DSpace at VNU: Three new cassane-type furanoditerpenes from the seed of Vietnamese Caesalpinia bonducella

Constituents of Caesalpinia crista from Indonesia.. Novel norcassane-type diterpene from the seed kernels of Caesalpinia 230 crista.. New antiviral cassane 234 furanoditerpenes from Caes

1 Three new cassane-type furanoditerpenes from the seed of vietnamese

3 Q2 Phu Hoang Danga, Mai Thanh Thi Nguyena,b, Hai Xuan Nguyena, Dung Thuy Thi Vua,

4 Son Van Truonga, Nhan Trung Nguyena,b,*

5 a Faculty of Chemistry, University of Science, Vietnam National University, Hochiminh City, Viet nam

Cancer Research Laboratory, Vietnam National University, Hochiminh City, Viet nam

A R T I C L E I N F O

Article history:

Received 6 April 2015

Received in revised form 18 May 2015

Accepted 20 May 2015

Available online xxx

Keywords:

Caesalpiniaceae

Cassane-type furanoditerpenes

A B S T R A C T Threenewcassane-typefuranoditerpenes,bonducellpinH(1),bonducellpinI(2),and 7-acetoxycae-salpininP(3),togetherwithsevenknowncompounds(4–10)havebeenisolatedfromtheMeOHextract

oftheseedkernelsofCaesalpiniabonducellafromVietnam.Thestructuresofthesecompoundswere elucidatedbyusingspectroscopictechniques

ã2015PublishedbyElsevierB.V.onbehalfofPhytochemicalSocietyofEurope

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furanodi-32

7-33

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(8)(Awaleetal.,2006),2-acetoxycaesaldekarinE(9)(Kalaunietal.,

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HR-41

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* Corresponding author at: Faculty of Chemistry, University of Science, Vietnam

National University – Hochiminh City, Viet nam Tel.: +84 907 426 332;

fax: +84 838 353 659.

E-mail address: ntnhan@hcmus.edu.vn (P.H Dang).

http://dx.doi.org/10.1016/j.phytol.2015.05.018

1874-3900/ã 2015 Published by Elsevier B.V on behalf of Phytochemical Society of Europe.

Phytochemistry Letters xxx (2015) xxx–xxx

57 C-7.Thelocationoftheacetoxylsubstituentsweredeterminedto

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HR-77

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of 2(Table 1)showed25 carbonsignals includingfourolefinic

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Fig 1 Chemical structures of three new cassane-type furanoditerpenes.

Table 1

The NMR data of compounds 1–3 in CDCl 3 ( in ppm, multiplicities, J in Hz) a

1

C

2.75 (1H, dd, 13.0, 8.0)

1.91 (1H, m)

2.96 (1H, d, 12.0) 2.60 (1H, dd, 16.5, 10.5)

5.09 (1H, s)

5-OH 2.95 (1H, d, 1.5)

a

The 1

H and 13

C NMR spectra were measured at 500 and 125 MHz, respectively.

2 P.H Dang et al / Phytochemistry Letters xxx (2015) xxx–xxx

89 169.6),andamethoxylcarbon(C=52.1).ThepartialstructureC(2)

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7-147

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rear-149

C-150

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spectropho-156

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Fig 3 ROESY correlations of compounds 1 and 2.

Fig 2 Key HMBC and 1

H- 1

H COSY correlations of three new compounds 1–3.

P.H Dang et al / Phytochemistry Letters xxx (2015) xxx–xxx 3

158 aninternalstandard,andchemicalshiftsareexpressedin values.

202 (10mg)and8(8mg)

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Acknowledgements

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References

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