Đặc điểm lâm sàng và cận lâm sàng ở bệnh nhân hội chứng mạch vành cấp được can thiệp động mạch vành qua da tại Bệnh viện Đa khoa Trung ương Thái Nguyên (Luận văn thạc sĩ)Đặc điểm lâm sàng và cận lâm sàng ở bệnh nhân hội chứng mạch vành cấp được can thiệp động mạch vành qua da tại Bệnh viện Đa khoa Trung ương Thái Nguyên (Luận văn thạc sĩ)Đặc điểm lâm sàng và cận lâm sàng ở bệnh nhân hội chứng mạch vành cấp được can thiệp động mạch vành qua da tại Bệnh viện Đa khoa Trung ương Thái Nguyên (Luận văn thạc sĩ)Đặc điểm lâm sàng và cận lâm sàng ở bệnh nhân hội chứng mạch vành cấp được can thiệp động mạch vành qua da tại Bệnh viện Đa khoa Trung ương Thái Nguyên (Luận văn thạc sĩ)Đặc điểm lâm sàng và cận lâm sàng ở bệnh nhân hội chứng mạch vành cấp được can thiệp động mạch vành qua da tại Bệnh viện Đa khoa Trung ương Thái Nguyên (Luận văn thạc sĩ)Đặc điểm lâm sàng và cận lâm sàng ở bệnh nhân hội chứng mạch vành cấp được can thiệp động mạch vành qua da tại Bệnh viện Đa khoa Trung ương Thái Nguyên (Luận văn thạc sĩ)Đặc điểm lâm sàng và cận lâm sàng ở bệnh nhân hội chứng mạch vành cấp được can thiệp động mạch vành qua da tại Bệnh viện Đa khoa Trung ương Thái Nguyên (Luận văn thạc sĩ)
Trang 1Chuyeen ngành
: NT 62.72.20.50
N
Trang 5DANH M C CH VI T T T
(American College of cardiology)
(American Diabetic Association)
AHA : H i tim m ch Hoa k
(American Heart Association)
Trang 6(High density lipoprotein cholesterol)
(Left ventricular end diastolic diameter)
(Left ventricular end systolic diameter) MSCT :Ch p c t l
(Multislice computer tomography).
Trang 7NMCT : Nh
NMCTSTC : Nh
NMCTKSTC : Nh
(Percutaneous coronary intervention)
Trang 8M C L C
1
3
3
1.2 .8
12
1.4 26
1.5 27
: 30
30
31
31
31
33
45
46 47
47
50
50
50
59
64
Trang 964
71 771
782
79 80
81
Trang 10DANH M
i 4 6
41
Trang 11DANH M C BI U
50
54 58
60 63
Trang 12DANH M C B NG
11
16
( 17
17
18
18
19
B ng 1.8 Ch 23
B i ch s kh i 33
B VIII 33
B n v t ng c theo h i tim m ch Canada 34
B n v Killip b 34
B nh r i lo n chuy ESC/ESH 2013 35
B n v t c a c b nh 35
B ng 2.7 i t n su t t ACC/AHA 2013 36
B n v ng c tim 36
B t ng m 37
B ng 3.1 T l b u 48
B m v tu i, gi i c u 48
Trang 13B m v ngh nghi p 49
B m v th tr ng c 49
B ng 3.5 S u t c can thi p 50
B ng c u 51
B m v m t s tri u ch ng th c th c can thi p 52
B m tr s huy n s nh i ch ng m p 52
B killip c a ng u 53
B ng 3.10 K t qu a u 53
B ng 3.11 m v nh 54
B ng 3.12 M a th n vi i lo n nh p tim 55
B ng 3.13 V ng m 55
B ng 3.14 M c t u 56
B ng 3.15 M t u 56
B ng 3.16 M t c u 57
B ng 3.17 S t c a u 57
B ng 3.18 m r i lo n v b i ch p 58
B ng 3.19 i v c c c sau can thi p 59
B ng 3.20 p c u 59
B ng 3.21 T l b i thi n v huy p 60
B ng 3.22 p 61
B ng 3.23 K t qu ki t s YTNC sau can thi p 61
B ng 3.24 S a b i ch ng p sau can thi 62
Trang 14B ng 3.25 S i th a b i ch
c p sau can thi 62
gi c can thi p 63
Trang 15tim [4], [52], [53], [81], [83], [85],
Trang 19* (Right coronary artery-RCA)
((
Trang 20
-+
Trang 23u [30], [36], [84].
Trang 2514% (nam)(
Trang 28nh cao kho ng 24 gi v ng sau 48-72 gi
Trang 29*
,NMCT (
[7]
-.K-MB
Trang 30
I
Trang 31.Trung
Trang 32
B 1.5 C [16]
2,44,3
1,61
Trang 33trong
30 n (%)
trong n (%)
1.3.3
*
Trang 34(, n
Trang 4283,9%; HbA1C :
[33]
-C [75]
((
[62]
((
(Vd)
Trang 43[46]
1.5.2.
[21]
Trang 45.+
Trang 50
B ng 2 i u t t
theo ACC/AHA 2013 [84]
ngSuy tim EF b o t n
Trang 55i lo n v
Trang 56d, Vs theo Simpson
Trang 59- i huy t , c i thi n ho i thi n
i thi n C i thi m n i v i triglycerid, cholesterol,
Trang 60m ch
Trang 61nghi m:
Bilan lipidHbA1C
tim
t
Trang 66, NMCTKSTC ( n = 48)
Trang 67NMCTKSTC ( n = 48)
NMCTSTC ( n = 25) (n=73)
Trang 68CTKSTC ( n = 48)
Trang 69NMCTKSTC ( n =48 )
Trang 70NMCTSTC ( n =25 )
Trang 74ng 3.19.
NMCTKSTC (n=48)
NMCTSTC (n=25)
Trang 76p<0,05.
Trang 77m MCTKSTC
(n=48)
NMCTSTC (n=25)
m
MCTKSTC (n=48)
NMCTKSTC (n=25)
Trang 79(60%> 45%) [6], [74],
Trang 80c
Trang 82NMCT
[13]
chu
Trang 8414,6%
Trang 87i c a thu ng th i can thi ng m ch
Trang 88c v
Theo bi s trong bilan lipid sau can thi p d u
gi t so v c can thi p c th : T l r i lo
(43,8% xu l r i lo n Triglycerid gi m t 31,5% xu ng 10,9%, t l r i lo n HDL-C gi m t 23,3% xu ng 15,1% , t l r i lo n LDL-
Trang 8919,17%, theo b ng [3.22], [3.23] HbA1C sau can thi u c i thi n t t c
a HbA1C sau can thi p gi
i p<0,05 c bi t sau can thi p t l b m
c HbA1C chi m 64,3%
Trang 91p<0,01 [46]
[70].Mahmoud Momtahen
[62]
Trang 92[45].
Trang 93(62,5%)
Trang 95
-,
Trang 96gi can thi ng m a",Tim m ch h c Vi t Nam, 58,tr
Trang 98tim", Tim m ch h c Vi t Nam, 54,tr 65-73.
u Ti ng Anh
22 ACCF/AHA (2011), Pocket guideline management of patient undergoing
coronary artery revascularization,pp 37.
23 Asaf Bitton, Thomas Gazianoet al (2010), "The Framingham Heart
",53(1),pp 68-78.
24 M D Ashen, R S Blumenthal (2005), "Clinical practice Low HDL
cholesterol levels",N Engl J Med, 353(12), pp 1252-1312.
25 Kranenburg and associates (2015), "The Relation Between HbA1c and
Cardiovascular Events in Patients With Type 2 Diabetes With and
Without Vascular Disease",Diabetes Care, pp 1-6.
26 P Barter, A M Gotto, J C LaRosa, J Maroni, M Szarek, S M Grundy,
J J Kastelein, V Bittner, J C Fruchart (2007), "HDL cholesterol, very
low levels of LDL cholesterol, and cardiovascular events",N Engl J Med, 357(13),pp 1301-1311.
27 D L Bhatt (2013), "Timely PCI for STEMI still the treatment of
choice",N Engl J Med, 368(15), pp 1446-1453.
28 Steg PG Bhatt DL, Ohman EM (2006),"International prevalence,
recognition, and treatment of cardiovascular risk factors in outpatients
with atherothrombosis",JAMA, 295,pp 180-189.
29 K Bibbins-Domingo, P Coxson, M J Pletcher, J Lightwood, L
Goldman (2007), "Adolescent overweight and future adult coronary
heart disease",N Engl J Med, 357(23),pp 2371-2380.
30 European Society of Cardiology (2013), "ESC Guidelines for the
management of acute coronary syndromes in patients presenting
Trang 9931 M D Cheitlin, W F Armstrong, G P Aurigemma, G A Beller, F Z
Bierman, J L Davis (2003), "ACC/AHA/ASE 2003 guideline update for the clinical application of echocardiography: summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/ASE Committee to Update the 1997 Guidelines for the Clinical Application
of Echocardiography)", Circulation,108(9),pp 1146-1208.
32 A V Chobanian, G L Bakris, H R Black, W C Cushman, L A Green,
J L Izzo, Jr., D W Jones, B J Materson, S Oparil, J T Wright, Jr.,
E J Roccella (2003), "The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of
High Blood Pressure", JAMA, 289(19),pp 2560-2620.
33 Choi Y.J, Park J.S, Kim Ung (2013), "Changes in smoking behavior and
adherence to preventive guidelines among smokers after a heart
attack".Journal of Geriatric Cardiology, 10,pp 146-150.
34 J C Cohen, E Boerwinkle, T H Mosley, Jr., H H Hobbs (2006),
"Sequence variations in PCSK9, low LDL, and protection against
coronary heart disease", N Engl J Med, 354(12),pp 1264-1336.
35 A.warell David, M.Cox Timothy, et al (2004), Textbook of medicine 4
ed Management of acute coronary syndromes, Oxford university press,pp 1840-1854
36 E Agabiti-Rosei, M L Muiesan (2005), Hypertension& Left Ventricular
Hypertrophy, Dialogues in Cardiovascular Medicine, 10(1),pp 1-23.
37 Edoardo Mannucci,Laria Dicembrini (2013), "Is Glucose Control
Important for Prevention of Cardiovascular Disease in
Diabetes?"Diabetes Care, 36,pp 259-262.
Trang 100pp 1-40.
39 A S Go, D Mozaffarian, V L Roger, E J Benjamin, J D Berry, W B
Borden, D M Bravata, S Dai, E S Ford, C S Fox, S Franco, H J Fullerton, C Gillespie, S M Hailpern, J A Heit, V J Howard, M D Huffman, B M Kissela, S J Kittner, D T Lackland, J H Lichtman,
L D Lisabeth, D Magid, G M Marcus, Marelli (2013), "Heart disease and stroke statistics 2013 update: a report from the American Heart
Association",Circulation, 127(1),pp 6-245.
40 Grigorios, T.sigkas, et al (2011), "Stent restentnosis, pathophysiology and
treatment options: A 2010 update",Hellenic J cardiol, 52,pp 149-157.
41 Guido Parodi, Nazario Carrabba, Giovanni M Santoro, Gentian Memisha
(2006), "Heart Failure and Left Ventricular Remodeling After Reperfused Acute Myocardial Infarction in Patients With
Hypertension", Hypertension, 47,pp 707-710.
42 Hesham Rashid, Hesham Abu El-Enien, Maher Ibraheem (2014), "The
Predictive Value of Tissue Doppler for Left Ventricular Recovery and Remodeling after Primary Percutaneous Coronary Intervention",
Journal of Cardiology & Current Research, 1(6),pp 1-7.
43 Hokanson et al (1998), "Hypertriglyceridemia as a Cardiovascular Risk
Factor",Am J Cardiol, 3, pp 213-219.
44 IDF (2012), "International diabetes federation, Global guideline for type 2
diabetes",Diabetes, pp 5-98.
45 (2012), "Occurrence and predictors of left
ventricular systolic dysfunct
percutaneous coronary intervention",Kardiol Pol, 70(4),pp 329-340.
Trang 101function after primary angioplasty for acute myocardial
infarction",European Heart Journal, 22,pp 785-790.
47 P A James, S Oparil, B L Carter, W C Cushman, C
Dennison-Himmelfarb, J Handler, D T Lackland, M L LeFevre, T D MacKenzie, O Ogedegbe, S C Smith, Jr., L P Svetkey, S J Taler, R
R Townsend, J T Wright, Jr., A S Narva, E Ortiz (2014), "2014 Evidence-Based Guideline for the Management of High Blood Pressure
in Adults Report From the Panel Members Appointed to the Eighth
Joint National Committee (JNC 8)",JAMA, 5,pp 507-527.
48 D Berry Jarett et al (2012), "Lifetime Risks of Cardiovascular Diseasea a
meta-analysis study at the individual level using data from 18 cohort
studies involving", N Engl J Med, 366,pp 312-321.
49 Jeffrey, R.Bender et al (2011), Oxford America Handbook of Cardiology
1 ed Coronary artery disease, Oxford university express, pp 89-111
50 P Jha,R Peto (2014), "Global effects of smoking, of quitting, and of
taxing tobacco",N Engl J Med, 370(1),pp 60-68.
51 P Jha, C Ramasundarahettige, V Landsman, B Rostron, M Thun, R N
Anderson, T McAfee, R Peto (2013), "21st-century hazards of
smoking and benefits of cessation in the United States", N Engl J Med,
368(4),pp 341-391
52 Jukema et al (2012), "Restenosis after PCI Part 1: pathophysiology and
risk factors",Nat Rev Cardiol, 9,pp 53-62.
53 Kassaian et al (2012), "Glycosylated hemoglobin (HbA1c) levels and
clinical outcomes in diabetic patients following coronary artery
stenting",Cardiovascular Diabetology, 11,pp 1-10.
54 Morton Kern et al (2013), "The intervention cardiac catheterization
handbook", 3 ed, Elsevier,p 466.
Trang 102ed, Risk factors for cardiovascular disease, Elsevier,pp 312-314.
56 Leonardo Bolognese et al, "Left Ventricular Remodeling After Primary
Coronary Angioplasty Patterns of Left Ventricular Dilation and
Long-Term Prognostic Implications",Circulation, 106,pp 2351-2357.
57 G N Levine et al (2011), "2011 ACCF/AHA/SCAI Guideline for
Percutaneous Coronary Intervention",Circulation, 124(23),pp 574-651.
58 G.N Levine (2011), "ACCF/AHA Guideline management of patient with
UA/NSTEMI".J Am Coll Cardiol, 58(24),pp 215-367.
59 Peter Libby (2011), "Current Concepts of the Pathogenesis of the Acute
Coronary Syndromes, Circulation, 104, pp 365-372.
60 Peter Libby (2013), "Mechanisms of Acute Coronary Syndromes and
Their Implications for Therapy", N Engl J Med, 368,pp 2004-2017.
61 Lopez et al (2013), "Guiline and Standards Recommendations for
Quantification Methods During the Performance of a Pediatric Echocardiogram: A Report From the Pediatric Measurements Writing Group of the American Society of Echocardiography Pediatric and
Congenital Heart Disease Council",Journal of American Society of Echocardiography, 23, pp 465-560.
62 Mahmoud Momtahen, Seifolah Abd, Zahra Ojaghi, Zahra Javady-nejad ,
Shabnam Momtahen (2007), "Global and Regional Left Ventricular Function Improvement Following Successful Percutaneous Coronary Intervention in Patients with Ischemic Left Ventricular
Dysfunction",Arch Iranian Med, 10(3),pp 387-389.
63 Giuseppe Manacia et al (2013), "ESH/ESC Guidelines for the
management of arterial hypertension",Journal of Hypertension, 31,pp
1281-1333
Trang 103acute coronary syndromes in patients presenting without persistent
ST-segment elevation",European Heart Journal, 2015, pp 3-14.
65 Michael Crawford (2002), Current Diagnosis and Treatment in
Cardiology, 2 ed, Lipid disorder, MCGraw-Hill, pp 16-63.
66
Eric L Michelson (2008), "Impact of diabetes on outcomes in patients
with low and preserved ejection fraction heart failure", Eur Heart J,
29,pp 1377-1385
67 M.Gulizia Michele (2007), "Current news in Cardiology" Acute coronary
syndrome, Springer,pp 375-382
68 Moscaritolo et al (2007), "Evidence-based guidelines for cardiovascular
disease prevention in women: 2007 update",Circulation, 115(11),pp
1481-1960
69 Lung National Health and Blood Institute (2002), National Cholesterol
Education Program-NCEP ATP III, inDetection,Evaluation,and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III), pp 2-128.
70 Nazario Carrabba, Renato Valenti, Guido Parodi (2004), "Left Ventricular
Remodeling and Heart Failure in Diabetic Patients Treated With
Primary Angioplasty for Acute Myocardial Infarction",Circulation,
110,pp 1974-1979
71 R.Colledge Nicki, R.Walker Brian et al (2010), Davidson's Principles &
Practice of Medicine, Diabetes Mellitus, Churchill Livingstone
Elsevier,pp 795-834
72 Paolo Palange, Anita Simonds (2010), Smoking-Related Diseases, ERS
Handbook Respiratory medicine, 1,pp 291-294
Trang 104McConnachie, S Pringle, D Murdoch, F Dunn, K Oldroyd, P Macintyre, B O'Rourke, W Borland (2008), "Smoke-free legislation
and hospitalizations for acute coronary syndrome",N Engl J Med,
359(5),pp 482-573
Marcelo Rodrigues Pinto (2013), "Middle-Term Assessment of Cardiovascular Risk Factor Control in a Prospective Cohort of High-
risk Patients Treated by Percutaneous Coronary Intervention", Rev Bras Cardiol Invasiva, 21(2),pp 121-148.
75 Seyed Kianoosh Hosseini, Maryam Tahvildari, Mohammad Javad
Alemzadeh Ansari, Manouchehr Nakhjavani, Alireza Esteghamati(2013), "Clinical Lipid Control Success Rate Before and After Percutaneous Coronary Intervention in Iran; a Single Center
Study",Iranian Red Crescent Medical Journal, 15(6),pp 476-548.
76 Stampfer et al (2000), "Primary prevention of coronary heart disease in
women through diet and lifestyle",N Engl J Med, 343,pp 18-22.
77 Stampfer, Manson JE et al (1990), "A prospective story of obessity and
risk of coronary heaart disease in woman",N Engl J Med, 322, pp
882-889
78 S T Stewart, D M Cutler, A B Rosen (2009), "Forecasting the Effects
of Obesity and Smoking on U.S Life Expectancy",N Engl J Med,
361(23),pp 2252-2312
79 F Taylor, M D Huffman, A F Macedo, T H Moore, M Burke, G
Davey Smith, K Ward, S Ebrahim (2013), "Statins for the primary
prevention of cardiovascular disease", Cochrane Database Syst Rev,
pp 1654-67
Trang 105Derazne, D Tzur, A Shamis, S Vinker, A Rudich (2011),
"Adolescent BMI trajectory and risk of diabetes versus coronary
disease",N Engl J Med, 364(14),pp 1315-1340.
81 Venkata, Kishore et al (2013), "Long-Term Follow Up of Percutaneous
Years of Age", Am J Cardiol, 112,pp 918-922.
82 WHO (2013), The Asia Pacific perspective: Re
treatment, pp 1-18.
83 M.J Wolk, S.R Bailey, J.U Doherty, P.S Douglas, R.C Hendel (2014),
"ACCF/AHA/ASE/ASNC/HFSA/HRS/SCAI/SCCT/SCMR/STS 2013 Multimodality Appropriate Use Criteria for the Detection and Risk
Assessment of Stable Ischemic Heart Disease",J Am Coll Cardiol,pp
380-406
84 Yancy et al (2013), "ACCF/AHA Guideline for the Management of Heart
Failure", Circulation, 128,pp 1810-1852.
85 S Yusuf et al (2014), "Cardiovascular Risk and Events in 17 Low-,
Middle-, and High-Income Countries",N Engl J Med, 371(9),pp
818-845
86 S Yusuf, S Hawken, S Ounpuu, T Dans, A Avezum, F Lanas, M
McQueen, A Budaj, P Pais, J Varigos, L Lisheng (2004), "Effect of potentially modifiable risk factors associated with myocardial infarction
in 52 countries (the INTERHEART study",Lancet, 364,pp 937-989.