8 5 K Tai mui hong Rubeola Keratitis(1)

Rubeola Keratitis Physiology: Vitamin A  Throdopsin, tế bào que của võng mạc  Tiết bã nhờn, tạo phim nước mắt  Biệt hóa biểu mô, lành sẹo  Biệt hóa biểu mô, lành sẹo  Tăng cường mi

15.000 children

38 countries

15 years

Introduction

Rubeola Keratitis

Rubeola Keratitis

 Physiology: Tear film

Rubeola Keratitis

 Physiology: Vitamin A

 Throdopsin, tế bào que của võng mạc

 Tiết bã nhờn, tạo phim nước mắt

 Biệt hóa biểu mô, lành sẹo

 Biệt hóa biểu mô, lành sẹo

 Tăng cường miễn dịch

Rubeola Keratitis

 Signs: Conjunctivitis

Rubeola Keratitis

 Signs: Conjunctival hemorrhages

Rubeola Keratitis

 Signs: Bitot’s spots

Rubeola Keratitis

 Signs: Xerophthalmia

Rubeola Keratitis

 Signs: Superficial punctate corneal epithelial

Rubeola Keratitis

 Signs: Keratitis

Rubeola Keratitis

 Signs: Corneal ulceration

Rubeola Keratitis

 Signs: Corneal scarring

Rubeola Keratitis

 Night blindness

 MEDLINE, 2000 Mar; PMID 10806435

 61 measles, < 15 y.o

 29.5% in both eyes.

 65.6% had measles conjunctivitis.

 65.6% had measles conjunctivitis.

 22.9% had subconjunctival hemorrhages.

 57.4% had superficial punctate corneal

epithelial

 8.2% had corneal ulceration.

 African Index Medicus (4/2010)

 Meta-Register of Controlled Trials

 Cochran Central Register of Controlled Trials

 43 trials enrolling

 215.633 children under 5 y.o

 Vitamin A supplementation (VAS):

 100.000 UI : 6 – 12 months

 200.000 UI : 13 – 60 months

 1 st – 2 nd – 14 th day

 Result: Vitamin A supplementation

Reduce Relative Risk

(RR)

Confidence Interval (CI)

1 VITAMIN A

2 NOT use eye drops CORTICOID

3 EYE EXAMINATION

1 Allen Foster, Alfred Sommer (1987), “Corneal ulceration,measles and childhood blindness in Tanzania”; BritishJournal of Ophthalmology, 1987, 71, 331-343

2 Clark Gilbert (2012), “Worldwide Causes of Blindness inChildren”; Pediatric Ophthalmology – Current Thought andPractical Guide, 46-60

3 Clive E West (2000), “Vitamin A and Measles”, NutritionReviews, Vol 58, No.2, 46-54

4 Goergios P Pavlopoulos (2008), “Rubeola keratitis: a

4 Goergios P Pavlopoulos (2008), “Rubeola keratitis: aphotographic of corneal lesions”, PubMed, PMID10831097

5 Kayikcioglu O (2000), “Ocular funding in measlesepidemic among young aldults”, PubMed, PMID10806435

6 Reddy V (1992), “Relationship between measles,malnutrition and blindness: a prospective study in Indianchildren”; American Journal Clinical Nutrition, 146, 924-930

7 Pediatric Eye Disease Investigator Group (2008), “PrimaryTreatment of Rubeola Karatitis in Children Younger than 5

Years” Ophthalmology, 115 (3), pp.577-583.

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