NEW FINDINGS OF THE THESIS Thesis title Study on chemical constituents and biological activities of two specie Markhamia stipulata var canaenses V S Dang and Stereospermum binhchaunesis V S Dang of Bi[.]
Trang 1NEW FINDINGS OF THE THESIS Thesis title:
Study on chemical constituents and biological activities of two specie
Markhamia stipulata var canaenses V.S Dang and Stereospermum
binhchaunesis V.S Dang of Bignoniaceae
Code: 9440117
Major: Chemistry of natural compounds
Name: Ngô Trọng Nghĩa
Year: 2016 -2020
Supervisors : Assoc Prof Dr Mai Đinh Tri, Assoc Prof Dr Tran Cong Luan Imlementing institution : Graduate University of Science and Technology – Viet Nam Academy of Science and Technology
New findings of the thesis :
1 From the leaves of Markhamia stipulata var canaense V.S Dang has isolated and
determined the structure of 17 compounds, including 5 new compounds: Markhacanasin A, Markhacanasin B, Markhacanasin C, epi-Markhacanasin C and Markhasphingolipid A For the first time discovered in the genus Markhamia there is
a cycloartane triterpenoid with aglycon part cycloart-24-en triterpen while in Markhamia lutea species cycloart -23-en and cycloart-25-en It was first discovered
in the genus Markhamia that contains glycolipid compounds in the form of glycerol
derivatives and phytosphingolipid
2 From the leaves of Stereospermum binhchaunesis V.S Dang has isolated and
determined the structure of 11 compounds, of which 10 were first isolated from
Stereospermum For the first time discovered in the genus Stereospermum has group
of flavonoid compounds
3 Evaluated cytotoxic activity of 11 compounds The results showed that there are 4 compounds with cytotoxic activity: Markhacanasin A, 24-epi markhacanasin C,
apienin 7-O-β-D-glucopyranoside, 2,3-dihydroxypropyl palmitate Espcially, the new
compound Markhacanasin A has cytotoxic activity on all 5 cell lines of breast cancer (MCF-7), cervical cancer (HeLa), liver cancer (Hep G2), lung cancer (NCI) H460),
1.06, 24.21 ± 0.38, 14.72 ± 0.38 (µg/mL)
Signature of supervisor Signature of PhD student
Assoc Prof Dr Mai Đinh Tri