Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation.. Expression of nodal, lefty-a, and lefty-B in undifferentiated human embryonic stem
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References
Trang 2
5 Reference
Abdollah, S., Macias-Silva, M., Tsukazaki, T., Hayashi, H., Attisano, L., and Wrana, J L (1997) TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for
Smad2-Smad4 complex formation and signaling J Biol Chem 272, 27678-27685
Ambrosetti, D C., Basilico, C., and Dailey, L (1997) Synergistic activation of the fibroblast growth factor 4 enhancer by Sox2 and Oct-3 depends on protein-protein interactions facilitated by a specific spatial arrangement of factor binding sites Mol Cell
Biol 17, 6321-6329
Attisano, L., Wrana, J L., Montalvo, E., and Massague, J (1996) Activation of
signalling by the activin receptor complex Mol Cell Biol 16, 1066-1073
Aubert, J., Dunstan, H., Chambers, I., and Smith, A (2002) Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation Nat
Biotechnol 20, 1240-1245
Avilion, A A., Nicolis, S K., Pevny, L H., Perez, L., Vivian, N., and Lovell-Badge, R (2003) Multipotent cell lineages in early mouse development depend on SOX2 function
Genes Dev 17, 126-140
Bakre, M M., Hoi, A., Mong, J C., Koh, Y Y., Wong, K Y., and Stanton, L W (2007) Generation of multipotential mesendodermal progenitors from mouse embryonic stem
cells via sustained Wnt pathway activation J Biol Chem 282, 31703-31712
Beattie, G M., Lopez, A D., Bucay, N., Hinton, A., Firpo, M T., King, C C., and Hayek,
A (2005) Activin A maintains pluripotency of human embryonic stem cells in the
absence of feeder layers Stem Cells 23, 489-495
Besser, D (2004) Expression of nodal, lefty-a, and lefty-B in undifferentiated human
embryonic stem cells requires activation of Smad2/3 J Biol Chem 279, 45076-45084
Bhattacharya, B., Miura, T., Brandenberger, R., Mejido, J., Luo, Y., Yang, A X., Joshi,
B H., Ginis, I., Thies, R S., Amit, M., et al (2004) Gene expression in human embryonic stem cell lines: unique molecular signature Blood 103, 2956-2964
Boyer, L A., Lee, T I., Cole, M F., Johnstone, S E., Levine, S S., Zucker, J P.,
Guenther, M G., Kumar, R M., Murray, H L., Jenner, R G., et al (2005) Core transcriptional regulatory circuitry in human embryonic stem cells Cell 122, 947-956
Brandenberger, R., Khrebtukova, I., Thies, R S., Miura, T., Jingli, C., Puri, R., Vasicek, T., Lebkowski, J., and Rao, M (2004) MPSS profiling of human embryonic stem cells
BMC Dev Biol 4, 10
Trang 3Brennan, J., Lu, C C., Norris, D P., Rodriguez, T A., Beddington, R S., and Robertson,
E J (2001) Nodal signalling in the epiblast patterns the early mouse embryo Nature 411,
965-969
Brennan, J., Norris, D P., and Robertson, E J (2002) Nodal activity in the node governs
left-right asymmetry Genes Dev 16, 2339-2344
Brons IG, Smithers LE, Trotter MW, Rugg-Gunn P, Sun B, Chuva de Sousa Lopes SM, Howlett SK, Clarkson A, Ahrlund-Richter L, Pedersen RA, Vallier L (2007), Derivation
of pluripotent epiblast stem cells from mammalian embryos., Nature 448, 191-195 Brown, K A., Pietenpol, J A., and Moses, H L (2007) A tale of two proteins: differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling J Cell
Biochem 101, 9-33
Burns, C J., Persaud, S J., and Jones, P M (2006) Diabetes mellitus: a potential target
for stem cell therapy Curr Stem Cell Res Ther 1, 255-266
Camus, A., Perea-Gomez, A., Moreau, A., and Collignon, J (2006) Absence of Nodal
signaling promotes precocious neural differentiation in the mouse embryo Dev Biol 295,
743-755
Chambers, I., Colby, D., Robertson, M., Nichols, J., Lee, S., Tweedie, S., and Smith, A (2003) Functional expression cloning of Nanog, a pluripotency sustaining factor in
embryonic stem cells Cell 113, 643-655
Chambers, I., and Smith, A (2004) Self-renewal of teratocarcinoma and embryonic stem
cells Oncogene 23, 7150-7160
Chen, C., and Shen, M M (2004) Two modes by which Lefty proteins inhibit nodal
signaling Curr Biol 14, 618-624
Chen, Y., and Schier, A F (2001) The zebrafish Nodal signal Squint functions as a
morphogen Nature 411, 607-610
Chew, J L., Loh, Y H., Zhang, W., Chen, X., Tam, W L., Yeap, L S., Li, P., Ang, Y S., Lim, B., Robson, P., and Ng, H H (2005) Reciprocal transcriptional regulation of
Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells Mol Cell Biol 25,
6031-6046
Chu, J., Ding, J., Jeays-Ward, K., Price, S M., Placzek, M., and Shen, M M (2005) Non-cell-autonomous role for Cripto in axial midline formation during vertebrate
embryogenesis Development 132, 5539-5551
Ciardiello, F., Dono, R., Kim, N., Persico, M G., and Salomon, D S (1991a) Expression of cripto, a novel gene of the epidermal growth factor gene family, leads to in
Trang 4vitro transformation of a normal mouse mammary epithelial cell line Cancer Res 51,
1051-1054
Ciardiello, F., Kim, N., Saeki, T., Dono, R., Persico, M G., Plowman, G D., Garrigues, J., Radke, S., Todaro, G J., and Salomon, D S (1991b) Differential expression of epidermal growth factor-related proteins in human colorectal tumors Proc Natl Acad Sci
U S A 88, 7792-7796
Conlon, F L., Lyons, K M., Takaesu, N., Barth, K S., Kispert, A., Herrmann, B., and Robertson, E J (1994) A primary requirement for nodal in the formation and
maintenance of the primitive streak in the mouse Development 120, 1919-1928
Daheron, L., Opitz, S L., Zaehres, H., Lensch, W M., Andrews, P W., Itskovitz-Eldor, J., and Daley, G Q (2004) LIF/STAT3 signaling fails to maintain self-renewal of
human embryonic stem cells Stem Cells 22, 770-778
Darr, H., Mayshar, Y., and Benvenisty, N (2006) Overexpression of NANOG in human
ES cells enables feeder-free growth while inducing primitive ectoderm features
Development 133, 1193-1201
Davila, J C., Cezar, G G., Thiede, M., Strom, S., Miki, T., and Trosko, J (2004) Use
and application of stem cells in toxicology Toxicol Sci 79, 214-223
Di-Gregorio A, Sancho M, Stuckey DW, Crompton LA, Godwin J, Mishina Y, Rodriguez TA.(2007) BMP signalling inhibits premature neural differentiation in the mouse embryo Development 134, 3359-69
Dunn, N R., Vincent, S D., Oxburgh, L., Robertson, E J., and Bikoff, E K (2004) Combinatorial activities of Smad2 and Smad3 regulate mesoderm formation and
patterning in the mouse embryo Development 131, 1717-1728
Dvash T, Sharon N, Yanuka O, Benvenisty N (2007), Molecular analysis of LEFTY-expressing cells in early human embryoid bodies, Stem Cells 25, 465-472
Fan, L., and Collodi, P (2006) Zebrafish embryonic stem cells Methods Enzymol 418,
64-77
Feldman, B., Gates, M A., Egan, E S., Dougan, S T., Rennebeck, G., Sirotkin, H I., Schier, A F., and Talbot, W S (1998) Zebrafish organizer development and germ-layer
formation require nodal-related signals Nature 395, 181-185
Fukuda, H., and Takahashi, J (2005) Embryonic stem cells as a cell source for treating
Parkinson's disease Expert Opin Biol Ther 5, 1273-1280
Trang 5Funaba, M., Zimmerman, C M., and Mathews, L S (2002) Modulation of
Smad2-mediated signaling by extracellular signal-regulated kinase J Biol Chem 277,
41361-41368
Gliniak, B C., McKenna, H J., Papayannopoulou, T., Thoma, B., and et al (1995) Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death
Development 121, 1283-1299
Goldin, S N., and Papaioannou, V E (2003) Paracrine action of FGF4 during
periimplantation development maintains trophectoderm and primitive endoderm Genesis
36, 40-47
Gu, Z., Nomura, M., Simpson, B B., Lei, H., Feijen, A., van den Eijnden-van Raaij, J., Donahoe, P K., and Li, E (1998) The type I activin receptor ActRIB is required for egg
cylinder organization and gastrulation in the mouse Genes Dev 12, 844-857
Hamada, H., Meno, C., Watanabe, D., and Saijoh, Y (2002) Establishment of vertebrate
left-right asymmetry Nat Rev Genet 3, 103-113
Hamatani, T., Carter, M G., Sharov, A A., and Ko, M S (2004) Dynamics of global
gene expression changes during mouse preimplantation development Dev Cell 6,
117-131
Harms, P W., and Chang, C (2003) Tomoregulin-1 (TMEFF1) inhibits nodal signaling
through direct binding to the nodal coreceptor Cripto Genes Dev 17, 2624-2629
Hendrix, M J., Seftor, E A., Seftor, R E., Kasemeier-Kulesa, J., Kulesa, P M., and Postovit, L M (2007) Reprogramming metastatic tumour cells with embryonic
microenvironments Nat Rev Cancer 7, 246-255
Hirano, T., Ishihara, K., and Hibi, M (2000) Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine
receptors Oncogene 19, 2548-2556
Ho, H Y., and Li, M (2006) Potential application of embryonic stem cells in Parkinson's
disease: drug screening and cell therapy Regen Med 1, 175-182
Iannaccone, P M., Taborn, G U., Garton, R L., Caplice, M D., and Brenin, D R (1994) Pluripotent embryonic stem cells from the rat are capable of producing chimeras
Dev Biol 163, 288-292
Inman, G J., Nicolas, F J., Callahan, J F., Harling, J D., Gaster, L M., Reith, A D., Laping, N J., and Hill, C S (2002) SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK)
receptors ALK4, ALK5, and ALK7 Mol Pharmacol 62, 65-74
Trang 6James, D., Levine, A J., Besser, D., and Hemmati-Brivanlou, A (2005) TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in
human embryonic stem cells Development 132, 1273-1282
Jiang J, Chan YS, Loh YH, Cai J, Tong GQ, Lim CA, Robson P, Zhong S, Ng HH.(2008),
A core Klf circuitry regulates self-renewal of embryonic stem cells, Nat Cell Biol 10, 353-360
Jinnin, M., Ihn, H., and Tamaki, K (2006) Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-beta1-induced
extracellular matrix expression Mol Pharmacol 69, 597-607
Jornvall, H., Reissmann, E., Andersson, O., Mehrkash, M., and Ibanez, C F (2004) ALK7, a receptor for nodal, is dispensable for embryogenesis and left-right patterning in
the mouse Mol Cell Biol 24, 9383-9389
Kitamura, R., Takahashi, T., Nakajima, N., Isodono, K., Asada, S., Ueno, H., Ueyama, T., Yoshikawa, T., Matsubara, H., and Oh, H (2007) Stage-specific role of endogenous
Smad2 activation in cardiomyogenesis of embryonic stem cells Circ Res 101, 78-87
Larsson, J., Goumans, M J., Sjostrand, L J., van Rooijen, M A., Ward, D., Leveen, P.,
Xu, X., ten Dijke, P., Mummery, C L., and Karlsson, S (2001) Abnormal angiogenesis
but intact hematopoietic potential in TGF-beta type I receptor-deficient mice Embo J 20,
1663-1673
Levine, A J., and Brivanlou, A H (2006) GDF3, a BMP inhibitor, regulates cell fate in
stem cells and early embryos Development 133, 209-216
Li, J., Pan, G., Cui, K., Liu, Y., Xu, S., and Pei, D (2007) A dominant-negative form of mouse SOX2 induces trophectoderm differentiation and progressive polyploidy in mouse
embryonic stem cells J Biol Chem 282, 19481-19492
Li, M., Sendtner, M., and Smith, A (1995) Essential function of LIF receptor in motor
neurons Nature 378, 724-727
Li, Y., McClintick, J., Zhong, L., Edenberg, H J., Yoder, M C., and Chan, R J (2005) Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the
zinc finger transcription factor Klf4 Blood 105, 635-637
Loh, Y H., Wu, Q., Chew, J L., Vega, V B., Zhang, W., Chen, X., Bourque, G., George,
J., Leong, B., Liu, J., et al (2006) The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells Nat Genet 38, 431-440
Lowe, L A., Yamada, S., and Kuehn, M R (2001) Genetic dissection of nodal function
in patterning the mouse embryo Development 128, 1831-1843
Trang 7Lu, C C., and Robertson, E J (2004) Multiple roles for Nodal in the epiblast of the
mouse embryo in the establishment of anterior-posterior patterning Dev Biol 273,
149-159
Matin, M M., Walsh, J R., Gokhale, P J., Draper, J S., Bahrami, A R., Morton, I., Moore, H D., and Andrews, P W (2004) Specific knockdown of Oct4 and beta2-microglobulin expression by RNA interference in human embryonic stem cells and
embryonic carcinoma cells Stem Cells 22, 659-668
Matsuda, T., Nakamura, T., Nakao, K., Arai, T., Katsuki, M., Heike, T., and Yokota, T (1999) STAT3 activation is sufficient to maintain an undifferentiated state of mouse
embryonic stem cells Embo J 18, 4261-4269
Mee, P J., O'Brien, C M., Thomson, H., van der Sar, S., Lakics, V., and Allsopp, T E (2006) Embryonic stem cells as a source of differentiated neural cells for
pharmacological screens Methods Mol Biol 329, 353-369
Meno, C., Gritsman, K., Ohishi, S., Ohfuji, Y., Heckscher, E., Mochida, K., Shimono, A.,
Kondoh, H., Talbot, W S., Robertson, E J., et al (1999) Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation Mol Cell
4, 287-298
Meno, C., Ito, Y., Saijoh, Y., Matsuda, Y., Tashiro, K., Kuhara, S., and Hamada, H (1997) Two closely-related left-right asymmetrically expressed genes, lefty-1 and lefty-2: their distinct expression domains, chromosomal linkage and direct neuralizing activity in
Xenopus embryos Genes Cells 2, 513-524
Meno, C., Saijoh, Y., Fujii, H., Ikeda, M., Yokoyama, T., Yokoyama, M., Toyoda, Y., and Hamada, H (1996) Left-right asymmetric expression of the TGF beta-family
member lefty in mouse embryos Nature 381, 151-155
Mitsui, K., Tokuzawa, Y., Itoh, H., Segawa, K., Murakami, M., Takahashi, K., Maruyama, M., Maeda, M., and Yamanaka, S (2003) The homeoprotein Nanog is
required for maintenance of pluripotency in mouse epiblast and ES cells Cell 113,
631-642
Moffat, J., and Sabatini, D M (2006) Building mammalian signalling pathways with
RNAi screens Nat Rev Mol Cell Biol 7, 177-187
Molofsky, A V., Pardal, R., and Morrison, S J (2004) Diverse mechanisms regulate
stem cell self-renewal Curr Opin Cell Biol 16, 700-707
Nakatake, Y., Fukui, N., Iwamatsu, Y., Masui, S., Takahashi, K., Yagi, R., Yagi, K., Miyazaki, J., Matoba, R., Ko, M S., and Niwa, H (2006) Klf4 cooperates with Oct3/4
Trang 8and Sox2 to activate the Lefty1 core promoter in embryonic stem cells Mol Cell Biol 26,
7772-7782
Nichols, J., Chambers, I., Taga, T., and Smith, A (2001) Physiological rationale for
responsiveness of mouse embryonic stem cells to gp130 cytokines Development 128,
2333-2339
Nichols, J., Zevnik, B., Anastassiadis, K., Niwa, H., Klewe-Nebenius, D., Chambers, I., Scholer, H., and Smith, A (1998) Formation of pluripotent stem cells in the mammalian
embryo depends on the POU transcription factor Oct4 Cell 95, 379-391
Niwa, H., Burdon, T., Chambers, I., and Smith, A (1998) Self-renewal of pluripotent
embryonic stem cells is mediated via activation of STAT3 Genes Dev 12, 2048-2060
Niwa, H., Miyazaki, J., and Smith, A G (2000) Quantitative expression of Oct-3/4
defines differentiation, dedifferentiation or self-renewal of ES cells Nat Genet 24,
372-376
Nomura, M., and Li, E (1998) Smad2 role in mesoderm formation, left-right patterning
and craniofacial development Nature 393, 786-790
Ogawa, K., Saito, A., Matsui, H., Suzuki, H., Ohtsuka, S., Shimosato, D., Morishita, Y., Watabe, T., Niwa, H., and Miyazono, K (2007) Activin-Nodal signaling is involved in
propagation of mouse embryonic stem cells J Cell Sci 120, 55-65
Oh, S P., and Li, E (1997) The signaling pathway mediated by the type IIB activin
receptor controls axial patterning and lateral asymmetry in the mouse Genes Dev 11,
1812-1826
Pease, S., and Williams, R L (1990) Formation of germ-line chimeras from embryonic
stem cells maintained with recombinant leukemia inhibitory factor Exp Cell Res 190,
209-211
Pera, M F., Andrade, J., Houssami, S., Reubinoff, B., Trounson, A., Stanley, E G., Ward-van Oostwaard, D., and Mummery, C (2004) Regulation of human embryonic
stem cell differentiation by BMP-2 and its antagonist noggin J Cell Sci 117, 1269-1280
Perea-Gomez, A., Vella, F D., Shawlot, W., Oulad-Abdelghani, M., Chazaud, C., Meno,
C., Pfister, V., Chen, L., Robertson, E., Hamada, H., et al (2002) Nodal antagonists in
the anterior visceral endoderm prevent the formation of multiple primitive streaks Dev
Cell 3, 745-756
Pesce, M., and Scholer, H R (2001) Oct-4: gatekeeper in the beginnings of mammalian
development Stem Cells 19, 271-278
Postovit, L M., Seftor, E A., Seftor, R E., and Hendrix, M J (2007) Targeting Nodal
in malignant melanoma cells Expert Opin Ther Targets 11, 497-505
Trang 9Pouton, C W., and Haynes, J M (2007) Embryonic stem cells as a source of models for
drug discovery Nat Rev Drug Discov 6, 605-616
Rao, M (2004) Conserved and divergent paths that regulate self-renewal in mouse and
human embryonic stem cells Dev Biol 275, 269-286
Raz, R., Lee, C K., Cannizzaro, L A., d'Eustachio, P., and Levy, D E (1999) Essential
role of STAT3 for embryonic stem cell pluripotency Proc Natl Acad Sci U S A 96,
2846-2851
Reubinoff, B E., Pera, M F., Fong, C Y., Trounson, A., and Bongso, A (2000) Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro Nat
Biotechnol 18, 399-404
Reynolds A, Leake D, Boese Q, Scaringe S, Marshall WS, Khvorova A (2004) Rational
siRNA design for RNA interference Nat Biotechnol 22,326–330
Rodda, D J., Chew, J L., Lim, L H., Loh, Y H., Wang, B., Ng, H H., and Robson, P
(2005) Transcriptional regulation of nanog by OCT4 and SOX2 J Biol Chem 280,
24731-24737
Rodriguez, R T., Velkey, J M., Lutzko, C., Seerke, R., Kohn, D B., O'Shea, K S., and Firpo, M T (2007) Manipulation of OCT4 levels in human embryonic stem cells results
in induction of differential cell types Exp Biol Med (Maywood) 232, 1368-1380
Ross S, Cheung E, Petrakis TG, Howell M, Kraus WL, Hill CS (2006) Smads orchestrate specific histone modifications and chromatin remodeling to activate transcription EMBO J 4, 490-502
Saijoh, Y., Adachi, H., Mochida, K., Ohishi, S., Hirao, A., and Hamada, H (1999) Distinct transcriptional regulatory mechanisms underlie left-right asymmetric expression
of lefty-1 and lefty-2 Genes Dev 13, 259-269
Saijoh, Y., Adachi, H., Sakuma, R., Yeo, C Y., Yashiro, K., Watanabe, M., Hashiguchi,
H., Mochida, K., Ohishi, S., Kawabata, M., et al (2000) Left-right asymmetric
expression of lefty2 and nodal is induced by a signaling pathway that includes the
transcription factor FAST2 Mol Cell 5, 35-47
Sakuma, R., Ohnishi Yi, Y., Meno, C., Fujii, H., Juan, H., Takeuchi, J., Ogura, T., Li, E., Miyazono, K., and Hamada, H (2002) Inhibition of Nodal signalling by Lefty mediated
through interaction with common receptors and efficient diffusion Genes Cells 7,
401-412
Saloman, D S., Bianco, C., Ebert, A D., Khan, N I., De Santis, M., Normanno, N.,
Wechselberger, C., Seno, M., Williams, K., Sanicola, M., et al (2000) The EGF-CFC
Trang 10family: novel epidermal growth factor-related proteins in development and cancer
Endocr Relat Cancer 7, 199-226
Sampath, K., Rubinstein, A L., Cheng, A M., Liang, J O., Fekany, K., Solnica-Krezel, L., Korzh, V., Halpern, M E., and Wright, C V (1998) Induction of the zebrafish
ventral brain and floorplate requires cyclops/nodal signalling Nature 395, 185-189
Sato, N., Meijer, L., Skaltsounis, L., Greengard, P., and Brivanlou, A H (2004) Maintenance of pluripotency in human and mouse embryonic stem cells through
activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor Nat Med 10,
55-63
Schier, A F., and Shen, M M (2000) Nodal signalling in vertebrate development
Nature 403, 385-389
Seiler, A E., Buesen, R., Visan, A., and Spielmann, H (2006) Use of murine embryonic
stem cells in embryotoxicity assays: the embryonic stem cell test Methods Mol Biol 329,
371-395
Shen, M M (2007) Nodal signaling: developmental roles and regulation Development
134, 1023-1034
Shi, W., Wang, H., Pan, G., Geng, Y., Guo, Y., and Pei, D (2006) Regulation of the
pluripotency marker Rex-1 by Nanog and Sox2 J Biol Chem 281, 23319-23325
Shiratori, H., Sakuma, R., Watanabe, M., Hashiguchi, H., Mochida, K., Sakai, Y., Nishino, J., Saijoh, Y., Whitman, M., and Hamada, H (2001) Two-step regulation of left-right asymmetric expression of Pitx2: initiation by nodal signaling and maintenance
by Nkx2 Mol Cell 7, 137-149
Smith, A G., Heath, J K., Donaldson, D D., Wong, G G., Moreau, J., Stahl, M., and Rogers, D (1988) Inhibition of pluripotential embryonic stem cell differentiation by
purified polypeptides Nature 336, 688-690
Smith, A G., and Hooper, M L (1987) Buffalo rat liver cells produce a diffusible activity which inhibits the differentiation of murine embryonal carcinoma and embryonic
stem cells Dev Biol 121, 1-9
Smith JR, Vallier L, Lupo G, Alexander M, Harris WA, Pedersen RA (2008), Inhibition
of Activin/Nodal signaling promotes specification of human embryonic stem cells into neuroectoderm, Dev Biol 313, 107-117
Stewart, C L., Kaspar, P., Brunet, L J., Bhatt, H., Gadi, I., Kontgen, F., and Abbondanzo,
S J (1992) Blastocyst implantation depends on maternal expression of leukaemia
inhibitory factor Nature 359, 76-79