Organic synthesis the disconnection approach 2nd edition by stuart warren (1)

Chichester，有部t Suss帜， P019 8S龟 UnitedKingdom For details of our global 时itorialoffices, for customer services and for infonnation about how to apply for permission to 陀usethe copyri在htma

This edition first published 2008

2008 John 飞的 ley& Sons, Inc

Registered 01.声

John 皆iley& Sons Ltd， τhe Atrium, Southem Gate Chichester，有部t Suss帜， P019 8S龟 UnitedKingdom For details of our global 时itorialoffices, for customer services and for infonnation about how to apply for permission to 陀usethe copyri在htmaterial in this book please see our website at www.wiley.com

τhe right of the author to be identified as the author of this work has been asserted in accordance with the Copyright, Desi盯1Sand Patents Act 1988

Al\ rights reserved N 0 P缸tof this publication 部aybe reproduced, stored in a retrieval system, or transmitted, in any fom1 or by any means, electronic, mechanical, photocopying, recording or otherwise, exc巳ptas by the UK Copyright, Designs and Patents Act 1988噎 withoutthe prior permissíon of the publisher

认Tileyalso publishes its books in a variety of electronic formats Some content that appears in print may not be avaHable in electronic books

Designations used by companies to distinguish their products are often daimed as trademarks AH brand names and product names used in this book are trade 凶m时，service marks, trademarks or registered trademarks of their respective owners‘ The publìsher is not associated with any product or v念ndormentioned in this book 丁hispublicatìon is designed to accurate and authoritative information in regard to the subject matter covered

It is sold on the understanding that the publisher is not engaged in rendering professional services If

advice or other expert 揣在istanceis require丛 theservices of cornpetent professional should be sought

The publísher and the author make no representations or warranties with respect to the accuracy or cornpleteness

of the contents of this work and 呼机ifically disclai 凯 all warranties, without limitation any implied warranties of 岳tnessfor a particular purpose This work sold with the understanding that the pubhsher is not engaged in rendering services τhe ad飞忧eand strategies contained herein rnay not be suitable for every situation In view of ongoing research, equiprnent modifications, changes in govemmental regulation笃，and the constant fiow of information relating to the use of experimental reagents, equipment警 anddevices, the reader

is u塔edto review and evaluate the information provided in the packagεinsert or instructions for each chemical, piece of equipment, reagent, or device for, arno只gother things‘any changes in the instructions or índication of usage and for added wamings and precautions The fact that an organization or Website is referred to in this work as a citation andJor a potential source of further informatìon does not mean that the author or the publisher endorses the information the organization or Website may pro飞lideor recornmendations it may rnake Furth时，readers should be aware that Internet Websites listed in this work may have changed or disappeared betw四只when this work was written and when it is re我d.No waπanty may be created or extended by any promotional statements for this work Neither the publisher nor the author shall be liable for any damages arising herefrom LibraηI 0/ Congress C.αtaloging-in-Pl￥blication Data

http://www.chem4all.vn

生 Strategy IV: Protecting

10 One Group C…C Disconnections 1: Alcohols

11 General St栩如前r A: a Disconnection

12 Strate玄v V:

(Alkynes)

15 Alkene

16 Strategy VII: 盯se of

17.τwo-Group C…C Disconnections 1: Diels-Ald时 Reactions

18 Strate2:v VIII: Introduction to

Conjugate (Michael) Addîtion and Robinson Annelation

22 X: 技itro

23 在NφGroup Disconnections IV: Compounds

24

26 Strategy XII: Reconnection

27 Two-Group C…C Disconn巳ctions VI:

28 General B: Strategy of Car七onyl Disconnections

29 XIII: Introduction to Synthesis: Saturated

Preface

In the 26 years since 有ileypublìshed Organic 1于zeDisconnection Approach 色yStuart

Warren，由自 approach to the learning of synthesis has become while the book Ìtself

is now dated in content and appearance‘ In 唱Tiley published Organic

and Control by Paul Wyatt and Stuart 轧Tarren.Thís muc如柱。okís as a

fourth year und巳 rgradu时esand research workers in universities and industry The

workbook was published ìn 2008.τ如is new book made thεold one look very dated ín and content and gaps between what students were expectεd to understand in the 1980s and what are to understand now This second edition is intended to fill some of those gaps

The of the book is the same in the second edítion It alternates chapters

new concepts wÌth strategy chapters that put 出e new work in the context of overall planning

丁he 40 chapters have the same titles: some have hardly been changed whíle others have a revision with considerable amounts of new m剖erial In most cases

from recent years are included

One source of new material is the courses 出atthe authors in the pharmaceutical

Our 色asic course is 'The Disconnection Approach' and the 削aterial we have for this course has reinforced our attempts to reasons for the of the various compounds which we 忧lieve enlivens the 加ok and makes it more for students We to

a second edítíon of the workbook after the publication of the

The 民rstedition of th巳 textbookwas in fact thεthird in a series of 品。okson

如 1974，is a book asking for a of interaction with the reader who

method has 岳阳 n suplersedt~d 七y interactive programmes on computers Paul Wyatt is writín革 an

electronic book to replace The Cαrbonyl Group which will a of an electronic

七ook and 七ooks with associated workbooks in a uniform format that we hope will prove of

value as students of organic develop their careers

Stuart 飞可arrenand Paul 研rya生在

March 2008

http://www.chem4all.vn