Chapter 083. Cancer of the Skin (Part 10) pps

Cancer of the Skin Part 10 Other Nonmelanoma Cutaneous Malignancies Neoplasms of cutaneous adnexa and sarcomas of fibrous, mesenchymal, fatty, and vascular tissues make up 1–2% of NMSC

Chapter 083 Cancer of the Skin

(Part 10)

Other Nonmelanoma Cutaneous Malignancies

Neoplasms of cutaneous adnexa and sarcomas of fibrous, mesenchymal, fatty, and vascular tissues make up 1–2% of NMSC (Table 83-6) Some can

portend a poor prognosis such as Merkel cell carcinoma, which is a neural

crest-derived, highly aggressive malignancy that exhibits a metastatic rate of 75% and a 5-year survival rate of 30–40% Others, such as the human herpes virus 8-induced,

HIV-related Kaposi's sarcoma, exhibit a more indolent course The marked

decrease in incidence of this tumor parallels the institution of the highly active antiretroviral therapy

Table 83-6 Other Nonmelanoma Cutaneous Malignancies

Tumor Type Most

Common Location

Recurrenc

e Rate,a %

Metastati

c Rate, %

Atypical

fibroxanthoma

Head and neck

Merkel cell

carcinoma

Head and neck

Dermatofibrosarcom

a protuberans

Sebaceous

carcinoma

Microcystic adnexal

carcinoma

y

Eccrine carcinoma Head and

neck

Angiosarcoma Head and

neck

a

Recurrence rates are the highest reported and were established prior to widespread use of Mohs micrographic surgery

Acknowledgment

Katarina G Chiller, MD, and Howard K Koh, MD, contributed to this chapter in the 16th edition and material from that chapter is included here

Further Readings

American Cancer Society: Website at www.cancer.org

Balch CM et al: Prognostic factors analysis of 17,600 melanoma patients: Validation of the American Joint Committee on Cancer melanoma staging system

J Clin Oncol 19:3622, 2001 [PMID: 11504744]

Balch CM et al: Final version of the AJCC staging system for cutaneous melanoma J Clin Oncol 19:3635, 2001 [PMID: 11504745]

Drake LA et al: Guidelines of care of basal cell carcinoma J Am Acad Dermatol 26:117, 1992 [PMID: 1732317]

——— et al: Guidelines of care for cutaneous squamous cell carcinoma J

Am Acad Dermatol 28:628, 1993

Geisse JK et al: Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: A double-blind, randomized, vehicle-controlled study J Am Acad Dermatol 47:390, 2002 [PMID: 12196749]

Johnson TM et al: Staging workup, sentinel node biopsy, and follow-up tests for melanoma: Update of current concepts, Arch Dermatol 140:107, 2004 [PMID: 14732667]

Morton DL et al: Sentinel-node biopsy on nodal observation in melanoma

N Engl J Med 355:1307, 2006 [PMID: 17005948]

Petrella T et al: Single agent interleukin-2 in the treatment of metastatic melanoma: A systematic review Cancer Treat Rev 2007 [epub ahead of print] [PMID: 17562357]

Rigel DS et al: ABCDE: An evolving concept in the early diagnosis of melanoma Arch Dermatol 141:1032, 2005 [PMID: 16103334]

Tsao H et al: Management of cutaneous melanoma N Engl J Med 351:998,

2004 [PMID: 15342808]

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