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Therapeutic strategies for Hypertrophic Cardiomyopathy patient with Syncope.. Nguyen Thi Mai Ngoc MD, PhD Viet Nam National Heart Institute Bach Mai General Hospital... Definition of sy

Therapeutic strategies for

Hypertrophic Cardiomyopathy patient with Syncope

Nguyen Thi Mai Ngoc MD, PhD Viet Nam National Heart Institute

Bach Mai General Hospital

Definition of syncope and sudden death

Syncope was defined as a sudden and brief loss of consciousness associated with a loss of postural tone and a spontaneous recovery

Prognosis profiles for HCM and targets for therapy

Clinical pathways in HCM

Indication for ICDs in HCM

Definition of syncope and sudden death

Family screening for HCM patients and family

members

Characteristic & prognosis implication of myosin missense mutation in HCM:

 High risk of sudden death:

Mutation Arg403Gln

Arg719Trp

Arg453Cys

 Intermediate risk of premature sudden death:

Arg249Gln

Glu930Lys

 Carrier of other MYH7 mutations would normal risk of premature sudden death: Gly256Glu, Val606Meth, Leu908Val

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