Sarcopenia Age-Related Muscle Wasting and Weakness: Mechanisms and Treatments P1 doc

Sarcopenia – Age-Related Muscle Wasting and Weakness... LynchEditor Sarcopenia – Age-Related Muscle Wasting and Weakness Mechanisms and Treatments... viii ContentsAge-Related Changes in

Sarcopenia – Age-Related Muscle Wasting and Weakness

Gordon S Lynch

Editor

Sarcopenia – Age-Related Muscle Wasting

and Weakness

Mechanisms and Treatments

Gordon S Lynch

Department of Physiology

Basic and Clinical Myology Laboratory

The University of Melbourne, Victoria

Australia

gsl@unimelb.edu.au

ISBN 978-90-481-9712-5 e-ISBN 978-90-481-9713-2

DOI 10.1007/978-90-481-9713-2

Springer Dordrecht Heidelberg London New York

© Springer Science+Business Media B.V 2011

No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose

of being entered and executed on a computer system, for exclusive use by the purchaser of the work Printed on acid-free paper

Springer is part of Springer Science+Business Media (www.springer.com)

Dedicated to my mentor Professor John A Faulkner, with great respect and affection

Contents

Overview of Sarcopenia 1 Gordon S Lynch

Muscle Wasting in Cancer and Ageing:

Cachexia Versus Sarcopenia 9 Josep M Argilés, Sílvia Busquets, Marcel Orpi,

Roberto Serpe, and Francisco J López-Soriano

Age-Related Remodeling of Neuromuscular Junctions 37

Carlos B Mantilla and Gary C Sieck

Aging-Related Changes Motor Unit Structure and Function 55

Alexander Cristea, David E Vaillancourt, and Lars Larsson

Age-Related Decline in Actomyosin Structure and Function 75

LaDora V Thompson

Excitation-Contraction Coupling Regulation

in Aging Skeletal Muscle 113

Osvaldo Delbono

Alterations in Mitochondria and Their Impact

in Aging Skeletal Muscle 135

Russell T Hepple

Skeletal Muscle Collagen: Age, Injury and Disease 159

Luc E Gosselin

Nuclear Apoptosis and Sarcopenia 173

Stephen E Alway and Parco M Siu

viii Contents

Age-Related Changes in the Molecular Regulation

of Skeletal Muscle Mass 207

Aaron P Russell and Bertrand Lèger

Genetic Variation and Skeletal Muscle Traits:

Implications for Sarcopenia 223

Stephen M Roth

Proteomic and Biochemical Profiling of Aged Skeletal Muscle 259

Kathleen O’Connell, Philip Doran, Joan Gannon,

Pamela Donoghue, and Kay Ohlendieck

Exercise and Nutritional Interventions to Combat

Age-Related Muscle Loss 289

René Koopman, Lex B Verdijk, and Luc J.C van Loon

Reactive Oxygen Species Generation

and Skeletal Muscle Wasting – Implications for Sarcopenia 317

Anne McArdle and Malcolm J Jackson

Exercise as a Countermeasure for Sarcopenia 333

Donato A Rivas and Roger A Fielding

Role of Contraction-Induced Injury in Age-Related Muscle

Wasting and Weakness 373

John A Faulkner, Christopher L Mendias, Carol S Davis,

and Susan V Brooks

Role of IGF-1 in Age-Related Loss of Skeletal Muscle Mass

and Function 393

Chris D McMahon, Thea Shavlakadze, and Miranda D Grounds

Role of Myostatin in Skeletal Muscle Growth and Development:

Implications for Sarcopenia 419

Craig McFarlane, Mridula Sharma, and Ravi Kambadur

Role of b-Adrenergic Signalling in Skeletal Muscle Wasting:

Implications for Sarcopenia 449

James G Ryall and Gordon S Lynch

Index 473

Contributors

Stephen E Alway

Department of Exercise Physiology, and Center for Cardiovascular

and Respiratory Sciences, West Virginia University School of Medicine,

Morgantown, WV 26506, USA

salway@hsc.wvu.edu

Josep M Argilés

Departament de Bioquímica i Biologia Molecular,

Universitat de Barcelona, Barcelona

jargiles@ub.edu

Susan V Brooks

Departments of Biomedical Engineering and Molecular and Integrative

Physiology, University of Michigan, Ann Arbor, MI 48109-2200, USA

Sílvia Busquets

Departament de Bioquímica i Biologia Molecular, Facultat de Biologia,

Universitat de Barcelona, Barcelona

Kathleen O’Connell

Department of Biology, National University of Ireland,

Maynooth, Co Kildare, Ireland

Alexander Cristea

Department of Neuroscience, Clinical Neurophysiology,

Uppsala University, Sweden

Carol S Davis

Departments of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109-2200, USA