Clostridium difficile type C produces a novel ADP-ribosyltransferase distinct from botulinum C2 toxin.. Toxin B-Positive Strain of Clostridium difficile Responsible for a Nosocomial Outb
Trang 1Chapter 7 Bibliography
Ailenberg, M., and Silverman, M (2003) Cytochalasin D disruption of actin filaments in 3T3 cells produces an anti-apoptotic response by activating gelatinase A extracellularly and initiating intracellular survival signals Biochim Biophys Acta 1593, 249-258
Aktories, K., Ankenbauer, T., Schering, B., and Jakobs, K H (1986a) ADP-ribosylation of platelet actin by botulinum C2 toxin Eur J Biochem 161, 155-162
Aktories, K., Barmann, M., Ohishi, I., Tsuyama, S., Jakobs, K H., and Habermann, E (1986b) Botulinum C2 toxin ADP-ribosylates actin Nature 322, 390-392
Aktories, K., and Just, I (1995) Monoglucosylation of low-molecular-mass GTP-binding Rho proteins by clostridial cytotoxins Trends Cell Biol 5, 441-443
Aktories, K., Rosener, S., Blaschke, U., and Chhatwal, G S (1988) Botulinum ribosyltransferase C3 Eur J Biochem 172, 445-450
ADP-Aktories, K., Weller, U., and Chhatwal, G S (1987) Clostridium difficile type C produces a novel ADP-ribosyltransferase distinct from botulinum C2 toxin FEBS Lett 212, 109-113
Al Saif, N., and Brazier, J S (1996) The distribution of Clostridium difficile in the environment
of South Wales J Med Microbiol 45, 133-137
Alfa, M J., Kabani, A., Lyerly, D., Moncrief, S., Neville, L M., Al-Barrak, A., Harding, G K
Trang 2Toxin B-Positive Strain of Clostridium difficile Responsible for a Nosocomial Outbreak of Clostridium difficile-Associated Diarrhea J Clin Microbiol 38, 2706-2714
Alfa, M J., Swan, B., van Dekerkhove, B., Pang, P., and Harding, G K M (2002) The diagnosis of Clostridium difficile-associated diarrhea: comparison of Triage Clostridium difficile panel, enzyme immunoassay for toxin A/B and cytotoxin assays Diagnostic Microbiol Infect Dis
43, 257-263
Al-Hasani, K., Rajakumar, K., Bulach, D., Robins-Browne, R., Adler, B., and Sakellaris, H (2001) Genetic organisation of the she pathogenicity island in Shigella flexneri 2a Microb Pathog 30, 1-8
Allen, W E., Jones, G E., Pollard, J W., and Ridley, A J (1997) Rho, Rac and Cdc42 regulate actin organization and cell adhesion in macrophages J Cell Sci 110 ( Pt 6), 707-720
Altschuler, D L., Peterson, S N., Ostrowski, M C., and Lapetina, E G (1995) Cyclic dependent activation of Rap1b J Biol Chem 270, 10373-10376
AMP-Angeles, D C., Leong, W Y., Koay, E., and Song, K P (2004) Comparative and quantitative transcription analyses of the binary ADP-ribosyltransferase cdt
from a variant Clostridium difficile strain with truncated pathogenicity locus J Infect Dis Submitted
Angeles, D C., and Song, K P (2005a) Clostridium difficile ADP-ribosylating CDT toxin induced shift in actin dynamics and stress signal transduction in colorectal carcinoma cell Res Microbiol Submitted
Trang 3Angeles, D C., and Song, K P (2005b) Peptide antibiotic and actin-binding protein as type inhibitors of Clostridium difficile CDT toxin activities Biochem Biophys Res Commun 327, 361-370
mixed-Apisarnthanarak, A., Razavi, B., and Mundy, L M (2002) Adjunctive intracolonic vancomycin for severe Clostridium difficile colitis: case series and review of literature Clin Infect Dis 35, 690-696
Bachellier, S., Clement, J M., Hofnung, M., and Gilson, E (1997) Bacterial interspersed mosaic elements (BIMEs) are a major source of sequence polymorphism in Escherichia coli intergenic regions including specific associations with a new insertion sequence Genetics 145, 551-562
Bacon, A E., Fekety, R., Schaberg, D R., and Faix, R G (1988) Epidemiology of Clostridium difficile colonization in newborns: results using a bacteriophage and bacteriocin typing system J Infect Dis 158, 349-354
Bagrodia, S., Derijard, B., Davis, R J., and Cerione, R A (1995) Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation J Biol Chem
Trang 4Barroso, L A., Moncrief, J S., Lyerly, D M., and Wilkins, T D (1994) Mutagenesis of the Clostridium difficile toxin B and effect on cytotoxic activity Microb Pathog 16, 297-303
Barroso, L A., Wang, S.-Z., Phelps, C J., Johnson, J L., and Wilkins, T D (1990) Nucleotide sequence of Clostridium difficile toxin B gene Nucleic Acids Res 18, 4004
Barth, H., Preiss, J C., Hofmann, F., and Aktories, K (1998) Characterization of the catalytic site of the ADP-ribosyltransferase Clostridium botulinum C2 toxin by site-directed mutagenesis J Biol Chem 273, 29506-29511
Bartlett, J G (1998) Pseudomembranous enterocolitis and antibiotic-associated colitis In Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology/ Diagnosis/ Management., M Feldman, B F Schar-Schmidt, and M H Sleisenger, eds (Philadelphia, USA, W.B Saunders Co.), pp 1633-1647
Bartlett, J G., Chang, T W., Gurwith, M., Gorbach, S L., and Onderdonk, A B (1978) Antibiotic-associated pseudomembranous colitis due to a toxin producing clostridia New England J Med 298, 531-534
Beckerle, M C., and Yeh, R K (1990) Talin: role at sites of cell-substratum adhesion Cell Motil Cytoskeleton 16, 7-13
Bell, C E., and Eisenberg, D (1996) Crystal structure of diphtheria toxin bound to nicotinamide adenine dinucleotide Biochemistry 35, 1137-1149
Trang 5Berg, J M., and Shi, Y (1996) The galvanization of biology: a growing appreciation for the roles of zinc Science 271, 1081-1085
Bethards, L A., Skadsen, R W., and Scandalios, J G (1987) Isolation and characterization of a cDNA clone for the Cat2 gene in maize and its homology with other catalases Proc Natl Acad Sci 84, 6830-6834
Bingley, P J., and Harding, G M (1987) Clostridium difficile colitis following treatment with metronidazole and vancomycin Postgrad Med J 63, 993-994
Binz, T., Kurazono, H., Wille, M., Frevert, J., Wernars, K., and Niemann, H (1990) The complete sequence of botulinum neurotoxin type A and comparison with other clostridial neurotoxins J Biol Chem 265, 9153-9158
Bishai, W R., Rappuoli, R., and Murphy, J R (1987) High-level expression of a proteolytically sensitive diphtheria toxin fragment in Escherichia coli J Bacteriol 169, 5140-5151
Blattner, F R., Plunkett, G., III, Bloch, C A., Perna, N T., Burland, V., Riley, M., Vides, J., Glasner, J D., Rode, C K., Mayhew, G F., et al (1997) The Complete Genome Sequence of Escherichia coli K-12 Science 277, 1453-1462
Collado-Blocker, D., Behlke, J., Aktories, K., and Barth, H (2001) Cellular uptake of the Clostridium perfringens binary iota-toxin Infect Immun 69, 2980-2987
Bochner, B R., Gadzinski, P., and Panomitros, E (2001) Phenotype microarrays for
Trang 6high-Bond, F., Payne, G., Borriello, S P., and Humphreys, H (1995) Usefulness of culture in the diagnosis of Clostridium difficile infection Eur J Clin Microbiol Infect Dis 14, 223-226
Bongaerts, G P A., and Lyerly, D M (1997) Role of bacterial metabolism and physiology in the pathogenesis of Clostridium difficile disease Microb Pathog 22, 253-256
Borriello, S P., and Carman, R J (1983) Association of iota-like toxin and Clostridium spiroforme with both spontaneous and antibiotic-associated diarrhea and colitis in rabbits J Clin Microbiol 17, 414-418
Borriello, S P., Davies, H A., and Barclay, F E (1988) Detection of fimbriae amongst strains of Clostridium difficile FEMS Microbiol Lett 49, 65-67
Borriello, S P., Davies, H A., Kamiya, S., Reed, P J., and Seddon, S (1990) Virulence factors
of Clostridium difficile Rev Infect Dis 12 Suppl 2, S185-S191
Borriello, S P., Wren, B W., Hyde, S., Seddon, S V., Sibbons, P., Krishna, M M., Tabaqchali, S., Manek, S., and Price, A B (1992) Molecular, immunological, and biological characterization
of a toxin A-negative, toxin B-positive strain of Clostridium difficile Infect Immun 60,
4192-4199
Boshans, R L., Szanto, S., van Aelst, L., and D'Souza-Schorey, C (2000) ADP-ribosylation factor 6 regulates actin cytoskeleton remodeling in coordination with Rac1 and RhoA Mol Cell Biol 20, 3685-3694
Trang 7Botteri, F M., Ballmer-Hofer, K., Rajput, B., and Nagamine, Y (1990) Disruption of cytoskeletal structures results in the induction of the urokinase-type plasminogen activator gene expression J Biol Chem 265, 13327-13334
Bowman, T., Garcia, R., Turkson, J., and Jove, R (2000) STATs in oncogenesis Oncogene 19, 2474-2488
Braun, M., Herholz, C., Straub, R., Choisat, B., Frey, J., Nicolet, J., and Kuhnert, P (2000) Detection of the ADP-ribosyltransferase toxin gene (cdtA) and its activity in Clostridium difficile isolates from Equidae FEMS Microbiol Lett 184, 29-33
Braun, V., Hundsberger, T., Leukel, P., Sauerborn, M., and von Eichel-Streiber, C (1996) Definition of the single integration site of the pathogenicity locus in Clostridium difficile Gene
cost-Bubb, M R., Senderowicz, A M., Sausville, E A., Duncan, K L., and Korn, E D (1994) Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin J Biol Chem 269, 14869-14871
Trang 8Buggy, B P., Fekety, R., and Silva, J J (1987) Theraphy of relapsing Clostridium associated diarrhea and colitis with the combination of vancomycin and rifampin J Clin Gastroenterol 9, 155-159
difficile-Busch, C., Hofmann, F., Selzer, J., Munro, S., Jeckel, D., and Aktories, K (1998) A common motif of eukaryotic glycosyltransferases is essential for the enzyme activity of large clostridial cytotoxins J Biol Chem 273, 19566-19572
Caiazza, N C., and O'Toole, G A (2003) Alpha-toxin is required for biofilm formation by Staphylococcus aureus J Bacteriol 185, 3214-3217
Calabi, E., Calabi, F., Phillips, A D., and Fairweather, N F (2002) Binding of Clostridium difficile surface layer proteins to gastrointestinal tissues Infect Immun 70, 5770-5778
Carlier, M F (1991) Actin: protein structure and filament dynamics J Biol Chem 266, 1-4
Carraway, K L (1990) Membranes and microfilaments: interactions and role in cellular dynamics Bioessays 12, 90-92
Carroll, S F., and Collier, R J (1984) NAD binding site of diphtheria toxin: identification of a residue within the nicotinamide subsite by photochemical modification with NAD Proc Natl Acad Sci U S A 81, 3307-3311
Caspar, M., Florin, I., and Thelestam, M (1987) Calcium and calmodulin in cellular intoxication with Clostridium difficile toxin B J Cell Physiol 132, 168-172
Trang 9Castagliuolo, I., Karalis, K., Valenick, L., Pasha, A., Nikulasson, S., Wlk, M., and Pothoulakis,
C (2001) Endogenous cortocosteroids modulate Clostridium difficile toxin A-induced enteritis
in rats Am J Physiol Gastrointest Liver Physiol 280, G539-G545
Castagliuolo, I., Keates, A C., Wang, C C., Pasha, A., Valenick, L., Kelly, C P., Nikulasson, S T., LaMont, J T., and Pothoulakis, C (1998) Clostridium difficile toxin A stimulates macrophage-inflammatory protein-2 production in rat intestinal epithelial cells J Immunol 160, 6039-6045
Cerquetti, M., Molinari, A., Sebastianelli, A., Diociaiuti, M., Petruzzelli, R., Capo, C., and Mastrantonio, P (2000) Characterization of surface layer proteins from different Clostridium difficile clinical isolates Microb Pathog 28, 363-372
Chaves-Olarte, E., Weidmann, M., Eichel-Streiber, C., and Thelestam, M (1997) Toxins A and
B from Clostridium difficile differ with respect to enzymatic potencies, cellular substrate specificities, and surface binding to cultured cells J Clin Invest 100, 1734-1741
Choi, J Y., Sifri, C D., Goumnerov, B C., Rahme, L G., Ausubel, F M., and Calderwood, S B (2002) Identification of virulence genes in a pathogenic strain of Pseudomonas aeruginosa by representational difference analysis J Bacteriol 184, 952-961
Ciesielski-Treska, J., Ulrich, G., Rihn, B., and Aunis, D (1989) Mechanism of action of Clostridium difficile toxin B: role of external medium and cytoskeletal organization in intoxicated cells Eur J Cell Biol 48, 191-202
Trang 10Ciesla, W P., Jr., and Bobak, D A (1998) Clostridium difficile toxins A and B are dependent UDP-glucose hydrolases with differing catalytic activities J Biol Chem 273, 16021-
cation-16026
Clark, G F., Krivan, H C., Wilkins, T D., and Smith, D F (1987) Toxin A from Clostridium difficile binds to rabbit erythrocyte glycolipids with terminal Gal alpha 1-3Gal beta 1-4GlcNAc sequences Arch Biochem Biophys 257, 217-229
Clement, J.-M., Wilde, C., Bachellier, S., Lambert, P., and Hofnung, M (1999) IS1397 Is Active for Transposition into the Chromosome of Escherichia coli K-12 and Inserts Specifically into Palindromic Units of Bacterial Interspersed Mosaic Elements J Bacteriol 181, 6929-6936
Collier, R J (1967) Effect of diphtheria toxin on protein synthesis: inactivation of one of the transfer factors J Mol Biol 25, 83-98
Cooper, J A (1987) Effects of cytochalasin and phalloidin on actin J Cell Biol 105, 1473-1478
Crawford Jr, E W., and Shimkets, L J (2000) The Myxococcus xanthus socE and csgA genes are regulated by the stringent response Mol Microbiol 37, 788-799
Dai, Z., Sirard, J C., Mock, M., and Koehler, T M (1995) The atxA gene product activates transcription of the anthrax toxin genes and is essential for virulence Mol Microbiol 16, 1171-
1181
Dailey, D C., Kaiser, A., and Schloemer, R H (1987) Factors influencing the phagocytosis of Clostridium difficile by human polymorphonuclear leukocytes Infect Immun 55, 1541-1546
Trang 11DeMali, K A., Wennerberg, K., and Burridge, K (2003) Integrin signaling to the actin cytoskeleton Curr Opin Cell Biol 15, 572-582
Ding, R., and Smulson, M (1994) Depletion of nuclear poly(ADP-ribose) polymerase by antisense RNA expression: influences on genomic stability, chromatin organization, and carcinogen cytotoxicity Cancer Res 54, 4627-4634
Djuretic, T., Wall, P G., and Brazier, J S (1999) Clostridium difficile: an update on its epidemiology and role in hospital outbreaks in England and Wales J Hosp Infect 41, 213-218
Doig, P., Emody, L., and Trust, T J (1992) Binding of laminin and fibronectin by the resistant major structural domain of the crystalline virulence surface array protein of Aeromonas salmonicida J Biol Chem 267, 43-49
trypsin-Domenighini, M., Magagnoli, C., Pizza, M., and Rappuoli, R (1994a) Common features of the NAD-binding and catalytic site of ADP-ribosylating toxins Mol Microbiol 14, 41-50
Domenighini, M., Montecucco, C., Ripka, W C., and Rappuoli, R (1991) Computer modelling
of the NAD binding site of ADP-ribosylating toxins: active-site structure and mechanism of NAD binding Mol Microbiol 5, 23-31
Domenighini, M., and Rappuoli, R (1996) Three conserved consensus sequences identify the NAD-binding site of ADP-ribosylating enzymes, expressed by eukaryotes, bacteria and T-even bacteriophages Mol Microbiol 21, 667-674
Trang 12Donta, S T., Sullivan, N., and Wilkins, T D (1982) Differential effects of Clostridium difficile toxins on tissue-cultured cells J Clin Microbiol 15, 1157-1158
dos Remedios, C G., Chhabra, D., Kekic, M., Dedova, I V., Tsubakihara, M., Berry, D A., and Nosworthy, N J (2003) Actin binding proteins: regulation of cytoskeletal microfilaments Physiol Rev 83, 433-473
Dove, C H., Wang, S Z., Price, S B., Phelps, C J., Lyerly, D M., Wilkins, T D., and Johnson,
J L (1990) Molecular characterization of the Clostridium difficile toxin A gene Infect Immun
58, 480-488
Dower, W J., Miller, J F., and Ragsdale, C W (1988) High efficiency transformation of E coli
by high voltage electroporation Nucleic Acids Res 16, 6127-6145
Drudy, D., O'Donoghue, D P., Baird, A., Fenelon, L., and O'Farrelly, C (2001) Flow cytometric analysis of Clostridium difficile adherence to human intestinal epithelial cells J Med Microbiol
Trang 13Eglow, R., Pothoulakis, C., and Itzkowitz, S e a (1992) Diminished Clostridium difficile toxin
A sensitivity in newborn rabbit ileum is associated with decreased toxin A receptor J Clin Invest
Faust, C., Ye, B., and Song, K P (1998) The enzymatic domain of Clostridium difficile toxin A
is located within its N-terminal region Biochem Biophys Res Commun 251, 100-105
Ferrigno, P., Posas, F., Koepp, D., Saito, H., and Silver, P A (1998) Regulated nucleo/cytoplasmic exchange of HOG1 MAPK requires the importin beta homologs NMD5 and XPO1 Embo J 17, 5606-5614
Trang 14Fiorentini, C., Donelli, G., Nicotera, P., and Thelestam, M (1993) Clostridium difficile toxin A elicits Ca(2+)-independent cytotoxic effects in cultured normal rat intestinal crypt cells Infect Immun 61, 3988-3993
Fiorentini, C., Fabbri, A., Falzano, L., Fattorossi, A., Matarrese, P., Rivabene, R., and Donelli, G (1998) Clostridium difficile toxin B induces apoptosis in intestinal cultured cells Infect Immun
66, 2660-2665
Fiorentini, C., Malorni, W., Paradisi, S., Giuliano, M., mastrantonio, P., and Donelli, G (1990) Interaction of Clostridium difficile toxin A with cultured cells: cytoskeletal changes and nuclear polarization Infect Immun 58, 2329-2336
Fiorentini, C., and Thelestam, M (1991) Clostridium difficile toxin A and its effects on cells Toxicon 29, 543-567
Flint, K J., and Jones, N C (1991) Differential regulation of three members of the ATF/CREB family of DNA-binding proteins Oncogene 6, 2019-2026
Foxall, P A., Hu, L T., and Mobley, H L (1992) Use of polymerase chain reaction-amplified Helicobacter pylori urease structural genes for differentiation of isolates J Clin Microbiol 30, 739-741
Frost, F., Craun, G F., and Calderon, R L (1998) Increasing hospitalisation and death possibly due to Clostridium difficile diarrheal disease Emerging Infect Dis 4, 619-625
Trang 15Fujii, N., Kubota, T., Shirakawa, S., Kimura, K., Ohishi, I., Moriishi, K., Isogai, E., and Isogai,
H (1996) Characterization of component-I gene of botulinum C2 toxin and PCR detection of its gene in clostridial species Biochem Biophys Res Commun 220, 353-359
Galloway, T S., and van Heyningen, S (1987) Binding of NAD+ by cholera toxin Biochem J
244, 225-230
Garcia, J G., Wang, P., Liu, F., Hershenson, M B., Borbiev, T., and Verin, A D (2001) Pertussis toxin directly activates endothelial cell p42/p44 MAP kinases via a novel signaling pathway Am J Physiol Cell Physiol 280, C1233-1241
George, W L., Sutter, V L., Citron, D., and Finegold, S M (1979) Selective and differential medium for isolation of Clostridium difficile J Clin Microbiol 9, 214-219
Geric, B., Johnson, S., Gerding, D N., Grabnar, M., and Rupnik, M (2003) Frequency of binary toxin genes among Clostridium difficile strains that do not produce large clostridial toxins J Clin Microbiol 41, 5227-5232
Geric, B., Rupnik, M., Gerding, D N., Grabnar, M., and Johnson, S (2004) Distribution of Clostridium difficile variant toxinotypes and strains with binary toxin genes among clinical isolates in an American hospital J Med Microbiol 53, 887-894
Gibert, M., Petit, L., Raffestin, S., Okabe, A., and Popoff, M R (2000) Clostridium perfringens iota-toxin requires activation of both binding and enzymatic components for cytopathic activity Infect Immun 68, 3848-3853
Trang 16Gilbert, R J., Pothoulakis, C., LaMont, J T., and Yakubovich, M (1995) Clostridium difficile toxin B activates calcium influx required for actin disassembly during cytotoxicity Am J Physiol
268, G487-495
Goncalves, C., Decre, D., Barbut, F., Burghoffer, B., and Petit, J C (2004) Prevalence and characterization of a binary toxin (actin-specific ADP-ribosyltransferase) from Clostridium difficile J Clin Microbiol 42, 1933-1939
Graves, M C., and Rabinowitz, J C (1986) In vivo and in vitro transcription of the Clostridium pasteurianum ferredoxin gene Evidence for "extended" promoter elements in gram-positive organisms J Biol Chem 261, 11409-11415
Groisman, E A., and Ochman, H (1996) Pathogenicity islands: bacterial evolution in quantum leaps Cell 87, 791-794
Guignot, J., Mock, M., and Fouet, A (1997) AtxA activates the transcription of genes harbored
by both Bacillus anthracis virulence plasmids FEMS Microbiol Lett 147, 203-207
Gulke, I., Pfeifer, G., Liese, J., Fritz, M., Hofmann, F., Aktories, K., and Barth, H (2001) Characterization of the enzymatic component of the ADP-ribosyltransferase toxin CDTa from Clostridium difficile Infect Immun 69, 6004-6011
Hacker, J., Blum-Oehler, G., Muhldorfer, I., and Tschape, H (1997) Pathogenicity islands of virulent bacteria: structure, function and impact on microbial evolution Mol Microbiol 23, 1089-
1097
Trang 17Hafiz, S., and Oakley, C L (1976) Clostridium difficile: isolation and characteristics J Med Microbiol 9, 129-136
Hai, T W., Liu, F., Coukos, W J., and Green, M R (1989) Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers Genes Dev 3, 2083-2090
Hall, A (1998) Rho GTPases and the actin cytoskeleton Science 279, 509-514
Hall, I C., and O'Toole, E (1935) Intestinal flora in newborn infants with a description of a new pathogenic anaerobe, Bacillus difficilis American Journal of Diseases of Children 49, 390-402
Hammond, G A., and Johnson, J L (1995) The toxigenic element of Clostridium difficile strain VPI 10463 Microb Pathog 19, 203-213
Hammond, G A., Lyerly, D M., and Johnson, J L (1997) Transcriptional analysis of the toxigenic element of Clostridium difficile Microb Pathog 22, 143-154
Han, S., Arvai, A S., Clancy, S B., and Tainer, J A (2001) Crystal structure and novel recognition motif of rho ADP-ribosylating C3 exoenzyme from Clostridium botulinum: structural insights for recognition specificity and catalysis J Mol Biol 305, 95-107
Han, S., Craig, J A., Putnam, C D., Carozzi, N B., and Tainer, J A (1999) Evolution and mechanism from structures of an ADP-ribosylating toxin and NAD complex Nat Struct Biol 6, 932-936
Trang 18Hancock, R E., and Chapple, D S (1999) Peptide antibiotics Antimicrob Agents Chemother
Hatheway, C L (1990) Toxigenic clostridia Clin Microbiol Rev 3, 66-98
Hauser, D., Eklund, M W., Boquet, P., and Popoff, M R (1994) Organization of the botulinum neurotoxin C1 gene and its associated non-toxic protein genes in Clostridium botulinum C 468 Mol Gen Genet 243, 631-640
Hawley, D K., and McClure, W R (1983) Compilation and analysis of Escherichia coli promoter DNA sequences Nucleic Acids Res 11, 2237-2255
He, D., Hagen, S J., Pothoulakis, C., Chen, M., Medina, N D., Warny, M., and
LaMont, J T (2000) Clostridium difficile toxin A causes early damage to mitochondria in cultured cells Gastroenterology 119, 139-150
Hecht, G., Potoulakis, C., LaMont, J T., and Madara, J L (1988) Clostridium difficile toxin A perturbs cytoskeletal structure and tight junction permeability of cultured human intestinal epithelial monolayers J Clin Invest 82, 1516-1524
Trang 19Henderson, B., Wilson, M., Mc Nab, R., and Lax, A J (1999) Cellular Microbiology Host Interaction in Health and Disease (England, John Wiley and Sons Ltd.)
Bacteria-Henriques, B., Florin, I., and Thelestam, M (1987) Cellular internalisation of Clostridium difficile toxin A Microb Pathog 2, 455-463
Hill, G B., Osterhaut, S., and Willett, H P (1988) Clostridium In Zinsser Microbiology, W K Joklik, H P Willett, D B Amos, and C M Wilfert, eds (Connecticut, U.S.A., Prentice-Hall International Inc.)
Hippenstiel, S., Tannert-Otto, S., Vollrath, N., Krull, M., Just, I., Aktories, K., von Streiber, C., and Suttorp, N (1997) Glucosylation of small GTP-binding Rho proteins disrupts endothelial barrier function Am J Physiol 272, L38-43
Eichel-Hirschhorn, L R., Trnka, Y., Onderdonk, A., Lee, M L., and Platt, R (1994) Epidemiology of community-acquired Clostridium difficile-associated diarrhea J Infect Dis 169, 127-133
Hitchcock, S E (1980) Actin deoxyroboncuclease I interaction Depolymerization and nucleotide exchange J Biol Chem 255, 5668-5673
Hoffmaster, A R., and Koehler, T M (1997) The anthrax toxin activator gene atxA is associated with CO2-enhanced non-toxin gene expression in Bacillus anthracis Infect Immun 65, 3091-
3099
Trang 20Hofmann, F., Busch, C., Prepens, U., Just, I., and Aktories, K (1997) Localization of the glucosyltransferase activity of Clotridium difficile toxin B to the N-terminal part of the holotoxin
J Biol Chem 272, 11074-11078
Holmes, K C., Popp, D., Gebhard, W., and Kabsch, W (1990) Atomic model of the actin filament Nature 347, 44-49
Howe, A K., and Juliano, R L (2000) Regulation of anchorage-dependent signal transduction
by protein kinase A and p21-activated kinase Nat Cell Biol 2, 593-600
Hundsberger, T., Braun, V., Weidmann, M., Leukel, P., Sauerborn, M., and Eichel-Streiber, C v (1997) Transcription analysis of the genes tcdA-E of the pathogeniciy locus of Clostridium difficile Eur J Biochem 244, 735-742
Hurley, B W., and Nguyen, C C (2002) The spectrum of pseudomembranous enterocolitis and antibiotic-associated diarrhea Arch Internal Med 162, 2177-2184
Isowa, N., Xavier, A M., Dziak, E., Opas, M., McRitchie, D I., Slutsky, A S., Keshavjee, S H., and Liu, M (1999) LPS-induced depolymerization of cytoskeleton and its role in TNF-alpha production by rat pneumocytes Am J Physiol 277, L606-615
Jander, G., Rahme, L G., and Ausubel, F M (2000) Positive correlation between virulence of Pseudomonas aeruginosa mutants in mice and insects Journal of Bacteriology 182, 3843-3845
Trang 21Jefferson, K.K., Smith, M.F Jr., and Bobak, D.A (1999) Roles of intracellular calcium and kappa B in the Clostridium difficile toxin A-induced upregulation and secretion of IL-8 from human monocytes J Immunol 163, 5183-5191
NF-Johnson, S., Clabots, C R., Linn, F V., Olson, M M., Peterson, L R., and Gerding, D N (1990) Nosocomial Clostridium difficile colonization and disease Lancet 336, 97-100
Johnson, S., and Gerding, D N (1998) Clostridium difficile-associated diarrhea Clin Infect Dis
26, 1027-1034
Just, I., Mohr, C., Schallehn, G., Menard, L., Didsbury, J R., Vandekerkhove, J., Damme, J V., and Aktories, K (1992) Purification and characterization of an ADP-ribosyltransferase produced
by Clostridium limosum J Biol Chem 267, 10274-10280
Just, I., Selzer, J., Hofmann, F., Green, G A., and Aktories, K (1996) Inactivation of Ras by Clostridium sordellii lethal toxin-catalyzed glucosylation J Biol Chem 271, 10149-10153
Just, I., Selzer, J., Wilm, M., Eichel-Streiber, C v., Mann, M., and Aktories, K (1995a) Glucosylation of Rho proteins by Clostridium difficile toxin B Nature (London) 375, 500-503
Just, I., Wilm, m., Selzer, J., Rex, G., Eichel-Streiber, C v., Mann, M., and Aktories, K (1995b) The entertotoxin from Clostridium difficile (ToxA) monoglucosylates the Rho proteins J Biol Chem 270, 13932-13936
Kabsch, W., Mannherz, H G., Suck, D., Pai, E F., and Holmes, K C (1990) Atomic structure
Trang 22Kabsch, W., and Vandekerckhove, J (1992) Structure and function of actin Annu Rev Biophys Biomol Struct 21, 49-76
Kamiya, S., Reed, P J., and Borriello, S P (1989) Purification and characterisation of Clostridium difficile toxin A by bovine thyroglobulin affinity chromatography and dissociation in denaturing conditions with or without reduction J Med Microbiol 30, 69-77
Karjalainen, T., Waligora-Dupriet, A J., Cerquetti, M., Spigaglia, P., Maggioni, A., Mauri, P., and Mastrantonio, P (2001) Molecular and genomic analysis of genes encoding surface-anchored proteins from Clostridium difficile Infect Immun 69, 3442-3446
Karlsson, S., Lindberg, A., Norin, E., Burman, L.G., and Akerlund, T (2000) Toxins, butyric acid and other short-chained fatty acids are coordinately expressed and down-regulated by cysteine in Clostridium difficile Infect Immun 68, 5881-5888
Kato, H., Kato, N., Watanabe, K., Iwai, N., Nakamura, H., Yamamoto, T., Suzuki, K., Kim, M., Chong, Y., and Wasito, E B (1998) Identification of toxin A-negative, toxin B-positive Clostridium difficile J Clin Microbiol 36, 2178-2182
S.-Keighley, M R B., Burdon, D W., and Arabi, Y., et al (1978) Randomised controlled trial of vancomycin for pseudomembranous colitis and post-operative diarrhoea British Med J 2, 1667-
1669
Kelly, C P., and LaMont, J T (1998) Clostridium difficile infection Ann Rev Med 49, 375-390
Trang 23Kelly, C P., Pothoulakis, C., and La Mont, J T (1994) Clostridium difficile colitis New England J Med 330, 257-262
Kelly, C P., Pothoulakis, C., Orellana, J., and La Mont, J T (1992) Human colonic aspirates containing immunoglobulin A antibody to Clostridium difficile toxin A inhibit toxin A receptor binding Gastroenterology 102, 35-40
Khurana, A., and Dey, C S (2003) p38 MAPK interacts with actin and modulates filament assembly during skeletal muscle differentiation Differentiation 71, 42-50
Kimura, K., Kubota, T., Ohishi, I., Isogai, E., Isogai, H., and Fujii, N (1998) The gene for component-II of botulinum C2 toxin Vet Microbiol 62, 27-34
Kinosian, H J., Selden, L A., Estes, J E., and Gershman, L C (1993) Nucleotide binding to actin Cation dependence of nucleotide dissociation and exchange rates J Biol Chem 268, 8683-
8691
Klee, S R., Nassif, X., Kusecek, B., Merker, P., Beretti, J.-L., Achtman, M., and Tinsley, C R (2000) Molecular and Biological Analysis of Eight Genetic Islands That Distinguish Neisseria meningitidis from the Closely Related Pathogen Neisseria gonorrhoeae Infect Immun 68, 2082-
2095
Klein, P., Kanehisha, M., and DeLisi, C (1985) The detection and classification of membrane spanning proteins Biochimica et Biophysica Acta 815, 468-476
Trang 24Knoop, F C., Owen, M., and Crocker, I C (1993) Clostridium difficile: clinical disease and diagnosis Clin Microbiol Rev 6, 251-265
Koehler, T M (2002) Bacillus anthracis genetics and virulence gene regulation Curr Top Microbiol Immunol 271, 143-164
Korn, E D (1982) Actin polymerization and its regulation by proteins from nonmuscle cells Physiol Rev 62, 672-737
Kotiranta, A., Lounatmaa, K., Kari, E., Kerusuo, E., and Haapasalo, M (1997) Function of the layer of some Gram-positive bacteria in phagocytosis FEMS Microbiol Rev 20, 110-114
S-Krivan, H C., Clark, G F., Smith, D F., and Wilkins, T D (1986) Cell surface binding site for Clostridium difficile enterotoxin: evidence for a glycoconjugate containing the sequence Gal alpha 1-3Gal beta 1-4GlcNAc Infect Immun 53, 573-581
Krull, M., Dold, C., Hippenstiel, S., Rosseau, S., Lohmeyer, J., and Suttorp, N (1996) Escherichia coli hemolysin and Staphylococcus aureus alpha-toxin potently induced neutrophil adhesion to cultured human endothelial cells J Immunol 157, 4133-4140
Kushnaryov, V., and Sedmak, J J (1989) Effect of Clostridium difficile enterotoxin A on ultrastructure of chinese hamster ovary cells Infect Immun 57, 3914-3921
Kyriakis, J M., and Avruch, J (2001) Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation Physiol Rev 81, 807-869
Trang 25Kyriakis, J M., Banerjee, P., Nikolakaki, E., Dai, T., Rubie, E A., Ahmad, M F., Avruch, J., and Woodgett, J R (1994) The stress-activated protein kinase subfamily of c-Jun kinases Nature
369, 156-160
Lachumanan, R., Armugam, A., Durairaj, P., Gopalakrishnakone, P., Tan, C H., and Jeyaseelan,
K (1999) In situ hybridization and immunohistochemical analysis of the expression of cardiotoxin and neurotoxin genes in Naja naja sputatrix J Histochem Cytochem 47, 551-560
Lan, R., and Reeves, P R (2000) Intraspecies variation in bacterial genomes: the need for a species genome concept Trends Microbiol 8, 396-401
Larson, H E., Parry, J V., Price, A B., Davies, P R., Dolby, J., and Tyrrell, D A J (1977) Undescribed toxin in pseudomembranous colitis British Med J 1, 1246-1248
Larson, H E., Price, A B., Honour, P., and Borriello, S P (1978) Clostridium difficile and the aetiology of pseudomembranous colitis Lancet 1, 1063-1066
Laudanna, C., Campbell, J J., and Butcher, E C (1997) Elevation of intracellular cAMP inhibits RhoA activation and integrin-dependent leukocyte adhesion induced by chemoattractants J Biol Chem 272, 24141-24144
Lebart, M C., Hubert, F., Boiteau, C., Venteo, S., Roustan, C., and Benyamin, Y (2004) Biochemical characterization of the L-plastin-actin interaction shows a resemblance with that of alpha-actinin and allows a distinction to be made between the two actin-binding domains of the molecule Biochemistry 43, 2428-2437
Trang 26Lebart, M C., Mejean, C., Roustan, C., and Benyamin, Y (1993) Further characterization of the alpha-actinin-actin interface and comparison with filamin-binding sites on actin J Biol Chem
268, 5642-5648
Lee, R J., Albanese, C., Stenger, R J., Watanabe, G., Inghirami, G., Haines, G K., 3rd, Webster, M., Muller, W J., Brugge, J S., Davis, R J., and Pestell, R G (1999) pp60(v-src) induction of cyclin D1 requires collaborative interactions between the extracellular signal-regulated kinase, p38, and Jun kinase pathways A role for cAMP response element-binding protein and activating transcription factor-2 in pp60(v-src) signaling in breast cancer cells J Biol Chem 274, 7341-7350
Lemaire, M., Myras, I., Gounon, P., and Beguin, P (1998) Identification of a region responsible for binding to the cell wall within the S-layer protein of Clostridium thermocellum Microbiology
Levine, B A., Moir, A J., and Perry, S V (1988) The interaction of troponin-I with the terminal region of actin Eur J Biochem 172, 389-397
N-Levy, D G., Stergachis, A., and McFarland, L V e a (2000) Antibiotics and Clostridum difficile diarrhea in the ambulatory care setting Clin Ther 22, 91-102
Trang 27Lima, A A., Lyerly, D M., Wilkins, T D., Innes, D J., and Guerrant, R L (1988) Effects of Clostridium difficile toxins A and B in rabbit small and large intestine in vivo and on cultured cells in vitro Infect Immun 56, 582-588
Limaye, A P., Turgeon, D K., Cookson, B T., and Fritsche, T R (2000) Pseudomembranous colitis caused by a toxin A(-) B(+) strain of Clostridium difficile J Clin Microbiol 38, 1696-1697
Li, M., Dyda, F., Benhar, I., Pastan, I., and Davies, D.R (1996) Crystal structure of the catalytic domain of Pseudomonas exotoxin A complexed with a nicotinamide adenine dinucleotide analog: implications for the activation process and for ADPribosylation Proc Natl Acad Sci U S A 93:6902-6906
Liu, S., Kulich, S M., and Barbieri, J T (1996) Identification of glutamic acid 381 as a candidate active site residue of Pseudomonas aeruginosa exoenzyme S Biochemistry 35, 2754-
Trang 28Madshus, H.I., and Stenmark, H (1992) Entry of ADP-ribosylating toxins into cells Curr Top Microbiol Immunol 175, 1-26
Mahida, Y R., Makh, S., Hyde, S., Gray, T., and Borriello, S P (1996) Effect of Clostridium difficile toxin A on human intestinal epithelial cells: Induction of interleukin 8 production and apoptosis after cell detachment Gut 38, 337-347
Mani, N., and Dupuy, B (2001) Regulation of toxin synthesis in Clostridium difficile by an alternative RNA polymerase sigma factor Proc Natl Acad Sci 98, 5844-5849
Mani, N., Lyras, D., Barroso, L., Howarth, P., Wilkins, T., Rood, J.I., Sonenshein, A.L., and Dupuy, B (2002) Environmental response and autoregulation of Clostridium difficile TxeR, a sigma factor for toxin gene expression J Bacteriol 184, 5971-5978
Mannherz, H G., Goody, R S., Konrad, M., and Nowak, E (1980) The interaction of bovine pancreatic deoxyribonuclease I and skeletal muscle actin Eur J Biochem 104, 367-379
Markillie, L M., Varnum, S M., Hradecky, P., and Wong, K.-K (1999) Targeted Mutagenesis
by Duplication Insertion in the Radioresistant Bacterium Deinococcus radiodurans: Radiation Sensitivities of Catalase (katA) and Superoxide Dismutase (sodA) Mutants J Bacteriol 181, 666-
669
Marvaud, J C., Eisel, U., Binz, T., Niemann, H., and Popoff, M R (1998) TetR is a positive regulator of the tetanus toxin gene in Clostridium tetani and is homologous to botR Infect Immun
66, 5698-5702
Trang 29McClane, B A., and Mietzner, T A (1999) Microbial Pathogenesis, 1st edn (Madison, Connecticut, Fence Creek Publishing)
McFarland, L V (1998) Epidemiology, risk factors and treatments for antibiotic-associated diarrhea Digest of Diseases 16, 292-307
McGough, A., Way, M., and DeRosier, D (1994) Determination of the alpha-actinin-binding site
on actin filaments by cryoelectron microscopy and image analysis J Cell Biol 126, 433-443
McKay, R T., Tripet, B P., Pearlstone, J R., Smillie, L B., and Sykes, B D (1999) Defining the region of troponin-I that binds to troponin-C Biochemistry 38, 5478-5489
McLaughlin, P J., Gooch, J T., Mannherz, H G., and Weeds, A G (1993) Structure of gelsolin segment 1-actin complex and the mechanism of filament severing Nature 364, 685-692
Menetrey, J., Flatau, G., Stura, E.A., Charbonnier, J.B., Gas, F., and Teulon, J.M (2002) NAD binding induces con formational changes in Rho ADP-ribosylating Clostridium botulinum C3 exoenzyme J Biol Chem 277, 30950-30957
Meyer, C J., Alenghat, F J., Rim, P., Fong, J H., Fabry, B., and Ingber, D E (2000) Mechanical control of cyclic AMP signalling and gene transcription through integrins Nat Cell Biol 2, 666-668
Milligan, R A., Whittaker, M., and Safer, D (1990) Molecular structure of F-actin and location
Trang 30Ming, L J., and Epperson, J D (2002) Metal binding and structure-activity relationship of the metalloantibiotic peptide bacitracin J Inorg Biochem 91, 46-58
Mitchison, T J., and Cramer, L P (1996) Actin-based cell motility and cell locomotion Cell 84, 371-379
Miyashita, M., Ohnishi, H., Okazawa, H., Tomonaga, H., Hayashi, A., Fujimoto, T T., Furuya, N., and Matozaki, T (2004) Promotion of Neurite and Filopodium Formation by CD47: Roles of Integrins, Rac, and Cdc42 Mol Biol Cell 15, 3950-3963
Moncrief, J S., Barroso, L A., and Wilkins, T D (1997) Positive regulation of Clostridium difficile toxins Infect Immun 65, 1105-1108
Moncrief, J S., Duncan, A J., Wright, R L., Barroso, L A., and Wilkins, T D (1998) Molecular Characterization of the Fragilysin Pathogenicity Islet of Enterotoxigenic Bacteroides fragilis Infect Immun 66, 1735-1739
Moore, R., Pothoulakis, C., LaMont, J T., Carlson, S., and Madara, J L (1990) Clostridium difficile toxin A increases intestinal permeability and induces Cl- Amer J Physiol 259, G165-G172
Mortensen, K., and Larsson, L I (2003) Effects of cytochalasin D on the actin cytoskeleton: association of neoformed actin aggregates with proteins involved in signaling and endocytosis Cell Mol Life Sci 60, 1007-1012
Trang 31Moss, J., and Vaughan, M (1988) ADP-ribosylation of guanyl nucleotide-binding regulatory proteins by bacterial toxins Advances 61, 303-379
Muldrow, L L., Ibeanu, G C., Lee, N I., Bose, N K., and Johnson, J (1987) Molecular cloning
of Clostridium difficile toxin A gene fragment in lambda gt11 FEBS Lett 213, 249-253
Nagahama, M., Sakaguchi, Y., Kobayashi, K., Ochi, S., and Sakurai, J (2000) Characterization
of the Enzymatic Component of Clostridium perfringens Iota-Toxin J Bacteriol 182, 2096-2103
Nakajima, H., Nagaso, H., Kakui, N., Ishikawa, M., Hiranuma, T., and Hoshiko, S (2004) Critical role of the automodification of poly(ADP-ribose) polymerase-1 in nuclear factor-kappaB-dependent gene expression in primary cultured mouse glial cells J Biol Chem 279, 42774-42786
Nakao, H., Pruckler, J M., Mazurova, I K., Narvskaia, O V., Glushkevich, T., Marijevski, V F., Kravetz, A N., Fields, B S., Wachsmuth, I K., and Popovic, T (1996) Heterogeneity of diphtheria toxin gene, tox, and its regulatory element, dtxR, in Corynebacterium diphtheriae strains causing epidemic diphtheria in Russia and Ukraine J Clin Microbiol 34, 1711-1716
Neiders, M E., Chen, P B., Suido, H., Reynolds, H S., Zambon, J J., Shlossman, M., and Genco, R J (1989) Heterogeneity of virulence among strains of Bacteroides gingivalis J Periodont Res 24, 192-198
Nemeth, Z H., Deitch, E A., Davidson, M T., Szabo, C., Vizi, E S., and Hasko, G (2004) Disruption of the actin cytoskeleton results in nuclear factor-kappaB activation and inflammatory mediator production in cultured human intestinal epithelial cells J Cell Physiol 200, 71-81