NGHIEN cCru TONG HOP S A N PHAM NGl/NG TU CLIA GLUCOZAMINCLOHYDRAT V6l MOT SO HOP CHAT CHLTA NHOM AMINO Nguyen Thi Thanh Phong, Phan Quang Thai Khna Hoa hoc Tririmg DHSP - DHQG Ha Ngi
Trang 1NGHIEN cCru TONG HOP S A N PHAM NGl/NG TU CLIA
GLUCOZAMINCLOHYDRAT V6l MOT SO HOP CHAT
CHLTA NHOM AMINO
Nguyen Thi Thanh Phong, Phan Quang Thai
Khna Hoa hoc Tririmg DHSP - DHQG Ha Ngi
I Ma dau
Nu6e ta eo san lirong hai san noi chung vei san luiTng tom noi rieng dude danh bat hang nam rttt Ion, irdfc tmh thai ra khoang 3().0()() ta'n vo torn [2] Trong luong phe thai do chi'ra mOt luimg ehitin dang kd Chung eo boat tfnh sinh hoe cao, mot trong cac dan xua't ciia chitin la
chitozan da duoc nghien ciifii rat ky b trong nude cung nhu a tren the gidii [3], [4], song eon mot
sd d&n xua't khae con chua duoc d6 cap nhidu trong cac nghien curu do Chinh vi vSy, trong bai nay chung toi mudn d6 cap den mot so san philm ngimg tu giua glucozaminclohydrat vdi thiosemicacbazit, axit glutiimie va cixit aspatie
II Thirc nghiem
Qua trinh tach chitin va chuySn thanh glucozaminclohydrat da duoc ehiing toi dang trong eOng trinh [1]
Phan ung ngung tu giua glucozaminclohydrat va mot so hop chat chura nhdm NH2 dirge thue hifin theo so d6 sau:
1 - f )i 1
N /
n 1 Dieu che san phrim ngimg tii giua glucozaminclohydrat va thiosemicacbaz.it (Glu - N
- thi)
Dun trong he thong cat (buy phan khoang 50 phiit hOn h(.tp gom 0,015 mol Glu, 0,01 mol thi va 20 ml nude cho den khi tao hdn hop dong nhat Lam lanh den nhiet do phong rdi them
vao do 10ml ete Ket tiia dirge tach ra eo mau v;uig nhat, Ige lay kfi't tiia va lam kh6 san p h i n b
nhifit do thich hgp
a^on
j-o
r / '•"
'NHCI
3
2 K
Trang 2n 2 miu chtf sSn phin ngung tu giiia Glucozaminclohydrat v^ axit glutamic (Glu N
-Glut)
Cho vho he thtfng cit thuy phSn h6n hgp gSn 0,02 mol Glu \k 0,015 raoI.Glut v^ 20ml etanol 96° Dun h6n hgp cho dffn khi tao h6n hgp ddng nh^t (khoang 2h) Di yen & nhiet d6 ph6ng, cho 15 ml axeton Lkn lanh cho d^n khi k.6t tinh hoan toan Lgc rfra b ^ g c6n tuyft ddi, Uten khO s&n phim 6 nhiet d6 thich hgp
n.3 Di^u cM phiia ngung tii giua glucozaminclohydrat v^ axit aspatie (Glu - N - Asp.)
CSch didu ch^ tuong tii nhu di^u ch^ Glu - N - Glut & tren
III Ket qua va thao luan
///./ Thdo ludn vesutSng hgp cac sdnphdm ngUng tu
itiing, I Mi>\ ^ il^c Uwijg oim Cik: fyau pItfCin «g»rng Uf
C C s i g U»»it; t^u tij«,>
atti
: '7^y
(on ),i,>is
M /
C l i O t !
j — ( j l l
\ in
Jiiiti}; j
i ' H O U
2 j l y n lutti
• A^ i
I I t a i iiitti
<iili« M A « t > €11* Jit
2t:*
1
.1
3(i
'IH
«i:i
Phdn dng ngung tu cd Vhk nSng xky ra theo 2 giai doan dd la c6ng vJi t^ch DQ nhdm
*NH3 hut electron manh diJng canh nhdm C = 0 nhdm dd 1 ^ tang dien tfch duong d cdcbon cabonyl di^u dd tao di^u kien thuan Igi cho nhdm NHj tSh cOng v^o C = 0 Mat khdc phSn ting
Trang 3duge thuc hien trong m5i trir^mg axit ycu nen phan ung cgng va tach deu thuAn Igi
C^c san phim thu duge deu la nhung chat rdn, eo nhiet d6 phan huy kha cao Khi so sanh
nhiet dd ndng chay ciia cac chat dau va cac san phdm, ta cd the nhan thay sir khae nhau kha ro (bang 1), chung to cac phan ung xay ra theo du doan
III.2 Bien lugn ve pho hong ngogi cua cac san phani ngimg tu
Nhin chung phd hong ngoai ciia cac chat nghien cuu diu xu^t hien cac pie dac trung cho dao ddng hoa tri va dao dong bien dang cua cac nhdm chiJc trong phan tir chSft dau va cac san phdm (bang 2)
Tren bang 2 chung la d6 dang nhan thay ngoai cac pic dac trung cua Glu, con xuat hien cac pie mdi dac trung cho dao dong hoa tri ciia nhdm iizometin Veh-n (1642 cm"') va dao dong bie'n dang cua lien ket C-H trong nhdm - CH = N- (5CH=N 997 - 950 em"')
IV Ket luan
1 Da thirc hien phan ung ngung tu giua glucozamin clohydrat vdi thiosemicacbazit, axit glutamic va axit aspatie
2 Da nhan dang san pham dua tren phd dd IR va nhiet dd ndng chay, va nhan th^y cd kha nang xay ra phan ngung tu giira gluzamin clohydrat vdi mdt so hgp chaft ehiJa nhdm amino
ki tren
Tai lieu ihani kluio
1 Nguyen Thi Thanh Phong, Phan Quang Thai, Nghien ciJii tach, ehuye'n hoa chitin thanh axit glucozaminic va boat tfnh sinh hoc cua Fe (II) Glucozaminat, tuydn tap bao cao Hoi nghj Hoa hoc toan qudc Ian thii 3, tr 160-161, Ha Ngi 1998
2 Nguyen Ngge Tu, Bao cao khoa hoe tai Hdi nghi Vien Hoa hoc Ian thu" II, Ha Ndi, ngay 22 thdng 2 nam 1995
3 G A F Roberts and J G Domszy inl J Biol Macromol., 4.374 - 377, 1982
4 Rinaudo M.and Desbrieres, J Macromol Chem 182 373, 1981
S U M M A R Y
We have investigation the condensation reactions of Glucosamine Chlohydratewith the Thiosemicarbazide, Glutamic and Aspatie acids
The condensation products weredetenninated base on Infrared adsorption Spectra and molten pxjints