DSpace at VNU: Tổng hợp một số dẫn xuất 2,5 đihyđroxiaxetophenon aroyl hyđrazon

khA ning itc chd in tndn kim loa: cira m6t sd 2-hydloxi- 3 - metyl axetophenon b enzoyl hy &'azon Study on r.elationship belween elech.onic structule and corlosion inhibitols effi.cency

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2,s-DI HYDROXIAXETOPHENON AROYL HYDRAZON

D 6 ' n to i L s o a n 2 6 - 1 1 ' 2 0 0 7

V u N I i n h T A n , P h a m V i n N h i 6 u , V i r P h t l o n g L i 6 n KJrca Hod lrcc, Dai ltoc Kh.oa ltoc Ttt Nliin, Dai hoc Qu6lc gta Hd l'lAi

SUMMARY

S Y N T H E S i S O F S O M E 2 , 5 D I H \ D R O X Y A C E T O P H E N O N E A R O \ ' L H Y D R A Z O N E

DERIRATIVES

condensation of' 2,5- dilrydr"oxyacetoplLenone witlt ltydrazides of substit.uted benzo.ic acids

Tlrc structure of these products haue been 'd.etermined by IR, t H-NMR and MS spectroscopies

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sin phirn quoc gia (GNP) Boi vay" ngll€n cuu ve

dn iriort va bao v6 kirn loai dd duoc cic Niri kiroa hoc quan tarn fu iau Co nhrdu pliuong phdp bao v'0

chong in mou krm lo4r n|uug phuong phap su

d u n g c i c c h i t u c c h 6 in r n o n d u o c s u d u n g s o r n v a ptrO Uien hon ca

Vi€t Nam li nuoc co khi hiu nhi6t doi, 6m bo bidn dai, la moi lruolg d6 qua frinh ln mort kinl loai xay ra Vo'i sLr phat tri6n cua ndn kinh t6 qudc

d a n , n r r o c t a s u d u n g k i n r l o a r n g a y c a n g n i i € u l v l 0 t frong nhrtng lTnli ruc ma nuoc ta phai su du.ng nhidu chit trc ch6 dn rnon do li cong nghiep kJrai

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D6 gop phdn khdc phuc hdu qua thiet liai do dn mon kim loai gd-v" ra noi chung va trong c6ng nghiOp sirn xudt, che br6n vdn chuy6n vir cdt gifr sin phim ddu mo n6i ndng chung t6i ti6n hanh t6ng hop va nghi6n cuu khi ndng uc ch6 dn mon cira nQt s6 din

xu at 2, j - drhydroxiaxetophenon aroyl hydrazou Cong rrinh [.2.4] clio bi6t v€ khi nang uc cl.:6

in nron kim loai cua niQt s6 din xu6t iiydrazon, cirng niru rn6i tuong quan gifra cdu tmc phdn tu io'i khi ning irc chd in mon kirn loai cua chung bang phuolg phdp tinh hod.hoc luo-ng tu.Cric hydrazon nay duoc t6ng ho.p bing phin ung ngung tu cua axetophenon th6 vdi hydrazit cria axit benzoic th6 tuorrg ung Trong c6ng trinh ndy chirng toi t6ng ho p nrot s6 din xu6t 2,5-dihydroxiaxetophenon aroyl hy&azon (goi tit hydrazon) tuong t.u, rrhung di hr hydroquinon vd cdc axit iienzoic chua nh6m tir6 o cac vi tri o- m-.va para theo so do duoi day

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p t r o t < t r o i l u g n g c r j a c i i c h i d r a z o n n h 4 n d u o c c s s o u r 6 i c 0 a p i c i o n p h d n t u ( M ) h m phdn tu kh6i crla cdc hydrazon tucrng ring C6c nndnh*ion b€n v0'ng nh6t lcuong dO 100%) phu r,hudc vdo

c6u tao cua tung phin tu o6i voi hydrazon IIIr ld cl-fs (mlz {t); III: ld ,/\7ct (dz

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N H : 8 , 9 I ( iH ) O H ' : 1 2 , 5 9 ( I H ) ,

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,Co-H :6,97 (1H),C2,,C6,-H :7,7 5(2H),

C 3 , , C 5 , - H : 6 , 7 5 ( 2 H ) , C H 3 u ' : 2 , 4 ( 3 H ) ,

C H 3 b : 2 , 4 ( 3 H )

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N H ; 8 , 8 9 ( 1 l { ) , O H u : 1 2 , 5 7 ( l H ) ,

O H b : 1 1 , I 9 ( 1 H ) , O H ' : 9 , 9 2 ( 1 H ) C3,C a-H:1,34(2H),C6-H :6.97 (lH),

C:,,Cs,-H : 7 , 0 0 ( 2 C:,,Cs,-H ) ,

C a',C 6' -H :7,29 (2H), CH3 :2,4(3H).

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O H b : I 0 , 9 9 ( 1 H ) , O H ' : 8 , 8 2 ( i H ) , C3,Ca-H:7,83(2H),C6-H:6,96(1H), C:,,Cs,-H:6,74(2H),

C2',C6'-H:6,88(2H), CH3 :2,39(3 H).

Mlz(%J)(tinh tir 5% trfi t6n)

c r 6 H r 6 o 3 N 2

2 8 4 ( 9 6 , 0 5 ) , 2 6 7 ( 3 9 , 5 4 ) , 2 5 1 ( 1 0 , 0 1 ) , 1 5 2 ( 1 5 , 6 0 ) ,

137(16,32), 134(10,11), 119(90,00), 107(12,20), 9i000.0),81(6,12),',79(10,0t),77(9,16), 73(19,5D,

6 5 ( 3 8 , i 1 )

C r o H r o O : N z

2 8 4 ( 6 0 , 1 5 ) , 2 6 ' 1 ( 1 7 , 5 6 ) , 178(6,00), 165(5,11), 149(29,22),.135(9,14), I 1g(100.0), 107(5,04), g1(80,09),

6 5 ( 1 2 , 3 5 ) , 5 2 ( 5 , 0 1 )

C 1 5 H 1 a O a N 2

286(60,37), 269(15,g4), t4g(21,1g), 136(5,10),

1 2 1 ( 1 00.0.), 10'7 (6,12), 65(14,22)

1 4 8 ( 1 5 , 2 4 ) , 1 3 7 ( 5 , 1 9 ) , i 2 1 ( 1 0 0 0 ) 1 0 3 ( 5 , 0 0 ) , 9 3 ( 2 0 , 2 1 ) ,

6 5 ( 1 4 , 3 2 )

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TN LIEU TTIAM KTAO

1 H Song Y Jiang, J Crystal Grouth, Vol 250,

p p 4 2 3 - 4 3 0 , ( 2 0 0 3 )

2 G Favero, B Colian, Inorg Chitn Acta.'Vol

I 2 2 , p 1 2 9 - 3 3 , (1 9 8 6 )

3 a1 Z L Tesrc, T J Janjic, G N Vuckovic ivl

B Celap J.Chrotnatograplry Vol ,156 (2), pp

3 4 6 - 5 0 , ( 1 9 9 8 ) , b) V G Isakova, L K lgurnenov, S V- Zemskov

Koordinat.sionaya Kh.itniya Vo} 1i(10), pp

1 3 7 7 - 8 0 , ( 1 9 8 5 )

4 O V h'okuda, V R Belosludov, I K Igumenov,

P A Stabnikov JournnJ of Plrysics: Confbre,nce Serres, VoL29, pp &13, (2006)

5 a) L Davignon, J Il{ Ivlanoli, A Derergne J

I-ess-Comtrnn Metals, VoL 21(3), pp 341-4,

(19?0) b) V G Isakova, P P Semyanikov, V

Nl Grankin, I K igumenov Kooi'dinatsionnaya Iiltuniya, Vol 14(i), pp 57-62, (1998)

6 a) T N{atsumoto, D.J Taube, R A Periana J Atn Chetn Soc., VoL 122(30),pp.74I4 - 74I5, (2000) b) M A Bennett, T R B Mirchell Inorg Chem Vol 1(11), pp-2986-8, (1926) c) G Bhal.la, X Y Liu, J Oxgaard_ J Am Cfum Soc VoI 127(32), pp 11372 - 89, (Z0Ob)

7 I K lgurnenov, V A Shipachev, G A Gorneva, N B Morozova, Russ Patent (1998)

8 a) T Kimrua, G Suzuki, T Goto J Metastable s,nd Nanocrystalline Materials, YoL 24-25, pp

589 - 592, (2005) b) Cl Bha[a, J Oxgaar.d, W

A Goddard- Organornetallics, \'oL 24(23), pp

5499-02, (2005).

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c a c

Tdt ca cac ho-p ch6t khao sat ddu co khd ndng uc Ei ti6n hdnh do kha nang uc cli6 an mon kim loai chd dn nron kim loar voi hieu suit uc ch6 cao theo cua cdc chdt kdn tiieo pliuo:rg phap dig' hori Cric

thu tu (3)<(4)<(1)<(2) chit d6u co khi ndng uc ch6 an mon kim loai cao Ngoy sau khi nirung di6n cuc vio dung drch ta Cac chit Fen ld cac chiit co ilrd su dung lam ch6t thdy, toc d6 dn rnon kim loai Cu trorLg moi tnrong uc cir€ trong c6ng nghigp 6iu mo

HNOT3M co urit cac chdt uc che grarn rnanh so voi

TAI LfEu ntAM KHAO m6i tnrong HNO33t\rt khi cliua co mdt chit ric chli

loar Cu trong nroi fuolg Fn{O33lv{ co nrat chit uc Tr.31l(2004)

c l r 6 r u i , c o t i n g n r o t l u o r l g n l r o s o v c r i t l i o r d i 6 n r v u a 4 n l nlrung dien cuc cu vao nhu,rg uin ginm ^oJrro.'^ ' flit Van Nhi€u' vfr Phuo'g Li€n, Tuydn tip

nr6i trucnrg rsror3rvl crrua co mdt crrat.,"

toc)n qu6c Dien

Kjir thoi gian tiep tuc tdng, toc d6 an mon dan 2 | I -den 6n Airui."Oicu niy tro thiy c6 t116 .;^1'-^.-.- 3 L€ Qu6c Hung' Hvong din su cfung thidt br ch€ da tao mdng phu l€n be mdt kirn roai a':.tuo'

ut

PGS-HH6'

Rahman.Brrl/, Koreq Chem Sr.tc., Vol.2l

Di tong ho-p duoc 4 hqp chdt thuoc din xr,L6t -;;.l0gj(2000) 2.5-dihy&oxiaxetoplienon aroyl hl,drazon tu cac

cirit diu la axit be*zoic tfie va hl:droquinon Ciu S Keio.Universiqv.Htyoshy.Yokohama Japan.

1 a p j

VIR

L l n

L 4 L

u a

! a I

uflr xrixr puAu ricu HoA, uY vn SINH HQc vtfif NAM

1 X6c di'h ddng thbi Ca:' vir Mg trong ni-ioc bdng p)rttclng ph6p tld.c quang diing phd to)'n phdn 3 Siinultaleous spectr,ophotornetr.ic d.etennination ol Ca2* and Md- - water by full spectla

Trdn Thrtc Binlr', Tran Tt HiEu Nghi6n citu xu iy dich a"n la.,g phuong ph6p oxy ho6 ting crrlng sii dung phin iing Fenton

Study on tleattrrent of black liquor by avalced oxid'ation process r-rsing fenton reaction

Dd, Sy Dttc, Trinlt.I-E Hil.ng, Dinh TTti Tltu Pluldng, Nguyfin T1i H6ng Tdng hgp vh xic dinh cdu h'irc m6t sdphitc chdt Niken-Xitrat

Synthesis 'and str.ucLur.e of some nickel citI.ate c$mplexes

Li Tli Hdng Hdi, Ti'6n Ngr,c Htty, Trii'n Thi Dit Nghi6n cilu mdi tridrg quan girla cdu trric elecbron vb khA ning itc chd in tndn kim loa: cira m6t

sd 2-hydloxi- 3 - metyl axetophenon b enzoyl hy &'azon

Study on r.elationship belween elech.onic structule and corlosion inhibitols effi.cency of some

2-hy dloxy- 3 - rn et2-hyl acetophenone b enzoyl 2-hydlazonr: cotnpounds

Vu Minlt l'd.n, Plrcun\titn Nhiiu, Nguydn TTzi Kim Ttty{t T6ng hop m6t so dan xudt 2,5-dihydloxraxetophenon aroyl hydrazon

Synthesis of some 2,5-dihyd-r'oxyacetophenone alol'l hydlazone derjratives

Vu Winh Td'n, PhatnViLn Nhi-6u, Vu Pltttong Libn T6ng hop va nghian ciiu c6c phirc chdt RodJ.(III) v6rL m6t sd p-dixeton dtioc flo hoa

Synthesis and stucly on sone r.hoclium (III) complexes containing fluonnated p-djketone ligands

Hod.ng Nhtu4 Nguydnlling Huy, Ngtty\n Bd' Tiin

L O

1 q

27

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7 Tdng hop v) nghi6n cilu m6t sdphirc chdt iricti(Ilf p-Dixetonat

Synthesis and study on sorne i:.idiurn(IlD p-diketonate compiexes

Ngd Sy Lxong, Ngty'in Httng Huy, Hodng Mtudn 8- Nghi6n crlu srt tao phrtc doyr, da phdi trr cria d'ysprosi, honrni v6i L-lcnrin, L-tryptophan, L-hrstr.drn vd axetyl axeton trong d,ung d-ich bing phrrong ph5,p chudn dq cIo pH

Sirrdv on for'ration of sirnple ligand, rnixed liga.nd cotnplexes of dysprosium @Y), hohnium (HO) wrth L-Ieucine, Ltryptophrur, L-histidine zrnd axetylaxetone in fluid by potentiometric titration in aqueous solution

LA Hxu Tlzidng, Da Tlti Huydn.Lan

9 X6c dinh AS(IID b5,trg phuorg ph6p von-ampe hod tan cat6t xung vi phAn khi c6 m5.t nah'i dietyl dithiocaebamat

Deter.mination of As(IIi) by cathodic sbipping voltammetry in the presence of sodjum drethyldith:oc alb arnat e

Hodng Tlwi Long, Hodng Nlfit Htng, Nguy|nVdn Hqp, TllVgng Nghi, Hodng Thg Tin

10 X6.c dinh lrfong vdt ddng trong nti6c b5,ng phddng trrh6p von-arrlpe hoi tan hip phrl

The detenrrinatron of coppel' in water samples by' adsorptive stripping voltammetry with t'esorcurol

Plwn Tltu Giang, LO Thi Htong Giang, TtlV7ng Ngli, Hoang Th"o Tin

4 5

TAP CHI KHOA HQC OHQGHN, KHTN & CN, T.XXII, 56 3A PT, 2006

NGHIEN CI'U NNCir TUdNG GIUA}.{ GIOA CAU TRUC PrrAN rr}

vA KHA NANG Uc cHf Alq *rox KrM LoAr cte rvrOr sci

HQp cHAr AXETorHUNoN - ARoyL HTDRAZoN

STUDY ON THE RELATION BETWEEN MOLECULAR

ACETOPHENONE - AROYL HYDRAZONE

Phg,m Vin Nhi6u, Vi Plhuong Li6n, LArn Nggc fUidm Khoa H6a hgc, Trxing Dai hqc Khoo hoc Tx nhiin, Doi hgc Qudc gia Hd Ni.i

Abstract Some acetophenone - aroyl Hydrazone compounds have been studied by

the inhibition of copper corrosion in 3lN nitric acid solution The structure of some

acetophenone - aroyl Hydrazone comp,ounds were optimized and calculated by using

the ZINDO/1 method of the quantum chemical program Hyperchem 7.0

Results of the above calculation is coordinated with inhibition efiiciency (P) thal is

dertermined by experimentation and both are applied to Statgraphic software to carry

out linear regression

1 MA ddu

An mdn kim loai ld sg ph6 hu;i kiim lo4i vi hgp kim do t6c dQne lf h6a cia m6i trrrdng Hgu qui cria sg dn mdn kim lo4i Ii lim thay ddi tfnh chdt, suy giim nhi6:u chfc ndng crl.a kim lo4i vi hgp kim, dAn tdi giim tudi thq cia c6c thidt bi, cdng trinh; gAy nhi6'u tdn thdt cho hQ sinh th6i vi ndn kinh td qudc dAn cria b^{t ki qudc gia nio Sg an mdn kh$ng bao gii ngritrg, nhrtng ph4m vi vi mrlc d0 c6 thd-eiim drrgc nhd c6c biQn ph{p chdng 6n mdn Trong sd c6c phriong ph6p bAo vQ, ch6'ng [n mdn kim lo4i thi ptu.ri"g ph6p str d\rng chdt irc chd dang dugc irng dgng mQt c6ch rQng rdi do viQc sfi a,r.tg th"att lqi vA d6 dang hdn so vdi c6<: phrrong phAp kh6c Vdn de'd+t ra li: phii tim drrgc chdt (rc chd d.n mdn c6 hiQu qui nhdt cho trlng loai vAt liQu vl trong ttrng m6i trdbng cs thd.[2]

Blng 1 C{c gli tr! ntng lupng, nhlQt Ininh thinh' momsn luang qp coa cic phln tfi

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142 Pharr Vtrn Nhieu, V[ Phucng Lien, t:m Ngqc Thi€m

Fong d6: En r: Ning luErg tdng hgp c0a phln t& {kcal/mol); Er: Ning lugng li€n k6t (kcaUmol); E.: Ning lugng

elecfon (kcaUmol); AH: Nhiet hlnh thdnh (kcaumol); p: Momen lu6ng cu c (D)

Trong ddi sdng vi ki thuft, Cu vi hgp kim cria Cu dugc sit drlng trong c6c hQ thdng nhiq;, cic bQ ph{n ngrrng trr hoi nd6c, C6c hG thdng niry thubng bi bao phri bdi c6c 16p cacbonat vi oxit Tr6n thgc td, ngrrdi ta thrrbng ding c6c dung dich axit HNOg ho4c HCt ad Um s4ch c6c b6'mqt niy Nhttng trong mdi trttdng axit hay nu6c tU nhiOn (c6 HCO'' , CO, , O), Cu vd hqp kim cria Cu d6 bi hda tan thhnh Cu2* Mdt trong s6'c6c tt,r6ng ad tndc pftrlc sg [n mdn Cu trong c6c mdi tr:rtdng d6ld str dr;ng chdt irc chd CAc ch{t ic chd [n mdn thrJdng duqc str dqng lir cic hqp ch{t hfru cd c6 chfa c6c nguy6n t6'

o, N, s, P [4, 5] c6c c6ng trinh nghien citu gan day [1, 3] cho thdy c6c hgp chdt axetophenon-"royl hydrazon c6 khA neng irc ch6'[:n mdn kim lo4i Cu trong m6i trdbng axit HNO, 3N cao

2 Thrfc nghiQm

Srl dgng phdn mdm HyperChem 7.0t81 dd thio s6t cdu trdc phAn trl cria c6c hop chdt axetoph"ttott aroyl hydraron birrg ph.rottg ph6p b6n kinh nghiQm X6c dinh khi

"e"g .f c5d qua trinh ln mdn Cu tron! m6i t^ti)ng axit HNO3 3N cria c6c hgp chdt r*"tl phenon aroyl hydrazon bi.ng phrrong ph6p dien h6a, stt dgng dttdng cong phAn

;;

-d;;hOne

sa't.iqng ttt thu dtrlc.tir tinhloan kdt hqp v6i hiQu sudt irc chd in mdn (p) thgc nghi[m dtrgc "drra v]ro phhn m6'm Statgraphic ad thgc hiQn -ph6p hdi qui- da Uian Ngoai suy tir pi,.rorrg trinh hdi quy aa Uldn Ctd: dg.do5'n drrqc khA ning rlc ch€ 5n mdn Critrong m6i tiubng axit HNO3 dN.,i" c6c d€rn xudt kh6c cria loli hgp chdt hrlu cd Irt", ad"S ttr-dl cO thd Udm tra l4i a9 ti" cAy cria p,hrrong trinh hdi qui thu drrgc Ci.n cit vao cau tifc cria c6c hgp chAt nghiOn ciru'chirng trSi dd tinh to6n c6c thdng sd lugng tit bing phrrone phap ZINDO/I cho mQt sd phdn tit axetophenon aroyl hydrazon'

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trong d6: Err*: NEng luong obitan phan tt} chua bi chi6m thrfp nhSt; E*orc: Ning lugng obitan ph6n tfi chua bi chiSm

thdp nhdt; S: Dien tich b6 mit c0a phdrr t0 1i'y;V: Thd ticn pnan tfi 1i'y

O H

3 Kdt qua vi th&o luAn

CAc phAn tir mA chtng t6i tien hdnh nghi€n cilu bao gdm:

< \ t : H N c

R - o _ , n _ , p _ N O r : o _ O H ; o _ N H r

( r ) ( : ) ( r ) ( r ) ( )

3.1 Khio sAt cdu trric phAn tfi cia 16 hgp chdt axeto phenon benzyl hydrazon bnng phrldng ph6p bAn ki,nh nghi@m ZINDO/I Cic tharn sd ld{ng tt? thu dtt'gc trl tinh to6n dtlQc tr:inh bdy tr6n c6c bing so liQu L ,2 ,3

Bing 3 Mft df dlgn tlcfr trin cic nguy6n td

1

4 -0.456 - 0 1 4 8 -0j22

'l

11 4 1 2 8 - 0 1 2 9 -0.132

Trong d6: 7o*,.t, Z n (n*),2, (r*, LA mit dQ di0n tich tr€n c6c nguyOn t0O vd N 6 c6c vitrf tuong trng

L44 ftr.

3.2 HiQu sudt itc chd qu6 trinh in mdn Cu trong m6i tnrdng axit HNO' 3N ctia 16 hgp chdt axeto phenon benzyl hydrazon, dr.l{c x6c dinh theo phrlong ph6p diQn h6a, sr? dgng drrdng cong phAn erfc Kdt qui niry ddgc ghi d b6ng 4

PMn tl 2 3 4 5 6 7 8 o 1 0 1 1 1 2 1 3 1 4 't5 1 6

H(Ir su{t

g.3 Mdi trtdng quan gifra cdu trric phAn t& vir khi ni.ng rlc chd in nr6n Cu trong m6i trrrdng axit HNO' 3N cria eic h{p chdt axetophenon benzyl hydrazon

C6c th6ng sd thu dugc tir tfnh to6n lrrgng trl kdt hgp vdi c9c gLh tri hiQu su{t itc chd dn mdn kiri loqi Cu trong m6i tnrbng HNO3 ilN (x6c dinh bing thgc nghiQm) drrgc

hien ph6p hdi quy tuydn tfnh, tim m6'i quan hQ glta hiQu sudt irc ch5 5n mdn thgc

"ghigm udi "4 th6ng sdluqng tir cia c6c chdt irc chd' [6,?,9]

Phtrong trinh hdi quY c6 d4ng:

P = f k " X " + c o n s t

P : HrQu sudt blo vQ cha cAc chSt (rc chd k"; Hf s6 cia phwng trinh h6i quY

X,,: Circ y6u t6 n6i quY (dnh hving) Phttong trinh hdi quy cho P stit udi th(c ngh,i€m nhdt (n'z* = 0.9538) c6 dsng:

Bing 5 Hlfu rudt ttru-t nghl$m vi Hl$u su{t ry tnuydt lheo phudng trinh (')

PMnB 1 L 1 1 5 6 I 8 ll 10 t l 12 t ? 1 4 { [ 16

PLT 57.2 58.3 32.1 66.6 66.1 70.5 78.0 7 r 9 83.6 88.4 67.2 77.2 oo.o 86.8 82.3 6 / J

y = 0 9 6 7 1 x + 2 5 8 5 8 R2 = 0.99148

Hinh 1 Tuong quan tuy6n tfnh glth PTlt vl PLT theo phuUng trinh (') Trf c6c sd liOu thu drroc trong c6c bing ghi 3 tr€n chfrng tdi nhAn thAy ring:

- C6c th6ng sd nhrr S; V; p hdu nhrr ft inh hudng tdi hiQu sudt fc ch6'in mdn (k, =1.52;k, =0.23;ku =0,25) Trong khi d6 mgt dQ diQn tich tr6n c6c trung tdm hdp phrl Znr;Z*:Zn lai inh hrrdng ldn t6i hi6u su{t r1c chd 6n mdn

- M?t khic khi phAn tfch kdt qui ph6p hdi quy dd chi ra ring vdi cdng nhi6'u ydu t6 inh hu&ng cia cAu truc thi kdt qui cria lhim mgc ti6u P chng s6t v6i thrrc nghi6m Nhrlng kdt qui niy sE grfp ta g:iai thfch drrrTc khi ndng r1c che 6n m6n khAc nhau cria c6c hydrazon, vh drr do6n khi nnng irc chd in mdn cia mQt s6'hydrazon chua duqc tdng hqp

9.4 Dg doAn khi ning irc chd in mdn Cu trong m6i trddng axit HNO' 3N

c&a cAc ddn xuA't kbAc cria loai hqp chdt hfiu cd trOn

Sil dyng phtong trinh h6i quy (*) di ngoq,i suy d6"r vdi m6t sd din xudt kh6c cria loqi hgp chdt axetophenon benzyl hydrazon Kdt qui thu duqc ghi trong bing 6

c - N - N t { - c

C " , d

Bing 6 Hl$u ruit bio v9 dr,r iloin atrruJ tlnh qua phuong trinh h6l guy (')

STT R Z o t * ) Z r t * n l Z n ( r + ) 8u* 8 o.rc v ( A ) tr PDD (%)

1 7 3-OH -0.403 4.157 -0.112 5.394 -6.013 809.29110.177 77.3

1 8 4'-OH -0.415 -0.159 -0.111 5.561-5.982808.8889.228 8 1 , 0

't9 2'-CH -0.419 -0.159 4 1 1 1 5.582 -5.936 827.6557.932 86.8

21 3 N H , -0.407 -0.156 -0.112 5.565 -5.936 824.3898.633 83.7

22 4.NH" -0.420 { 1 5 9 -0.109 5.748 -5.860 824.3551 0 1 3 8 93.7