We present a case of primary rectal small cell carcinoma in a patient with a history of UC.. Conclusions: This is the first case of small cell carcinoma in a background of UC reported to
Trang 1C A S E R E P O R T Open Access
Small cell carcinoma in ulcerative colitis
-new treatment option: a case report
Christoforos Kosmidis*, Christoforos Efthimiadis, Georgios Anthimidis, Kalliopi Vasiliadou, Ioanna Tzeveleki,
Panagiotis Fotiadis, Georgios Basdanis
Abstract
Background: The most common type of carcinoma associated with ulcerative colitis (UC) is adenocarcinoma We present a case of primary rectal small cell carcinoma in a patient with a history of UC
Methods: A 34-year-old male diagnosed with UC for 10 years was not consistent with the usual annual follow-up and presented with mucoid-bloody diarrhea Colonoscopy revealed a rectal mass 2 cm distant from the anal verge The patient underwent a total proctocolectomy with preservation of the anal sphincters, construction of an ileal reservoir, anastomosis of the reservoir to the anus (J configuration) and protective loop ileostomy
Results: Histological examination showed undifferentiated small cell carcinoma
Conclusions: This is the first case of small cell carcinoma in a background of UC reported to be treated surgically and the patient and has no reccurence 18 months postoperatively
Background
Primary small cell carcinoma (SCC) of the colon and the
rectum is very rare, with an incidence of less than 0,2%
of all colorectal cancers [1] The most common
histolo-gical type of carcinoma associated with ulcerative colitis
is adenocarcinoma [2] We present a case of primary
rectal small cell carcinoma in a patient with a history of
ulcerative colitis, which is the fifth case reported and
the first treated surgically
Methods
Case presentation
A 34-year-old male diagnosed with ulcerative colitis for
10 years presented with mucoid-bloody diarrhea and
none extraintestinal manifestation His haemoglobin was
10,6 gr/dl The patient had been prescribed
methylpred-nisolone 24 gr daily during the last years, but he was
not consistent with the usual annual follow-up A
colo-noscopy was immediately performed and revealed a
rec-tal mass 2 cm distant from the anal verge Biopsy
results of the colonoscopy showed an undifferentiated
small cell carcinoma positive to Thyroid transcription
factor-1 (TTF-1) Subsequently a primary location in the lung was also examined Magnetic resonance imaging (MRI) scan confirmed that finding by demonstrating a rectal tumor extending between 2 cm proximally to the anal verge and 7 cm in the rectal canal, and enlarged adjacent lymph nodes Abdominal, chest and brain com-puterized tomography (CT) showed no metastatis The patient underwent a total proctocolectomy with preser-vation of the anal sphincters, construction of an ileal reservoir, anastomosis of the reservoir to the anus (J configuration) and protective loop ileostomy (Figures 1 and 2)
Results
Histological examination showed small oval and round undifferentiated cells with oval hyperchromatic nuclei and scanty cytoplasm, as well as findings suggestive of ulcerative colitis (Figures 3, 4 and 5) Immunohisto-chemically the tumor was positive to synaptophysin, neuron specific enolase (NSE), CD56 and TTF1 (Figures
6, 7, 8 and 9) Based on these findings, the diagnosis was undifferentiated small cell carcinoma The post-operative period was uneventful and the patient was dis-charged on the twelfth postoperative day He received adjuvant chemotherapy with Carboplatin 400 mg/m2 and Etoposide (Vepesid) 250 mg/m2 and radiotherapy
* Correspondence: dr.ckosmidis@gmail.com
Department of Surgery, Interbalkan European Medical Center, Thessaloniki,
Greece
Kosmidis et al World Journal of Surgical Oncology 2010, 8:100
SURGICAL ONCOLOGY
© 2010 Kosmidis et al; licensee BioMed Central Ltd This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and
Trang 2Eighteen months post-surgery there is no sign of
recurrence
Discussion
The risk of colorectal cancer for any patient with
ulcera-tive colitis is known to be elevated, and is estimated to
be 2% after 10 years, 8% after 20 years and 18% after 30
years of disease Malignancy risk factors include extent
and duration of ulcerative colitis, primary sclerosing cholangitis, a family history of sporadic colorectal can-cer, severity of histologic bowel inflammation, and in some studies, young age at onset of colitis The exact mechanism for carcinogenesis is partly unknown; in some cases it can be explained by the more widespread use of maintenance therapy and surveillance colono-scopy [3] In our case the patient had had a history of
Figure 1 Total proctocolectomy specimen with ulcerative colitis and small cell carcinoma in the inferior part of the rectum.
Figure 2 Magnification of the small cell carcinoma in the inferior part of the rectum.
Trang 3ulcerative colitis for the last 10 years, specifically from
the age of 24 years old, a condition characterized by a
severe bowel inflammation
The most common histological type of carcinoma
associated with ulcerative colitis is adenocarcinoma [2]
We report this case because of the fact that SCC,
instead of adenocarcinoma, on a background of
ulcera-tive colitis is a very rare neoplasm [4] The same factors
that lead to adenocarcinoma in the background of
ulcerative colitis, are also responsible for SCC, as there
is the strong evidence that the tumorigenesis of all
his-tologic types of colorectal cancer arises from a
pluripo-tential stem cell in the mucosa of the large intestine [5]
Thus there are also other histological types of tumors
arising in the background of ulcerative colitis e.g
lym-phoma, lymphosarcoma, carcinoid, as the long-standing
history of inflammatory bowel diseases has been proved
to be responsible for carcinogenesis [6] Still, as far as
we could elicit from the literature our case is just the fifth report of SCC in ulcerative colitis [7-10], while the rarity of the histologic type of SCC in ulcerative colitis
be of great interest
Colorectal SCC is characterized by three histological types: the undifferentiated small cell carcinoma, the neu-roendocrine carcinoma and the stem cell carcinoma Each of these subtypes has different histological charac-teristics which reveal the differentiation of the tumor The most undifferentiated subtype consists of small tumor cells and scanty cytoplasm The neuroendocrine carcinoma is characterized by larger tumor cells and abundant cytoplasm The third type is a transitional his-tological type between the other two types [4] In our case, the small cell carcinoma was of the undifferen-tiated type
Figure 3 Small cell carcinoma with invasion of the mucosa
(H+E ×100).
Figure 4 Small cell carcinoma in deeper invasion (H+E ×200).
Figure 5 Small cell carcinoma in deeper invasion (H+E ×400).
Figure 6 Tumor cells are positive for Synaptophysin immunostain (×400).
Kosmidis et al World Journal of Surgical Oncology 2010, 8:100
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Trang 4The diagnosis of a small cell carcinoma can not be
based only on the microscopical appearance, as it is
often difficult to make a distinction among other“small
blue cell tumors” e.g lymphomas, melanomas,
cloaco-genic carcinomas [9] For that reason the diagnosis must
be confirmed immunohistochemically, as almost all
types of SCC react positive to synaptophysin,
chromo-granin, cytokeratine and neuron specific enolase (NSE)
[4] A positive reaction to synaptophysin is the most
reliable marker However, a tumor must be positive to
at least two of the markers to have a standard diagnosis
[4] In our case the tumor was positive to synaptophysin
and NSE, which confirmed the diagnosis There is a
positive correlation between high differentiation of the
tumor and the positivity of the above markers [4]
Nevertheless, even undifferentiated small cell
carcino-mas react positive to these markers, as in our case
Primary SCC can be found in different locations such
as the lung, the skin, the kidney, the thymus, the
pancreas, the uterus etc [11] The most common gastro-intestinal location is the rectum, followed by the cecum and the sigmoid whereas the descending colon has never been reported as a location [4] In our case tumor was also found in the rectum
Small cell carcinomas are very aggressive, specifically when compared with adenocarcinomas of the same stage [4] The 6-month survival rate is 58% and a 5-year survival rate is 6% [10] Seventy to eighty percent of patients have already liver metastases and lymph node involvement at presentation and the prognosis is very poor [12] For these cases multidrug chemotherapy and radiation therapy are strongly suggested [13] Neverthe-less, radical surgery offers a more favorable prognosis to some patients at an early stage, when no distant metas-tases are present [13] In our case the patient had no metastases at the time of presentation, so a radical sur-gery was performed Intraoperative exploration revealed
no metastasis and the patient underwent a total procto-colectomy with preservation of the anal sphincters, con-struction of an ileal reservoir, anastomosis of the reservoir to the anus (J configuration) and protective loop ileostomy He received adjuvant chemotherapy and radiotherapy and has no recurrence 18 months post-surgery
Conclusions
This is the first case of small cell carcinoma in a back-ground of UC reported to be treated surgically and the patient and has no reccurence 18 months postoperatively
Consent
Written informed consent was obtained from the patient for publication of this case report and accompanying images A copy of the written consent is available for review by the Editor-in-Chief of this journal
Figure 7 Tumor cells are positive for CD56 immunostain
(×400).
Figure 8 Tumor cells are positive for NSE (×400).
Figure 9 Nuclear positivity for TTF1 immunostain (×400).
Trang 5List of abbreviations
(SCC): Primary small cell carcinoma; (TTF-1): Thyroid transcription factor-1;
(MRI): Magnetic resonance imaging; (CT)computerized tomography; (NSE):
neuron specific enolase.
Authors ’ contributions
All authors contributed the same.
Competing interests
The authors declare that they have no competing interests.
Received: 29 June 2010 Accepted: 18 November 2010
Published: 18 November 2010
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doi:10.1186/1477-7819-8-100
Cite this article as: Kosmidis et al.: Small cell carcinoma in ulcerative
colitis - new treatment option: a case report World Journal of Surgical
Oncology 2010 8:100.
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