Hepatitis c virus infection in patients on maintenance dialysis

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4/2/2017 Hepatitis C virus infection in patients on maintenance dialysis

®

Authors

Svetlozar Natov, MD

Brian JG Pereira, MD

Section Editors Steve J Schwab, MD Martin S Hirsch, MD

Deputy Editor Alice M Sheridan, MD Hepatitis C virus infection in patients on maintenance dialysis

INTRODUCTION

Hepatitis C virus (HCV) infection is common and associated with significant morbidity and mortality among

dialysis patients

This topic reviews epidemiology of HCV infection among dialysis patients, including risk factors for and

prevention of HCV transmission within dialysis units The treatment of HCV infection among patients with

reduced renal function, including those on dialysis, is discussed elsewhere (See "Treatment of chronic

hepatitis C infection in adults with renal impairment", section on 'Severe renal impairment or dialysis'.)

General issues related to HCV infection among transplant kidney donors and recipients and recurrent or de

novo HCV-related renal disease in transplant recipients are discussed elsewhere (See "Hepatitis C virus

infection in kidney donors" and "Hepatitis C infection in kidney transplant candidates and recipients".)

EPIDEMIOLOGY

HCV infection is more common in dialysis patients than in healthy populations The best data regarding

prevalence among dialysis patients were provided by Dialysis Outcomes and Practice Patterns Study

(DOPPS), which was a prospective, observational study that reported the prevalence of HCV among adult

hemodialysis patients randomly selected from 308 representative dialysis facilities in France, Germany,

Italy, Japan, Spain, the United Kingdom, and the United States [1] The overall prevalence was 13.5 percent

(compared with global prevalence in the general population of approximately 3 percent) (See "Epidemiology

and transmission of hepatitis C virus infection", section on 'Global distribution'.)

DOPPS reported a wide variation among countries, from 2.6 to 22.9 percent From various studies, the

reported prevalence of anti-HCV antibodies among dialysis patients in different countries is:

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M artin S Hirsch, M D Editor-in-Chief — Infectious Diseases

Section Editor — Viral Infections Professor of Medicine

Harvard Medical School

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References

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Literature review current through: Jan 2017 | This topic last updated: thg 12 5, 2014

The content on the UpToDate website is not intended nor recommended as a substitute for medical advice, diagnosis, or treatment.

Always seek the advice of your own physician or other qualified health care professional regarding any medical questions or

1 Fissell RB, Bragg-Gresham JL, Woods JD, et al Patterns of hepatitis C prevalence and

seroconversion in hemodialysis units from three continents: the DOPPS Kidney Int 2004; 65:2335

2 Finelli L, Miller JT, Tokars JI, et al National surveillance of dialysis-associated diseases in the United

States, 2002 Semin Dial 2005; 18:52

3 Fabrizi F, Lunghi G, Raffaele L, et al Serologic survey for control of hepatitis C in haemodialysis

patients: third-generation assays and analysis of costs Nephrol Dial Transplant 1997; 12:298

4 Biamino E, Caligaris F, Ferrero S, et al [Prevalence of anti-HCV antibody positivity and

seroconversion incidence in hemodialysis patients] Minerva Urol Nefrol 1999; 51:53

5 Di Napoli A, Pezzotti P, Di Lallo D, et al Epidemiology of hepatitis C virus among long-term dialysis

patients: a 9-year study in an Italian region Am J Kidney Dis 2006; 48:629

6 Couroucé AM, Bouchardeau F, Chauveau P, et al Hepatitis C virus (HCV) infection in haemodialysed

patients: HCV-RNA and anti-HCV antibodies (third-generation assays) Nephrol Dial Transplant 1995;

10:234

7 Covic A, Iancu L, Apetrei C, et al Hepatitis virus infection in haemodialysis patients from Moldavia

Nephrol Dial Transplant 1999; 14:40

8 Othman B, Monem F Prevalence of antibodies to hepatitis C virus among hemodialysis patients in

Damascus, Syria Infection 2001; 29:262

9 Kamar N, Ribes D, Izopet J, Rostaing L Treatment of hepatitis C virus infection (HCV) after renal

transplantation: implications for HCV-positive dialysis patients awaiting a kidney transplant

Transplantation 2006; 82:853

10 Tokars JI, Miller ER, Alter MJ, Arduino MJ National surveillance of dialysis associated diseases in the United States, 1995 ASAIO J 1998; 44:98

11 Geerlings W, Tufveson G, Ehrich JH, et al Report on management of renal failure in Europe, XXIII

Nephrol Dial Transplant 1994; 9 Suppl 1:6

12 Valderrábano F, Jones EH, Mallick NP Report on management of renal failure in Europe, XXIV, 1993

Nephrol Dial Transplant 1995; 10 Suppl 5:1

13 Jadoul M, Poignet JL, Geddes C, et al The changing epidemiology of hepatitis C virus (HCV) infection

in haemodialysis: European multicentre study Nephrol Dial Transplant 2004; 19:904

14 Tokars JI, Miller ER, Alter MJ, Arduino MJ National surveillance of dialysis-associated diseases in the United States, 1997 Semin Dial 2000; 13:75

15 Baid-Agrawal S, Schindler R, Reinke P, et al Prevalence of occult hepatitis C infection in chronic

hemodialysis and kidney transplant patients J Hepatol 2014; 60:928

16 Pereira BJ, Levey AS Hepatitis C virus infection in dialysis and renal transplantation Kidney Int 1997; 51:981

17 Espinosa M, Martn-Malo A, Ojeda R, et al Marked reduction in the prevalence of hepatitis C virus

infection in hemodialysis patients: causes and consequences Am J Kidney Dis 2004; 43:685

18 Natov SN, Lau JY, Bouthot BA, et al Serologic and virologic profiles of hepatitis C infection in renal

transplant candidates New England Organ Bank Hepatitis C Study Group Am J Kidney Dis 1998;

31:920

Trang 3

19 Donahue JG, Muñoz A, Ness PM, et al The declining risk of post-transfusion hepatitis C virus

infection N Engl J Med 1992; 327:369

20 Cendoroglo Neto M, Draibe SA, Silva AE, et al Incidence of and risk factors for hepatitis B virus and

hepatitis C virus infection among haemodialysis and CAPD patients: evidence for environmental

transmission Nephrol Dial Transplant 1995; 10:240

21 Weinstein T, Tur-Kaspa R, Chagnac A, et al Hepatitis C infection in dialysis patients in Israel Isr Med Assoc J 2001; 3:174

22 dos Santos JP, Loureiro A, Cendoroglo Neto M, Pereira BJ Impact of dialysis room and reuse

strategies on the incidence of hepatitis C virus infection in haemodialysis units Nephrol Dial

Transplant 1996; 11:2017

23 Jadoul M, Cornu C, van Ypersele de Strihou C Incidence and risk factors for hepatitis C

seroconversion in hemodialysis: a prospective study The UCL Collaborative Group Kidney Int 1993;

44:1322

24 Petrosillo N, Gilli P, Serraino D, et al Prevalence of infected patients and understaffing have a role in

hepatitis C virus transmission in dialysis Am J Kidney Dis 2001; 37:1004

25 Bergman S, Accortt N, Turner A, Glaze J Hepatitis C infection is acquired pre-ESRD Am J Kidney

Dis 2005; 45:684

26 DuBois DB, Gretch D, dela Rosa C, et al Quantitation of hepatitis C viral RNA in sera of hemodialysis patients: gender-related differences in viral load Am J Kidney Dis 1994; 24:795

27 Jeffers LJ, Perez GO, de Medina MD, et al Hepatitis C infection in two urban hemodialysis units

Kidney Int 1990; 38:320

28 Alter MJ, Margolis HS, Krawczynski K, et al The natural history of community-acquired hepatitis C in

the United States The Sentinel Counties Chronic non-A, non-B Hepatitis Study Team N Engl J Med

1992; 327:1899

29 Stuyver L, Claeys H, Wyseur A, et al Hepatitis C virus in a hemodialysis unit: molecular evidence for

nosocomial transmission Kidney Int 1996; 49:889

30 Halfon P, Roubicek C, Gerolami V, et al Use of phylogenetic analysis of hepatitis C virus (HCV)

hypervariable region 1 sequences to trace an outbreak of HCV in an autodialysis unit J Clin Microbiol

2002; 40:1541

31 Grethe S, Gemsa F, Monazahian M, et al Molecular epidemiology of an outbreak of HCV in a

hemodialysis unit: direct sequencing of HCV-HVR1 as an appropriate tool for phylogenetic analysis J

Med Virol 2000; 60:152

32 Olmer M, Bouchouareb D, Zandotti C, et al Transmission of the hepatitis C virus in an hemodialysis

unit: evidence for nosocomial infection Clin Nephrol 1997; 47:263

33 Sypsa V, Psichogiou M, Katsoulidou A, et al Incidence and patterns of hepatitis C virus

seroconversion in a cohort of hemodialysis patients Am J Kidney Dis 2005; 45:334

34 Jadoul M, Fabrizi F What are the management issues for hepatitis C in dialysis patients?:

epidemiology and prevention of hepatitis C virus transmission in the hemodialysis setting Semin Dial

2014; 27:449

35 Kiyosawa K, Sodeyama T, Tanaka E, et al Hepatitis C in hospital employees with needlestick

injuries Ann Intern Med 1991; 115:367

36 Mitsui T, Iwano K, Masuko K, et al Hepatitis C virus infection in medical personnel after needlestick

accident Hepatology 1992; 16:1109

37 Alter MJ The epidemiology of acute and chronic hepatitis C Clin Liver Dis 1997; 1:559

38 Lanphear BP, Linnemann CC Jr, Cannon CG, et al Hepatitis C virus infection in healthcare workers:

risk of exposure and infection Infect Control Hosp Epidemiol 1994; 15:745

39 Puro V, Petrosillo N, Ippolito G Risk of hepatitis C seroconversion after occupational exposures in

health care workers Italian Study Group on Occupational Risk of HIV and Other Bloodborne

Infections Am J Infect Control 1995; 23:273

40 Okuda K, Hayashi H, Kobayashi S, Irie Y Mode of hepatitis C infection not associated with blood

transfusion among chronic hemodialysis patients J Hepatol 1995; 23:28

41 Gilli P, Moretti M, Soffritti S, et al Non-A, non-B hepatitis and anti-HCV antibodies in dialysis patients

Trang 4

Int J Artif Organs 1990; 13:737

42 Centers for Disease Control and Prevention (CDC) Hepatitis C virus transmission at an outpatient

hemodialysis unit New York, 2001-2008 MMWR Morb Mortal Wkly Rep 2009; 58:189

43 Alfurayh O, Sabeel A, Al Ahdal MN, et al Hand contamination with hepatitis C virus in staff looking

after hepatitis C-positive hemodialysis patients Am J Nephrol 2000; 20:103

44 Niu MT, Alter MJ, Kristensen C, Margolis HS Outbreak of hemodialysis-associated non-A, non-B

hepatitis and correlation with antibody to hepatitis C virus Am J Kidney Dis 1992; 19:345

45 Garcia-Valdescasas J, Bernal MC, Cerezo S, et al Strategies to reduce the transmission of HCV

infection in hemodialysis (HD) units (abstract) J Am Soc Nephrol 1993; 4:347

46 Jadoul M, Cornu C, van Ypersele de Strihou C Universal precautions prevent hepatitis C virus

transmission: a 54 month follow-up of the Belgian Multicenter Study The Universitaires Cliniques

St-Luc (UCL) Collaborative Group Kidney Int 1998; 53:1022

47 Froio N, Nicastri E, Comandini UV, et al Contamination by hepatitis B and C viruses in the dialysis

setting Am J Kidney Dis 2003; 42:546

48 Brugnano R, Francisci D, Quintaliani G, et al Antibodies against hepatitis C virus in hemodialysis

patients in the central Italian region of Umbria: evaluation of some risk factors Nephron 1992; 61:263

49 Mitwalli A, al-Mohaya S, al Wakeel J, et al Hepatitis C in chronic renal failure patients Am J Nephrol

1992; 12:288

50 Rais-Jalali G, Khajehdehi P Anti-HCV seropositivity among haemodialysis patients of Iranian origin

51 Vagelli G, Calabrese G, Guaschino R, Gonella M Effect of HCV+ patients isolation on HCV infection

incidence in a dialysis unit Nephrol Dial Transplant 1992; 7:1070

52 Calabrese G, Vagelli G, Guaschino R, Gonella M Transmission of anti-HCV within the household of

haemodialysis patients Lancet 1991; 338:1466

53 Taskapan H, Oymak O, Dogukan A, Utas C Patient to patient transmission of hepatitis C virus in

hemodialysis units Clin Nephrol 2001; 55:477

54 Taal MW, van Zyl-Smit R Hepatitis C virus infection in chronic haemodialysis patients relationship to

blood transfusions and dialyser re-use S Afr Med J 2000; 90:621

55 Hubmann R, Zazgornik J, Gabriel C, et al Hepatitis C virus does it penetrate the haemodialysis

membrane? PCR analysis of haemodialysis ultrafiltrate and whole blood Nephrol Dial Transplant 1995; 10:541

56 Caramelo C, Navas S, Alberola ML, et al Evidence against transmission of hepatitis C virus through

hemodialysis ultrafiltrate and peritoneal fluid Nephron 1994; 66:470

57 Noiri E, Nakao A, Oya A, et al Hepatitis C virus in blood and dialysate in hemodialysis Am J Kidney

Dis 2001; 37:38

58 Lombardi M, Cerrai T, Dattolo P, et al Is the dialysis membrane a safe barrier against HCV infection?

59 Castelnovo C, Sampietro M, De Vecchi A, et al Diffusion of HCV through peritoneal membrane in HCV positive patients treated with continuous ambulatory peritoneal dialysis Nephrol Dial Transplant 1997;

12:978

60 Recommendations for preventing transmission of infections among chronic hemodialysis patients

MMWR Recomm Rep 2001; 50:1

61 Kidney Disease: Improving Global Outcomes (KDIGO) KDIGO clinical practice guidelines for the

prevention, diagnosis, evaluation, and treatment of hepatitis C in chronic kidney disease Kidney Int

Suppl 2008; :S1

62 Natov SN, Pereira BJG Transmission of disease by organ transplantation In: Organ and Tissue

Donation for Transplantation, Chapman JD, Deierhoi M, Wight C (Eds), Edward Arnold, London 1996

63 Fabrizi F, Martin P, Dixit V, et al Meta-analysis: Effect of hepatitis C virus infection on mortality in

dialysis Aliment Pharmacol Ther 2004; 20:1271

64 Terrault NA, Adey DB The kidney transplant recipient with hepatitis C infection: pre- and

posttransplantation treatment Clin J Am Soc Nephrol 2007; 2:563

65 Fabrizi F, Martin P, Lunghi G, Locatelli F Membrane compatibility, flux and HCV infection in dialysis

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patients: newer evidence Int J Artif Organs 2000; 23:296

66 Stehman-Breen CO, Emerson S, Gretch D, Johnson RJ Risk of death among chronic dialysis

patients infected with hepatitis C virus Am J Kidney Dis 1998; 32:629

67 Pereira BJ, Natov SN, Bouthot BA, et al Effects of hepatitis C infection and renal transplantation on

survival in end-stage renal disease The New England Organ Bank Hepatitis C Study Group Kidney Int 1998; 53:1374

68 Nakayama E, Akiba T, Marumo F, Sato C Prognosis of anti-hepatitis C virus antibody-positive

patients on regular hemodialysis therapy J Am Soc Nephrol 2000; 11:1896

69 Seeff LB, Buskell-Bales Z, Wright EC, et al Long-term mortality after transfusion-associated non-A,

non-B hepatitis The National Heart, Lung, and Blood Institute Study Group N Engl J Med 1992;

327:1906

70 Marcelli D, Stannard D, Conte F, et al ESRD patient mortality with adjustment for comorbid

conditions in Lombardy (Italy) versus the United States Kidney Int 1996; 50:1013

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