Bài giảng CHĂM SÓC DA BẰNG ÁNH SÁNG LED ( combo full slides )

Combination blue 415 nm and red 633 nm LED phototherapy in the treatment of mild to severe acne METHODS: Twenty-four subjects, Fitzpatrick skin types II-V.. CONCLUSIONS: Combination blu

CHAM SOC DA BANG ANH SANG LED

ĐẠI CƯƠNG

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SNCBL Resoưces (v) How To

PublfY\ed o› PubMed y

US National Library of Medicine `

National Institutes of Health Ad vanced

Expert Opin Investig Drugs 2001 Feb:10/2):309-20

Antimicrobial properties of porphyrins

Stojilikovic |', Evavold BD Kumar V

+ Author information

A large number of natural and synthetic porphyrins of diverse chemical compositions and characteristics can be isolated from nature

or synthesised in the laboratory Antimicrobial and antiviral activities of porphyrins are based on their ability to catalyse peroxidase

and oxidase reactions, absorb photons and generate reactive oxygen species (ROS) and partition into lipids of bacterial membranes Light-dependent, photodynamic activity of natural and synthetic porphyrins and pthalocyanines against Gram-positive and Gram-

negative bacteria has been well demonstrated Some non-iron metalloporphyrins (MPs) possess a powertul light-independent

antimicrobial activity that is based on the ability of these compounds to increase the sensitivity of bacteria to ROS or directly produce ROS MPs mimic haem in their molecular structure and are actively accumulated by bacteria via high affinity haem-uptake systems

The same uptake systems can be used to deliver antibiotic-porphyrin and antibacterial peptide-porphyrin conjugates Haemin, the

most well known natural porphyrin, possesses a significant antibacterial activity that is augmented by the presence of physiological

concentrations of hydrogen peroxide or a reducing agent Natural and synthetic porphyrins have relatively low toxicity in vitro and in

vivo The ability for numerous chemical modifications and the large number of different mechanisms by which porphyrins affect

microbial and viral pathogens place porphyrins into a group of compounds with an outstanding potential for discovery of novel agents, procedures and materials active against pathogenic microorganisms

PMID: 11178343 DOI: 10.1517/13543784.10.2.309

US National Library of Medicine

National Institutes of Health

Format: Abstract +

J Cosmet Laser Ther 2006 Jun;8(2):71-5

Combination blue (415 nm) and red (633 nm) LED phototherapy in the treatment of mild to severe acne

METHODS: Twenty-four subjects, Fitzpatrick skin types II-V with mild to severe symmetric facial acne vulgaris were recruited for the

study Subjects were well matched at baseline in terms of both age and duration of acne Subjects were treated over eight sessions,

two per week 3 days apart, alternating between 415 nm blue light (20 minutes/session, 48 J/cm2) and 633 nm red light (20

minutes/session, 96 J/cm2) from a light-emitting diode (LED)-based therapy system Patients received a mild microdermabrasion

before each session Acne was assessed at baseline and at weeks 2, 4, 8 and 12

RESULTS: Twenty-two patients completed the trial A mean reduction in lesion count was observed at all follow-up points At the 4-

week follow-up, the mean lesion count reduction was significant at 46% (p=0.001) At the 12-week follow-up, the mean lesion count

reduction was also significant at 81% (p=0.001) Patient and dermatologist assessments were similar Severe acne showed a

marginally better response than mild acne Side effects were minimal and transitory Comedones did not respond as well as

inflammatory lesions

CONCLUSIONS: Combination blue and red LED therapy appears to have excellent potential in the treatment of mild to severe acne

Treatment appears to be both pain- and side effect-free

©SNCBL Resoucesí(v) How To

S National Library of Medicine

Xé ional Institutes of Health Advanced

Lasers Surg Med 2007 Feb;39(2):180-8

Blue and red light combination LED phototherapy for acne vulgaris in patients with skin phototype IV

Lee SY' You CE Park MY

+) Author information

Abstract

BACKGROUND AND OBJECTIVES: Blue light is effective for acne treatment, inducing photodynamic destruction of Propionibacterium

acnes (P acnes) This study was designed to investigate the efficacy of combined blue and red light-emitting diode (LED)

phototherapy for acne vulgaris

MATERIALS AND METHODS: Twenty-four patients with mild to moderately severe facial acne were treated with quasimonochromatic

LED devices, alternating blue (415 nm) and red (633 nm) light The treatment was performed twice a week for 4 weeks Objective

assays of the skin condition were carried out before and after treatment at each treatment session Clinical assessments were

conducted before treatment, after the 2nd, 4th, and 6th treatment sessions and at 2, 4, and 8 weeks after the final treatment by

grading and lesion counting

RESULTS: The final mean percentage improvements in non-inflammatory and inflammatory lesions were 34.28% and 77.93%,

respectively Instrumental measurements indicated that the melanin levels significantly decreased after treatment Brightened skin

tone and improved skin texture were spontaneously reported by 14 patients

CONCLUSION: Blue and red light combination LED phototherapy is an effective, safe and non-painful treatment for mild to moderately severe acne vulgaris, particularly for papulopustular acne lesions

(c) 2007 Wiley-Liss, Inc

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Publf*\ed gov PubMed

US National Library of Medicine

National Insttutes of Health Advanc ed

J Photochem Photobiol B 2007 Jul 27;88(1):51-67 Epub 2007 May 1

A prospective, randomized, placebo-controlled, double-blinded, and split-face clinical study on LED

phototherapy for skin rejuvenation: clinical, profilometric, histologic, ultrastructural, and biochemical

evaluations and comparison of three different treatment settings

ee SY! Park KH Choi JW Kwon JK Lee DR Shin MS, Lee JS You CE Park MY

+ Author information

Light-emitting diodes (LEDs) are considered to be effective in skin rejuvenation We investigated the clinical efficacy of LED

phototherapy for skin rejuvenation through the comparison with three different treatment parameters and a control, and also examined the LED-induced histological, ultrastructural, and biochemical changes Seventy-six patients with facial wrinkles were treated with

quasimonochromatic LED devices on the right half of their faces All subjects were randomly divided into four groups treated with

either 830nm alone, 633nm alone, a combination of 830 and 633nm, or a sham treatment light, twice a week for four weeks Serial

photography, profilometry, and objective measurements of the skin elasticity and melanin were performed during the treatment period

with a three-month follow-up period The subject's and investigator's assessments were double-blinded Skin specimens were

evaluated for the histologic and ultrastructural changes, alteration in the status of matrix metalloproteinases (MMPs) and their tissue

inhibitors (TIMPs), and the changes in the MRNA levels of IL-1ss, TNF-alpha, ICAM-1, IL-6 and connexin 43 (Cx43), by utilizing

specific stains, TEM, immunohistochemistry, and real-time RT-PCR, respectively In the results, objectively measured data showed

Significant reductions of wrinkles (maximum: 36%) and increases of skin elasticity (maximum: 19%) Compared to baseline on the

treated face in the three treatment groups Histologically, a marked increase in the amount of collagen and elastic fibers in all

treatment groups was observed Ultrastructural examination demonstrated highly activated fibroblasts, surrounded by abundant

elastic and collagen fibers Immunohistochemistry showed an increase of TIMP-1 and 2 RT-PCR results showed the MRNA levels of

IL-1ss, TNF-alpha, ICAM-1, and Cx43 increased after LED phototherapy whereas that of IL-6 decreased This therapy was well-

tolerated by all patients with no adverse effects We concluded that 830 and 633nm LED phototherapy is an effective approach for

skin rejuvenation

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Publfled PubMed

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National Institutes of Health Advanced

J Cosmet Laser Ther 2005 Dec :7(3-4):196-200

A study to determine the efficacy of combination LED light therapy (633 nm and 830 nm) in facial skin

rejuvenation

reilly LR

+ Author information

BACKGROUND: The use of visible or near infrared spectral light alone for the purpose of skin rejuvenation has been previously

reported A method of light emitting diode (LED) photo rejuvenation incorporating a combination of these wavelengths and thus

compounding their distinct stimulation of cellular components is proposed Objective To assess the efficacy and local tolerability of

combination light therapy in photo rejuvenation of facial skin

METHODS: Thirty-one subjects with facial rhytids received nine light therapy treatments using the Omnilux LED system The treatments

combined wavelengths of 633 nm and 830 nm with fluences of 126 J/cm(2) and 66 J/cm(2) respectively Improvements to the skin

Surface were evaluated at weeks 9 and 12 by profilometry performed on periorbital casts Additional outcome measures included

assessments of clinical photography and patient satisfaction scores

RESULTS: Key profilometry results Sq, Sa, Sp and St showed significant differences at week 12 follow-up; 52% of subjects showed a

9%-50% improvement in photoaging scores by week 12; 81% of subjects reported a significant improvement in periorbital wrinkles on completion of follow-up

CONCLUSION: Omnilux combination red and near infrared LED therapy represents an effective and acceptable method of photo

rejuvenation Further study to optimize the parameters of treatment is required

stiona! Library of Medicine

Ne 360 ynal institutes y Heath Advanced

Dermatology 2011:223(3):251-9 doi: 10.1159/000333364 Epub 2011 Nov 18

Prospective randomized study o on the efficacy of blue light in the treatment of psoriasis vulgaris

Weinstabl A’ Hoff-Lesch S Merk HF von Felbert V

—) Author information

Department of Dermatology and Allergology, University Hospital, RVVTH Aachen University, Pauwelstrasse 30, Aachen, Germany

BACKGROUND: Blue light has no known toxic effects on human skin, but reduces the proliferative capacity of keratinocytes in vitro We

therefore investigated the efficacy of blue light in the treatment of psoriasis vulgaris (PV)

METHODS: Forty patients with mild to moderate PV and bilateral plaques were assigned to two groups Group 1 (n = 20) received

irradiation at home with blue light (light-emitting diode, LED, emission maximum: 420 nm) once daily for 4 weeks In parallel, group 2

(n = 20) performed irradiations with another blue light device (LED emission maximum: 453 nm) The contralateral control plaques

remained untreated in both groups

RESULTS: Thirty-seven patients completed the trial The main study parameter, the difference of Local Psoriasis Severity Index (LPSI)

scores of the irradiated plagues compared to the control plaques, showed Statistically significant improvement after 4 weeks of

treatment in both groups [group 1 (420 nm): n= 17, p = 0.04: group 2 (453 nm): n = 20, p = 0.04] Accordingly, plaque status as

assessed by both the physicians and the patients improved continuously during the 4 weeks of treatment and steadily declined

thereafter

CONCLUSION: Blue light appears to be a promising treatment modality in PV that warrants further evaluation in larger studies

Copyright © 2011 S Karger AG, Base!

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Photomed Laser Surg 2010 Feb;28(1):141-6 doi: 10.1089/pho.2009.2484

Combination 830-nm and 633-nm light-emitting diode phototherapy shows promise in the treatment of

recalcitrant psoriasis: preliminary findings

1

Ablon G

—) Author information

Ablon Skin Institute, Los Angeles, California, USA grablon@verizon.net

BACKGROUND AND OBJECTIVES: Psoriasis is one of the major problems facing dermatologists worldwide Planar arrays of light-

emitting diodes (LEDs) have recently attracted attention in the treatment of difficult dermatological entities, 830 nm in near infrared

(near-IR) and 633 nm in visible red This study was designed to assess the efficacy of combination 830-nm and 633-nm LED

phototherapy in the treatment of recalcitrant psoriasis

SUBJECTS AND METHODS: Nine informed and consenting patients with psoriasis were enrolled in this preliminary study, (3 men, 6

women, mean age 34.3, skin types | to IV) All had chronic psoriasis, which in most cases had proved resistant to conventional

treatments They were treated sequentially with LED arrays delivering continuous-wave 830 nm (near-IR) and 633 nm (red) in two 20-

min sessions over 4 or 5 weeks, with 48 h between sessions (830 nm, 60 J/cm(2): 633 nm, 126 J/cm(2))

RESULTS: All patients completed their LED regimens (4 requiring 1 regimen, 5 requiring a second) Follow-up periods were from 3 to 8

months, except in two patients who were lost to follow-up Clearance rates at the end of the follow-up period ranged from 60% to

100% Satisfaction was universally very high

CONCLUSIONS: The antiinflammatory effects of LED energy at 830 nm and 633 nm have been well documented, as has their use in

wound healing LED phototherapy is easy to apply pain free and side-effect free, and is well tolerated by patients of all skin types

The promising results of this preliminary study warrant a proper controlled double-blind study with a larger patient population