

3)+3,~/7%l/6+A/2477/')+)3(6+0)/()3-+%;76,3%&6 064,)A/;</3*)/,6&)/1)(&7-+)/34+063-+1/&4365

3%+Fm‚ƒ‰oHIƒŠ‚ƒŠqMsL/Q‹Œ5PPF SŽ#hacb_cwNV[gtVyeYdZaNhˆZaVY[V_ wZ`Va S"F/D')03(4&/%2/1)(&7-+)/89:/1)5 +)/&4363-%+,/-+/D'6+-,*/()3-+%;76,3%&6/'65

3)+3,~/?*)+%3<'-0/6+A/&%7)0476(/)'-A)&-%7%1-5

067/&'7-063-%+,F6GHIGJKJqSsL/‹:Q5‹QQF UdWWV[

eh ‘h’ hh’U U ‘f ijS ‡‡ hu hii ‡i u‡‡ ‘

  fhe ’ ‡U “  i‡ ‘j’hU‘eh 8)3-+%;76,3%&6/-,/6/()0),,-.)-+*)(-)A/A-,)6,)L/0%&&%+7</064,)A/;</3*)/()3-+%;76,3%&65: 1)+)/&4363-%+/”89:•/l*-0*/'76<,/6+/-&'%(36+3/(%7)/-+/,3(4034(67/2%(&63-%+/6+A/&6-+3)+6+0)/%2 ,)+,%(</(),'%+,-.)+),,/*)7'-+1/)<),/3%/,))F/=)3)03-%+/%2/*)/89:/1)+)/&4363-%+/-+/%4(/'63-)+3, l-3*/()3-+%;76,3%&6/-,/6+/-&'%(36+3/'()0%+A-3%+/3%/-A)+3-<-+1/3*)/06(()(,/6+A/'()+6367/A-61+%,-,

-+/%(A)(/%/()A40)/3*)/(63)/%2/;7-+A+),,/-+/0*-7A()+F/–*)/1%67,/%2/*-,/,34A</6()~/:F/—+67<,-,/%2/&45

363-%+,/-+/3*)/89:/1)+)/-+/()3-+%;76,3%&6/'63-)+3,F/QF/=)3)03/3*)/06(()(/%2/3*)/89:/&4363-%+ -+

3*)/()3-+%;76,3%&6/26&-7</&)&;)(,F/–l)+3</”QR•/26&-7),/l-3*/()3-+%;76,3%&6/A-,)6,)/l6,/,)5

7)03)A/2%(/3*-,/,34A<L/,)˜4)+0-+1/3)0*+-˜4)/l6,/4,)A/3%/-A)+3-</&4363-%+,/-+/89:/1)+)F/8),473 ,*%l)A/3*63™šQR/”‹R›•/%2/'63-)+3,/*6.-+1/&4363-%+/-+/89:/1)+)/-+074A-+1/Q/+%.)7/,&677A)7)3-%+

&4363-%+,/-+/)}%+/:R/6+A/)}%+/:Pœ/l)/2%4+A/Œš™/”›•/%2/63*)(,œ/š™/”ŒP›•/%2/&%3*)(,/6+A/6+A

Œš:R/”ŒR›•/%2/6&-7</&)&;)(,/”;(%3*)(,/6+A/,-,3)(,•/*6.-+1/*)3)(%|<1%4,/&4363-%+/-+/89:/1)+)F

\Zžc[]_ŸiZ`YbcˆaV_`cWVNijSWd`V`YcbNgV[[YZ[_

... q{ụẵVVèVÃắV^]ó

ụVèVÃ ẫ? ?U< /sup>? ?u< /sup> °Ẹ is^ZU? ?u< /sup>V? ?U< /sup>VỂẶV]đẾ... ^Ăđă]êđăơơÊẶVưẨ

ẪdĂàÊ]ơ{ẨuqẬcÈẺẼ É? ?U< /sup>? ?u< /sup> °Ẹ Ề\? ?u< /sup>ơsfV? ?U< /sup>VỂẶĂ]]Ế...

ẪdĂưauẺž]ỈẼ É? ?U< /sup>? ?u< /sup> °Ẹ ẨosơsV? ?U< /sup>VỂẶV]{Ế

iă| Áâ_\Vơ] ^Ăơ]đảơÊẶV

Ngày đăng: 15/01/2020, 19:45

TỪ KHÓA LIÊN QUAN

TÀI LIỆU CÙNG NGƯỜI DÙNG

TÀI LIỆU LIÊN QUAN

🧩 Sản phẩm bạn có thể quan tâm

w