Vi sóng (microwave), tính chất, đặc trưng, tổng hợp và ứng dụng các loại vi sóng

Một bài tiểu luận Cao học rất hay và mới về Vi sóng (microwave), tính chất, đặc trưng, tổng hợp và ứng dụng các loại vi sóng, dùng vi sóng trong tổng hợp, dùng làm tác nhân sấy, và các dụng dụng khác,...

MICROWAVE

Instructor: Assoc.Prof.Dr Phan Thanh Son Nam

Students:

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DIPOLE

ROTATION

6

IONIC CONDUCTION

INTERACTION OF MATERIALS

WITH MICROWAVES

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10

Publications

2 Dry media reaction

3 Microwave for Extractions

APPLICATION

MICROWAVE

FOR SYNTHESIS

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 Benzimidazole and their chalcone derivatives play a vital role in pharmaceutical research and exhibit various pharmacological activities like antimicrobial, analgesic, anti-inflammatory, anticancer activity

 Both conventional and microwave irradiated synthesis of chalcone has been carried out to compare their yield and reaction time

Method

 Microwave and conventional method

 Determining melting points

 TLC

 IR

 NMR

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 Both conventional and microwave irradiated synthesis of Schiff bases has been carried out to compare their yield and reaction time.

Method

 Microwave and conventional method

 Determining melting points

 TLC

 IR

 NMR

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 Pyrazoline nucleus shows various biological and pharmacological activities such as antimicrobial, antiinflammatory, antitumor, anticonvulsant, antiviral, diuretic, antidiabetic, Analgesic, and anticancer

 Both conventional and microwave irradiated synthesis of some new pyrazoline derivatives has been carried out to compare their yield and reaction time

 Invitro antimicrobial study

Method

 Microwave and conventional method

 Determining melting points

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DRY MEDIA REACTION

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 The chromene ring moiety has been identified as one of the privileged scaffolds for drug discovery due to its broad spectrum of biological activity including antiviral, anti-tumor, anti-bacterial/antimicrobial, fungicidal, antioxidative, insecticidal agents, and activator of potassium channels effects

 Using a solvent-free methodology for the synthesis of (trifluoromethyl)-2H-chromenes from salicylaldehydes and ethyl trifluoroacetoacetate under solvent-free conditions in the presence of silica-immobilized L-proline (L-proline/SiO2)

2-hydroxy-2-Method

 Microwave and conventional method

 Determining melting points

 TLC

 IR, MS

 NMR

 X-ray diffraction

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 Chalcones and their derivatives have attracted increasing attention due to numerous biological and pharmacological applications such as antimalarial, anticancer, antiprotozoal, anti-inflammatory, antibacterial, antifilarial, antifungal, antimicrobial, larvicidal, anticonvulsant, antioxidant activities

 imidazole derivatives have been reported a diverse biological activities such

as antimicrobial, antitumor, antifungal, anticancer, antiviral activities

 A solvent-free synthesis of propionyl]-3-aryl-propenones under microwave irradiation using Micheal addition of chalcones with imidazoles in the presence of glacial acetic acid as catalyst

1-{2,4-dihydroxy-5-[3-imidazol-1-yl-3-aryl- antibacterial activity study

Method

 Microwave and conventional method

 Determining melting points, TLC, IR, NMR

 antibacterial activity study

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 The efficient synthesis of amides is important because of their wide range of applications in academia and industry specially as intermediates in organic synthesis or peptide and protein synthesis

 Microwave-enhanced solvent free synthesis of the N-alkylbenzamides carried out in the presence of various heterogenous catalysts

 Optimizing reaction conditions and studying various ways of catalytic activation of reactants

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MICROWAVE FOR EXTRACTIONS

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 Dwarfed Cinnamomum Camphora Var Linaolifera Fujita (D-CCLF) Leaves and Twigs.

 MAHD is proposed to perform for the extraction of essential oils from D-CCLF leaves and twigs and the results of extraction time, extraction yield, chemical composition, quality of the essential oil and operation cost are compared with those of traditional HD

linalool

INTRODUCTION

RESULTS

37,5

Step1: the heating phase from room temperature to boiling temperature

Step 2: extracted essential oils at the surface of vegetable particles

Step 3: the internal diffusion of the essential oil

Step 4: a horizontal line which marked the end of the extraction process.

79%

62%

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CONCLUSION

 MAHD offer important advantages over traditional HD for the extraction of leaf essential oil, but it has no obvious advantage in extracting essential oil of twig.

 A similar extraction yield of leaf essential oils is achieved at shorter extraction time (37.5 min for MAHD vs 120 min for HD) and lower energy consumption (0.21 kWh/g of essential oil for MAHD vs 0.67 kWh/g of essential oil for HD).

 Microwaves seems to cause a higher extraction efficiency of rupture for the glandular cells than in conventional HD.

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 many biological properties:

hypoglycemic, antimicrobial,

analgesic, antioxidant etc.

 Comparative Study of Essential

Oils Extracted from Algerian

Myrtus communis L Leaves

Using solvent-free

-microwave-extraction and conventional

Hydrodistillation

INTRODUCTION

METHOD

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RESULTS

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 Solvent Free Microwave extraction SFME was found to be highly effective enabling a considerable reduction in extraction time (30 min against 180 min), providing an essential oil with a chemical composition enriched in oxygenated compounds but with yields similar

to those of steam distillations

 SFME required only the initial water content of the raw material Thus,

it consumed much less energy than hydrodistillation.

 SFME is a good alternative to other extraction techniques.

CONCLUSION

REFERENCES

1 Hayes, B.L. Microwave Synthesis: Chemistry at the Speed of Light; CEM Publishing:

Matthews, NC, 2002.

2 Bharat Parashar, Sudhir Bhardwaj, Sharda Sharma, G D Gupta, V K Sharma and P B

Punjabi Comparative Conventional and Microwave assisted synthesis of some pyrazoline

derivatives and their antimicrobial activity J Chem Pharm Res., 2(3):33-42, 2010

3 Sahoo Biswa Mohan, Behera T.P., Ravi Kumar B.V.V Microwave Irradiation Versus

Conventional Method: Synthesis of Benzimidazolyl Chalcone Derivatives International Journal

of ChemTech Research Vol.2, No.3, pp 1634-1637, 2010

4 Baya Berka-Zougali, Mohamed-Amine Ferhat, Aicha Hassani, Farid Chemat and Karim S

Allaf Comparative Study of Essential Oils Extracted from Algerian Myrtus communis L Leaves

Using Microwaves and Hydrodistillation Int J Mol Sci 13, 4673-4695, 2012

5 Cuilian Xu , Guoyu Yang, Caixia Wang, Sufang Fan, Lixia Xie and Ya Gao An Efficient

Solvent-Free Synthesis of 2-Hydroxy-2-(trifluoromethyl)-2H-chromenes Using Silica-Immobilized

L-Proline Molecules ,18, 11964-11977, 2013

6 Enamul Hassain S, Chaluvaraju KC, Niranjan MS, Zaranappa, Santhosh C Studies On

Microwave Assisted Synthesis Of Some Schiff Bases J Pharm.4 (11), 2013.

7 K Aravind, Arram Ganesh and D Ashok Efficient solvent-free microwave assisted organic

synthesis of 1-{2,4-dihydroxy-5-[3-imidazol-1-yl-3-aryl-propionyl]}-3-aryl-propenone and their

antibacterial activity Journal of Chemical and Pharmaceutical Research, 5(6):34-39, 2013

8 Linsheng Wei, Yafang Zhang and Boquan Jiang Comparison of Microwave-assisted

Hydrodistillation with the Traditional Hydrodistillation Method in the Extraction of Essential Oils from Dwarfed Cinnamomum Camphora var Linaolifera Fujita Leaves and Twigs Advance

Journal of Food Science and Technology 5(11): 1436-1442, 2013.

THANK YOU!

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