1. Aakriti Gupta. Extrapulmonary manifestations of COVID19. Nature Medicine | VOL 26 | July 2020 | 1017–1032 | www.nature.comnaturemedicine. 2. Faxiang Chen et al. Clinical features and risk factors of COVID19associated liver injury and function: A retrospective analysis of 830 cases. Annals of Hepatology 21 (2021) 100267. 3. http:www.drthuthuy.com , https:hasld.org , 4. K. Rajender Reddy. SarsCov2 and the liver: Considerations in Hepatitis B and Hepatitis C infections. CliniCal liver Disease, vOl 15, nO 5, MaY 2020. 5. Thomas Marjot et al. Outcomes following SARSCoV2 infection in patients with chronic liver disease: An international registry study. Journal of Hepatology 2021 vol. 74 j 567–577. 6. Wim Trypsteen et al. On the whereabouts of SARSCoV2 in the human body: A systematic review. PLOS Pathogens | https:doi.org10.1371journal.ppat.1009037 October 30, 2020.
Trang 1COVID 19 & Bệnh gan.
BS Phan Hữu Bội Hoàn Khoa Gan, MEDIC.
Case report :
Trang 2I TRƯỜNG HỢP LÂM SÀNG
Trang 6Gan có bị tổn thương do Covid 19
không?
Trang 7Nature Medicine | VOL 26 | July 2020 | 1017–1032 | www.nature.com/naturemedicine
II BÀN LUẬN
Trang 8On the whereabouts of SARS-CoV-2 in the human body: A systematic review PLOS Pathogens | https://doi.org/10.1371/journal.ppat.1009037 October 30, 2020
Trang 9Gradient color (purple) indicates low to high evidence for SARS-CoV-2 detection in this organ, tissue or body fluid Highest expression was found in upper airways, lungs and oral cavity
together with the gastrointestinal tract and urinary system
On the whereabouts of SARS-CoV-2 in the human body: A systematic review PLOS Pathogens | https://doi.org/10.1371/journal.ppat.1009037 October 30, 2020
Trang 10Liver injury caused by coronavirus infection After entry into the human body through the respiratory tract, coronaviruses can lead to liver injury via several approaches, including ACE2/DPP4-mediated hepatocyte injury, immune-mediated liver injury, ischemia and hypoxia, thrombosis, and drug hepatotoxicity The manifestations of liver injury involve abnormalities in liver function test and pathological examination
Xinyi Wang et al Front Med., 27 September 2021 | https://doi.org/10.3389/fmed.2021.651658.
Trang 11Nature Medicine | VOL 26 | July 2020 | 1017–1032 | www.nature.com/naturemedicine
Trang 12Faxiang Chen et al Annals of Hepatology 21 (2021).
Mechanism of liver injury in patients with coronavirus disease 2019 (COVID-19)
Trang 13Esperance A K Schaefer et al CliniCal liver Disease, vOl 15, nO 5, May 2020
Trang 14Journal of Hepatology 2021 vol 74 j 567–577
Trang 15CliniCal liver Disease, vOl 15, nO 5, MaY 2020 An Official Learning Resource of AASLD
Trang 16III KẾT LUẬN
- Nhiễm COVID 19 gây tổn thương đa cơ quan.
- Gan là cơ quan ít ảnh hưởng do COVID 19.
Vấn đề bệnh gan nền của bệnh nhân như thế nào.
- Điều nguy hiểm khi dịch bệnh:
Điều trị không thường xuyên.
Thuốc điều trị: Không đúng & Không đủ.
Các biến chứng của bệnh không được phát hiện kịp thời.
- Phòng ngừa: Tiêm ngừa cúm, covid, viêm phổi.
Trang 18Tài liệu tham khảo
1 Aakriti Gupta Extrapulmonary manifestations of COVID-19 Nature Medicine | VOL
26 | July 2020 | 1017–1032 | www.nature.com/naturemedicine
2 Faxiang Chen et al Clinical features and risk factors of COVID-19-associated liver injury and function: A retrospective analysis of 830 cases Annals of Hepatology 21
(2021) 100267
3 http://www.drthuthuy.com , https://hasld.org ,
4 K Rajender Reddy Sars-Cov-2 and the liver: Considerations in Hepatitis B and
Hepatitis C infections CliniCal liver Disease, vOl 15, nO 5, MaY 2020
5 Thomas Marjot et al Outcomes following SARS-CoV-2 infection in patients with chronic liver disease: An international registry study Journal of Hepatology 2021 vol
74 j 567–577
6 Wim Trypsteen et al On the whereabouts of SARS-CoV-2 in the human body: A
systematic review PLOS Pathogens | https://doi.org/10.1371/journal.ppat.1009037
October 30, 2020