A RETROSPECTIVE ANALYSIS OF COMORBID TRAITS AFFECTING FEEDING IN INFANTS WITH DOWN SYNDROME

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A RETROSPECTIVE ANALYSIS OF COMORBID TRAITS AFFECTING FEEDING

IN INFANTS WITH DOWN SYNDROME

A Thesis Submitted to the Faculty

of Purdue University

by Nichole L Duvall

In Partial Fulfillment of the Requirements for the Degree

of Master of Science

December 2011 Purdue University Indianapolis, Indiana

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viii

ABSTRACT

Duvall, Nichole L, M.S Purdue University, December, 2011 A retrospective analysis of comorbid traits affecting feeding in infants with Down syndrome Major Professor: Randall Roper

Down syndrome (DS) is the most common aneuploidy to affect humans and occurs in approximately 1 of 750 live births Individuals with DS present with a wide range of clinical phenotypes Common craniofacial phenotypic expressions include a small mandible, protruding tongue, and a flattened nasal bridge These traits may affect the feeding, breathing, and swallowing of individuals with DS Because some

complications may go unnoticed for longer periods of time, we hypothesize that

significant cardiac and GI defects may be indicative of feeding and airway difficulties In order to better understand the secondary phenotypes resulting from DS, we have

implemented a retrospective chart review of 137 infants between zero and six months of age who were evaluated through the Down Syndrome Program at Riley Hospital for Children from August 2005 to August 2008 Data regarding cardiac, gastrointestinal, endocrine, airway, auditory, and feeding abnormalities have been collected and

incedences and comorbidites of these traits has been examined

Comprehensive results indicate cardiac abnormalities occur in 80% of infants, 60% experience gastrointestinal complications, feeding difficulties occur in 46%, and

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