Bài thuốc bổ dương hòa ngũ có nhiều triển vọng trong điều trị các biến chứng của bệnh đái tháo đường, nghiên cứu thử nghiệm bài thuốc này trên giai đoạn sớm của bệnh nhân đái tháo đường typ 2.
Trang 1!"#$%&$' ()*%+,
#-*./0"#$12-*-(345
6789:; <9=>?7@A9:BCDEFG5>HI9?EFG (JDK
6LMNOPQ5RSTMULM3VWYZ[Q\OPW4]^_
82XS`QabcOULM56d4eOfgPQUNOPQ4eO2OhW2XYQaSiQa
gdOWUYjMkVlSiQaUmdQQan9gR64MoQUO[YWXpQNLQaWXmQaqO[YWXMsMkOhQMUtQaMu]kPQUqsO
WUsmqS`QavNwNxZMUyQaWzOQaUO{QMtYWU|QaUOP^kdOWUYjMQdZWX{QaO]OqmcQ}~^Mu]kPQUWUxQqsO
WUsmqS`QaW8hWYMUmWU ZvkPQUQUQQUo^ZULMUOPQqcOYVO MUOh^ NdQUo^kV lSiQaUmdQQanMUOh^ 2U`OaO]Q^MkPQUWQ^MUOh^8fvfvkOhQMUtQaWUxQMUuZhYaO]O qmcQ8Ndf6YZhWsNdMQQQaUzQaWU]ZqVO}YjWWU`OaO]QqO[YWX [YWXkVlSiQa UmdQQand^aO^qS`QaUYZhWvaO^XmWOQQOPY8v89 vWQaqSTM6R3ffv
vaO^R37v9 3UtMQQaa]QvMUtMQQaWUxQUzQaWU]ZqVOgdOUYjMkVlSiQa UmdQQanMoWsMlQaUWTWmQaqO[YWaO]OqmcQ}~^kPQUWUxQqsOUsmqS`Qa
:8B9?:HI99?> ¡F¢:¡H B£9?>¤9:¢:¥9 ¡F¢:¡H B£9?
br ] MU¦ O {Q UP§ ¨ ©Y]Q 2UhRQv 6LMNO PQ5RSTMULM3V
W XYZ[Q \O PW 4]^
ª^]O Y]QW Ul]Q«a^]O Mm^¬ ¬ 4adZ QUxQ§
4adZ qSTM MU W UYxQ§ 8
®-¯°±-²
³´µ¨¶·´¸¨¹º»¼½¨¾¿¨Ă¶¨Đʼ·¨Ô·´¨Ơ·Ư¨ĐµÌ¼Ỉ¨
Ĩ·µÌè¶Í¨¾Ê¨Į̣ͨÎÌϨ¶Ð¸¼½¨¶Ư¼½¨ÑÒ¨Ĩ´Ĩ¨Đʼ·¨
¼·Ó¼¨¼Âµ¨¶µÌ¶Ô¨ÕÖè×ÌØØỈ¨¶¸¿¼¨¶·Ì¨½µÙµ¨ĨÚ¨ÛỊỊ¨
¶Êܨ¼½º»µ¨¹´µ¨·´¸¨¹º»¼½Ỉ¨ÝÞ¨Đ´¸¨¼Öè×ÌŲ̂
ÑߨĨÚ¨ăăר¶ÐÊܨ¼½º»µ¨ĂâĨ¨¹´µ¨¶·´¸¨¹º»¼½Ỉ¨
Ĩ·µÌèăỈđϨÝÓ¼¨ÑÒ¨¶·Ì¨½µÙµ¨ØôÔơ¨ưµÊ¶¨Õìè¶Í¨
¾Ê¨¹´µ¨¶·´¸¨¹º»¼½¨¶ỉƠ¨×¨ĩ¨¶·¿¼·¨¶·í¨¶ị¨¼Öè
Øìį̀¹Ì¼¨¼Öè×ÌĮ̀¶Ö¼½¨¶ị¨×Ϩ¾í¼¨đϨê×ôÔ
³´µ¨¶·´¸¨¹º»¼½¨¶ỉƠ¨×¨½Óî¨¼í¼¨¶Ư¼¨¶·ºï¼½¨
Ĩ´Ĩ¨ĂðĨ·¨Ă´Ü¨¾Ù¼¨ñ¿¨ñµ¨ĂðĨ·Ỉ¨¶ị¨¹Ú¨½Óî¨Ðì¨
Ĩ´Ĩ¨ĐµÌ¼¨Ĩ·ò¼½¨Ă𼨶ó¼·Ỉ¨¶Ð¸¼½¨¹Ú¨ĨÚ¨ĐµÌ¼¨
Ĩ·ò¼½¨¶·ô¼¨êÛôÔ¨õºÙµ¨¶´Ĩ¨¹Â¼½¨Ĩö쨽¾ÜĨ¸Ñ÷¨
ôܨ¶Ö¼½¨Ĩì¸Ỉ¨Ĩ´Ĩ¨¶·ìƯµ¨ñø¨·Üî̶¨¹Â¼½¨ñ¿¨
Ĩ´Ĩ¨îÌܨ¶Ò¨·¸´¨·ùĨ¨¼úî¨Ñµ¼·¨¶ị¨ÐÒµ¨¸ð¼¨Ĩ·Üîû¼¨
·¸´Ỉ¨Ă¿¼½¨¹´î¨¶µûܨĨüܨ¶·ô¼¨¶Ö¼½¨Ñµ¼·Ỉ¨Ý¿î¨
¾í¼Ỉ¨¼ò¶¨ñý¨¾¿Ă¨þÜÿ¶¨·µÊ¼¨Ĩ´Ĩ¨ì¾ĐÜõ¼¨¼µÊÜỈ¨
Ýü¼¨Ýü¼¨Ĩ´Ĩ¨¶ûܨĨüܨ¶·ô¼¨ñ¿¨Ò¼½¨¶·ô¼¨¶ĩ¨¼í¼¨
þ嘆¸´Ỉ¨Ĩ·òĨ¨¼Ö¼½¨¾ùĨ¨½µúèÝü¼¨Ý0¼¨¹Ì¼¨ÑÜî¨
¶·ô¼¨êđô¨1´Ĩ¨ĐµÊ¼¨Ơ·´Ơ¨¹µøÜ¨¶Ð¨Đʼ·¨¶·ô¼¨Ý¸¨
¹´µ¨¶·´¸¨¹º»¼½¨¶ỉƠ¨×¨·µÊ¼¨Ĩ2¼¨Ðÿ¶¨·ð¼¨Ĩ·Ì3¨ Đ4¼½¨ñµÊĨ¨ÔµûĂ¨Ñ¸´¶¨Ò¶¨¹º»¼½¨·Üî̶ỈÑ5¨Ý6¼½¨
¶·ÜÒĨ¨òĨ¨Ĩ·Ì¨Ă÷¼¨Ĩ·Üîû¼Ỉ¨½µúè¾µƠµÝ¨Ă´Ü¨ĨÚ¨
¶´Ĩ¨Ý6¼½¨¾¿Ă¨Ĩ·ôèÑÞ¨¶µÌ¼¨¶Ðû¼¨Ĩöì¨ĐµÌ¼¨ Ĩ·ò¼½¨¶·ô¼Ô¨1´Ĩ¨·ºÙ¼½¨¼½·µí¼¨ĨòܨĨ·Ò¼½¨ÐÒµ¨
¾¸ð¼¨¼Âµ¨ĂðĨ¨ĂðĨ·¨Ă´ÜỈ¨Ĩ·Ò¼½¨¸þµ¨·Ú쨹º7Ĩ¨ Đ´¸¨Ĩ´¸¨ĨÚ¨Ô̶¨8Üú¨¶Ð¸¼½¨¹µøÜ¨¶Ð¨ĐµÌ¼¨Ĩ·ò¼½¨
¶·ô¼¨Ý¸¨¹´µ¨·´¸¨¹º»¼½¨ê×ôÔ95¨Ý6¼½¨î¨·ùĨ¨ĨƯ¨
¶Üîø¼¨¶Ð¸¼½¨¹µøÜ¨¶Ð¨¹´µ¨¶·´¸¨¹º»¼½¨¶
ĨÚ¨¼·µøÜ¨Ô̶¨8Üú¨¶Ð¸¼½¨½µìµ¨¹¸ð¼¨ÑÙè¼·º¼½¨¨
¹µøÜ¨¶¨Đʼ·¨½µìµ¨¹¸ð¼¨ĨÚ¨Ĩ´Ĩ¨ĐµÌ¼¨Ĩ·ò¼½¨Ĩ2¼¨
󨹺7Ĩ¨¼½·µí¼¨ĨòÜỈ¨¹Ĩ¨ĐµÊ¶¨¾¿¨Ĩ´Ĩ¨¼½·µí¼¨ Ĩòܨ¶Ðí¼¨ĐµÌ¼¨Ĩ·ò¼½¨¶·ô¼Ô¨¿µ¨¶·ÜÒĨ¨Ư¨
¼·¨ ĨÚ¨¶´Ĩ¨Ý6¼½¨¶Ò¶¨¶Ðí¼¨Ĩ´Ĩ¨Đʼ·¨ĨÚ¨Ĩï¨Ĩ·Ì¨¶Ư¼¨
¶·ºï¼½¨ĂðĨ·¨Ă´Ü¨¼·º¨¶ìµ¨Đµ
¼·µ¨Ă´Ü¨Ĩ喝ĂỈ¨ñ¨ñôî¨ÑߨĨÚ¨¼·µøÜ¨¶û¼¨ñù¼½¨
¶¸¼½¨¹µøÜ¨¶Ð¨ĐµÌ¼¨Ĩ·ò¼½¨¶·ô¼¨Ý¸¨¹´µ¨¶·´¸¨
¹º»¼½¨¶ỉƠ¨×¨êăôÔ¨³ø¨¶¿µ¨¼½·µí¼¨Ĩòܨ¼·4èĂ6Ĩ¨
¶íÜ3¨Õ½·µí¼¨Ĩòܨ¶´Ĩ¨Ý6¼½¨Ĩöì¨Đ¿µ¨¶·ÜÒĨ¨ĐƯ¨ ݺ]¨·¸¿¼¨ ¶·ì¼½¨¶Ðí¼¨Ă¶¨ÑÒ¨Ĩ·¨ÑҨѵ¼·¨
·Úì¨Ĩö쨽µìµ¨¹¸ð¼¨ÑÙèĐʼ·¨¶·ô¼¨¹´µ¨¶·´¸¨
¹º»¼½¨¶ỉƠ¨×Ô¨
Trang 2
! "# $% "& '
()*+./
0123567839:52;938<63=>3?@A9:35B1939:C3
DE839:6F;93GH634B9:3=12356783J@K83?L9:3
?@M23?N9:39:6F;93G2H63O5P3Q13JN4342;63856R93
4B9:3S@K83J2T93U2H43VWX3YUZ3
[\]^_`abc^def^gchi3S@K83G2H63J@K8385j93
45kB342;63856R93S@K83J2T93U2H43VWX3lm3J@K83
8n9345kB34o3GH38pW3=12345678m3qr839:st39@M83
4B9:3Qu9:3v3:2wm3qW63O523GxF39@M83qr83Gy93v3
GN23zt34{83J@K83qr83Gy93|395@34I;9m3=}9:3XEF3
qr834567834~3J9:3F69:3ẢkB3v3333 |l3
193678ZẢW63J35uW38569:3|39@M83qr83JT3
J9:3:23X235W9:3 |3423vẮ 3XGZ
-Ế
\^gc\b^bcb^dbc^bcb^ef^bcỚ^
bcb^g \^
¡30H95395n93J@K8385R93JBE93JE2345EB3
J@w9:34ằt3|345kB34;63856R9385R93JBE93ẳẵ3
vặặỠ3Q13JW9:3J@K83J2ớ63434ờ8538~8395}X3JN43
X{8342;63J2ớ634I3474345kB3@M9:3?ở9385R93
JBE93Q13J2ớ634I3JE2345EB3J@w9:34ằt3|38pW303
ỡ34z3| vv3ŨỨợZ
¡3D3=2z9385<9:345s9345kB34;63856R9385R93
JBE93ỪSỪ3| v|3Ũổ3ỠợZ
\^gc\b^ỬfỲ^`³^
D3=H95345s93?B39:6F;9395n93O5E839:B123
Ả29535B19:3OÍ3ÌộỈĨÓửữÒỎộ¾ộựĨ v 3:WX
6F3Qầ3ÌộỈĨÓửÁ¾ÂựĨấộữĨÁÂữĨữ Ỡ3:WX3
ẩờ85345@K83ÌộỈĨÓẫộÂÁậÁÂộỎđẻỎÂộ Ứ3:WX3
ẩ6F;93O569:3ÌÉĨÊậẹộỉĨ¾đữÒĨấĨễộựựấ l3:WX3
ị1B395n93ỹÂẹÂÁẫÂỎữĨấộÂ l3:WX3
Ư9:35BW3Ủựậữ4ộỎÒÉộẹĨ l3:WX3
ịÙW3GB9:3ỉđẹẻỎĨấđữ l3:WX3
3D3=H9538xt34ờ9535Bồ83JK4342z934IT938xt3 8pW3=H953Xố93495m3O5P9:3452z63XE6m38345W2Z
5P9:346n9345p3J2ớ634Z ÔỏơÈừ+./ÈứÚ)Ếũ+.
3ưEF3q29535W34~3J9:302BẢFq4kX3ẢtW293 Q138E83GBN23Oờ4JÙ953G@K9:385Ý3q73q29535WZ3
3243Q13XEF345Ẻ3J@w9:3XE63ẵ9k3ßB6853 8pW3àB59qB93á3àB59qB9Z3
âãả-ạăÈứ+)ç--ã)-èơé/
ịớ34123J@K8345~8352H934N235BW3V2342z43Q13
5BW3ß5s9342z4392H6330H953Q2H93ß6H3ßầ953
45683j83Q2H93ỡ3S@K835j838>34I6Fớ93U2H43 VWXZ3V:52;938<63J@K8342z93519534ê345E9:3
lẽ| v3Jz9345E9:3|ẽ| vlZ3 ì)ẾũÚ)ỏÚ
ß5Ẻ39:52HX3GnX3q19:m39:ở63952;9m3qB3 qE9534@M83qW6m383J72385<9:Z3
ắîĩî^[\]^_`abc^bcb^g \^
3Ứ 3=H95395n934I;93J@K83:5ðt38ồt345kB3
46>2m3:2M2m3X<83J3=H953451953|395Xm3X23 95X3 3=H95395n9Z3
¡3V5X3J2ớ634I3=}9:3F35j8352H93JN2Đ3J@K83 J2ớ634I34ờ8538~83=}9:3456783F35j8352H93JN23
45kB3t5E83JƯ3?B303ỡ34z3=W935195395}X3JN43 X{834;63J2ớ634374Z
¡3V5X3=>3?@A9:35B1939:CĐ3J@K83J2ớ6343
=}9:3F35j8352H93JN234@A9:34~3GP385<9:3Q13=>3 q69:3=>3?@A9:35B1939:C3 |3423vẮ 3XG3X23 9:1FZ3
3ò2H634Ió953 39:1FZ30H95395n93J@K83 O5EX3GnX3q19:3519:39:1F3Q13G1X3ôð439:52HX3 9:1F3S 3Q139:1F3S Z3
ắîõî^öƠg^gcụ^\^_cùf^úủ^
üG68Bqk3XE63G83J2Z
3DE8385Ý3q73q29535W3XE6Đ36Ikm38IkW42929m3
ỪẢßm3Ừòßm385BGkq4kIBG34B193t5y9m34I:GF8kI2?m3
Trang 3!"# #$% &' &()$ $*+ ),-# (/01 230#4&56
784.5()69(#84+3:09();
<=>?@ABC@DEF G' 3(H0 I,J# KL 3M $54 #"# 7$,N)2 7$"7 .$')2 OP Q $R# 8P) 7$S) 9T9 GUGG VW;X;
YZ.[0\ #* M )2$]+ $')2 OP 7 ^ X6XW;
_=`abcdefghDifedF jH)$ )$k) I,J# #0)2 #l7 $m)2 ) ISQ In
op $4p) 4p) q )20QH) $+9 2(+ )2$(P) #r06 :\4 9s .$m)2 ()6 $54 tu( KL 8 Ow7 $x( #"#
:(Z) #'6 $m)2 :"4 8y)2 8z( OZ [0\ )2$(P)
#r0;jH)$ )$k) #* $/ 8{.0(O$|( )2$(P) #r0 :l O} 3{# )p4 9p O$m)2 \)$ $,~)2 IZ) [0QT) 3J(I(T0 ;
=ĂÂ
Ê=`ÔecDƠ ƯEfhfhffghDifedF
ÀẢ
S0 $Z.:H)$ )$k) Đ WX 0(~ 3P)6)$*9 .0( Đ ÃX Ã #$(Z9 I+ &' Xă ~ )$*9
#$r)26 WÃă ~ )$*9 I(T0 8 : t,N)2 $4p) )2Áâ; đê 3H :H)$ )$k) )+96)ô ,N)2 I,N)2;
ơ(ô+ $+( )$*9 O$m)2 #* &q O$"# :(H oT 7$k) :' 0(62(-(;
ÀẶÀÀÀưẨÀẪàẬÈẺ
ẶÀẼÉÀÉẨẼ°Ẫ
G' )2,x( :H)$ 9-( I,J# 7$" $(H) I"( $"4 I,x)2 t,-( W )Ẹ9 #$(Z9 ỀỂ6Ểă; G' )2,x( I"( $"4 I,x)2 Đ Ã VX )Ẹ9 #$(Z9 Ễ
Xă;Y$m)2 #* &q O$"# :(H oT $x(2(+) 9Ế# I"($"4 I,x)2 2(ô+ $+()$*9
ÀẶÀÀÀưẨÀ·ÌỈ
ẺÀãÀÍẼÉÀÉẨẼ°Ẫ
Ị½fgÊ=¾fhÒáafgƯDạfehdfgÒhằfcẳDÒhẳbcẵắfgÒáẵặecDầFÒáẩ
ỊDạfehdfgÒhằf cẳDÒhẳbcẵắfgẫấậèẻẫ hẽehDEfcaDấéẻẫ
ỊÐẹẵềfghbểf fgễẫfấéẻẫ ếẫ
ơ(+(I4ệ) V Ứ X 93ì7$âỉ Ề Ã6ĩăâỉ V Ểăâỉ í X6XWỉ
ơ(+(I4ệ) Ề ÃX ị 93ì7$âỉ V ::4É4::ĩăâỉ VW WXăâỉ í X6XWỉ
ơ(+(I4ệ) Ể ỂX W 93ì7$âỉ V ::4É4::ĩăâỉ V ::4É4::ĩăâỉ í X6XWỉ
ơ(+(I4ệ) VW Ề 93ì7$âỉ X Xăâỉ X Xăâỉ í X6XWỉ
ơ(+(I4ệ) W ^ VW 93ì7$âỉ X Xăâỉ X Xăâỉ í X6XWỉ
j(Z) #$r)2 $s) #n+ :H)$ )$k) )2$(P) #r0 #$n QZ0 ~ 2(+(I4ệ) Ề op Ể;
ò=ẳeehỏBChFõạÒẳếóểỊậÒáẵặeóểBọFcDầFÒáẩ
!"# #$% &' $0QZ "7 op jồổ O$m)2 #* &q O$"# :(H 2(ô+ $+( )$*9 op t0Q 8 &0' IJ I(T0 8
:\)2 Ềâ; Ý=ẳeẹốfgeộọƯÐẹẵềfghbểffgễÒáifcẵắfgẳF ờ,x)2 9"0 80)2 :ỗ)$ 3m #$r)2 op 3m : t,N)2 $4p) )2Á ,-# op &+0 I(T0 ,N)2 I,N)2 )$+0ỉ:\)2 Ểâ;
Trang 4
!"#$%&'()&*+,-./01 234567(8*9:;*-3<
&'()
&=>?@"ABCD &=> E@"ABCD /@EF
EDG /@ECFEBCD
EC EBC EC EBC
HIJKL
MN
OPPHQR
STPU
LVI WXYZ[U\U]^Z_ W][ZXU\UW]Z[ WX`ZaU\UW^Z_ W]_U\UW]Z^ bUU`Z`^ STPU
LdefQ a[Z^U\UaZ] agZ[U\U_Z] [[ZXU\U[Z] [WZ`U\U_ZW bUU`Z`^
UhijUkQlP]R ]]ZagU\U]ZW_ ]]Z U\U]Z[^ ]]ZU_gU\U]ZX[ ]]Z^gU\U]]ZU]` bUU`Z`^
m677no6pqrpstuvwsxyz75o{|}~upuu
!"#B% *6(>.*@>> D68"&"&"(8*9:;*-3<
&=>@"ABCD ECED EBCED /@CEBCD
UVUVfUU aZaaU\UWZa[U aZ_YU\UWZ_[U bU`Z`^U hUdefQUVfUfQU aZX[U\UWZ[`U aZY_U\U]Z``U bU`Z`^U
!"# %¡"&-3¢"#£:¤>(.-# *6(>.*-345601(8*9:;*-3<
2¥69¦£:¤>
(.-G
EC"7§DG
/G EBC"7§DG /G
S¨L ^UOW_ZaR _UO]`Z`R bU`Z`^ YUOWXZXR W`UOXXZXR ©U`Z`^ ªV«NUfV¬f ^UOW_ZaR aUO]XZXR bU`Z`^ aUO]XZXR [UO]_ZaR bU`Z`^
®P ]`UO ZaR WaO^_ZaR bU`Z`^ WgO_XZXR W]UOY`Z`R ©U`Z`^ SfQ X`UOW``R X`UOW``R U X`UOW``R X`UOW``R U
m677no6pqrpstuvwsxyz75o{|}~upuu
U
¯°IUX`UfQJZUPU±Uk²PU³MLUQ´I³µUPMIUL¨LU¶°UfV·PU¸IULcUkKLUVºNUUdefQUVfU fQUL»fQUL¼U]`½U´¾fUXXZX½ZUV°JUU·U¿UfQVÀ°ULV¨fQUk¾UONU©U`Z`^RÁ
%.6ÂÃ"#68ÄÂ4Å"#&1""#Æ-3Ç" /:Â>.*
hUdefQUVfUfQUÈUVfUcÉUcLUMUc¨UfU´NUPMIU¶°UfVUfVTfUMUVMUdÊfQUL¿NU ]ËU»fQUdºUHÌÍUªULÎUXXZ_[½ZUQÈPUdºUÍÌÍUUªUWgZ^Y½ZUNU©U`Z`WUOÈfQU^RÁ
Trang 5!"#$%&%'()*+((,-.$/01234 5 56 72*89 !:;7<'= !3>'?@ !5,: !A
5B(C D89C
E9C + FGE/C
E89C + FGE/C +&C9H
E89/
5,C I;C E$C $E$C 5,C I;C E$C $E$C JKKLM NOPQRSR
TOTNM
POQNRSR
TOUVM
VOQWRSR
VOPPM
XOPYRSR
VOUUM
NOTNRSR
VOYUM
POYTRSR
TOXZM
VOUQRSR
VOPQM
POUWRSR
VOQPM [RVOVNM
\]K^M NOTXRSR
VOQUM
POPNRSR
TOZPM
VOUNRSR
VOPTM
XOZTRSR
TOVWM
NOVVRSR
VOQZM
POZNRSR
TOXTM
TOPYRSR
VOPY_M
POYNRSR
VOQY_M _`RVOVTM
abJRc\dM [RVOVNM [RVOVNM [RVOVNM [RVOVNM [RVOVNM [RVOVNM `RVOVNM [RVOVNM R
e566fg5hijhklmnokpqr64gstuvwmxhyzmmx{|
"#)0'= !0123>'?@ !5,: !A}I~ (Ă !2
!#ÂĂ !2 +.$/01234 5 56 72*89 !:;7<'= !3>'?@ !5,: !A
5B(
D89C
E9C + FGE/M
E89C + FGE/M &C
+9HE89/
JKKLM ZTOPVRSRPZONPM XTOYWRSRTUOYWM ZYOVWRSRTZOUYM XTOWXRSRTQOZTM [RVOVNM
\]K^M XNOUWRSRTNOPUM XVOTVRSRTPOYTM ZPOQXRSRTUONXM XTOPVRSRTNOYYM [RVOVNM
aRM [RVOVNM [RVOVNM [RVOVNM [RVOVNM R
e566fg5hijhklmnokpqr64gstuvwmxhyzmmx{|
\ƯRƯƯRÀƯRRƯRƯRƯRXVRƯRẢRĐƯRÃƯRÊÔORƠÔRƯRẢRRăẢRÁâRR
đêÁRêẢRơÁẶÀRâRđRRđêÁRƯĐRẢẨƯR
#)0'= !0123>'?@ !5,: !A}I~ 05Ẫ0 à !}5Ậ
!È#Ẻ 5Ẽ*6 (Ẫ0-É00°*}5Ậ +(-.&5Ẹ}/01234 5 56 }I?Ề0Ể:72*Ễ%Ế*}Iả
·
·
5B(C+ D89/C E9C+ FGE/C E89C+ FGE/C &C+E9HE89/
JRÌẢRÁƯRơỈÁR WVOXVRSRTUOZQM WTOVVRSRTNOUXM [RVOVNM
\RƯRƯRƯR WPOXVRSRPVOPXM WPOQXRSRTXOUQM [RVOVNM
·
·
ãẨẢRÍÌẢRẢỊÀRâ½ƯRƯRẢRRâÃRơÁRÃÀRXVRƯRơÁẶÀRâR¾RẢÒRÃÁRƯĐáM
Trang 6
!"#$%&'()!!)*+,-./*!0!01!'%23,456.+7)8+'%9
0:;<=!>?@A< B@CDBA B?@CDBA E<=B@B?@A
GHIJKHILMNHOPLHRSTUV WXYHZH[\] W]\HZH[\] ^H\_\` abHcdeNSHIfgNHNShHQRSTUV W[YHZHij ]\\HZHkj lH\_\[
nIoRHOLpqHrsHubHcdeNSHIfgNHNShHSLvRHmsfrwLNHNLMqHxfHyzLHrsdzKHOLpqHrsHygHxfHyzLHNIoRH KI{NSHKoH|HNSI}~HrINSHHQmHlH\_\[V
$
aMNIHNINHK~HKINSHrLHIqHIrHrsNH`\H
rqbL_H{~HrqbLHX\HHXiHKILRHj\HNIoRHKI{NSH
ygH`XHNIoRHubHcdeNSHIfgNHNShHILHSL~NH
RKHuMNIHrH\H`HNRHKILRH]k_k_HKI{NSHrH
IHNILpqHuMNIHNINHOdKHmIrHILMNHOLHIfH
OdNSHRqNHNNHOHKoHuLNHKI{NSHrINH
qrHmHygHKNHNNSHINSHrI~HObLHxqrHILH
SL~NHOLpqHrsHNIHrsPNSHL RHxfrHSqKfxwH
RqH¡RHK~HNIoRHHIJKHILMNHOPLHKoH]\Tk\H
QXX_WVHuMNIHNIN_HNIoRHubHcdeNSHIfgNHNShHH
KoH[WTk\HQ`X_WVHNIHrsPNSHuLNHKI{NSHrINH
OLHrIfHOdNSHK~HuMNIHNINHrsdzKHOLpqHrs¢H
IqHIrHuMNIHNINHNSILNHK{qHOHRKHuMNIHH
rINHOLHrIfHOdNSHSL~LHOfPNH]HQKoH~uqRLNH
NLMq_HR{KHJKHKqHrINHX\HHYiHRTmIrVHygHSL~LH
OfPNHkHQKoH~uqRLNHNLMq_HR{KHJKHKqHrINHk\H
H`iHRTmIrVH£vHI~LHNIoRHINSHKoHuMNIH
NINHuLNHKI{NSHrINHSL~LHOfPNHjHIfKH`H
qrHmHrsdzKHNSILNHK{qHK~HI~LHNIoRHgH
rdeNSHOdeNSHNI~q_HNIoRHKI{NSH[kj_YTWY_`H
RRS_HNIoRHubHcdeNSHIfgNHNShH[k\_WTYY_kH
¤~qHk\HNSgHOLpqHrsHIqrHmHK~HKvHI~LH
NIoRHOpqHSLvRHNI¥HypHR{KHL RHxfrHrr¦HQH
IJKHILNHOPLH[]Y_kTWi_YHRRS_HubHcdeNSH
IfgNHNShHH[]XTY[HRRSV_HrsfNSHOoHIqrHmH
rRHrIqHK~HNIoRHKI{NSHSLvRHKoH|HNSI}~H
rINSH_HmHlH\_\`H§{KHOHSLvRHSL¨~HI~LH
NIoRHINSHKoHx©HIKHuLMrH£IªHxHa§«HK~H
L RHxfrHrrHK~HbHKI{KHGHrHIHSLzLHQrH [Y_`HH]]_iVHL¨~HI~LHNIoRHOLpqHrsHINSHKoH x©HIKHuLMr¤~qHk\HNSgHOLpqHr_Ha§«HINSH KoHx©HrI~HObLHKoH|HNSI}~H
sNHNSdLHx~qHk\HNSgHOLpqHrsHubHcdeNSH IfgNHNSh_HrqHrsHxHrsqNSHuNIHK~HSqKfxwH RqHK~HKvH]HNIoRHINSHrI~HObL_HNIdNSH R{KHOHL RHxfrHSqKfxwHRqHK~HNIoRHubH cdeNSHIfgNHNShHKvLHrILMNHs®HsMrHxfHyzLHrsdzKH
OLpqHrstHR{KHL RHxfrHrrHrNSHrHXTk\HuMNIH NINHQ]\VHNH[\Tk\HuMNIHNINHQkk_kV_H R{KHL RHxfrH¡RHSLvRHrH[WTk\HuMNIHNINH
Q`X_WVH¯qNSH[]Tk\HuMNIHNINHQj\VH°IKH
uLMrHSL¨~HNIoRHHIJKHILMNHOPLHygHubHcdeNSH IfgNHNShHKoH|HNSI}~HrINSHHnIdHy_HugLH
rIqKHubHcdeNSHIfgNHNShHmILHImHyzLHrIqKH
HIJKHILMNHOPLHKoHrKHc±NSHKvLHrILMNHrrHrNIH
rPNSHL RHxfrHSqKfxwHRqHrsNHuMNIHNINH OLHIfHOdNSHKHc±NSHK~HubHcdeNSHIfgNH NShHIPHSqKfxwHRqHrsNHONSHyrHKINSHrLH OHKoHufHKfH²i³nSILNHK{qHxqHIeNHypHKeH KIHrKHc±NSHK~HubHcdeNSHIfgNHNSh_HKoHrI H
rI~RHIvfHKKHNSILNHK{qHypHIfgNSH´_HytH
rIqKHKILRHdNSHKIHqHK~HugLHrIqKHubH cdeNSHIfgNHNShHGfNSHµqHQ]\\`VH²[\³Hx~qH
OLpqHrsHu¬NSHIfgNSH´HNINHrI¶HgRHSLvRH
dNSH··[aHrNHKeHyN_HNIdNSHINSHSLvRH
rNHS~NHnIdHy_HIfgNSH´HKoHrKHc±NSHgRH
SLvRHx©HOpHINSHLNxqLNHrsNHKeHyNHnRH
Trang 7!"#$%&'(&)!*+!(,%-&!.&/!&01,!(2*!
&345&!6! !78!9!(:(! !;<%!*=)!7>&!(2! !
;<%!*=!&4?!(@,!ABA!6!CD!E<!7>&! !;<%!*=!
(04+F!G'&/!H%4!IJKKLM!NDJO!&0P&!0@,!
"378/8543!(Q!:(!#R&/!S!7>&!(04,T&!0Q8!
/54(%3'!#%!-U(0!0%1!(%&!VWX&/!(04,T&!0Q8!
Y48!"Z[\F! CW]&/!5$#!*:4!(^8!&0Q*!;_!#W`&/!0%<&!
&/a!(Q!(2!0b&!3%!Ec!&0Q*!,!0d(!0b&!V1F!
eS!;b&0!&0f&!(^8!&0Q*!Vg4!7!;i&/!;_!
#W`&/!0%<&!&/a!(Q!*j(!(0%5'3'7%5!-T*!
3%:!S!.&/!9!klAK!;b&0!&0f&!IDm)noM!5>&!
LlAK!;b&0!&0f&!IAKoMp!*j(!-T*!3%:!(0@$!
&0P&!VW](!/2*!9!DAlAK!;b&0!&0f&!IqA)AM!
r4S&/!LlAK!;b&0!&0f&!IAKoMp!3S!;b&0!&0f&!
-T*!3%:!-s*!-0?&/!08,!V_)!3%!3:&0!Ec!
&0Q*!,!0d(!0b&!V1!3t!-0:(!;b!(Q!u!&/0v8!
0S&/!->F!B:(!#R&/!(2!0b&!!Eg!5$#!*:4!(w&!
0T!0b&!7x!0`&!y!3t!(2!0b&!0<&0!$0z&!(^8!
(0%5'3'7%5F!e84!Vg4!7!*j(!;{&0!Y4f&!! C|C!6!}!/2*!9!A)qD!**%5lC!r4S&/!J)nk!
**%5lC)!~|C!6!}!.&/!9!K)Lk!**%5lC!5>&!D)Jn!
**%5lCp!3t!08,!V_!(Q!u!&/0v8!0S&/!->!!
$!!K)KDF!Z&/6'&!4!IJKKmM!!NLO!8378/85%3#'!
!I0%1!(0@!(0U&0!(^8!Eh!04S(!0%<&/!-M!(Q!
:(!#R&/!Vg4!7!S!0+!(0j&/!(04,T&!0%:)!
Vg4!0%<!(:(!7S!5%1&!5$#!*:4F!B7>&!5f*!
3<&/)!&0P&!0@,!(:(!;b&0!&0f&!(^8!&0Q*!
Vg4!!;_!#W`&/!0%<&!&/a!(Q!*'&!"eB)!"CB!
-0?&/!(Q!08,!V_!3%!Ec!7Wc(!Vg4!7!E<!3%!
Ec!&0Q*!(0j&/!,!0d(!0b&!V1F!\ !Y42!(:(!
(0!3S!04, !0d(!-0?&/!08,!V_!7>&!&0Q*!
Vg4!!- !0]$!;_!#W`&/!0%<&!&/aF [7%'&!&b4!(^8!&0Q*!,!0d(!0b&!V1!/2*!
&0 !384!!&/0>&!(j4!I9!nm!*/lC!(w&!nJK!
*/lCM)(0W8!(Q!u!&/0v8!0S&/!->Fmo)!/2*!C|C!6!}!DL)kqo)!$!!K)KDF! }0j(!&.&/!/8&)!(0j(!&.&/!0P&)!04, !:$!E<! (f&!&&/!;b&0!&0f&!-0?&/!08,!V_!34S!V]! Vg4!F
}0&/!?!r&!7f&!7d&/!(2*!`&!\0%8!+!
!}04,T&!0%:)!\0%8!B0P&!6!B !&b4)!b&0! Eb&!B4b!Bv&0)!~d(!Eb&!!#W](!0d(!}_!4,g&!
b!8*!V!/$!V=!(0&/!?!0%<&!0<&0!Vg!
<!&<,F!
¡¢
£¤¥¦§¨©ª«¬§«¬¦¬¬®¯¥¬° ±
²³´££µF!|G!#8;''3!8583!/5%;85!'3*8'3!%¶!
0'!$7'E85'&('!%¶!#8;''3!¶%7!JKDD!8&#!JKAKF!
·¸¹º»¼»½¾»½3¿¸ÀÁ¹üF£´)!ADD!6AJDF!
³¥Äŧ Æ«¬§ ²³´£³µF!B0t(!0<&0!
5f*!3<&/!;b&0!V:!0:%!VWX&/F!0<!r4@!;2&!!
!0d(F!
Trang 8
! "#$%!#&'()*+, ./0812245674
8695:2365;5<=>0?@A0CDEAFG0>0HIJKLM0N0OEP>0
QCM0RFKS>0TUV0N0VVVW0
X Y Y#Z[\']]^! _ ))`'+, a/ 0
bBLA0c0ABC0dCIBLGEcd0Fe0dEIKFLPfgdEGgKEL0EG0
DELfCACch0L0KFPC0eFK0ABC0iPFdCKgPLK0CGDFABCN
Pgdj0k31lmn5;5<31o0pq>0r?s0NrTtW0
p u[vwx*$y*z%{|[`w*\+, ,/ 0
}~6<n~:W0g G0TW0QB0gA0fG0R0BI0
QBG0DG>0?TV0N?VVW0
+,-q,/0ALGDLKDc0Fe0HCDEILP0LKC0
EG0ELfCACc0T?TW0k31lmnm4:12m>0,a+q/>??0N@VW0
{Z+,-qq/0E0PEg0IBgG0dG0
BGi0DG0IBG0FG0 0E¡g0AK0fGB0E0
ABF0£Gi0A¤¥0T>0fLG0BGB0S¦d0ABCF0g§A0
¢GB0c¨0VTU©ªN«R0Gi00ABGi00G¬d0
T??0IL0«®0A¯Gi0«®0R0A§W0
a #Zw)*#]°w±*'%²)y*±#Zw)*+, /³©
´µ0IPEGEILP0¥KLIAEIC0igEDCPEGC0LGD0IPEGEILP0
¥KLIAEILP0KCIFddCGDLAEFGc0eFK0DELfCACc00LGD0
IBKFGEI0SEDGC0DEcCLcCW0¶· ¸ ¹396m= k34o0
,q+X/ºtt@0Nt@VW0
» ¼y#*\½*ºzy%¾*y%\y¿*º
zy%¾*\ÀÁ[°w&+,-q/0I0DÂGi0IL0
fE0ABg¨I0fÃ0DÄGi0BFG0GiÅ0ABLGi0AKG0d0
BÆGB0ABÇI0GiBEd0IBg®A0E0BF0£Gi0A¤¥0TW0 7~:n~È:~É6~Êa»p>0U0N??W0
q- )*zËy+, p/W0O¥FiPICdEI0CeeCIA0
Fe0ÌcAKLiLPgc0¥FPcLIIBLKEDC0LGD0EAc0CeeCIA0FG0 ÍÍ?«W0¶:n1 }~12·1:5;5<3:1 Î363:1>0,.+/º0 Vst0Ï0VtTW0
qq w&w*Ðy+, »/CPCIAE C0ÑPC LAEFG0
Fe0ÌDE¥FGCIAEG0ÍKFDgIAEFG0f0ABC0QLAgKLP0FdN
¥FgGDc0CKE CD0eKFd0L0HCDEIEGLP0OCKf0ÌPPC EN
LACc0µGcgPEG0ÒCcEcALGIC0LGD0JPgIFcC0µGAFPCKN LGIC0EG0´fCcC0HEICW08695:2365;5<=Óqp-+,/º
@Tt0N0@VVW0
q, ²'*zÔ)y+, »/0ÌcAKLiLPgc0¥FPcLIN IBLKEDCc0 LPPC ELACc0 iPgIFcC0 AFEIEA0 LGD00
KCcAFKCc0iPgIFcC0BFdCFcALcEc0EG0DELfCAEI0
cALACc0 EL0LIAE LAEFG0Fe0ÌHͳW0ÌIAL0ÍBLKdLN IFPFiEIL0EGEIL>0-º0?@r0N0?@?tW0
q Ðw#)Õw*zw*+, ./00BC0ÌGAEFEDLN
A C0ÑeeCIAc0Fe0ÌcAKLiLPgc0L¥FGEG0µ0ÍKFACIA0 ÌiLEGcA0C CPF¥dCGA0Fe0ÑLKP0ELfCAEI0QC¥BN
KF¥LABW0¸}~12·1:5;Î:3oq-q>0?@@0N?rVW0
qX Y\w*Z#$) #`#&#`w +,-qq/ 00 ÌDE¥FGCIAEG0KCDgICc0¥KFACEGgKEL0EG0cAKC¥AFÖFAFN
IEGNEGDgICD0DELfCAEI0bEcALK0KLAcW08רm23·m6n1; Ù35;5<=169Úm93:36m>0,.>0@?s0N@TW0
Yy&&#$%
0
ß«g0LGi0BgLG0Mgà0á0«OQ0â0LKC0dFKC0¥KFdEcEGi0EG0ABC0AKCLAdCGA0Fe0IFd¥PEILAEFGc0Fe0DELfCACc0 dCPPgc>0cF0MC0ACcACD0LPPcAgD0DKgic0FG0CLKP0cALiCc0Fe0DELfCAEI0GC¥BKF¥LABW0BC0KCcgPAc0cBFMCD0
ABLA0¥LAECGAc0LiC0á@0N0@â0Fe0IFGAKFP0iKFg¥0Fe0LKC0sã0LGD0t@ã0EG0«OQ0iKFg¥W0EcCLcC0DgKLAEFG0
eKFd00N0t0CLKc0LIIFgGACD0eFK0TVWVã>0¥KEdLKE0KCGLP0IFd¥PEILAEFGc0EG0cALiCc0T0LGD0VW0«PFFD00
¥KCccgKC0LGD0fFD0MCEiBA0DED0GFA0IBLGiC0DgKEGi0AKCLAdCGAW0ÌeACK0V0DLc0Fe0AKCLAdCGA0«OQ0
iKFg¥0KCDgICc0¥KFACEGgKEL0rTW?Tã0á¥0ä0W?â>GIKCLcC0EG0Oå0N00MLc0VVW@Uã0á¥0ä0W?â>åå0N0 DCIKCLcCD0?Wtsã0á¥0ä0W?â0LGD0KCDgIC0fPFFD0iPgIFcCW0åE CK0egGIAEFG>0KCGLP0egGIAEFG0DED0GFA0 IBLGiCW0µG0IFGIPgcEFG>0dCDEIEGLP0«OQ0cg¥¥FKA0CeeCIAE C0EG0ABC0AKCLAdCGA0Fe0CLKP0cALiC0Fe0DELN fCAEI0GC¥BKF¥LABW0
°'%æ)$±(ç{y%#*z\y#*æyº±w#è'Z'(º±w#è'Zw[*'é\$)é#Z\%ê
...DE839:6F;93GH634B9:3= 123 56783J@K83?L9:3
?@M23?N9:39:6F;93G2H63O5P3Q13JN43 42; 63856R93
4B9:3S@K83J2T93U2H43VWX3YUZ3
[\]^_`abc^def^gchi3S@K83G2H63J@K8385j93
45kB3 42; 63856R93S@K83J2T93U2H43VWX3lm3J@K83... Q138E83GBN23Oờ4JÙ953G@K9:385Ý3q73q29535WZ3
3? ?24 3Q13XEF345Ẻ3J@w9:3XE63ẵ9k3ßB6853 8pW3àB59qB93á3àB59qB9Z3
õó-ẩ+)ỗ--ó)-ốộ/
34 123 J@K8345~8352H934N235BW3V 23 42z43Q13
5BW3ò5s9342z4392H6330H953Q2H93ò6H3ò953... jH)$ )$k) I,J# #0 )2 #l7 $m )2 ) ISQ In
op $4p) 4p) q )20 QH) $+9 2( + )2$ (P) #r06 :\4 9s .$m )2 ()6 $54 tu( KL Ow7 $x( #"#
:(Z) #''6 $m )2 :"4 8y )2 8z( OZ [0\ )2$ (P)
#r0;jH)$