CD161 NKR-P1A costimulation of CD1d-dependent activation of human T cells expressing invariant Vα24 JαQ T cell receptor α chains.. Targeted expression of human CD1d in transgenic mice re
Trang 184 Skold M, Xiong X, Illarionov PA, Besra GS, Behar SM 2005 Interplay of cytokines and
microbial signals in regulation of CD1d expression and NKT cell activation J Immunol.
175:3584–93
85 de Lalla C, Galli G, Aldrighetti L, Romeo R, Mariani M, et al 2004 Production of profi-brotic cytokines by invariant NKT cells characterizes cirrhosis progression in chronic
viral hepatitis J Immunol 173:1417–25
86 Wei DG, Lee H, Park SH, Beaudoin L, Teyton L, et al 2005 Expansion and long-range differentiation of the NKT cell lineage in mice expressing CD1d exclusively on cortical
thymocytes J Exp Med 202:239–48
87 Busshoff U, Hein A, Iglesias A, Dorries R, Regnier-Vigouroux A 2001 CD1 expression
is differentially regulated by microglia, macrophages and T cells in the central nervous
system upon inflammation and demyelination J Neuroimmunol 113:220–30
88 Kang SJ, Cresswell P 2002 Calnexin, calreticulin, and ERp57 cooperate in disulfide
bond formation in human CD1d heavy chain J Biol Chem 277:44838–44
89 Jayawardena-Wolf J, Benlagha K, Chiu YH, Mehr R, Bendelac A 2001 CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and
by the invariant chain Immunity 15:897–908
90 Kang SJ, Cresswell P 2002 Regulation of intracellular trafficking of human CD1d by
association with MHC class II molecules EMBO J 21:1650–60
91 Roberts TJ, Sriram V, Spence PM, Gui M, Hayakawa K, et al 2002 Recycling CD1d1 molecules present endogenous antigens processed in an endocytic compartment to NKT
cells J Immunol 168:5409–14
92 Lawton AP, Prigozy TI, Brossay L, Pei B, Khurana A, et al 2005 The mouse CD1d cytoplasmic tail mediates CD1d trafficking and antigen presentation by adaptor protein
3-dependent and -independent mechanisms J Immunol 174:3179–86
93 Cernadas M, Sugita M, van der Wel N, Cao X, Gumperz JE, et al 2003 Lysosomal localization of murine CD1d mediated by AP-3 is necessary for NK T cell development
J Immunol 171:4149–55
94 Sugita M, Cao X, Watts GF, Rogers RA, Bonifacino JS, Brenner MB 2002 Failure of
trafficking and antigen presentation by CD1 in AP-3-deficient cells Immunity 16:697–706
95 Sanchez DJ, Gumperz JE, Ganem D 2005 Regulation of CD1d expression and function
by a herpesvirus infection J Clin Invest 115:1369–78
96 Yuan W, Dasgupta A, Cresswell P 2006 Herpes simplex virus evades natural killer T cell
recognition by suppressing CD1d recycling Nat Immunol 7:835–42
97 van den Elzen P, Garg S, Leon L, Brigl M, Leadbetter EA, et al 2005
Apolipoprotein-mediated pathways of lipid antigen presentation Nature 437:906–10
98 Prigozy TI, Sieling PA, Clemens D, Stewart PL, Behar SM, et al 1997 The mannose receptor delivers lipoglycan antigens to endosomes for presentation to T cells by CD1b
molecules Immunity 6:187–97
99 Hunger RE, Sieling PA, Ochoa MT, Sugaya M, Burdick AE, et al 2004 Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells
J Clin Invest 113:701–8
100 Marks DL, Pagano RE 2002 Endocytosis and sorting of glycosphingolipids in
sphin-golipid storage disease Trends Cell Biol 12:605–13
101 Gadola SD, Silk JD, Jeans A, Illarionov PA, Salio M, et al 2006 Impaired selection of invariant natural killer T cells in diverse mouse models of glycosphingolipid lysosomal
storage diseases J Exp Med 203:2293–303
Trang 2102 Sagiv Y, Hudspeth K, Mattner J, Schrantz N, Stern RK, et al 2006 Cutting edge: impaired glycosphingolipid trafficking and NKT cell development in mice lacking
Niemann-Pick type C1 protein J Immunol 177:26–30
103 Sandhoff K, Kolter T 2003 Biosynthesis and degradation of mammalian
glycosphin-golipids Philos Trans R Soc London B Biol Sci 358:847–61
104 Moody DB, Briken V, Cheng TY, Roura-Mir C, Guy MR, et al 2002 Lipid length con-trols antigen entry into endosomal and nonendosomal pathways for CD1b presentation
Nat Immunol 3:435–42
105 Ernst WA, Maher J, Cho S, Niazi KR, Chatterjee D, et al 1998 Molecular interaction
of CD1b with lipoglycan antigens Immunity 8:331–40
106 Cheng TY, Relloso M, Van Rhijn I, Young DC, Besra GS, et al 2006 Role of lipid
trimming and CD1 groove size in cellular antigen presentation EMBO J 25:2989–99
107 Gadola SD, Zaccai NR, Harlos K, Shepherd D, Castro-Palomino JC, et al 2002
Struc-ture of human CD1b with bound ligands at 2.3 ˚A, a maze for alkyl chains Nat Immunol.
3:721–26
108 Schuette CG, Pierstorff B, Huettler S, Sandhoff K 2001 Sphingolipid activator proteins:
proteins with complex functions in lipid degradation and skin biogenesis Glycobiology
11:81–90R
109 Brozovic S, Nagaishi T, Yoshida M, Betz S, Salas A, et al 2004 CD1d function is regulated
by microsomal triglyceride transfer protein Nat Med 10:535–39
110 Dougan SK, Salas A, Rava P, Agyemang A, Kaser A, et al 2005 Microsomal triglyceride
transfer protein lipidation and control of CD1d on antigen-presenting cells J Exp Med.
202:529–39
111 de la Salle H, Mariotti S, Angenieux C, Gilleron M, Garcia-Alles LF, et al 2005
Assis-tance of microbial glycolipid antigen processing by CD1e Science 310:1321–24
112 Honey K, Benlagha K, Beers C, Forbush K, Teyton L, et al 2002 Thymocyte expression
of cathepsin L is essential for NKT cell development Nat Immunol 3:1069–74
in the early stages of embryogenesis Proc Natl Acad Sci USA 93:6516–20
114 Shimamura M, Ohteki T, Beutner U, MacDonald HR 1997 Lack of directed
115 Bendelac A, Hunziker RD, Lantz O 1996 Increased interleukin 4 and immunoglobulin
E production in transgenic mice overexpressing NK1 T cells J Exp Med 184:1285–93
with a transgenic variant TCR J Immunol 165:168–74
117 Benlagha K, Weiss A, Beavis A, Teyton L, Bendelac A 2000 In vivo identification of
gly-colipid antigen specific T cells using fluorescent CD1d tetramers J Exp Med 191:1895–
903
118 Matsuda JL, Naidenko OV, Gapin L, Nakayama T, Taniguchi M, et al 2000 Tracking
the response of natural killer T cells to a glycolipid antigen using CD1d tetramers J Exp Med 192:741–54
119 Karadimitris A, Gadola S, Altamirano M, Brown D, Woolfson A, et al 2001 From the cover: human CD1d-glycolipid tetramers generated by in vitro oxidative refolding
chromatography Proc Natl Acad Sci USA 98:3294–98
120 Benlagha K, Wei DG, Veiga J, Teyton L, Bendelac A 2005 Characterization of the early
stages in thymic NKT cell development J Exp Med 202:485–92
121 Gapin L, Matsuda JL, Surh CD, Kronenberg M 2001 NKT cells derive from
double-positive thymocytes that are double-positively selected by CD1d Nat Immunol 2:971–78
Trang 3122 Bezbradica JS, Hill T, Stanic AK, Van Kaer L, Joyce S 2005 Commitment toward the
Acad Sci USA 102:5114–19
123 Egawa T, Eberl G, Taniuchi I, Benlagha K, Geissmann F, et al 2005 Genetic evidence supporting selection of the Vα14i NKT cell lineage from double-positive thymocyte
precursors Immunity 22:705–16
124 Pellicci DG, Hammond KJ, Uldrich AP, Baxter AG, Smyth MJ, Godfrey DI 2002
A natural killer T (NKT) cell developmental pathway involving a thymus-dependent
125 Benlagha K, Bendelac A 2000 CD1d-restricted mouse Vα14 and human Vα24 T cells:
lymphocytes of innate immunity Semin Immunol 12:537–42
126 Gumperz JE, Miyake S, Yamamura T, Brenner MB 2002 Functionally distinct subsets
of CD1d-restricted natural killer T cells revealed by CD1d tetramer staining J Exp Med 195:625–36
127 Lee PT, Benlagha K, Teyton L, Bendelac A 2002 Distinct functional lineages of human
vα24 natural killer T cells J Exp Med 195:637–41
128 Crowe NY, Coquet JM, Berzins SP, Kyparissoudis K, Keating R, et al 2005 Differential
antitumor immunity mediated by NKT cell subsets in vivo J Exp Med 202:1279–88
129 Berzins SP, Cochrane AD, Pellicci DG, Smyth MJ, Godfrey DI 2005 Limited correla-tion between human thymus and blood NKT cell content revealed by an ontogeny study
of paired tissue samples Eur J Immunol 35:1399–407
130 Stetson DB, Mohrs M, Reinhardt RL, Baron JL, Wang ZE, et al 2003 Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector
function J Exp Med 198:1069–76
131 Robson MacDonald H, Lees RK, Held W 1998 Developmentally regulated extinction
Med 187:2109–14
132 Exley M, Porcelli S, Furman M, Garcia J, Balk S 1998 CD161 (NKR-P1A) costimulation
of CD1d-dependent activation of human T cells expressing invariant Vα24 JαQ T cell
receptor α chains J Exp Med 188:867–76
133 Ikarashi Y, Mikami R, Bendelac A, Terme M, Chaput N, et al 2001 Dendritic cell maturation overrules H-2D-mediated natural killer T (NKT) cell inhibition Critical
role for β7 in CD1d-dependent NKT cell interferon gamma production J Exp Med.
194:1179–86
134 Eberl G, Fehling HJ, von Boehmer H, MacDonald HR 1999 Absolute requirement
Immunol 29:1966–71
135 Wei DG, Curran SA, Savage PB, Teyton L, Bendelac A 2006 Mechanisms imposing the Vβ bias of Vα14 natural killer T cells and consequences for microbial glycolipid
recognition J Exp Med 203:1197–207
136 Chun T, Page MJ, Gapin L, Matsuda JL, Xu H, et al 2003 CD1d-expressing dendritic
cells but not thymic epithelial cells can mediate negative selection of NKT cells J Exp Med 197:907–18
137 Xu H, Chun T, Colmone A, Nguyen H, Wang CR 2003 Expression of CD1d under the control of a MHC class Ia promoter skews the development of NKT cells, but not
138 Voyle RB, Beermann F, Lees RK, Schumann J, Zimmer J, et al 2003 Ligand-dependent inhibition of CD1d-restricted NKT cell development in mice transgenic for the activating
receptor Ly49D J Exp Med 197:919–25
Trang 4139 Schumann J, Pittoni P, Tonti E, Macdonald HR, Dellabona P, Casorati G 2005 Targeted expression of human CD1d in transgenic mice reveals independent roles for thymocytes
and thymic APCs in positive and negative selection of Vα14i NKT cells J Immunol.
175:7303–10
18
141 Zimmer MI, Colmone A, Felio K, Xu H, Ma A, Wang CR 2006 A cell-type specific CD1d expression program modulates invariant NKT cell development and function
J Immunol 176:1421–30
142 Gadue P, Morton N, Stein PL 1999 The Src family tyrosine kinase Fyn regulates natural
killer T cell development J Exp Med 190:1189–96
143 Eberl G, Lowin-Kropf B, MacDonald HR 1999 Cutting edge: NKT cell development
is selectively impaired in Fyn-deficient mice J Immunol 163:4091–94
144 Pasquier B, Yin L, Fondaneche MC, Relouzat F, Bloch-Queyrat C, et al 2005 Defec-tive NKT cell development in mice and humans lacking the adapter SAP, the X-linked
lymphoproliferative syndrome gene product J Exp Med 201:695–701
145 Nichols KE, Hom J, Gong SY, Ganguly A, Ma CS, et al 2005 Regulation of NKT cell
development by SAP, the protein defective in XLP Nat Med 11(3):340–45
146 Chung B, Aoukaty A, Dutz J, Terhorst C, Tan R 2005 Signaling lymphocytic activation
molecule-associated protein controls NKT cell functions J Immunol 174:3153–57
147 Sayos J, Wu C, Morra M, Wang N, Zhang X, et al 1998 The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the
coreceptor SLAM Nature 395:462–69
148 Chan B, Lanyi A, Song HK, Griesbach J, Simarro-Grande M, et al 2003 SAP couples
Fyn to SLAM immune receptors Nat Cell Biol 5:155–60
149 Latour S, Gish G, Helgason CD, Humphries RK, Pawson T, Veillette A 2001 Regulation
of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene
product Nat Immunol 2:681–90
150 Latour S, Roncagalli R, Chen R, Bakinowski M, Shi X, et al 2003 Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signaling in immune
regulation Nat Cell Biol 5:149–54
151 Veillette A, Latour S 2003 The SLAM family of immune-cell receptors Curr Opin Immunol 15:277–85
152 Gadue P, Yin L, Jain S, Stein PL 2004 Restoration of NK T cell development in
fyn-mutant mice by a TCR reveals a requirement for Fyn during early NK T cell ontogeny
J Immunol 172:6093–100
153 Borowski C, Bendelac A 2005 Signaling for NKT cell development: the SAP-Fyn
con-nection J Exp Med 201:833–36
154 Stanic AK, Bezbradica JS, Park JJ, Matsuki N, Mora AL, et al 2004 NF-κB controls cell fate specification, survival, and molecular differentiation of immunoregulatory natural T
lymphocytes J Immunol 172:2265–73
155 Sivakumar V, Hammond KJ, Howells N, Pfeffer K, Weih F 2003 Differential require-ment for Rel/nuclear factor κB family members in natural killer T cell developrequire-ment
J Exp Med 197:1613–21
differentiation and PKC-θ-mediated activation of NF-κB1 Immunity 21:693–706
Trang 5157 Schmidt-Supprian M, Tian J, Grant EP, Pasparakis M, Maehr R, et al 2004 Differential
to NF-κB activation Proc Natl Acad Sci USA 101:4566–71
158 Stanic AK, Bezbradica JS, Park JJ, Van Kaer L, Boothby MR, Joyce S 2004 Cutting edge: the ontogeny and function of Vα14Jα18 natural T lymphocytes require signal processing
by protein kinase Cθ and NF-κB J Immunol 172:4667–71
159 Wang N, Satoskar A, Faubion W, Howie D, Okamoto S, et al 2004 The cell surface
receptor SLAM controls T cell and macrophage functions J Exp Med 199:1255–64
160 Townsend MJ, Weinmann AS, Matsuda JL, Salomon R, Farnham PJ, et al 2004
T-bet regulates the terminal maturation and homeostasis of NK and Vα14i NKT cells Immunity 20:477–94
161 Intlekofer AM, Takemoto N, Wherry EJ, Longworth SA, Northrup JT, et al 2005
6:1236–44
162 Matsuda JL, Zhang Q, Ndonye R, Richardson SK, Howell AR, Gapin L 2006 T-bet con-comitantly controls migration, survival, and effector functions during the development
of Vα14i NKT cells Blood 107:2797–805
163 Atherly LO, Lucas JA, Felices M, Yin CC, Reiner SL, Berg LJ 2006 The Tec family
Immunity 25:79–91
164 Broussard C, Fleischecker C, Horai R, Chetana M, Venegas AM, et al 2006 Altered
Immunity 25:93–104
165 Li W, Kim MG, Gourley TS, McCarthy BP, Sant’Angelo DB, Chang CH 2005 An alternate pathway for CD4 T cell development: thymocyte-expressed MHC class II selects
a distinct T cell population Immunity 23:375–86
166 Kunisaki Y, Tanaka Y, Sanui T, Inayoshi A, Noda M, et al 2006 DOCK2 is required in
T cell precursors for development of Vα14 NK T cells J Immunol 176:4640–45
167 Williams KL, Zullo AJ, Kaplan MH, Brutkiewicz RR, Deppmann CD, et al 2003 BATF
transgenic mice reveal a role for activator protein-1 in NKT cell development J Immunol.
170:2417–26
168 Zullo AJ, Benlagha K, Bendelac A, Taparowsky E 2007 Sensitivity of NKT cells to transgenic BATF defines a role for AP-1 in the expansion and maturation of NKT cells
in the thymus J Immunol 178:58–66
169 Elewaut D, Shaikh RB, Hammond KJ, De Winter H, Leishman AJ, et al 2003 NIK-dependent RelB activation defines a unique signaling pathway for the development of
Vα14i NKT cells J Exp Med 197:1623–33
170 Boehm T, Scheu S, Pfeffer K, Bleul CC 2003 Thymic medullary epithelial cell differenti-ation, thymocyte emigrdifferenti-ation, and the control of autoimmunity require lympho-epithelial
cross talk via LTβR J Exp Med 198:757–69
171 Iizuka K, Chaplin DD, Wang Y, Wu Q, Pegg LE, et al 1999 Requirement for membrane
lymphotoxin in natural killer cell development Proc Natl Acad Sci USA 96:6336–40
172 Elewaut D, Brossay L, Santee SM, Naidenko OV, Burdin N, et al 2000 Membrane lymphotoxin is required for the development of different subpopulations of NK T cells
J Immunol 165:671–79
173 Franki AS, Van Beneden K, Dewint P, Hammond KJ, Lambrecht S, et al 2006 A unique lymphotoxin αβ-dependent pathway regulates thymic emigration of Vα14 invariant
nat-ural killer T cells Proc Natl Acad Sci USA 103:9160–65
Trang 6174 Bezbradica JS, Gordy LE, Stanic AK, Dragovic S, Hill T, et al 2006 Granulocyte-macrophage colony-stimulating factor regulates effector differentiation of invariant
nat-ural killer T cells during thymic ontogeny Immunity 25:487–97
175 Tomura M, Yu WG, Ahn HJ, Yamashita M, Yang YF, et al 1999 A novel function of
the innate immune system J Immunol 163:93–101
176 Kitamura H, Iwakabe K, Yahata T, Nishimura S, Ohta A, et al 1999 The natural killer T (NKT) cell ligand α-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression
on NKT cells J Exp Med 189:1121–28
177 Carnaud C, Lee D, Donnars O, Park SH, Beavis A, et al 1999 Cutting edge: cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells
J Immunol 163:4647–50
178 Eberl G, MacDonald HR 2000 Selective induction of NK cell proliferation and
cyto-toxicity by activated NKT cells Eur J Immunol 30:985–92
179 Gonzalez-Aseguinolaza G, Van Kaer L, Bergmann CC, Wilson JM, Schmieg J, et al
2002 Natural killer T cell ligand α-galactosylceramide enhances protective immunity
induced by malaria vaccines J Exp Med 195:617–24
180 Fujii S, Shimizu K, Smith C, Bonifaz L, Steinman RM 2003 Activation of natural killer
T cells by α-galactosylceramide rapidly induces the full maturation of dendritic cells in vivo and thereby acts as an adjuvant for combined CD4 and CD8 T cell immunity to a
coadministered protein J Exp Med 198:267–79
181 Fujii S, Liu K, Smith C, Bonito AJ, Steinman RM 2004 The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen
presentation and CD80/86 costimulation J Exp Med 199:1607–18
182 Silk JD, Hermans IF, Gileadi U, Chong TW, Shepherd D, et al 2004 Utilizing the adjuvant properties of CD1d-dependent NK T cells in T cell-mediated immunotherapy
J Clin Invest 114:1800–11
183 Parekh VV, Wilson MT, Van Kaer L 2005 iNKT-cell responses to glycolipids Crit Rev Immunol 25:183–213
184 Yoshimoto T, Paul WE 1994 CD4pos NK1.1pos T cells promptly produced IL-4 in
response to in vivo challenge with anti-CD3 J Exp Med 179:1285–95
185 Miyamoto K, Miyake S, Yamamura T 2001 A synthetic glycolipid prevents autoimmune
186 Oki S, Chiba A, Yamamura T, Miyake S 2004 The clinical implication and molecular mechanism of preferential IL-4 production by modified glycolipid-stimulated NKT cells
J Clin Invest 113:1631–40
187 Eberl G, MacDonald HR 1998 Rapid death and regeneration of NKT cells in anti-CD3epsilon- or IL-12-treated mice: a major role for bone marrow in NKT cell
home-ostasis Immunity 9:345–53
188 Uldrich AP, Crowe NY, Kyparissoudis K, Pellicci DG, Zhan Y, et al 2005 NKT cell stimulation with glycolipid antigen in vivo: costimulation-dependent expansion,
Bim-dependent contraction, and hyporesponsiveness to further antigenic challenge J Im-munol 175:3092–101
189 Parekh VV, Wilson MT, Olivares-Villagomez D, Singh AK, Wu L, et al 2005 Glycolipid
antigen induces long-term natural killer T cell anergy in mice J Clin Invest 115:2572–83
190 Fujii S, Shimizu K, Kronenberg M, Steinman RM 2002 Prolonged IFN-γ-producing
NKT response induced with α-galactosylceramide-loaded DCs Nat Immunol 3:867–74
Trang 7191 Chang DH, Osman K, Connolly J, Kukreja A, Krasovsky J, et al 2005 Sustained expan-sion of NKT cells and antigen-specific T cells after injection of α-galactosyl-ceramide
loaded mature dendritic cells in cancer patients J Exp Med 201:1503–17
192 Goff RD, Gao Y, Mattner J, Zhou D, Yin N, et al 2004 Effects of lipid chain lengths
in α-galactosylceramides on cytokine release by natural killer T cells J Am Chem Soc.
126:13602–3
193 Yu KO, Im JS, Molano A, Dutronc Y, Illarionov PA, et al 2005 Modulation of
CD1d-restricted NKT cell responses by using N-acyl variants of α-galactosylceramides Proc Natl Acad Sci USA 102:3383–88
194 Bezbradica JS, Stanic AK, Matsuki N, Bour-Jordan H, Bluestone JA, et al 2005 Dis-tinct roles of dendritic cells and B cells in Vα14Jα18 natural T cell activation in vivo
J Immunol 174:4696–705
195 Cui J, Shin T, Kawano T, Sato H, Kondo E, et al 1997 Requirement for Vα14 NKT
cells in IL-12-mediated rejection of tumors Science 278:1623–26
196 Park SH, Kyin T, Bendelac A, Carnaud C 2003 The contribution of NKT cells, NK cells, and other γ-chain-dependent non-T non-B cells to IL-12-mediated rejection of
tumors J Immunol 170:1197–201
197 Nieuwenhuis EE, Matsumoto T, Exley M, Schleipman RA, Glickman J, et al 2002
CD1d-dependent macrophage-mediated clearance of Pseudomonas aeruginosa from lung Nat Med 8:588–93
198 Muhlen KA, Schumann J, Wittke F, Stenger S, Van Rooijen N, et al 2004 NK cells, but
not NKT cells, are involved in Pseudomonas aeruginosa exotoxin A-induced hepatotoxicity
in mice J Immunol 172:3034–41
199 Dieli F, Sireci G, Russo D, Taniguchi M, Ivanyi J, et al 2000 Resistance of natural killer
T cell-deficient mice to systemic Shwartzman reaction J Exp Med 192:1645–52
200 Emoto M, Miyamoto M, Yoshizawa I, Emoto Y, Schaible UE, et al 2002 Critical role
mice J Immunol 169:1426–32
201 Kaplan MM, Gershwin ME 2005 Primary biliary cirrhosis N Engl J Med 353:1261–73
202 Selmi C, Balkwill DL, Invernizzi P, Ansari AA, Coppel RL, et al 2003 Patients with primary biliary cirrhosis react against a ubiquitous xenobiotic-metabolizing bacterium
Hepatology 38:1250–57
203 Kita H, Naidenko OV, Kronenberg M, Ansari AA, Rogers P, et al 2002 Quantitation and phenotypic analysis of natural killer T cells in primary biliary cirrhosis using a human
CD1d tetramer Gastroenterology 123:1031–43
204 Schofield L, McConville MJ, Hansen D, Campbell AS, Fraser-Reid B, et al 1999 CD1d-restricted immunoglobulin G formation to GPI-anchored antigens mediated by NKT
cells Science 283:225–29
205 Molano A, Park SH, Chiu YH, Nosseir S, Bendelac A, Tsuji M 2000 Cutting edge: the IgG response to the circumsporozoite protein is MHC class II-dependent and CD1d-independent: exploring the role of GPIs in NK T cell activation and antimalarial
re-sponses J Immunol 164:5005–9
206 Romero JF, Eberl G, MacDonald H, Corradin G 2001 CD1d-restricted NK T cells are dispensable for specific antibody responses and protective immunity against liver stage
malaria infection in mice Parasite Immunol 23:267–69
207 Mallevaey T, Zanetta JP, Faveeuw C, Fontaine J, Maes E, et al 2006 Activation of
invariant NKT cells by the helminth parasite Schistosoma mansoni J Immunol 176:2476–
85
Trang 8208 Ilyinskii PO, Wang R, Balk SP, Exley MA 2006 CD1d mediates T-cell-dependent re-sistance to secondary infection with encephalomyocarditis virus (EMCV) in vitro and
immune response to EMCV infection in vivo J Virol 80:7146–58
209 Huber S, Sartini D, Exley M 2003 Role of CD1d in coxsackievirus B3-induced
my-ocarditis J Immunol 170:3147–53
210 Durante-Mangoni E, Wang R, Shaulov A, He Q, Nasser I, et al 2004 Hepatic CD1d expression in hepatitis C virus infection and recognition by resident proinflammatory
CD1d-reactive T cells J Immunol 173:2159–66
211 Grubor-Bauk B, Simmons A, Mayrhofer G, Speck PG 2003 Impaired clearance of herpes simplex virus type 1 from mice lacking CD1d or NKT cells expressing the semivariant
Vα14-Jα281 TCR J Immunol 170:1430–34
212 Cornish AL, Keating R, Kyparissoudis K, Smyth MJ, Carbone FR, Godfrey DI 2006
NKT cells are not critical for HSV-1 disease resolution Immunol Cell Biol 84:13–19
213 Wilson SB, Kemt SC, Patton KT, Orban T, Jackson RA, et al 1998 Extreme Th1 bias
of invariant Vα24JαQ T cells in type I diabetes Nature 391:177–81
214 Kukreja A, Cost G, Marker J, Zhang C, Sun Z, et al 2002 Multiple immuno-regulatory
defects in type-1 diabetes J Clin Invest 109:131–40
215 Redondo MJ, Gottlieb PA, Motheral T, Mulgrew C, Rewers M, et al 1999 Heterophile antimouse immunoglobulin antibodies may interfere with cytokine measurements in
pa-tients with HLA alleles protective for type 1A diabetes Diabetes 48:2166–70
216 Wang B, Geng YB, Wang CR 2001 CD1-restricted NK T cells protect nonobese diabetic
mice from developing diabetes J Exp Med 194:313–20
217 Shi FD, Flodstrom M, Balasa B, Kim SH, Van Gunst K, et al 2001 Germ line deletion
of the CD1 locus exacerbates diabetes in the NOD mouse Proc Natl Acad Sci USA
98:6777–82
218 Bach JF, Bendelac A, Brenner MB, Cantor H, De Libero G, et al 2004 The role of
innate immunity in autoimmunity J Exp Med 200:1527–31
219 Lehuen A, Lantz O, Beaudoin L, Laloux V, Carnaud C, et al 1998 Overexpression of natural killer T cells protects Vα14-Jα281 transgenic nonobese diabetic mice against
diabetes J Exp Med 188:1831–39
220 Sharif S, Arreaza GA, Zucker P, Mi QS, Sondhi J, et al 2001 Activation of natural killer T cells by α-galactosylceramide treatment prevents the onset and recurrence of
autoimmune Type 1 diabetes Nat Med 7:1057–62
221 Hong S, Wilson MT, Serizawa I, Wu L, Singh N, et al 2001 The natural killer T-cell ligand α-galactosylceramide prevents autoimmune diabetes in nonobese diabetic mice
Nat Med 7:1052–56
222 Beaudoin L, Laloux V, Novak J, Lucas B, Lehuen A 2002 NKT cells inhibit the onset
of diabetes by impairing the development of pathogenic T cells specific for pancreatic β
cells Immunity 17:725–36
223 Griseri T, Beaudoin L, Novak J, Mars LT, Lepault F, et al 2005 Invariant NKT cells
exacerbate type 1 diabetes induced by CD8 T cells J Immunol 175:2091–101
224 Forestier C, Molano A, Im JS, Dutronc Y, Diamond B, et al 2005 Expansion and hyper-activity of CD1d-restricted NKT cells during the progression of systemic lupus
225 Zeng D, Liu Y, Sidobre S, Kronenberg M, Strober S 2003 Activation of natural killer T
cells in NZB/W mice induces Th1-type immune responses exacerbating lupus J Clin Invest 112:1211–22
Trang 9226 Chan OT, Paliwal V, McNiff JM, Park SH, Bendelac A, Shlomchik MJ 2001 Deficiency
in-hibiting nephritis in MRL-Fas(lpr) nice: an example of disease regulation at the organ
level J Immunol 167:2985–90
227 Yang JQ, Chun T, Liu H, Hong S, Bui H, et al 2004 CD1d deficiency exacerbates
inflammatory dermatitis in MRL-lpr/lpr mice Eur J Immunol 34:1723–32
228 Yang JQ, Singh AK, Wilson MT, Satoh M, Stanic AK, et al 2003 Immunoregulatory
role of CD1d in the hydrocarbon oil-induced model of lupus nephritis J Immunol.
171:2142–53
229 Singh AK, Yang JQ, Parekh VV, Wei J, Wang CR, et al 2005 The natural killer T cell
ligand α-galactosylceramide prevents or promotes pristane-induced lupus in mice Eur.
J Immunol 35:1143–54
230 Tahir SM, Cheng O, Shaulov A, Koezuka Y, Bubley GJ, et al 2001 Loss of IFN-γ
production by invariant NK T cells in advanced cancer J Immunol 167:4046–50
231 Dhodapkar MV, Geller MD, Chang DH, Shimizu K, Fujii S, et al 2003 A reversible defect in natural killer T cell function characterizes the progression of premalignant to
malignant multiple myeloma J Exp Med 197:1667–76
232 Sriram V, Cho S, Li P, O’Donnell PW, Dunn C, et al 2002 Inhibition of glycolipid
cells Proc Natl Acad Sci USA 99:8197–202
233 Smyth MJ, Thia KY, Street SE, Cretney E, Trapani JA, et al 2000 Differential tumor
surveillance by natural killer (NK) and NKT cells J Exp Med 191:661–68
234 Crowe NY, Smyth MJ, Godfrey DI 2002 A critical role for natural killer T cells in
immunosurveillance of methylcholanthrene-induced sarcomas J Exp Med 196:119–27
235 Terabe M, Matsui S, Noben-Trauth N, Chen H, Watson C, et al 2000 NKT cell-mediated repression of tumor immunosurveillance by IL-13 and the IL-4R-STAT6
path-way Nat Immunol 1:515–20
236 Terabe M, Swann J, Ambrosino E, Sinha P, Takaku S, et al 2005 A nonclassical non-Vα14Jα18 CD1d-restricted (type II) NKT cell is sufficient for down-regulation of tumor
immunosurveillance J Exp Med 202:1627–33
237 Renukaradhya GJ, Sriram V, Du W, Gervay-Hague J, Van Kaer L, Brutkiewicz RR 2006 Inhibition of antitumor immunity by invariant natural killer T cells in a T-cell lymphoma
model in vivo Int J Cancer 118:3045–53
238 Lisbonne M, Diem S, de Castro Keller A, Lefort J, Araujo LM, et al 2003 Cutting edge: invariant Vα14 NKT cells are required for allergen-induced airway inflammation and
hyperreactivity in an experimental asthma model J Immunol 171:1637–41
239 Akbari O, Stock P, Meyer E, Kronenberg M, Sidobre S, et al 2003 Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway
hyperreactivity Nat Med 9:582–88
241 Thomas SY, Lilly CM, Luster AD 2006 Invariant natural killer T cells in bronchial
asthma N Engl J Med 354:2613–16
242 Tupin E, Nicoletti A, Elhage R, Rudling M, Ljunggren HG, et al 2004 CD1d-dependent
activation of NKT cells aggravates atherosclerosis J Exp Med 199:417–22
243 Askenase PW, Szczepanik M, Itakura A, Kiener C, Campos RA 2004 Extravascular
Trang 10244 Sonoda KH, Exley M, Snapper S, Balk SP, Stein-Streilein J 1999 CD1-reactive natural killer T cells are required for development of systemic tolerance through an
immune-privileged site J Exp Med 190:1215–26
245 Palmer JL, Tulley JM, Kovacs EJ, Gamelli RL, Taniguchi M, Faunce DE 2006 Injury-induced suppression of effector T cell immunity requires CD1d-positive APCs and
CD1d-restricted NKT cells J Immunol 177:92–99
246 Porcelli SA 2005 Bird genes give new insights into the origins of lipid antigen
presen-tation Proc Natl Acad Sci USA 102:8399–400
247 Gadola SD, Dulphy N, Salio M, Cerundolo V 2002 Vα24-JαQ-independent,
lym-phocytes J Immunol 168:5514–20
248 Brigl M, van den Elzen P, Chen X, Meyers JH, Wu D, et al 2006 Conserved and
hetero-geneous lipid antigen specificities of CD1d-restricted NKT cell receptors J Immunol.
176:3625–34
249 Zerrahn J, Held W, Raulet DH 1997 The MHC reactivity of the T cell repertoire prior
to positive and negative selection Cell 88:627–36
250 Huseby ES, White J, Crawford F, Vass T, Becker D, et al 2005 How the T cell repertoire
becomes peptide and MHC specific Cell 122:247–60