INTERNATIONAL AGENCY FOR RESEARCH ON CANCER BIENNIAL REPORT 2006 -2007 pptx

IARC MEDALS OF HONOURRoger Sohier Lecture 1993 Gérard Orth Institut Pasteur, Paris – Papilloma virus and human cancer 1994 Guy Blaudin de Thé Institut Pasteur, Paris – Epidémiologie mol

Biennial Report

2006 - 2007

International Agency for Research on

International Agency for Research on Cancer

Centre International de Recherche sur le Cancer

SC/44/2 GC/50/2

WORLD HEALTH ORGANIZATION

INTERNATIONAL AGENCY FOR RESEARCH ON CANCER

ISSN 0250-8613ISBN 978-92-832-1092-4Printed in France

©International Agency for Research on Cancer, 2007

150 cours Albert-Thomas, 69372 Lyon Cedex 08, FranceDistributed on behalf of IARC by the Secretariat

of the World Health Organization, Geneva, Switzerland

International Agency for Research on Cancer

2006-2007

Table of Contents

IARC Medals of Honour vii

Director’s Introduction viii

IARC Scientific Structure xv

Biostatistics and Epidemiology Cluster 1

Epidemiology Methods and Support Group 2

Nutrition and Hormones Team 4

Data Analysis and Interpretation Group 12

Descriptive Epidemiology Production Group 17

Information Technology Services Group 23

Radiation Group 24

Epidemiology and Biology Cluster 33

Infections and Cancer Biology Group 34

Infections and Cancer Epidemiology Group 37

Molecular Carcinogenesis Cluster 44

Carcinogen Identification and Evaluation Group 45

Molecular Carcinogenesis and Biomarkers Group 48

Epigenetics Group 54

Genetics and Epidemiology Cluster 58

Lifestyle, Environment and Cancer Group 59

Genetic Epidemiology Group 68

Genetic Susceptibility Group 74

Pathogenesis and Prevention Cluster 79

Pathology Group 80

Screening Group 85

Screening Quality Control Group 91

IARC Communications Group 95

Education and Training 97

Division of Administration and Finance 101

IARC Ethics Review Committee and Institutional Review Board 102

IARC Governing and Scientific Councils 104

Meetings and Seminars Organised at IARC 108

Staff Publications 114

IARC MEDALS OF HONOUR

Roger Sohier Lecture

1993 Gérard Orth (Institut Pasteur, Paris) – Papilloma virus

and human cancer

1994 Guy Blaudin de Thé (Institut Pasteur, Paris) –

Epidémiologie moléculaire des rétrovirus oncogènes

1995 Richard Peto (Oxford University, UK) – Avoidance of

premature death

1996 Dirk Bootsma (Erasmus University, Rotterdam,

Netherlands) – DNA repair: maintaining nature’s

perfection

1997 Luca Cavalli-Sforza (Stanford University, CA, USA) –

Gènes, peuples, langues, cultures

1998 Charles Weissmann (University of Zurich, Switzerland) –

Biology and transmission of prion diseases

1999 Jan Pontén (Uppsala University, Sweden) – Sunlight and

skin cancer: New insights

2000 Richard Klausner (National Cancer Institute, Bethesda,

USA) – The war on cancer: Where we are and where

research is taking us

2001 Oliver Brüstle (Institut für Neuropathologie, University of

Bonn, Germany) – Embryonic stem cells: Basic concepts

and therapeutic applications

2002 Jeffrey Koplan (Centers for Disease Control, Atlanta,

USA) – Bioterrorism and public health preparedness

2003 Paul Kleihues (Director, IARC) – Poverty, affluence and

the global burden of cancer

2004 Umberto Veronesi (European Institute of Oncology,

Milan, Italy) – Breast cancer management and care:

Current results and future perspectives

2005 David Lane (University of Dundee, UK) – p53 and human

cancer: The next 25 years

2006 Georg Klein (Karolinska Institute, Sweden) - Viral

contributions to tumorigenesis

2007 Mariano Barbacid (Centro Nacional de Investigaciones

Oncológicas, Spain) - Ras genes, Ras oncogenes and

cancer

Richard Doll Lecture

2004 Richard Doll (London, UK) – Fifty years follow-up ofBritish doctors

2005 Brian MacMahon (Needham, MA, USA) – Epidemiologyand the causes of breast cancer

2006 Joseph Fraumeni Jr (National Institutes of Health, UnitedStates of America) – Genes and the environment in cancercausation: An epidemiologic perspective

2007 Dimitrios Trichopoulos (Harvard School of Public Health,USA) – Breast cancer: Epidemiology and etiology

IARC Lecture

2005 Tadao Kakizoe (National Cancer Centre, Tokyo, Japan)

– Bladder cancer: A model of human cancer determined

by environmental factors and genetics

2006 Ketayun Dinshaw (Tata Memorial Hospital, Mumbai,

India) – Cancer Treatment and Control

2007 Komen Foundation, USA Lecture given by LaSalle D

Leffall on behalf of Ambassador Nancy G Brinker

The staff of the International Agency for

Research on Cancer (IARC), and the

Agency diaspora, were saddened to hear of

the death of Dr Lorenzo Tomatis, the

second Director of the IARC and the

founder of the IARC Monographs

Programme for Carcinogen Identificationand Evaluation

Dr Tomatis was a welcome visitor tothe Agency He had been participating inthe planning meetings for the 100thVolume of the Monographs and had

agreed to prepare a history of theMonograph Programme for this 100thvolume An appreciation of the life of DrTomatis has been prepared by his lifelongfriend and ex-IARC scientist, Dr RuggeroMontesano

Director’s Introduction

‘My first contact with Lorenzo Tomatis was not as a scientist but as

a writer, when in 1965 he published the book “Il Laboratorio”,

describing his frustration working in a research and academic

environment in Italy that motivated his decision not to go back to his

home country but to stay in the USA This lead to a successful and

outstanding career in cancer research, firstly in Chicago and then in

Lyon (France)

Whilst working in the laboratory of Dr Philippe Shubik in

Chicago he became interested in chemical carcinogenesis and in

particular he produced the original observation of an increased risk of

cancer in mice in the offspring of mothers exposed to chemical

carcinogens During this period his conviction matured that primary

prevention of cancer was the underlining theme and the goal for all

his future research This motivation was a determinant in his decision

to move to the IARC in Lyon in 1967 to become Chief of the Unit

of Chemical Carcinogenesis In 1982 he became Director of the

Agency, succeeding John Higginson, the first Director of the Agency.

He foresaw in this newly formed WHO institution a place where he

could develop and implement his ideas on cancer prevention.

This was a very interesting and exciting time for the Agency,

devoted to the development of programmes and recruitment of staff.

The overall goal of the Agency was to integrate cancer epidemiology

and basic (laboratory) research with the objectives of assessing cancer

incidence and their variations world-wide and understanding, with

the integration of laboratory science (molecular epidemiology), the

aetiopathogenesis of various types of cancers This approach was very

attractive to epidemiologists and laboratory scientists and resulted in

the recruitment of staff who were successful in implementing

molecular epidemiological studies in parallel with more traditional

cancer epidemiological studies and cancer registries During this

time, and later as a Director, he gave priority to the recruitment of

high quality staff and was able to implement programmes that were,

and still are, recognized by the international scientific cancer

community In addition to the establishment at the Agency of cancer

research laboratories therefore, Lorenzo Tomatis was directly

responsible for the initiation and implementation of some major

research projects One of these, the ‘IARC Monographs on the Evaluation of Carcinogenic Risk to Humans’, begun in the late sixties was, and still is, a major programme of the IARC It was something

he particularly valued and he continued to keep a critical eye on it even after his retirement from the Agency.

He was also interested in cancer in developing countries Under his Directorship two major projects were initiated on the role of viruses in human cancers One is The Gambia Hepatitis Intervention Study, which aims to assess the efficacy of HBV vaccination in the prevention of chronic liver diseases and the role of other risk factors, namely aflatoxins and HCV infection in hepatocellular carcinoma The other project concerns epidemiological studies on the role of human papilloma virus in the aetiology of cervical cancer

Another major project initiated under his Directorship was the prospective study on nutrition and cancer involving thousands of individuals from many European countries Other activities which he supported were cancer epidemiology and cancer registries, and the IARC Fellowship Programme.

The initiation and support of these various projects shows the broad interest of Lorenzo Tomatis in cancer research and underlines the importance he always gave to primary cancer prevention as the most effective approach to reduce cancer mortality world-wide The implementation of these ideas was, and remains, not always easy and

he was able to overcome, with great determination, the difficulties encountered among the scientific communities and elsewhere in this respect.

Since his first book “Il Laboratorio”, many other successful books (all in Italian) have been published, describing with humour and an acute eye the various personages and situations encountered in his professional and social life.’

Lorenzo Tomatis died on 21st September 2007 in Lyon, France Our thoughts go to his wife and son, Delia and Paolo.

Dr Ruggero Montesano

Another sad event was the death of DrBrian MacMahon, who had been one ofthe original members of the IARCScientific Council during the 1960’s andhad made a significant contribution to thedevelopment of the Agency DrMacMahon made an outstandingcontribution to the development of cancerepidemiology when he was Chairman ofthe Department of Epidemiology atHarvard School of Public Health inBoston, Massachusetts Dr MacMahonreceived the IARC Medal of Honour in

2005 in recognition of his outstandingcontribution to cancer epidemiology andthe Agency An appreciation of the life of

Dr MacMahon appears on this page

At a personal level, these deaths wereparticularly sad since I had worked withboth I was on the Faculty of theDepartment of Epidemiology at Harvardwhen Brian was Chairman and it wasLorenzo who appointed me to the Agencystaff when I left Harvard

Dr Brian MacMahon during his last visit to the Agency

The International Agency for Research on Cancer joins the

international cancer community in mourning the passing, on 5

December 2007, of Brian MacMahon, longtime chair of the

Department of Epidemiology at Harvard School of Public Health

and a giant in the field of cancer epidemiology.

In 1960, Dr MacMahon co-authored Epidemiologic Methods.

This textbook became Epidemiology: Principles and Methods,

recognised for decades as the definitive text in the field Besides his

work in epidemiology in general, Dr MacMahon was known in

particular for his advances in breast cancer etiology He was the lead author on a landmark 1970 study that identified an association between breast cancer risk and the age at which a woman first gives birth These findings provided new insight into the protective mechanisms of pregnancy and stimulated broad reconsideration of the etiology of breast cancer.

In addition to his own work in the field, Dr MacMahon built an epidemiology program at Harvard that produced many leaders in academia and government research He was honoured with awards from the American Cancer Society, the American Public Health Association and the General Motors Cancer Research Foundation, and was elected to the Institute of Medicine in 1973 In addition, he was awarded honorary doctorates from the University of Athens, the State University of New York, and the University of Birmingham, England.

Dr MacMahon was one of the members of the IARC Scientific Council at its inception in the mid-1960’s and made a significant contribution to determining the direction which the Agency took In addition, he was a long-term collaborator with IARC In 2005, in recognition of his contributions to cancer research and his contribution to the Agency, Dr MacMahon delivered the 2005 Richard Doll lecture, entitled “Epidemiology and the Causes of Breast Cancer”, and was awarded the IARC Medal of Honour

Brian MacMahon died on 5th December 2007.

Our thoughts go to his children Mary, Kathleen, Kevin and Michael

The four Heads of the IARC Monographs Programme reunited in 2006

Director’s Introduction

The International Agency for Research on

Cancer was established by a resolution of

the 18th World Health Assembly in 1965

with a defined mission to conduct and

promote international collaboration in

cancer research with the objective of

improving health through a reduction in

the incidence of and mortality from cancer

throughout the world The IARC Statutes

specify the role of the Agency in planning,

promoting and conducting research in all

phases of the causation, treatment and

prevention of cancer; in the collection and

dissemination of information on the

epidemiology of cancer, on cancer research

and on the prevention and causation of

cancer throughout the world; studies on

the natural history of cancer; and

education and training of personnel for

research on cancer

The core values which underpin IARC

scientific programmes are expressed

through its commitment to meet the

highest scientific standards; to adhere to the

highest standards of international ethical

guidelines; and to retain flexibility to be

responsive to new scientific opportunities

The Scientific Programme has a focus

on prevention and is based on high quality,

uniqueness and additional value over and

above what could be achieved in a singlenational centre Apart from its internalprogramme, the IARC infrastructureencourages collaborations between leadingcancer research institutes to take place

During the biennium, IARC has hadscientific collaborations underway in some

90 countries of the world: the numberswould be larger if Cancer Registry andCourse activities are taken into account

In fulfilling the requirements of theStatutes, IARC has developed someunique programmes which are outstandingand are of great scientific value includingthe IARC Monographs Programme forCarcinogen Identification and Evaluation,the Descriptive Epidemiology Programme,the Infections and Cancer Programme, theMechanisms of Carcinogenesisprogramme, the Gambia HepatitisIntervention Study, the ScreeningProgramme, the Genetic EpidemiologyProgramme, the Lifestyle and CancerProgramme and the Fellowships andTraining Programme

This Report comprises two distinctparts The first part describes the work andachievements of each Group in the Agencyduring the biennium 2006-2007 Thesereports are presented by Cluster A secondpart contains selected highlights of some

key findings and publications arising fromthe work of the IARC during each of thetwo years of the biennium and, whereverpossible, attempts to place these findings

an Impact Factor This was higher than in

2006 and represents a regular growth sincethe baseline period (2002-2003) Peer-reviewed publications were increased by45% in 2007 compared to 2002-2003(Figure 2)

The Total Impact Factor of theseIARC publications again continued toincrease and the total for the biennium2006-2007 was over 50% increased over2002-2003 (Figure 3)

In January 2004, a list of prominentjournals was selected as a benchmark forIARC to publish their best work There hasbeen a substantial increase in publications

in these chosen journals in 2004-2007(Figure 4)

This shows a substantial strengthening

of the IARC research activity and this isreflected in the success achieved in

Figure 1 Countries with active IARC collaborations (coloured in red)

Director’s Introduction

Figure 2 IARC Publications in journals with an impact factor Figure 3 Total Impact Factor Score of IARC Scientific

obtaining competitive research grants from

external sources A determined effort was

made in this direction and the results have

been quite remarkable (Figure 5)

The increased thoroughness of the

review process has contributed to this

outcome The majority of the Groups

reviewed have scored very highly on “future

plans” and this has been reflected again in

the obtention of competitive funding

Scientific Highlights

The ninth volume of “Cancer Incidence in

Five Continents” has been completed and

made available on the IARC website

Cancer Incidence in Five Continents is the

recognised reference source on the

incidence of cancer in populations around

the world The ninth volume has a wider

coverage than before presenting data from

around the year 2000 not only for entire

populations but also for sub-populations

living in the same geographic area

This volume presents incidence data

from populations all over the world for

which good quality data are available

Scanning through the information gives a

clear presentation of the changing cancerpatterns worldwide With this volume,much more use is made of the web ratherthan continued reliance on the printedvolume All tables previously found onprinted page are now available on theelectronic version which has many positivebenefits Before this new volume is madeavailable in print, it is accessible online

The first volume in the fourth edition ofthe WHO Pathological Classification ofTumours (“Blue Books”) was publishedduring 2007 This volume on “Tumours ofthe Central Nervous System” will be shortlyfollowed by publication of the secondvolume on “Haematological Malignancies”

During the Biennium, IARCcontinued its international surveys of theprevalence of Human Papillomavirus(HPV ) types in many diverse regions ofthe world Quality Control Guidelines forCervix Cancer Screening were publishedand the results of a randomized trial ofcervix cancer screening by visual inspectionwere published This latter study, conducted

in India, demonstrated the value of such asimple screening approach to significantly

reducing the incidence of invasive cervixcancer in a low-income setting

There have been many other importantfindings published in peer-reviewedscientific journals and these are discussed

in more detail throughout this Report

IARC Working Group Reports

There have been three Working Group

reports (Green Books) published The first

concluded that exposure to artificial sources

of sunlight for tanning purposes, such assunbeds or sunlamps, at young ages wasassociated with an increased risk ofmelanoma

The second produced a comprehensivereview of guidelines for BiologicalResource Centres and focused onrecommendations for minimal standardsfor the creation and organisation of suchresources

A Working Group Report on

“Attributable Causes of Cancer in France”was produced in conjunction with the

Académie de Médecine and the Académie des Sciences of France This employed as much

French exposure data as possible and used

Director’s Introduction

the classification base provided by the

IARC Monographs and the IARC

Handbook series to determine

quantitatively the attributable fraction of

cancer incidence and mortality in France

attributable to identified causes Tobacco

and alcohol consumption emerged as the

key causes of cancer in men

There are Working Groups on-going

on “Vitamin D and Cancer Risk” and “The

Global Cancer Burden Attributable to

Asbestos” which are scheduled to report

during 2008

Key Elements

Research Training is a key element of the

IARC Mission and the Research Training

Fellowship Programme has been a major

success since its inception This has been

supplemented with a Master’s and

Doctoral Programme and the IARC

Summer School is now an annual event in

the IARC calendar Eligibility for each

programme is restricted to candidates from

low- and medium-resource countries

although for the Master’s Programme and

Summer School candidates from

high-resource countries can attend but do not

receive any financial support

While some students spend the entire time

researching their Masters or PhD at

IARC, there are many others who spend

part of their programme here learning a

technique or working on part of their

assigned thesis project During 2006-2007

five students obtained a Master’s degree

and who spent more than half their

programme working at the Agency Eight

students spent more that two years at

IARC and obtained a doctoral degree:

these students came from France,

Australia, the Netherlands

IARC Ethics Committees

A revised process of submitting and

obtaining ethical approval for studies was

introduced by the Governing Council in

May 2005 Under the new structure, an

IARC Institutional Review Board was

created and an international Ethics Review

Committee was established There is a good

interaction established between the two

committees and this arrangement appears

to be working in practice The IRB met five

times during 2007 and reviewed an average

of eight projects at each meeting

The Ethics Review Committee meetstwice each year, once in Lyon, a jointmeeting with the IRB, and once in adifferent Region of the world In January

2007, the ERC met in Peru and had theopportunity to see at first hand the fieldconditions in which IARC Studies wereconducted In January 2008, the EthicsCommittee will meet in Mumbai, Indiawhere there are a number of on-goingIARC studies centred The Ethics ReviewCommittee was given a new task by theIARC Governing Council to monitorthose IARC studies which have industrialfunding

Expanding IARC activities in resource settings

low-IARC has always had research activities inlow-resource countries and this work isnow expanding Looking ahead, with therapidly rising cancer burden in low-incomeand medium-income countries more high-quality incidence data are needed fromregions and countries in such settings

Reliable data are needed to establish thecancer burden and to monitor its evolution

in all parts of the world, particularly inresponse to cancer control activities

Nurturing the development of cancerregistration in such countries is of majorimportance and one which theInternational Agency for Research onCancer is addressing

IARC has long-standing associationswith Cancer Registries in low-resourcesettings and a meeting was held in Lyon(2007) with representatives from Africa,Asia and Latin America The purpose was

to identify ways in which IARC couldassist in the development of cancerregistration in such low-resource settings

Discussion included the subject of ameeting which was held at IARC in July,

2007 to discuss how best to fund suchcancer registries As a result, IARC will belaunching a competition whose outcomewill be to provide long-term, stablefunding for a small number of cancerregistries in low-resource countries

Criteria have been established to evaluatethe likely success and sustainability ofcancer registries and these will be applied

in addition to the long-term GambiaHepatitis Intervention Study Therandomized trial of Oral Cancer screening,

in Trivandrum, India, is still beingfollowed-up and there is a key study ofNasopharyngeal Cancer on-going inIndonesia and other parts of Asia

A new IARC Research Group willbecome functional in 2008 to act as a focalpoint for the coordination and expansion

of the IARC portfolio in low-resourcecountries

Arrivals and Departures

Two Group Heads resigned during theBiennium Dr Zhao Qi Wang (IARC1997-2006), who was head of the GeneEnvironment Biology Group, departed totake up a position of Professor at theUniversity of Jenna, Germany Dr CarolynDresler (IARC 2004-2006), who was Head

of the Tobacco Group, resigned to take up

a position within State Government in theUnited States Two Acting Group Headsalso resigned from the Agency Dr PaolaPisani took up a post at Oxford Universityand Dr Rudolf Kaaks accepted a position

as Head of Epidemiology at DKFZ inHeidelberg, Germany All at IARC thankthem for their service to IARC and wishthem the very best for the future

Dr Hai Rim Shin (Republic of Korea)was appointed as Head of the DescriptiveEpidemiology Analysis Group and DrMaria-Paula Curado (Brazil) wasappointed Head of the DescriptiveEpidemiology Production Group DrPhilippe Autier (Belgium) moved tobecome Head of the EpidemiologyMethods and Support Group and DrZdenko Herceg (Croatia) was appointed tothe position of Head of the EpigeneticsGroup Dr Elisabeth Cardis (Canada) wasconfirmed as Head of the Radiation Groupand Dr Lawrence von Karsa (United States

of America) was confirmed as Head of theScreening Quality Control Group MrMarkus Pasterk (Austria) was appointed to

a new position of Scientific Coordinator

Publications

Baglietto L, Jenkins MA, Severi G, Giles GG,

Bishop DT, Boyle P and Hopper JL Measures

of familial aggregation depend on definition of

family history: meta-analysis for colorectal

cancer.J Clin Epidemiol 2006

Feb;59(2):114-124.

Boffetta P, McLaughlin JK, La Vecchia C.,

Autier P, Boyle P (2007) 'Environment' in

cancer causation and etiological fraction:

limitations and ambiguities Carcinogenesis28:

913-915.

Boyle P The Globalisation of Cancer Lancet

2006; 368: 629-630

Boyle P, Ariyaratne MA, Barrington R, Bartelink

H, Bartsch G, Berns A, de Valeriola D, Dinshaw

KA, Eggermont AM, Gray N, Kakizoe T, Karki

BS, Kaslar M, Kerr DJ, Khayat D, Khuhaprema

T, Kim IH, Martin-Moreno J, McVie G, Park

JG, Philip T, Ringborg U, Rodger A, Seffrin JR,

Semiglazov V, Soo KC, Sun YT, Thomas R,

Tursz T, Veronesi U, Wiestler O, Yoo KY,

Zatonski W and Zhao P Tobacco: deadly in any

form or disguise Lancet. 2006 May

27;367(9524): 1710-2.

Cardis E, Krewski D, Boniol M, Drozdovitch

V, Darby SC, Gilbert ES, Akiba S, Benichou J, Ferlay J, Gandini S, Hill C, Howe G, Kesminiene A, Moser M, Sanchez M, Storm

H, Voisin L, Boyle P (2006) Estimates of the cancer burden in Europe from radioactive fallout from the Chernobyl accident Int J Cancer 119: 1224-1235.

Ferlay J, Autier P, Boniol M, Heanue M, Colombet M, Boyle P (2007) Estimates of the cancer incidence and mortality in Europe in

2006 Ann Oncol 18: 581-592.

Ferlay J, Randi G, Bosetti C, Levi F, Negri E, Boyle P, La Vecchia C Declining mortality from bladder cancer in Europe BJU Int 2007 Oct 30; [Epub ahead of print]

Hayes VM, Severi G, Padilla EJ, Morris HA, Tilley WD, Southey MC, English DR, Sutherland RL, Hopper JL, Boyle P, Giles GG (2007) 5alpha-Reductase type 2 gene variant associations with prostate cancer risk, circulating hormone levels and androgenetic alopecia Int J Cancer 120: 776-780.

Koutros S, Zhang Y, Zhu Y, Mayne ST, Zahm

SH, Holford TR, Leaderer BP, Boyle P, Zheng

T Nutrients Contributing to One-Carbon Metabolism and Risk of Non-Hodgkin Lymphoma Subtypes Am J Epidemiol 2007 Lan Q, Zheng T, Chanock S, Zhang Y, Shen

M, Wang SS, Berndt SI, Zahm SH, Holford

TR, Leaderer B, Yeager M, Welch R, Hosgood

D, Boyle P, Rothman N (2007) Genetic variants in caspase genes and susceptibility to non-Hodgkin lymphoma Carcinogenesis 28: 823-827.

Lan Q, Zheng T, Rothman N, Zhang Y, Wang

SS, Shen M, Berndt SI, Zahm SH, Holford

TR, Leaderer B, Yeager M, Welch R, Boyle P, Zhang B, Zou K, Zhu Y and Chanock S Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma Blood.2006 Jan 31; [Epub ahead of print]

Lan Q, Zheng T, Shen M, Zhang Y, Wang SS, Zahm SH, Holford TR, Leaderer B, Boyle P, Chanock S (2007) Genetic polymorphisms in the oxidative stress pathway and susceptibility

to non-Hodgkin lymphoma Hum Genet 121: 161-168.

Director’s Introduction

Interaction among IARC, WHO and

other International Organisations

The Director gave a Media Briefing at the

United Nations in New York (April, 2007)

which was well received In this, the

problem of the Globalisation of Cancer

was emphasized

There was a meeting held in Lyon in

September 2007 of WHO HQ Directors

working in areas in common with IARC

This emphasized the extent of the

collaborations which IARC had with

many groups in Headquarters and we have

agreed to hold this meeting every six

months In addition, IARC hosts an

Annual Meeting with

Non-Communicable Disease Directors from

WHO Regional Offices to discuss mutual

problems and how IARC can assist in

cancer prevention research activities

IARC has also developed a strong

partnership with the International Atomic

Energy Agency (IAEA) on the

Programme of Action on Cancer Therapy

(PACT) Funded initially by the Nobel

Prize Fund, this programme aims to

deliver cancer prevention and treatment

facilities to underserved communities

worldwide The initial focus is on the 30+

countries which do not have a singleRadiotherapy machine and the IARCcommitment is to provide or improve,cancer registration in such areas wherefacilities are provided and also to search foropportunities for the establishment ofsustainable early detection programmes

Six countries have been selected in a pilotprogramme: Sri Lanka, Tanzania, VietNam, Nicaragua, Albania and Yemen

IARC Medal of Honour

In 2006, the fourteenth Roger SohierLecture was given by George Klein(Sweden); the third Richard Doll Lecturewas given by Joseph Fraumeni Jr (UnitedStates of America); and the second IARCLecture was given by Dr Katayun Dinshaw(India)

In 2007, the fifteenth Roger SohierLecture was given by Mariano Barbacid(Spain); the fourth Richard Doll Lecturewas given by Dimitri Trichopoulos(Greece); and the third IARC Lecture wasgiven by Dr LaSalle D Leffalle, on behalf

of Nancy Brinker who founded the KomenFoundation, which celebrated its 25thAnniversary in 2007

Each has made a significantcontribution to cancer research andprevention and all received the IARCMedal of Honour

Participating States

During the biennium a further fourParticipating States were admitted to theAgency: Republic of India, Republic ofKorea, the Russian Federation and Ireland.This brings the number of ParticipatingStates to 20 This expansion of theAgency’s membership also introduces anew dimension into the governancestructure of the Agency

Cancer is no longer a disease of resource, industrialized, western countries

high-as whigh-as the chigh-ase when the IARC whigh-asfounded forty years ago Today themajority of the world cancer burden occurs

in low- and medium-resource countriesand the Agency must adopt a new focus ofactivity in the face of this development The adhesion of new ParticipatingStates is a vote of confidence in the aimsand activities of the Agency

Director’s Introduction

Robertson C, Link CL, Onel E, Mazzetta C,

Keech M, Hobbs R, Fourcade R, Kiemeney L,

Lee C, Boyle P and McKinlay JB The impact of

lower urinary tract symptoms and

comorbidities on quality of life: the BACH and

UREPIK studies BJU Int. 2007

Feb;99(2):347-54.

Scully C, Boyle P, Day T, Hill B, Joshi V,

Leupold NE, Shah JP and Lefebvre JL.

International Consortium on Head and Neck

Cancer Awareness (ICOHANCA) Oral

Oncol 2007: Oct;43(9):841-842.

Severi G, Hayes VM, Neufing P, Padilla EJ,

Tilley WD, Eggleton SA, Morris HA, English

DR, Southey MC, Hopper JL, Sutherland RL,

Boyle P and Giles GG Variants in the

prostate-specific antigen (PSA) gene and prostate cancer

risk, survival, and circulating PSA Cancer

Epidemiol Biomarkers Prev 2006 Jun;15(6):

1142-7.

Severi G, Hayes VM, Tesoriero AA, Southey

MC, Hoang HN, Padilla EJ, Morris HA,

English DR, Sutherland RL, Boyle P, Hopper

JL, Giles GG The rs743572 common variant

in the promoter of CYP17A1 is not associated

with prostate cancer risk or circulating

hormonal levels BJU Int.2007 Nov 6; [Epub

ahead of print]

Severi G, Morris HA, MacInnis RJ, English

DR, Tilley WD, Hopper JL, Boyle P and Giles

GG Circulating insulin-like growth factor-I and binding protein-3 and risk of prostate cancer Cancer Epidemiol Biomarkers Prev.

2006 Jun;15(6):1137-41.

Severi G, Morris HA, MacInnis RJ, English

DR, Tilley W, Hopper JL, Boyle P and Giles

GG Circulating steroid hormones and the risk

of prostate cancer Cancer Epidemiol Biomarkers Prev 2006 Jan;15(1):86-91 Shen M, Zheng T, Lan Q, Zhang Y, Zahm SH, Wang SS, Holford TR, Leaderer B, Yeager M, Welch R, Kang D, Boyle P, Zhang B, Zou K, Zhu Y, Chanock S, Rothman N.

Polymorphisms in DNA repair genes and risk

of non-Hodgkin lymphoma among women in Connecticut Hum Genet 2006 Jul;119(6):

659-68

Veronesi U, Maisonneuve P, Rotmensz N, Bonanni B, Boyle P, Viale G, Costa A, Sacchini

V, Travaglini R, D'Aiuto G, Oliviero P, Lovison

F, Gucciardo G, del Turco MR, Muraca MG, Pizzichetta MA, Conforti S, Decensi A; Italian Tamoxifen Study Group Tamoxifen for the prevention of breast cancer: late results of the Italian Randomized Tamoxifen Prevention Trial among women with hysterectomy J Natl Cancer Inst 2007 May 2;99(9):727-37.

Zatonski W, Mikucka M, La Vecchia C and Boyle P Infant mortality in Central Europe: effects of transition Gac Sanit. 2006 Jan- Feb;20(1):63-6.

Zhang Y, Holford TR, Leaderer B, Boyle P, Zhu Y, Wang R, Zou K, Zhang B, Wise JP, Qin

Q, Kilfoy B, Han J, Zheng T (2007) Ultraviolet radiation exposure and risk of non- Hodgkin's lymphoma Am J Epidemiol 165: 1255-1264.

Zhang Y, Wang R, Holford TR, Leaderer B, Zahm SH, Boyle P, Zhu Y, Qin Q, Zheng T (2007) Family history of hematopoietic and non-hematopoietic malignancies and risk of non-Hodgkin lymphoma Cancer Causes Control 18: 351-359.

Zhu Y, Leaderer D, Guss C, Brown HN, Zhang Y, Boyle P, Stevens RG, Hoffman A, Qin Q, Han X and Zheng T Ala394Thr polymorphism in the clock gene NPAS2: A circadian modifier for the risk of non- Hodgkin's lymphoma Int J Cancer 2007( Jan 15); 120(2) :432-5.

Zhu Y, Zheng T, Stevens RG, Zhang Y and Boyle P Does "clock" matter in prostate cancer?

Cancer Epidemiol Biomarkers Prev. 2006 Jan;15(1):3-5.

Dr Hiroko Ohgaki

Pathology Group (PAT)

Dr Hiroko Ohgaki

Screening Group (SCR)

Dr Rengaswamy Sankara- narayanan

Screening Quality Control Group (ECN)

Dr Lawrence von Karsa

Gambia Hepatitis Intervention Study (GHIS)

Dr Pierre Hainaut

Genetics and Epidemiology Cluster (GEC)

Dr Paolo Boffetta

Genetic Epidemiology Group (GEP)

Dr Paul Brennan

Genetic Susceptibility Group (GSC)

Dr Sean Tavtigian

Lifestyle, ronment and Cancer Group (GEE)

Envi-Dr Paolo Boffetta

Molecular Carcinogenesis and Biomarkers Group (MCB)

Dr Pierre Hainaut

Epigenetics Group (EGE)

Dr Zdenko Herceg

Carcinogen Identification and Evaluation Group (CIE) Dr Vincent Cogliano

Reports to Office

of the Director

Molecular Carcinogenesis Cluster (MCC)

Dr Pierre Hainaut

Nutrition and Hormones Group (ICE)

Dr Silvia Franceschi (Acting)

Infections and Cancer Epi- demiology Group (ICE)

Dr Silvia Franceschi

Infections and Cancer Biology Group (ICB)

Dr Massimo Tommasino

Epidemiology and Biology Cluster (EBC)

Dr Silvia Franceschi

Dr P Autier, Cluster Coordinator

Dr P Boffetta, Cluster Coordinator

Dr S Franceschi, Cluster Coordinator

Dr P Hainaut, Cluster Coordinator

Dr H Ohgaki, Cluster Coordinator

Dr S Tavtigian, Member without portfolio

Mr M Pasterk, Scientific Coordinator

Mr M Johnson, Director of Administration and Finance

Dr P Boyle, Director

The Biostatistics and Epidemiology

Cluster (BEC) comprises five Groups: the

Epidemiology Methods and Support

Group (BIO), The Data Analysis and

Interpretation Group (DEA), the

Descriptive Epidemiology Production

Group (DEP), the Information

Technology Services Group (ITS) and the

Radiation Group (RAD)

One of the important goals of this

Cluster is communicating information

about cancer to the public This is a

principal focus of the Data Analysis and

Interpretation (DEA) Group, headed by

Hai-Rim Shin

The Descriptive Epidemiology

Production (DEP) Group, headed by

Maria-Paula Curado, analyses data

describing cancer incidence, mortality and

survival to identify and clarify the role of

etiological factors in cancer The Group

works closely with cancer registries and

national statistics systems to assemble data

on incidence, survival and mortality and to

ensure that these data are coherent and

accurate

The Epidemiology Methods and

Support Group (BIO), headed by Philippe

Autier, combines expertise in mapping and

analysis of epidemiological data and

temporal trends with statistical methods

for time-projection of data on cancer

incidence and mortality These

competencies are developed and improved

in the course of conducting multiple

ongoing projects in the BIO Group as well

as in other Groups at IARC

The Information Technology Services(ITS) Group, headed by Michel Smans,exists to manage the central computingframework at IARC This ranges fromresponding to the needs of individual users,

to managing centralised services forstatistical analysis, database storage,management and access to establishingnew scientific and management systemsfor the Agency

Exposure to electromagnetic fields andionizing radiation is a ubiquitous part ofdaily life, and the Radiation Group(RAD), headed by Elisabeth Cardis, exists

to conduct targeted epidemiologicalstudies of particular types of exposure

These studies not only respond to theneeds of the scientific community, but alsoserve to address widespread concerns in thegeneral population

All in all, the projects of the Clusteraddress 11 specific research areas:

6 Attributable causes of cancer;

7 Skin cancer and ultraviolet radiation;

8 Vitamin D and cancer;

9 Evaluation of methods for cancerdetection;

10 Ionizing radiation and cancer; and

11 Non-ionizing radiation (other thanUV) and cancer

These projects are relevant to theoverall mission of the IARC, as theycontribute to the search for the causes ofcancer More specifically, the activities ofthe BEC Cluster compile data fromaround the world aiming at assessing theburden of cancer and evaluating cancercontrol efforts Other BEC activitiesdirectly address known or possible causes

of cancer and investigate possible methodsfor preventing and detecting cancer ThusBEC activities reflect several parts ofIARC’s mission: emphasis on theincidence and impact of human cancer;elucidation of the causes of cancer;prevention and early detection; andmethodological research The BEC clusteralso participates in training activities, such

as training cancer registries worldwide instandardised methods for data collection There is a great deal of symbiosisamong the five different Groups in theCluster, which work closely together onmany projects Therefore, a project assigned

to a specific group may be coordinated by

a scientist of another group if such astructure will maximise the efficiency andscientific benefit of the project

Biostatistics and Epidemiology Cluster (BEC)

Cluster Coordinator: Dr Philippe Autier

Epidemiology Methods and Support Group (BIO)

Head

Dr Philippe Autier (since 01/2007)

- Head of BEC Cluster since 09/2006

Mr Michel Smans (acting

Dr Mazda Jenab (until 07/2007)

Dr Rudolf Kaaks (until 07/2006)

Dr Sabina Rinaldi

Dr Nadia Slimani (from 05/2007)

Dr Marit van Bakel (from 08/20006

Ms Corrine Casagrande

Mr Thomas Cler (until 02/2007)

Mr Sébastien Cuber (until 06/2006)Mrs Geneviève Deharveng

Dr Ivan Plesko

Dr Jonathan WakefieldProf Witold ZatonskiProf Tongzhang Zheng

Students

Mr Mustafa Al-Zoughool (until 08/2006)

Ms Mariana Castillo-Beltran (until 08/2007)

Mrs Inge Huybrechts (from 02/2007)

Mr Anthony Montella (from 03/2007 to 08/2007)

Consultant

Dr Rodolfo Saracci

The Epidemiology Methods and Support

Group (BIO) exists at IARC to provide

analysis, management, coordination of data

collection, management and technical

support for its biological material storage

The group encompasses the former

Biostatistics Group and is currently made

up of the Epidemiological Support Team

(EST) and the Nutritional and Database

Resource Team (NTR), with a new

Biostatistics Team to be created in the future

Epidemiological Support Team

The EST is working on several large

projects funded by grants by the European

of international societies on skin cancersuch as Euroskin and the EORTCMelanoma Group

EST staff are regularly invited topresent worldwide at all of the majorconferences on this topic Most recently,staff were present at conferences hosted bythe European Society of Skin CancerPrevention and by the Karolinska

Institutet Multiple articles have also beenpublished on this topic

The most recent project on theUV/skin cancer topic is the

“Quantification of sun exposure in Europeand its effects on health”, known as theEurosun Project, a three-year projectdesigned to monitor ultraviolet exposure inthe European Union and its effects on theincidence of skin cancers and cataracts.Meteorological satellite data will be used

to calculate exposure to various UVwavelengths for European populations;these data will be used to produce an atlas

of UV exposure in Europe These data willalso serve to predict the global EU burden

of UV-related diseases in the future.

Concurrent with this project is a similar

one, limited to France, funded by AFSSET

(Agence Française de Sécurité Sanitaire de

l’Environnement et du Travail, Paris)

IARC working group on avoidable

causes of cancer in France

This group contributes to the elaboration

of bio-statistical methods to estimate the

proportion of cancer caused by major risk

factors Its main interests are to estimate

attributable fractions for multiple

categories of exposure, including

continuous exposure, as well as considering

interaction between risk factors and

statistical uncertainties

In July 2005, a workshop at IARC

brought together cancer epidemiologists

who concluded that studies on attributable

causes of cancer should begin by examining

a few selected countries in the five

continents In September 2005, the French

Académie Nationale de Médecine and the

French Académie des Sciences proposed to

IARC to collaborate on a study on

attributable causes of cancer in France This

work took two years and involved a

considerable number of collaborators in

France and other countries

The results of the study were made

public in September 2007, and the full

report is available on the IARC website The

conclusion of the report is that about 40%

and 25% of cancers occurring today in

French men and women, respectively, are

attributable to specific causes (and therefore

theoretically preventable); it also stresses the

limitations of current knowledge on human

carcinogenesis While it is expected that in

the future the evidence in favour of or

against a role of other risk factors will

accumulate and eventually contribute to

elucidating their contribution to human

cancer, recommendations can be formulated

to improve this process

Vitamin D and cancer

A Working Group on Vitamin D is

currently being established to examine the

possible association between vitamin D

and cancer This Working Group is

reviewing the epidemiological and

laboratory evidence and will try to come

up with consensus evaluations, with results

beginning to be published early in 2008

Given the controversies and thepolarisation of opinions on this subject, wehave set up a group of independentresearchers of international reputation Wedid not only seek experts in Vitamin Dissues, but also senior scientists withextensive experience in laboratory andepidemiological studies

The IARC secretariat will review thearticles and prepare a draft workingdocument which will be reviewed andexpanded upon by the Working Groupmembers Writing tasks have beendistributed among Working Groupmembers, and a FTP website with all thedocumentation has been created,representing the common library of theWorking Group Meta-analyses of studies

on the effects of vitamin D on severaldifferent cancers are underway

A meeting in December 2007 has beendevoted to sorting out points ofdisagreement, finding a consensusconclusion, and identifying the criticalstudies that are still needed for defining therole of vitamin D in cancer, including theneed to mount randomised trials

The Group has attended the HealthStrategies in Europe meeting (summer2007) as well as the High LevelConference on the Future of Science andTechnology in Europe (fall 2007), bothheld in Lisbon, in addition to being asked

to present papers at multiple conferences,including ones on cancer and theenvironment and breast cancer

Eurocadet

The EST is strongly involved in aEuropean project called Eurocadet, whichaims to contribute to the prevention ofcancer in Europe via estimating the effects

of successful implementation of preventionstrategies on the incidence of cancer BIO

is responsible for two key work packages inthis effort:

The first work package has theresponsibility of collecting data onprevalence of exposure to major establishedcancer risk factors in Europe This datagathering benefits from the Group’sprevious experience on the projectevaluating avoidable causes of cancer inFrance Preliminary analysis showeddisparities on the evolution of risk factors;

for example, important differences exist in

Western Europe with Nordic countriespresenting great success in tobacco controlwhereas Southern European countries areonly beginning to get results on tobaccosmoking It also revealed the emergence of

an epidemic in Central Europe withimportant increases in tobacco smokingamong both men and women This workpackage is finalising the database onprevalence of risk factors in Europe andpreparing scientific publications of thesedata

The second work package is dedicated

to estimating projections of incidence andmortality from cancer in Europe from

2005 to 2015 based on data from cancerregistries These estimations were finalisedfor 2006 in a preliminary study (Estimates

of the cancer incidence and mortality inEurope in 2006)

Statistical method for analysis of cancer incidence, mortality and temporal changes

The group is closely linked to the activities

of the DEP and DEA Groups to providestatistical supervision of incidence,mortality and time trend analysis Timetrend analysis requires everything fromjoinpoint regression used in descriptiveepidemiology (such as those performed inthe analysis of trends in breast cancerincidence and mortality) to more complexexplorative methods Within the WorkingGroup on cancer following the Chernobylaccident, the group developed a statisticalanalysis of time trends of cancer incidenceand mortality with an age-period-cohortmodel applied to multiple countries In thisproject random effect models of cancerincidence and mortality were also built todisentangle residual country effects fromdoses of radiation

Another activity concerns theestimation of incidence worldwide—thegroup is a member of the Cancer Incidence

in Five Continents (CI5) Volume IXgroup BIO developed methods based onprincipal component analysis to identifysources of variability in the database and toclear errors that could be missed by regularchecking for outliers The BIO Group alsoprovided statistical support for statisticsused in CI5 This activity led the group toevaluate current data on non-melanomaskin cancer in the world This cancer site isEpidemiology Methods and Support Group

a forgotten cancer in many reports, and a

specific report was produced on worldwide

incidence of non-melanoma skin cancer

The BIO Group is involved in various

international collaborations, such as those

which resulted in the epidemiological

publications Lung Cancer and Cannabis in

Tunisia and in Maghreb and Tobacco

Smoking and Cancer: A Meta-Analysis.

Other activities of EST

EST is an active participant in the IARC

Summer School program In addition, over

the last two years the BIO Group has

provided regular statistical support to other

IARC groups

Nutrition and Hormone Team (NTR)

The NTR team has three axes of activities:

1) Support the coordination and

management of EPIC, including the

maintenance of its central database; 2)

Conduct advanced research on dietary and

statistical methodologies and laboratory

activities relevant to international

epidemiological studies; 3) Conduct

research on diet, metabolic factors and

cancer and other chronic diseases

Support the coordination and management of

the EPIC network

Over the last two years, the NTR team has

ensured technical support and preparation

of a series of common and project-specific

datasets for a large network of 25 EPIC

working groups and related projects (e.g

EPIC coordination project, INTERACT,

Diogenes, EuroGast, EPIC-Elderly,

Panscan, breast and prostate cohort

consortium) In particular, an update of the

follow-up cancer and mortality data andother dietary and lifestyle variables wascirculated to the EPIC network in March

as well as the development of a complexdatabase management system programme(EnMan) to handle international nutrientdatabases Two review papers on ENDBwere published in 2007 In addition, theNTR team has developed statisticalmodels to analyse diet-disease associations,after correction for measurement errors indietary assessments

Over the years, the NTR team hasanswered continuously increasing requests

to use its dietary methodologies,particularly after an independent EUworking group (EFCOSUM)recommended EPIC-SOFT as thereference method for future pan-Europeansurveys During this biennium, the NTRteam supported the implementation of theEPIC-SOFT methodology in differentnational and regional monitoring surveys

in Germany, The Netherlands andBelgium In addition, the team extended

its international collaborations throughdifferent recently funded EU projects(EFCOVAL, IDAMES, EuroFIR) inorder to further develop and adapt theEPIC-SOFT methodology for futurelarge international nutritional studies,including pan-European monitoringsurveys A fully operational upgradedEPIC-SOFT programme is expected to

be ready by 2009 through the on-goingEFCOVAL project In parallel, thefeasibility of adapting EPIC-SOFT tonon-European countries (e.g India) hasbeen initiated through an IARC projectcoordinated by P Boffetta In addition,new standardised databases on glycemicindex/glycemic load, animal/plant proteinsand fats have been developed to extend thereach of nutritional research activities Thedevelopment of an acrylamide database isalso ongoing

The NTR team has been involved inthe coordination of the EPIC statisticalworking group The group intends toprovide scientists in the EPIC networkwith guidelines for the analysis of therelationship between dietary and non-dietary factors and disease outcomes Inaddition, the group is conducting fore-front methodological research in the field

of nutritional epidemiology In April 2007,

a workshop meeting was held in Lyon,with the participation of over 20statisticians working in the EPIC network,

as well as a number of scientists worldwide.The meeting focused on three mainresearch aspects: the evaluation of thediet/disease association in multi-centricstudies, measurement error correctionprocedures for the diet/disease association,and the definition of statistical techniquefor the search of dietary patterns

Another important responsibility ofthe NTR team is its laboratory activitysupport for hormone analyses for largeepidemiological studies Over the lastbiennium, the laboratory has focussedmainly on the measurements of sexsteroids, growth factors and C-peptide ofinsulin, as well as of adiponectin and leptin,

in serum or plasma samples from severallarge-scale epidemiological studies,including EPIC In addition to routineanalyses, a very sensitive method for themeasurements of circulating estrogens andestrogen metabolites (hydroxy andBiostatistics and Epidemiology Cluster

Epidemiology Methods and Support Group

methoxy estrogens) in serum and in urine

samples using negative chemical ionisation

gas chromatography/mass spectrometric

detection has been set up The NTR team

was also involved in validating the stability

of nutritional biomarkers such as vitamin

C, vitamin D status, iron status and

oxidative stress by comparing

measurements from EPIC blood samples

stored for many years under liquid nitrogen

and those taken at earlier time intervals

before or during storage

Furthermore, a complex Laboratory

Information Management System (LIMS)

has also been developed to handle biological

samples movements and related results

Initially developed for EPIC, this LIMS will

also be used for other IARC projects

Research activities

Cross-sectional studies on diet and biomarkers

of diet The NTR team is coordinating the

preparation of a Special issue on Nutrient

Intakes and Patterns in EPIC (SNIPE) of

15 papers to be published by summer 2008,

as a principal activity of the nutritional

EPIC working group led by the NTR team

Over this biennium, a series of common and

paper-specific databases, as well as common

guidelines and SAS programs, were prepared

to support this project Team scientists were

also involved in major cross-sectional

analyses of blood phytoestrogen, acrylamide

and fatty acids levels, and consumption

patterns and portion sizes of nuts and seeds

across Europe

Diet and cancer A major role of the NTR

team is to use data from the EPIC study

to investigate the association of diet andnutrition with risk of cancers, particularlythose of the colorectum, stomach andprostate Team scientists have led studiesshowing that increased intake of alcohol,both at baseline and over a lifetime, isassociated with higher risk of colorectalcancer As a follow-up to these findings,the team is leading a study onpolymorphisms in genes regulating themetabolism of alcohol Another NTR-ledstudy showed that higher bloodconcentrations of some carotenoids andvitamin C are associated with a decreasedrisk of gastric cancer through, for vitamin

C, inhibition of endogenous n-nitrosocompound formed from high intake of redand processed meats The team has alsohad a major collaborative role in studiesshowing that higher blood levels ofvitamin B12 (but not folate) are associatedwith decreased risk, and also that higherblood levels of carotenoids, includinglycopene, are not associated with localizedprostate cancer, but were significantlyassociated with risk of advanced disease

Other research projects on bloodconcentrations of vitamin D, body ironstatus, oxidative stress parameters andblood lipid profiles in relation to risk ofcolorectal cancers are on-going Moreadvanced studies ready to be submittedshow that higher intake of dietary fat,particularly monounsaturated fats, isassociated with an increased risk of gastriccancer, particularly in northern Europeancountries where monounsaturated fat ismostly derived from meats and meatproducts These results were confirmed by

measurement of blood phospholipid fattyacid profiles, showing that higher bloodlevels of oleic acid, the mainmonounsaturated fat in the blood stream, isassociated with increased gastric cancer risk

Hormones and cancer In the current

biennium, this research has focused oncancers of the endometrium, ovary andprostate cancers An EPIC nested case-control study on endometrial cancershowed about a two-fold increase in cancerrisk with increasing prediagnostic serumC-peptide concentrations, with elevatedglucose levels and with low HDL levels inblood and lower concentrations ofadiponectin Obesity and greater adultweight gain were also associated withincreased risk of endometrial cancer,supporting further that hyperinsulinemiaand obesity are risk factors for this cancer.This team has also shown that higherblood levels of C-peptide, a marker ofinsulin release, as well as elevated measures

of glycosylated haemoglobin, are associatedwith increased risk of colorectal cancers Inanother nested case-control study, elevatedserum levels of IGF-I were associated with

a strong increase in ovarian cancer inpremenopausal women with an ovariancancer diagnosed at a relative young age.Similarly, in EPIC and in the US PLCOcohort study, endogenous concentrations

of IGF-I were not strongly associated withprostate cancer risk, although theassociation with risk was more pronouncedfor advanced-stage or aggressive disease

The BIO Group is grateful to the following for their collaboration in its projects:

Sara Gandini - IEO, Milan, Italy; Jan Willem Coeberg - Erasmus University, Rotterdam, Netherlands;

Anna Gavin - Northern Ireland Cancer registry, Belfast, Ireland; Laufey Triggvadottir - Icelandic Cancer Society,

Reykjavik, Iceland; Lucien Wald - Ecole des Mines de Paris, Sophia Antipolis, France;

Eduardo Roseblatt - IAEA, Vienna, Austria; Maurice Tubiana - Académie de Médecine, Paris, France;

Julian Peto - London School of Hygiene and Tropical Medicine, London, UK

Financial Support from the following bodies is gratefully acknowledged:

Agence Française de Sécurité Sanitaire de l'Environnement et du Travail (AFSSET), Directorate General for Health and Consumer Protection of the European Commission (DG Sanco), Directorate General for Research of the European Commission (DG Research), World Cancer Research Fund International

(WCRF)

Publications

Arbyn M, Raifu AO, Autier P, Ferlay J (2007).

Burden of cervical cancer in Europe: estimates

for 2004 Ann Oncol Oct;18(10):1708-1715.

Autier P, Gandini S (2007) Vitamin D

supplementation and total mortality: A

meta-analysis of randomized controlled trials Arch

Intern Med; 167:1730-1737.

Autier P, Boniol M, Doré JF (2007) Sunscreen

use and increased duration of intentional sun

exposure: Still a burning issue Int J

Cancer;121:1-5.

Bleiberg H, Grivegnee A, Hendlisz A, Autier P

(2006) Screening colorectal cancer: the selection

of patients at risk Rev Med Brux;27:S221-223

Bleiberg H, Autier P, Huet F, Schrauwen AM,

Staquet E, Delaunoit T, Hendlisz A, Wyns C,

Panzer JM, Caucheteur B, Eisendrath P,

Grivegnee A (2006) Colorectal cancer (CRC)

screening using sigmoidoscopy followed by

colonoscopy: a feasibility and efficacy study on a

cancer institute based population Ann Oncol;

17:1328-1332.

Boffetta P, McLauglin JK, la Vecchia C, Autier

P, Boyle P (2007) ‘Environment’ in cancer

causation and etiological fraction: limitations

and ambiguities Carcinogenesis;28:913-915.

Boniol M, Dore JF, Autier P (2007) Changing

the Labeling of Suncreen, Will We Transform

Sun Avoiders into Sunscreen Users? J Invest

Dermatol;19 Epub ahead of print As supplied

by publisher.

Boniol M, Armstrong BK, Dore JF Variation in

incidence and fatality of melanoma by season of

diagnosis in new South Wales, Australia Cancer

Epidemiol Biomarkers Prev 2006;15(3):524-526.

Boniol M, Verriest JP, Pedeux R, Dore JF

(2007) Proportion of skin surface area of

children and young adults from 2 to 18 years

old J Invest Dermatol Epub ahead of print.

Cardis E, Krewski D, Boniol M, Drozdovitch

V, Darby SC, Gilbert ES, Akiba S, Benichou J,

Ferlay J, Gandini S, Hill C, Howe G,

Kesminiene A, Moser M, Sanchez M, Storm H,

Voisin L, Boyle P (2006) Estimates of the

cancer burden in Europe from radioactive

fallout from the Chernobyl accident Int J

Cancer;119(6):1224-1235.

Ferlay J, Autier P, Boniol M, Heanue M,

Colombet M, Boyle P (2007) Estimates of the

cancer incidence and mortality in Europe in

2006 Ann Oncol.;18(3):581-592 Epub 2007

Feb 7.

Gandini S, Botteri E, Lodice S, Boniol M,

Lowenfels AB, Maisonneuve P, Boyle P (2007).

Tobacco smoking and cancer: A Meta-analysis.

Int J Cancer Epub ahead of print.

International Agency for Research on Cancer Working Group on artificial ultraviolet (UV) light and skin cancer, Autier P, Boniol M, Boyle

P, Daniel J, Dore JF, Gandini S, Green A, Newton-Bishop J, Weinstock MA, Westerdahl

J, Secretan B, Walter SD (2006) The association

of use of sunbeds with cutaneous malignant melanoma and other skin cancers: A systematic

review Int J Cancer;120:1116–1122.

International Agency for Research on Cancer (2007) Attributable Causes of Cancer in France

in the year 2000 Report from an IARC Working Group, Lyon.

Pedeux R, Sales F, Pourchet J, Kallassy M, Fayolle C, Boniol M, Severi G, Ghanem G, Nakazawa HN, Autier P, Dore JF (2006).

Ultraviolet B sensitivity of peripheral lymphocytes as an independent risk factor for

cutaneous melanoma Eur J

Cancer;42(2):212-215.

Scelo G, Boffetta P, Autier P, Hemminki K, Pukkala E, Olsen JH Weiderpass E, Tracey E, Brewster DH, McBride ML, Kliewer EV, Tonita JM, Pompe-Kirn V, Chia KS, Jonasson

JG, Martos C, Giblin M, Brennan P (2007).

Associations between ocular melanoma and other primary cancers: an international

population-based study Int J

Cancer;120:151-159.

Voirin N, Berthillet J, Benhaim-Luzon V, Boniol M, Straif K, Ben Ayoud W, Ben Ayed F, Sasco A (2006) Risk for lung cancer and past

use of cannabis in Tunisia J Thorac Oncol;1:577–

579.

Nutritional and Database Resource Team

Agudo A, Sala N, Pera G, Capella G, Berenguer

A, Garcia N, Palli D, Boeing H, Del Giudice G, Saieva C, Carneiro F, Berrino F, Sacerdote C, Tumino R, Panico S, Berglund G, Siman H, Stenling R, Hallmans G, Martinez C, Bilbao R, Barricarte A, Navarro C, Quiros JR, Allen N, Key T, Bingham S, Khaw KT, Linseisen J, Nagel

G, Overvad K, Tjonneland A, Olsen A, de-Mesquita HB, Boshuizen HC, Peeters PH, Numans ME, Clavel-Chapelon F, Boutron- Ruault MC, Trichopoulou A, Lund E, Offerhaus J, Jenab M, Ferrari P, Norat T, Riboli

Bueno-E, Gonzalez CA (2006).Polymorphisms in metabolic genes related to tobacco smoke and the risk of gastric cancer in the European prospective investigation into cancer and nutrition Cancer Epidemiol Biomarkers Prev.;15(12):2427-2434.

Agudo A, Sala N, Pera G, Capella G, Berenguer

A, Garcia N, Palli D, Boeing H, Del Giudice G, Saieva C, Carneiro F, Berrino F, Sacerdote C, Tumino R, Panico S, Berglund G, Siman H,

Stenling R, Hallmans G, Martinez C, Amiano

P, Barricarte A, Navarro C, Quiros JR, Allen N, Key T, Bingham S, Khaw KT, Linseisen J, Nagel

G, Overvad K, Tjonneland A, Olsen A, de-Mesquita HB, Boshuizen HC, Peeters PH, Numans ME, Clavel-Chapelon F, Boutron- Ruault MC, Trichopoulou A, Lund E, Blaker

Bueno-H, Jenab M, Ferrari P, Norat T, Riboli E, Gonzalez CA (2006) No association between polymorphisms in CYP2E1, GSTM1, NAT1, NAT2 and the risk of gastric adenocarcinoma

in the European prospective investigation into

cancer and nutrition Cancer Epidemiol

Biomarkers Prev;15(5):1043-1045.

Al-Delaimy WK, Jansen EH, Peeters PH, van der Laan JD, van Noord PA, Boshuizen HC, van der Schouw YT, Jenab M, Ferrari P, Bueno- de-Mesquita HB (2006) Reliability of biomarkers of iron status, blood lipids, oxidative stress, vitamin D, C-reactive protein and fructosamine in two Dutch cohorts.

Biomarkers;11(4):370-382

Allen NE, Key TJ, Appleby PN, Travis RC, Roddam AW, Rinaldi S, Egevad L, Rohrmann

S, Linseisen J, Pischon T, Boeing H, Johnsen

NF, Tjonneland A, Gronbaek H, Overvad K, Kiemeney L, Bueno-de-Mesquita HB, Bingham S, Khaw KT, Tumino R, Berrino F, Mattiello A, Sacerdote C, Palli D, Quiros JR, Ardanaz E, Navarro C, Larranaga N, Gonzalez

C, Sanchez MJ, Trichopoulou A, Travezea C, Trichopoulos D, Jenab M, Ferrari P, Riboli E, Kaaks R (2007) Serum insulin-like growth factor (IGF)-I and IGF-binding protein-3 concentrations and prostate cancer risk: results from the European Prospective Investigation

into Cancer and Nutrition Cancer Epidemiol

BiomarkersPrev; 16(6):1121-1127.

Al-Zoughool M, Dossus L, Kaaks R, Chapelon F, Tjonneland A, Olsen A, Overvad

Clavel-K, Boutron-Ruault MC, Gauthier E, Linseisen

J, Chang-Claude J, Boeing H, Schulz M, Trichopoulou A, Chryssa T, Trichopoulos D, Berrino F, Palli D, Mattiello A, Tumino R, Sacerdote C, Bueno-de-Mesquita HB, Boshuizen HC, Peeters PH, Gram IT, Braaten

T, Lund E, Chirlaque MD, Ardanaz E, Agudo

A, Larranaga N, Quiros JR, Berglund G, Manjer

J, Lundin E, Hallmans G, Khaw KT, Bingham

S, Allen N, Key T, Jenab M, Cust AE, Rinaldi S, Riboli E (2007) Risk of endometrial cancer in relationship to cigarette smoking: Results from the EPIC study Int J Cancer Jul 26; [Epub ahead of print]

Bamia C, Trichopoulos D, Ferrari P, Overvad K, Bjerregaard L, Tjonneland A, Halkjaer J, Clavel- Chapelon F, Kesse E, Boutron-Ruault MC, Boffetta P, Nagel G, Linseisen J, Boeing H, Hoffmann K, Kasapa C, Orfanou A, Travezea

C, Slimani N, Norat T, Palli D, Pala V, Panico

S, Tumino R, Sacerdote C, Bueno-de-Mesquita Biostatistics and Epidemiology Cluster

Epidemiology Methods and Support Group

HB, Waijers PM, Peeters PH, van der Schouw

YT, Berenguer A, Martinez-Garcia C, Navarro

C, Barricarte A, Dorronsoro M, Berglund G,

Wirfalt E, Johansson I, Johansson G, Bingham

S, Khaw KT, Spencer EA, Key T, Riboli E,

Trichopoulou A (2007) Dietary patterns and

survival of older Europeans: the EPIC-Elderly

Study (European Prospective Investigation into

Cancer and Nutrition) Public Health

Nutr.;10(6):590-598

Berrington de Gonzalez A, Spencer EA,

Bueno-de-Mesquita HB, Roddam A,

Stolzenberg-Solomon R, Halkjaer J,

Tjonneland A, Overvad K, Clavel-Chapelon F,

Boutron-Ruault MC, Boeing H, Pischon T,

Linseisen J, Rohrmann S, Trichopoulou A,

Benetou V, Papadimitriou A, Pala V, Palli D,

Panico S, Tumino R, Vineis P, Boshuizen HC,

Ocke MC, Peeters PH, Lund E, Gonzalez CA,

Larranaga N, Martinez-Garcia C, Mendez M,

Navarro C, Quiros JR, Tormo MJ, Hallmans G,

Ye W, Bingham SA, Khaw KT, Allen N, Key

TJ, Jenab M, Norat T, Ferrari P, Riboli E

(2006) Anthropometry, physical activity, and

the risk of pancreatic cancer in the European

prospective investigation into cancer and

nutrition Cancer Epidemiol Biomarkers

Prev;15(5):879-885.

Boeing H, Dietrich T, Hoffmann K, Pischon T,

Ferrari P, Lahmann PH, Boutron-Ruault MC,

Clavel-Chapelon F, Allen N, Key T, Skeie G,

Lund E, Olsen A, Tjonneland A, Overvad K,

Jensen MK, Rohrmann S, Linseisen J,

Trichopoulou A, Bamia C, Psaltopoulou T,

Weinehall L, Johansson I, Sanchez MJ, Jakszyn

P, Ardanaz E, Amiano P, Chirlaque MD,

Quiros JR, Wirfalt E, Berglund G, Peeters PH,

van Gils CH, Bueno-de-Mesquita HB,

Buchner FL, Berrino F, Palli D, Sacerdote C,

Tumino R, Panico S, Bingham S, Khaw KT,

Slimani N, Norat T, Jenab M, Riboli E (2006).

Intake of fruits and vegetables and risk of

cancer of the upper aero-digestive tract: the

prospective EPIC-study Cancer Causes

Control;17(7):957-969

Bremnes Y, Ursin G, Bjurstam N, Rinaldi S,

Kaaks R, Gram IT (2007) Endogenous sex

hormones, prolactin and mammographic

density in postmenopausal Norwegian women.

Int J Cancer;26 [Epub ahead of print] PMID:

17657735 [PubMed - as supplied by publisher]

Canzian F, McKay JD, Cleveland RJ, Dossus L,

Biessy C, Rinaldi S, Landi S, Boillot C,

Monnier S, Chajes V, Clavel-Chapelon F,

Tehard B, Chang-Claude J, Linseisen J,

Lahmann PH, Pischon T, Trichopoulos D,

Trichopoulou A, Zilis D, Palli D, Tumino R,

Vineis P, Berrino F, Bueno-de-Mesquita HB,

van Gils CH, Peeters PH, Pera G, Ardanaz E,

Chirlaque MD, Quiros JR, Larranaga N,

Martinez-Garcia C, Allen NE, Key TJ,

Bingham SA, Khaw KT, Slimani N, Norat T, Riboli E, Kaaks R (2006) Polymorphisms of genes coding for insulin-like growth factor 1 and its major binding proteins, circulating levels of IGF-I and IGFBP-3 and breast cancer

risk: results from the EPIC study Br J

Cancer;30;94(2): 299-307

Cox DG, Blanche H, Pearce CL, Calle EE, Colditz GA, Pike MC, Albanes D, Allen NE, Amiano P, Berglund G, Boeing H, Buring J, Burtt N, Canzian F, Chanock S, Clavel- Chapelon F, Feigelson HS, Freedman M, Haiman CA, Hankinson SE, Henderson BE, Hoover R, Hunter DJ, Kaaks R, Kolonel L, Kraft

P, LeMarchand L, Lund E, Palli D, Peeters PH, Riboli E, Stram DO, Thun M, Tjonneland A, Trichopoulos D, Yeager M; Breast and Prostate Cancer Cohort Consortium (2006) A comprehensive analysis of the androgen receptor gene and risk of breast cancer: results from the National Cancer Institute Breast and Prostate

Cancer Cohort Consortium (BPC3) Breast

Cancer Res;8(5):R54

Cust AE, Allen NE, Rinaldi S, Dossus L, Friedenreich C, Olsen A, Tjonneland A, Overvad K, Clavel-Chapelon F, Boutron-Ruault

MC, Linseisen J, Chang-Claude J, Boeing H, Schulz M, Benetou V, Trichopoulou A, Trichopoulos D, Palli D, Berrino F, Tumino R, Mattiello A, Vineis P, Quiros JR, Agudo A, Sanchez MJ, Larranaga N, Navarro C, Ardanaz

E, Bueno-de-Mesquita HB, Peeters PH, van Gils CH, Bingham S, Khaw KT, Key T, Slimani

N, Riboli E, Kaaks R (2007) Serum levels of peptide, IGFBP-1 and IGFBP-2 and endometrial cancer risk; results from the European prospective investigation into cancer

C-and nutrition Int J

Cancer;15;120(12):2656-2664.

Cust AE, Kaaks R, Friedenreich C, Bonnet F, Laville M, Lukanova A, Rinaldi S, Dossus L, Slimani N, Lundin E, Tjonneland A, Olsen A, Overvad K, Clavel-Chapelon F, Mesrine S, Joulin V, Linseisen J, Rohrmann S, Pischon T, Boeing H, Trichopoulos D, Trichopoulou A, Benetou V, Palli D, Berrino F, Tumino R, Sacerdote C, Mattiello A, Quiros JR, Mendez

MA, Sanchez MJ, Larranaga N, Tormo MJ, Ardanaz E, Bueno-de-Mesquita HB, Peeters

PH, van Gils CH, Khaw KT, Bingham S, Allen

N, Key T, Jenab M, Riboli E (2007) Plasma adiponectin levels and endometrial cancer risk

in pre- and postmenopausal women J Clin

Endocrinol Metab; 92(1):255-263

Cust AE, Armstrong BK, Friedenreich CM, Slimani N, Bauman A (2007) Physical activity and endometrial cancer risk: a review of the current evidence, biologic mechanisms and the quality of physical activity assessment methods.

Cancer Causes Control 18(3):243-258

Danesh J, Saracci R, Berglund G, Feskens E, Overvad K, Panico S, Thompson S, Fournier A, Clavel-Chapelon F, Canonico M, Kaaks R, Linseisen J, Boeing H, Pischon T, Weikert C, Olsen A, Tjonneland A, Johnsen SP, Jensen

MK, Quiros JR, Svatetz CA, Perez MJ, Larranaga N, Sanchez CN, Iribas CM, Bingham S, Khaw KT, Wareham N, Key T, Roddam A, Trichopoulou A, Benetou V, Trichopoulos D, Masala G, Sieri S, Tumino R, Sacerdote C, Mattiello A, Verschuren WM, Bueno-de-Mesquita HB, Grobbee DE, van der Schouw YT, Melander O, Hallmans G, Wennberg P, Lund E, Kumle M, Skeie G, Ferrari P, Slimani N, Norat T, Riboli E; EPIC- Heart (2007) EPIC-Heart: the cardiovascular component of a prospective study of nutritional, lifestyle and biological factors in 520,000 middle-aged participants from 10 European

countries Eur J Epidemiol.;22(2):129-141

Dechaud H, Denuziere A, Rinaldi S, Bocquet J, Lejeune H, Pugeat M (2007) Age-associated discrepancy between measured and calculated

bioavailable testosterone in men Clin

Chem;53(4):723-728

Engeset D, Alsaker E, Lund E, Welch A, Khaw

KT, Clavel-Chapelon F, Thiebaut A, Chajes V, Key TJ, Allen NE, Amiano P, Dorronsoro M, Tjonneland A, Stripp C, Peeters PH, van Gils

CH, Chirlaque MD, Nagel G, Linseisen J, Ocke

MC, Bueno-de-Mesquita HB, Sacerdote C, Tumino R, Ardanaz E, Sanchez MJ, Panico S, Palli D, Trichopoulou A, Kalapothaki V, Benetou

V, Quiros JR, Agudo A, Overvad K, Bjerregaard

L, Wirfalt E, Schulz M, Boeing H, Slimani N, Riboli E (2006) Fish consumption and breast cancer risk The European Prospective Investigation into Cancer and Nutrition (EPIC).

Int J Cancer;1;119(1):175-182.

Feigelson HS, Cox DG, Cann HM, Wacholder

S, Kaaks R, Henderson BE, Albanes D, Altshuler D, Berglund G, Berrino F, Bingham

S, Buring JE, Burtt NP, Calle EE, Chanock SJ, Clavel-Chapelon F, Colditz G, Diver WR, Freedman ML, Haiman CA, Hankinson SE, Hayes RB, Hirschhorn JN, Hunter D, Kolonel

LN, Kraft P, LeMarchand L, Linseisen J, Modi

W, Navarro C, Peeters PH, Pike MC, Riboli E, Setiawan VW, Stram DO, Thomas G, Thun

MJ, Tjonneland A, Trichopoulos D (2006) Haplotype analysis of the HSD17B1 gene and risk of breast cancer: a comprehensive approach

to multicenter analyses of prospective cohort

studies Cancer Res; 15;66(4):2468-2475.

Ferrari P, Friedenreich C, Matthews CE (2007) The Role of Measurement Error in Estimating

Levels of Physical Activity Am J Epidemiol;

2007 Aug 1; [Epub ahead of print] PMID:

17670910 [PubMed - as supplied by publisher].

Ferrari P, Jenab M, Norat T, Moskal A, Slimani

N, Olsen A, Tjonneland A, Overvad K, Jensen

MK, Boutron-Ruault MC, Rohrmann S,

Linseisen J, Boeing H, Bergmann M,

Kontopoulou D, Trichopoulou A, Kassapa C,

Masala G, Krogh V, Vineis P, Panico S, Tumino

R, Gils CH, Peeters P, Bueno-de-Mesquita

HB, Ocke MC, Skeie G, Lund E, Agudo A,

Ardanaz E, Lopez DC, Sanchez MJ, Quiros JR,

Amiano P, Berglund G, Manjer J, Palmqvist R,

Guelpen BV, Allen N, Key T, Bingham S,

Mazuir M, Boffetta P, Kaaks R, Riboli E,

Clavel-Chapelon F, Morois S (2007).Lifetime

and baseline alcohol intake and risk of colon

and rectal cancers in the European prospective

investigation into cancer and nutrition (EPIC).

Int J Cancer; Jul 19; [Epub ahead of print]

PMID: 17640039 [PubMed - as supplied by

publisher].

Friedenreich C, Cust A, Lahmann PH,

Steindorf K, Boutron-Ruault MC,

Clavel-Chapelon F, Mesrine S, Linseisen J, Rohrmann

S, Pischon T, Schulz M, Tjonneland A, Johnsen

NF, Overvad K, Mendez M, Arguelles MV,

Garcia CM, Larranaga N, Chirlaque MD,

Ardanaz E, Bingham S, Khaw KT, Allen N,

Key T, Trichopoulou A, Dilis V, Trichopoulos

D, Pala V, Palli D, Tumino R, Panico S, Vineis

P, Bueno-de-Mesquita HB, Peeters PH,

Monninkhof E, Berglund G, Manjer J, Slimani

N, Ferrari P, Kaaks R, Riboli E (2007) Physical

activity and risk of endometrial cancer: the

European prospective investigation into cancer

and nutrition Int J Cancer; 15;121(2):347-355.

Friedenreich C, Cust A, Lahmann PH,

Steindorf K, Boutron-Ruault MC,

Clavel-Chapelon F, Mesrine S, Linseisen J, Rohrmann

S, Boeing H, Pischon T, Tjonneland A,

Halkjaer J, Overvad K, Mendez M, Redondo

ML, Garcia CM, Larranaga N, Tormo MJ,

Gurrea AB, Bingham S, Khaw KT, Allen N,

Key T, Trichopoulou A, Vasilopoulou E,

Trichopoulos D, Pala V, Palli D, Tumino R,

Mattiello A, Vineis P, Bueno-de-Mesquita HB,

Peeters PH, Berglund G, Manjer J, Lundin E,

Lukanova A, Slimani N, Jenab M, Kaaks R,

Riboli E (2007) Anthropometric factors and

risk of endometrial cancer: the European

prospective investigation into cancer and

nutrition Cancer Causes Control; 18(4):399-413

Friedenreich C, Norat T, Steindorf K,

Boutron-Ruault MC, Pischon T, Mazuir M,

Clavel-Chapelon F, Linseisen J, Boeing H,

Bergman M, Johnsen NF, Tjonneland A,

Overvad K, Mendez M, Quiros JR, Martinez

C, Dorronsoro M, Navarro C, Gurrea AB,

Bingham S, Khaw KT, Allen N, Key T,

Trichopoulou A, Trichopoulos D, Orfanou N,

Krogh V, Palli D, Tumino R, Panico S, Vineis P,

Bueno-de-Mesquita HB, Peeters PH,

Monninkhof E, Berglund G, Manjer J, Ferrari

P, Slimani N, Kaaks R, Riboli E (2006).

Physical activity and risk of colon and rectal cancers: the European prospective investigation into cancer and nutrition Cancer Epidemiol Biomarkers Prev; 15(12):2398-2407.

Gonzalez CA, Jakszyn P, Pera G, Agudo A, Bingham S, Palli D, Ferrari P, Boeing H, del Giudice G, Plebani M, Carneiro F, Nesi G, Berrino F, Sacerdote C, Tumino R, Panico S, Berglund G, Siman H, Nyren O, Hallmans G, Martinez C, Dorronsoro M, Barricarte A, Navarro C, Quiros JR, Allen N, Key TJ, Day

NE, Linseisen J, Nagel G, Bergmann MM, Overvad K, Jensen MK, Tjonneland A, Olsen

A, Bueno-de-Mesquita HB, Ocke M, Peeters

PH, Numans ME, Clavel-Chapelon F, Boutron-Ruault MC, Trichopoulou A, Psaltopoulou T, Roukos D, Lund E, Hemon B, Kaaks R, Norat T, Riboli E( 2006) Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and

Nutrition (EPIC) J Natl Cancer Inst;

1;98(5):345-354

Gonzalez CA, Pera G, Agudo A, Mesquita HB, Ceroti M, Boeing H, Schulz M, Del Giudice G, Plebani M, Carneiro F, Berrino

Bueno-de-F, Sacerdote C, Tumino R, Panico S, Berglund

G, Siman H, Hallmans G, Stenling R, Martinez C, Dorronsoro M, Barricarte A, Navarro C, Quiros JR, Allen N, Key TJ, Bingham S, Day NE, Linseisen J, Nagel G, Overvad K, Jensen MK, Olsen A, Tjonneland

A, Buchner FL, Peeters PH, Numans ME, Clavel-Chapelon F, Boutron-Ruault MC, Roukos D, Trichopoulou A, Psaltopoulou T, Lund E, Casagrande C, Slimani N, Jenab M, Riboli E (2006).Fruit and vegetable intake and the risk of stomach and oesophagus adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) Int J Cancer;

15;118(10):2559-2566.

Gram IT, Norat T, Rinaldi S, Dossus L, Lukanova A, Tehard B, Clavel-Chapelon F, van Gils CH, van Noord PA, Peeters PH, Bueno- de-Mesquita HB, Nagel G, Linseisen J, Lahmann PH, Boeing H, Palli D, Sacerdote C, Panico S, Tumino R, Sieri S, Dorronsoro M, Quiros JR, Navarro CA, Barricarte A, Tormo

MJ, Gonzalez CA, Overvad K, Paaske Johnsen

S, Olsen A, Tjonneland A, Travis R, Allen N, Bingham S, Khaw KT, Stattin P, Trichopoulou

A, Kalapothaki V, Psaltopoulou T, Casagrande

C, Riboli E, Kaaks R (2006) Body mass index, waist circumference and waist-hip ratio and serum levels of IGF-I and IGFBP-3 in European women. Int J Obes (Lond);

Cohort Nutr Cancer; 58(2):136-145.

Hunt KJ, Lukanova A, Rinaldi S, Lundin E, Norat T, Palmqvist R, Stattin P, Riboli E, Hallmans G, Kaaks R (2006) A potential inverse association between insulin-like growth factor I and hypertension in a cross-sectional

study Ann Epidemiol; 16(7):563-571.

Jakszyn P, Bingham S, Pera G, Agudo A, Luben

R, Welch A, Boeing H, Del Giudice G, Palli D, Saieva C, Krogh V, Sacerdote C, Tumino R, Panico S, Berglund G, Siman H, Hallmans G, Sanchez MJ, Larranaga N, Barricarte A, Chirlaque MD, Quiros JR, Key TJ, Allen N, Lund E, Carneiro F, Linseisen J, Nagel G, Overvad K, Tjonneland A, Olsen A, Bueno-de- Mesquita HB, Ocke MO, Peeters PH, Numans

ME, Clavel-Chapelon F, Trichopoulou A, Fenger C, Stenling R, Ferrari P, Jenab M, Norat

T, Riboli E, Gonzalez CA (2006) Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)

study Carcinogenesis; 27(7):1497-1501.

Jenab M, Riboli E, Cleveland RJ, Norat T, Rinaldi S, Nieters A, Biessy C, Tjonneland A, Olsen A, Overvad K, Gronbaek H, Clavel- Chapelon F, Boutron-Ruault MC, Linseisen J, Boeing H, Pischon T, Trichopoulos D, Oikonomou E, Trichopoulou A, Panico S, Vineis P, Berrino F, Tumino R, Masala G, Peters PH, van Gils CH, Bueno-de-Mesquita

HB, Ocke MC, Lund E, Mendez MA, Tormo

MJ, Barricarte A, Martinez-Garcia C, Dorronsoro M, Quiros JR, Hallmans G, Palmqvist R, Berglund G, Manjer J, Key T, Allen NE, Bingham S, Khaw KT, Cust A, Kaaks R (2007) Serum C-peptide, IGFBP-1 and IGFBP-2 and risk of colon and rectal cancers in the European Prospective

Investigation into Cancer and Nutrition Int J

Cancer 15;121(2):368-376

Jenab M, Riboli E, Ferrari P, Sabate J, Slimani

N, Norat T, Friesen M, Tjonneland A, Olsen A, Overvad K, Boutron-Ruault MC, Clavel- Chapelon F, Touvier M, Boeing H, Schulz M, Linseisen J, Nagel G, Trichopoulou A, Naska

A, Oikonomou E, Krogh V, Panico S, Masala

G, Sacerdote C, Tumino R, Peeters PH, Numans ME, Bueno-de-Mesquita HB, Buchner FL, Lund E, Pera G, Sanchez CN, Sanchez MJ, Arriola L, Barricarte A, Quiros JR, Hallmans G, Stenling R, Berglund G, Bingham

S, Khaw KT, Key T, Allen N, Carneiro F, Mahlke U, Del Giudice G, Palli D, Kaaks R, Gonzalez CA (2006) Plasma and dietary vitamin C levels and risk of gastric cancer in the European Prospective Investigation into Biostatistics and Epidemiology Cluster

Epidemiology Methods and Support Group Cancer and Nutrition (EPIC-EURGAST).

Carcinogenesis; 27(11):2250-2257.

Kaaks R, Ferrari P (2006) Dietary intake

assessments in epidemiology: can we know

what we are measuring? Ann Epidemiol;

16(5):377-380

Linseisen J, Rohrmann S, Miller AB,

Bueno-de-Mesquita HB, Buchner FL, Vineis P, Agudo

A, Gram IT, Janson L, Krogh V, Overvad K,

Rasmuson T, Schulz M, Pischon T, Kaaks R,

Nieters A, Allen NE, Key TJ, Bingham S,

Khaw KT, Amiano P, Barricarte A, Martinez C,

Navarro C, Quiros R, Clavel-Chapelon F,

Boutron-Ruault MC, Touvier M, Peeters PH,

Berglund G, Hallmans G, Lund E, Palli D,

Panico S, Tumino R, Tjonneland A, Olsen A,

Trichopoulou A, Trichopoulos D, Autier P,

Boffetta P, Slimani N, Riboli E (2007) Fruit and

vegetable consumption and lung cancer risk:

Updated information from the European

Prospective Investigation into Cancer and

Nutrition (EPIC) Int J Cancer

121(5):1103-1114

Linseisen J, Rohrmann S, Norat T, Gonzalez

CA, Dorronsoro Iraeta M, Morote Gomez P,

Chirlaque MD, Pozo BG, Ardanaz E,

Mattisson I, Pettersson U, Palmqvist R, Van

Guelpen B, Bingham SA, McTaggart A,

Spencer EA, Overvad K, Tjonneland A, Stripp

C, Clavel-Chapelon F, Kesse E, Boeing H,

Klipstein-Grobusch K, Trichopoulou A,

Vasilopoulou E, Bellos G, Pala V, Masala G,

Tumino R, Sacerdote C, Del Pezzo M,

Bueno-de-Mesquita HB, Ocke MC, Peeters PH,

Engeset D, Skeie G, Slimani N, Riboli E (2006).

Dietary intake of different types and

characteristics of processed meat which might be

associated with cancer risk—results from the

24-hour diet recalls in the European Prospective

Investigation into Cancer and Nutrition (EPIC).

Public Health Nutr; 9(4):449-464

Lukanova A, Bjor O, Kaaks R, Lenner P,

Lindahl B, Hallmans G, Stattin P (2006) Body

mass index and cancer: results from the

Northern Sweden Health and Disease C ohort.

Int J Cancer; 15;118(2):458-466

Ma M, Pera G, Agudo A, Bueno-de-Mesquita

HB, Palli D, Boeing H, Carneiro F, Berrino F,

Sacerdote C, Tumino R, Panico S, Berglund G,

Manjer J, Johansson I, Stenling R, Martinez C,

Dorronsoro M, Barricarte A, Tormo MJ,

Quiros JR, Allen N, Key TJ, Bingham S,

Linseisen J, Kaaks R, Overvad K, Jensen M,

Olsen A, Tjonneland A, Peeters PH, Numans

ME, Ocke MC, Clavel-Chapelon F,

Boutron-Ruault MC, Trichopoulou A, Lund E, Slimani

N, Jenab M, Ferrari P, Riboli E, Gonzalez CA.

(2007) Cereal fiber intake may reduce risk of

gastric adenocarcinomas: The

EPIC-EURGAST study Int J Cancer.; [Epub ahead

of print] PMID: 17582605 [PubMed - as supplied by publisher].

Manuguerra M, Matullo G, Veglia F, Autrup

H, Dunning AM, Garte S, Gormally E, Malaveille C, Guarrera S, Polidoro S, Saletta F, Peluso M, Airoldi L, Overvad K, Raaschou- Nielsen O, Clavel-Chapelon F, Linseisen J, Boeing H, Trichopoulos D, Kalandidi A, Palli D, Krogh V, Tumino R, Panico S, Bueno-De- Mesquita HB, Peeters PH, Lund E, Pera G, Martinez C, Amiano P, Barricarte A, Tormo MJ, Quiros JR, Berglund G, Janzon L, Jarvholm B, Day NE, Allen NE, Saracci R, Kaaks R, Ferrari

P, Riboli E, Vineis P (2007) Multi-factor dimensionality reduction applied to a large prospective investigation on gene-gene and

gene-environment interactions Carcinogenesis;

28(2):414-422 Epub 2006 Sep 6.

Maskarinec G, Takata Y, Chen Z, Gram IT, Nagata C, Pagano I, Hayashi K, Arendell L, Skeie G, Rinaldi S, Kaaks R (2007) IGF-I and mammographic density in four geographic

locations: A pooled analysis Int J Cancer; 22;

[Epub ahead of print] PMID: 17520679 [PubMed - as supplied by publisher].

McKay JD, Kaaks R, Johansson M, Biessy C, Wiklund F, Balter K, Adami HO, Boillot C, Gioia-Patricola L, Canzian F, Stattin P, Gronberg H (2007) Haplotype-based analysis

of common variation in the growth hormone

receptor gene and prostate cancer risk Cancer

Epidemiol Biomarkers Prev; 16(1):169-173

Moskal A, Norat T, Ferrari P, Riboli E (2007) Alcohol intake and colorectal cancer risk: a dose-response meta-analysis of published

cohort studies Int J Cancer;1;120(3):664-671.

Nagel G, Linseisen J, Boshuizen HC, Pera G, Del Giudice G, Westert GP, Bueno-de- Mesquita HB, Allen NE, Key TJ, Numans ME, Peeters PH, Sieri S, Siman H, Berglund G, Hallmans G, Stenling R, Martinez C, Arriola

L, Barricarte A, Chirlaque MD, Quiros JR, Vineis P, Masala G, Palli D, Panico S, Tumino

R, Bingham S, Boeing H, Bergmann MM, Overvad K, Boutron-Ruault MC, Clavel- Chapelon F, Olsen A, Tjonneland A, Trichopoulou A, Bamia C, Soukara S, Sabourin

JC, Carneiro F, Slimani N, Jenab M, Norat T, Riboli E, Gonzalez CA (2007) Socioeconomic position and the risk of gastric and oesophageal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST).

Int J Epidemiol; 36(1):66-76

Norat T, Dossus L, Rinaldi S, Overvad K, Gronbaek H, Tjonneland A, Olsen A, Clavel- Chapelon F, Boutron-Ruault MC, Boeing H, Lahmann PH, Linseisen J, Nagel G, Trichopoulou A, Trichopoulos D, Kalapothaki

V, Sieri S, Palli D, Panico S, Tumino R, Sacerdote C, Bueno-de-Mesquita HB, Peeters

PH, van Gils CH, Agudo A, Amiano P, Ardanoz E, Martinez C, Quiros R, Tormo MJ, Bingham S, Key TJ, Allen NE, Ferrari P, Slimani N, Riboli E, Kaaks R (2007) Diet, serum insulin-like growth factor-I and IGF-

binding protein-3 in European women Eur J

Clin Nutr; 61(1):91-98

Orfanos P, Naska A, Trichopoulos D, Slimani

N, Ferrari P, van Bakel M, Deharveng G, Overvad K, Tjonneland A, Halkjaer J, Santucci

de Magistris M, Tumino R, Pala V, Sacerdote

C, Masala G, Skeie G, Engeset D, Lund E, Jakszyn P, Barricarte A, Chirlaque MD, Martinez-Garcia C, Amiano P, Quiros JR, Bingham S, Welch A, Spencer EA, Key TJ, Rohrmann S, Linseisen J, Ray J, Boeing H, Peeters PH, Bueno-de-Mesquita HB, Ocke M, Johansson I, Johansson G, Berglund G, Manjer

J, Boutron-Ruault MC, Touvier M, Chapelon F, Trichopoulou A (2007) Eating out

Clavel-of home and its correlates in 10 European countries The European Prospective Investigation into Cancer and Nutrition

(EPIC) study Public Health Nutr; 21:1-11.

Palli D, Masala G, Del Giudice G, Plebani M, Basso D, Berti D, E Numans M, Ceroti M, Peeters PH, de Mesquita HB, Buchner FL, Clavel-Chapelon F, Boutron-Ruault MC, Krogh V, Saieva C, Vineis P, Panico S, Tumino

R, Nyren O, Siman H, Berglund G, Hallmans

G, Sanchez MJ, Larranaga N, Barricarte A, Navarro C, Quiros JR, Key T, Allen N, Bingham S, Khaw KT, Boeing H, Weikert C, Linseisen J, Nagel G, Overvad K, Thomsen

RW, Tjonneland A, Olsen A, Trichoupoulou A, Trichopoulos D, Arvaniti A, Pera G, Kaaks R, Jenab M, Ferrari P, Nesi G, Carneiro F, Riboli

E, Gonzalez CA (2007) CagA+ Helicobacter pylori infection and gastric cancer risk in the

EPIC-EURGAST study Int J Cancer;

15;120(4):859-867.

Peeters PH, Slimani N, van der Schouw YT, Grace PB, Navarro C, Tjonneland A, Olsen A, Clavel-Chapelon F, Touillaud M, Boutron- Ruault MC, Jenab M, Kaaks R, Linseisen J, Trichopoulou A, Trichopoulos D, Dilis V, Boeing H, Weikert C, Overvad K, Pala V, Palli

D, Panico S, Tumino R, Vineis P, Mesquita HB, van Gils CH, Skeie G, Jakszyn P, Hallmans G, Berglund G, Key TJ, Travis R, Riboli E, Bingham SA (2007) Variations in plasma phytoestrogen concentrations in

Bueno-de-European adults J Nutr; 137(5):1294-1300

Peeters PH, Lukanova A, Allen N, Berrino F, Key T, Dossus L, Rinaldi S, van Gils CH, Bueno-de-Mesquita HB, Boeing H, Schulz M, Chang-Claude J, Linseisen J, Panico S, Sacerdote

C, Palli D, Tumino R, Trichopoulou A, Trichopolos D, Bamia C, Larranaga N, Ardanaz

E, Pera G, Quiros JR, Martinez-Garcia C, Navarro C, Bingham SA, Khaw KT, Clavel F,

Tjonneland A, Olsen A, Overvad K, Tetsche

MS, Lund E, Lundin E, Berglund G, Riboli E,

Kaaks R (2007) Serum IGF-I, its major binding

protein (IGFBP-3) and epithelial ovarian cancer

risk: the European Prospective Investigation into

Cancer and Nutrition (EPIC) Endocr Relat

Cancer; 14(1):81-90.

Pischon T, Lahmann PH, Boeing H,

Friedenreich C, Norat T, Tjonneland A, Halkjaer

J, Overvad K, Clavel-Chapelon F,

Boutron-Ruault MC, Guernec G, Bergmann MM,

Linseisen J, Becker N, Trichopoulou A,

Trichopoulos D, Sieri S, Palli D, Tumino R,

Vineis P, Panico S, Peeters PH,

Bueno-de-Mesquita HB, Boshuizen HC, Van Guelpen B,

Palmqvist R, Berglund G, Gonzalez CA,

Dorronsoro M, Barricarte A, Navarro C,

Martinez C, Quiros JR, Roddam A, Allen N,

Bingham S, Khaw KT, Ferrari P, Kaaks R,

Slimani N, Riboli E (2006) Body size and risk of

colon and rectal cancer in the European

Prospective Investigation Into Cancer and

Nutrition (EPIC) J Natl Cancer Inst;

5;98(13):920-931.

Pischon T, Lahmann PH, Boeing H,

Tjonneland A, Halkjaer J, Overvad K,

Klipstein-Grobusch K, Linseisen J, Becker N,

Trichopoulou A, Benetou V, Trichopoulos D,

Sieri S, Palli D, Tumino R, Vineis P, Panico S,

Monninkhof E, Peeters PH,

Bueno-de-Mesquita HB, Buchner FL, Ljungberg B,

Hallmans G, Berglund G, Gonzalez CA,

Dorronsoro M, Gurrea AB, Navarro C,

Martinez C, Quiros JR, Roddam A, Allen N,

Bingham S, Khaw KT, Kaaks R, Norat T,

Slimani N, Riboli E (2006) Body size and risk

of renal cell carcinoma in the European

Prospective Investigation into Cancer and

Nutrition (EPIC).Int J Cancer;118(3):728-738

Reeves GK, Kan SW, Key T, Tjonneland A,

Olsen A, Overvad K, Peeters PH,

Clavel-Chapelon F, Paoletti X, Berrino F, Krogh V,

Palli D, Tumino R, Panico S, Vineis P,

Gonzalez CA, Ardanaz E, Martinez C,

Amiano P, Quiros JR, Tormo MR, Khaw KT,

Trichopoulou A, Psaltopoulou T, Kalapothaki

V, Nagel G, Chang-Claude J, Boeing H,

Lahmann PH, Wirfalt E, Kaaks R, Riboli E.

(2006) Breast cancer risk in relation to

abortion: Results from the EPIC study Int J

Cancer; 1;119(7):1741-1745.

Rinaldi S, Dossus L, Lukanova A, Peeters PH,

Allen NE, Key T, Bingham S, Khaw KT,

Trichopoulos D, Trichopoulou A, Oikonomou

E, Pera G, Larranaga N, Martinez-Garcia C,

Ardanaz E, Quiros JR, Tormo MJ, Tjonneland

A, Olsen A, Overvad K, Chang-Claude J,

Linseisen J, Schulz M, Boeing H, van Gils CH,

Bueno-de-Mesquita BH, Pala V, Palli D,

Panico S, Tumino R, Vineis P, Clavel-Chapelon

F, Mesrine S, Boutron-Ruault MC, Lundin E,

Agren A, Berglund G, Manjer J, Kumle M, Lund E, Slimani N, Saracci R, Riboli E, Kaaks

R (2007) Endogenous androgens and risk of epithelial ovarian cancer: results from the European Prospective Investigation into

Cancer and Nutrition (EPIC) Cancer

Epidemiol Biomarkers Prev; 16(1):23-29.

Rinaldi S, Key TJ, Peeters PH, Lahmann PH, Lukanova A, Dossus L, Biessy C, Vineis P, Sac- erdote C, Berrino F, Panico S, Tumino R, Palli

D, Nagel G, Linseisen J, Boeing H, Roddam A, Bingham S, Khaw KT, Chloptios J, Tri- chopoulou A, Trichopoulos D, Tehard B, Clavel-Chapelon F, Gonzalez CA, Larranaga

N, Barricarte A, Quiros JR, Chirlaque MD, Martinez C, Monninkhof E, Grobbee DE, Bueno-de-Mesquita HB, Ferrari P, Slimani N, Riboli E, Kaaks R (2006) Anthropometric measures, endogenous sex steroids and breast cancer risk in postmenopausal women: a study

within the EPIC cohort Int J Cancer;

M, Kyriazi G, Thrichopoulou A, ault MC, Clavel-Chapelon F, Ferrari P, Slimani

Boutron-Ru-N, Saracci R, Riboli E, Kaaks R (2006) tionship of alcohol intake and sex steroid con- centrations in blood in pre- and post-menopausal women: the European Prospective Investigation into Cancer and Nu-

Rela-trition Cancer Causes Control; 17(8):1033-1043

Rinaldi S, Peeters PH, Berrino F, Dossus L, Biessy C, Olsen A, Tjonneland A, Overvad K, Clavel-Chapelon F, Boutron-Ruault MC, Tehard B, Nagel G, Linseisen J, Boeing H, Lahmann PH, Trichopoulou A, Trichopoulos

D, Koliva M, Palli D, Panico S, Tumino R, erdote C, van Gils CH, van Noord P, Grobbee

Sac-DE, Bueno-de-Mesquita HB, Gonzalez CA, Agudo A, Chirlaque MD, Barricarte A, Lar- ranaga N, Quiros JR, Bingham S, Khaw KT, Key T, Allen NE, Lukanova A, Slimani N, Saracci R, Riboli E, Kaaks R (2006) IGF-I, IGFBP-3 and breast cancer risk in women: The European Prospective Investigation into Can-

cer and Nutrition (EPIC) Endocr Relat Cancer;

13(2):593-605.

Rohrmann S, Becker N, Linseisen J, Nieters A, Rudiger T, Raaschou-Nielsen O, Tjonneland A, Johnsen HE, Overvad K, Kaaks R, Bergmann

MM, Boeing H, Benetou V, Psaltopoulou T, Trichopoulou A, Masala G, Mattiello A, Krogh

V, Tumino R, van Gils CH, Peeters PH, Bueno-de-Mesquita HB, Ros MM, Lund E,

Ardanaz E, Chirlaque MD, Jakszyn P, ranaga N, Losada A, Martinez-Garcia C, Agren A, Hallmans G, Berglund G, Manjer J, Allen NE, Key TJ, Bingham S, Khaw KT, Sli- mani N, Ferrari P, Boffetta P, Norat T, Vineis P, Riboli E (2007) Fruit and vegetable consump- tion and lymphoma risk in the European Prospective Investigation into Cancer and Nu-

Lar-trition (EPIC) Cancer Causes Control;

18(5):537-549.

Rohrmann S, Linseisen J, Boshuizen HC, Whittaker J, Agudo A, Vineis P, Boffetta P, Jensen MK, Olsen A, Overvad K, Tjonneland

A, Boutron-Ruault MC, Clavel-Chapelon F, Bergmann MM, Boeing H, Allen N, Key T, Bingham S, Khaw KT, Kyriazi G, Soukara S, Trichopoulou A, Panico S, Palli D, Sieri S, Tumino R, Peeters PH, Bueno-de-Mesquita

HB, Buchner FL, Gram IT, Lund E, Ardanaz

E, Chirlaque MD, Dorronsoro M, Perez MJ, Quiros JR, Berglund G, Janzon L, Rasmuson T, Weinehall L, Ferrari P, Jenab M, Norat T, Riboli

E (2006) Ethanol intake and risk of lung cancer in the European Prospective Investigation into Cancer and Nutrition

(EPIC) Am J Epidemiol 1;164(11):1103-1114.

Schulz M, Nothlings U, Allen N, Moret NC, Agnoli C, Engeset D, Galasso R, Wirfalt E, Tjonneland A, Olsen A, Overvad K, Boutron-Ruault MC, Chajes V, Clavel- Chapelon F, Ray J, Hoffmann K, Chang-Claude J, Kaaks R, Trichopoulos D, Georgila C, Zourna P, Palli D, Berrino F, Tumino R, Vineis P, Panico S, Bueno-de- Mesquita HB, Ocke MC, Peeters PH, Lund E, Gram IT, Skeie G, Berglund G, Lundin E, Hallmans G, Gonzalez CA, Quiros JR, Dorronsoro M, Martinez C, Tormo MJ, Barricarte A, Bingham S, Khaw KT, Key TJ, Jenab M, Rinaldi S, Slimani N, Riboli E ( 2007) No association of consumption of animal

Onland-foods with risk of ovarian cancer Cancer

Epidemiol Biomarkers Prev; 16(4):852-855.

Sinilnikova OM, McKay JD, Tavtigian SV, Canzian F, DeSilva D, Biessy C, Monnier S, Dossus L, Boillot C, Gioia L, Hughes DJ, Jensen MK, Overvad K, Tjonneland A, Olsen

A, Clavel-Chapelon F, Chajes V, Joulin V, Linseisen J, Chang-Claude J, Boeing H, Dahm

S, Trichopoulou A, Trichopoulos D, Koliva M, Khaw KT, Bingham S, Allen NE, Key T, Palli

D, Panico S, Berrino F, Tumino R, Vineis P, Bueno-de-Mesquita HB, Peeters PH, van Gils

CH, Lund E, Pera G, Quiros JR, Dorronsoro

M, Martinez Garcia C, Tormo MJ, Ardanaz E, Hallmans G, Lenner P, Berglund G, Manjer J, Riboli E, Lenoir GM, Kaaks R (2007).Haplotype-based analysis of common variation in the acetyl-coA carboxylase alpha gene and breast cancer risk: a case-control study nested within the European Prospective Biostatistics and Epidemiology Cluster

Epidemiology Methods and Support Group

Investigation into Cancer and Nutrition Cancer

Epidemiol Biomarkers Prev; 16(3):409-415.

Slimani N, Deharveng G, Unwin I, Southgate

DA, Vignat J, Skeie G, Salvini S, Parpinel M,

Moller A, Ireland J, Becker W, Farran A,

West-enbrink S, Vasilopoulou E, Unwin J,

Borge-jordet A, Rohrmann S, Church S, Gnagnarella

P, Casagrande C, van Bakel M, Niravong M,

Boutron-Ruault MC, Stripp C, Tjonneland A,

Trichopoulou A, Georga K, Nilsson S,

Mattis-son I, Ray J, Boeing H, Ocke M, Peeters PH,

Jakszyn P, Amiano P, Engeset D, Lund E,

San-tucci de Magistris M, Sacerdote C, Welch A,

Bingham S, Subar AF, Riboli E (2007) The

EPIC nutrient database project (ENDB): a first

attempt to standardize nutrient databases across

the 10 European countries participating in the

EPIC study Eur J Clin Nutr; 21; [Epub ahead

of print] PMID: 17375121 [PubMed - as

sup-plied by publisher].

Stattin P, Bjor O, Ferrari P, Lukanova A,

Lenner P, Lindahl B, Hallmans G, Kaaks R

(2007) Prospective study of hyperglycemia and

cancer risk Diabetes Care; 30(3):561-567.

Steindorf K, Friedenreich C, Linseisen J,

Rohrmann S, Rundle A, Veglia F, Vineis P,

Johnsen NF, Tjonneland A, Overvad K,

Raaschou-Nielsen O, Clavel-Chapelon F,

Boutron-Ruault MC, Schulz M, Boeing H,

Trichopoulou A, Kalapothaki V, Koliva M,

Krogh V, Palli D, Tumino R, Panico S,

Mon-ninkhof E, Peeters PH, Boshuizen HC,

Bueno-de-Mesquita HB, Chirlaque MD, Agudo A,

Larranaga N, Quiros JR, Martinez C,

Barri-carte A, Janzon L, Berglund G, Bingham S,

Khaw KT, Key TJ, Norat T, Jenab M, Cust A,

Riboli E (2006).Physical activity and lung

can-cer risk in the European Prospective

Investiga-tion into Cancer and NutriInvestiga-tion Cohort Int J

Cancer; 15;119(10):2389-2397

Stocks T, Lukanova A, Rinaldi S, Biessy C,

Dossus L, Lindahl B, Hallmans G, Kaaks R,

Stattin P (2007) Insulin resistance is inversely

related to prostate cancer: a prospective study

in Northern Sweden. Int J Cancer;

15;120(12):2678-2686.

Takata Y, Maskarinec G, Rinaldi S, Kaaks R,

Nagata C (2006) Serum insulin-like growth

factor-I levels among women in Hawaii and

Japan with different levels of tofu intake Nutr

Cancer; 56(2):136-142

Tjonneland A, Christensen J, Olsen A, Stripp

C, Thomsen BL, Overvad K, Peeters PH, van

Gils CH, Bueno-de-Mesquita HB, Ocke MC,

Thiebaut A, Fournier A, Clavel-Chapelon F,

Berrino F, Palli D, Tumino R, Panico S, Vineis

P, Agudo A, Ardanaz E, Martinez-Garcia C,

Amiano P, Navarro C, Quiros JR, Key TJ,

Reeves G, Khaw KT, Bingham S, Trichopoulou

A, Trichopoulos D, Naska A, Nagel G, Claude J, Boeing H, Lahmann PH, Manjer J, Wirfalt E, Hallmans G, Johansson I, Lund E, Skeie G, Hjartaker A, Ferrari P, Slimani N, Kaaks R, Riboli E (2007) Alcohol intake and breast cancer risk: the European Prospective Investigation into Cancer and Nutrition

Chang-(EPIC) Cancer Causes Control; 18(4):361-373.

Travis RC, Key TJ, Allen NE, Appleby PN, Roddam AW, Rinaldi S, Egevad L, Gann PH, Rohrmann S, Linseisen J, Pischon T, Boeing H, Johnsen NF, Tjonneland A, Overvad K, Kiemeney L, Bueno-de-Mesquita HB, Bingham S, Khaw KT, Tumino R, Sieri S, Vineis P, Palli D, Quiros JR, Ardanaz E, Chirlaque MD, Larranaga N, Gonzalez C, Sanchez MJ, Trichopoulou A, Bikou C, Trichopoulos D, Stattin P, Jenab M, Ferrari P, Slimani N, Riboli E, Kaaks R (2007) Serum androgens and prostate cancer among 643 cases and 643 controls in the European Prospective

Investigation into Cancer and Nutrition Int J

Cancer 2007 May 18; [Epub ahead of print]

PMID: 17514649 [PubMed - as supplied by publisher].

Verheus M, Peeters PH, Rinaldi S, Dossus L, Biessy C, Olsen A, Tjonneland A, Overvad K, Jeppesen M, Clavel-Chapelon F, Tehard B, Nagel G, Linseisen J, Boeing H, Lahmann PH, Arvaniti A, Psaltopoulou T, Trichopoulou A, Palli D, Tumino R, Panico S, Sacerdote C, Sieri

S, van Gils CH, Bueno-de-Mesquita BH, Gonzalez CA, Ardanaz E, Larranaga N, Garcia

CM, Navarro C, Quiros JR, Key T, Allen N, Bingham S, Khaw KT, Slimani N, Riboli E, Kaaks R (2006) Serum C-peptide levels and breast cancer risk: results from the European Prospective Investigation into Cancer and

Nutrition (EPIC) Int J Cancer;

1;119(3):659-667

Vineis P, Hoek G, Krzyzanowski M, Taglianti F, Veglia F, Airoldi L, Autrup H, Dunning A, Garte S, Hainaut P, Malaveille C, Matullo G, Overvad K, Raaschou-Nielsen O, Clavel-Chapelon F, Linseisen J, Boeing H, Trichopoulou A, Palli D, Peluso M, Krogh V, Tumino R, Panico S, Bueno-De-Mesquita HB, Peeters PH, Lund EE, Gonzalez CA, Martinez

Vigna-C, Dorronsoro M, Barricarte A, Cirera L, Quiros JR, Berglund G, Forsberg B, Day NE, Key TJ, Saracci R, Kaaks R, Riboli E (2006).

Air pollution and risk of lung cancer in a

prospective study in Europe Int J Cancer;

1;119(1):169-174.

Waijers PM, Ocke MC, van Rossum CT, Peeters

PH, Bamia C, Chloptsios Y, van der Schouw YT, Slimani N, Bueno-de-Mesquita HB (2006).

Dietary patterns and survival in older Dutch

women Am J Clin Nutr; 83(5):1170-1176.

Weikert S, Boeing H, Pischon T, Olsen A, Tjonneland A, Overvad K, Becker N, Linseisen

J, Lahmann PH, Arvaniti A, Kassapa C, Trichoupoulou A, Sieri S, Palli D, Tumino R, Vineis P, Panico S, van Gils CH, Peeters PH, Bueno-de-Mesquita HB, Buchner FL, Ljungberg B, Hallmans G, Berglund G, Wirfalt

E, Pera G, Dorronsoro M, Gurrea AB, Navarro

C, Martinez C, Quiros JR, Allen N, Roddam

A, Bingham S, Jenab M, Slimani N, Norat T, Riboli E (2006) Fruits and vegetables and renal cell carcinoma: findings from the European prospective investigation into cancer and

nutrition (EPIC) Int J Cancer;

15;118(12):3133-3139

Weiss JM, Huang WY, Rinaldi S, Fears TR, Chatterjee N, Chia D, Crawford ED, Kaaks R, Hayes RB (2007) IGF-1 and IGFBP-3: Risk

of prostate cancer among men in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial Int J Cancer 27; [Epub ahead

of print]

Wiren S, Stocks T, Rinaldi S, Hallmans G, Bergh A, Stenman UH, Kaaks R, Stattin P (2007) Androgens and prostate cancer risk:

A prospective study Prostate

1;67(11):1230-1237.

Zeleniuch-Jacquotte A, Lundin E, Micheli A, Koenig KL, Lenner P, Muti P, Shore RE, Johansson I, Krogh V, Lukanova A, Stattin P, Afanasyeva Y, Rinaldi S, Arslan AA, Kaaks R, Berrino F, Hallmans G, Toniolo P, Adlercreutz

H (2006) Circulating enterolactone and risk of

endometrial cancer Int J Cancer;

15;119(10):2376-2381

Books (written and edited)

IARC Working group on risk of skin cancer and exposure to artificial light, Autier P, Boniol

M, Boyle P, Daniel J, Dore JF, Gandini S, Green

A, Newton-Bishop J, Weinstock MA,

Westerdahl J, Secretan B, Walter SD Exposure

to artificial UV radiation and skin cancer IARC

Working Group Reports Volume 1, Lyon, 2006, IARC.

Book Chapters

Boniol M, Doré JF, Autier P, Smans M, Boyle

P Descriptive epidemiology of skin cancer

incidence and mortality pp 203-223 In Skin

Cancer Prevention, Ringborg U, Brandberg Y,

Breitbart EW, Greinert R, eds., Informa healthcare 2007.

Doré JF, Boniol M, Chignol MC, Autier P The

usefulness of sunscreens pp 241-278 In Skin

Cancer Prevention, Ringborg U, Brandberg Y,

Breitbart EW, Greinert R, eds., Informa healthcare 2007.

The DEA Group, created in the spring of

2006, has the objective to make the best

use of all existing descriptive epidemiology

data to develop better hypotheses on the

etiology of cancer, to report on the

development of prevention and screening

activities and efficacy of treatments

The overall objective of the Group is to

develop a comprehensive program of

activities on the creation of appropriate

statistical methodology for the analysis of

descriptive epidemiology data; to apply

statistical methods to the analysis of

available incidence and mortality data; to

provide assistance in data analysis to

Cancer Registries and Vital Statistics

Offices worldwide; to provide

interpretation of the available data and the

data analyses for the development of

priority hypotheses, and finally to work

with appropriate Teams and Groups

within IARC and external bodies to

develop and undertake appropriate

etiological studies

One of the major projects of the Group

during this biennium was the EC-funded

Eurocan+Plus Project, initiated to propose

a solution to the problem of fragmentation

and lack of sustainability in the cancer

research domain Eurocan+Plus, which

involves almost 300 participantsthroughout the EU and seeks the views ofall stakeholders in the cancer researchcommunity, is designed to identify barriers

to collaboration in research andrecommend methods of overcoming thesehurdles to improve cancer research inEurope Achieving this goal will bringabout real progress in cancer control andallow Europe to move beyond what iscurrently possible within our currentknowledge situation It will also havepositive effects on the efficient use ofresources, quality of cancer research, quality

of patient care, the attractiveness of Europefor the biomedical industry and theorganisation of education for doctors andresearchers

The Project has identified the mainbarriers to collaboration and the areas thatwould most benefit from coordination andbelieves that the best way to overcomethese barriers is the formation of a lightbut permanent European Cancer Initiative,which will mainly serve to do thefollowing:

1) Provide proactive leadership in thecancer research community,

2) Be an information exchange portal,

3) Manage networks active in cancerresearch,

4) Give guidance for translational, clinicaland epidemiological research,

5) Be a “one-stop shop” as a contactinterface with industry, and

6) Arrange targeted funding for projectsthat need rapid attention

The European Cancer Initiative will beformed to work with existing structures tomonitor, advise, and coordinate Europeancancer research

The final results of the two years ofstudies will be presented at the FinalGeneral Assembly of the Project inNovember 2007, and the Project will end

at the end of 2007 For more information,and for the results of the investigationwhen they become available, visit theProject website, www.eurocanplus.eu Thisproject was transferred to the BIO Group

in 2007

The Group is composed of two teams,the Cancer Intelligence Team (CIT) andthe Descriptive Epidemiology AnalysisTeam The goal of CIT is to describe andinterpret cancer incidence and mortalitydata, in close collaboration with the DEPGroup A specific focus of this team is the

Data Analysis and Interpretation Group (DEA)

Head

Dr Hai-Rim Shin (since July 2007)

Dr Philippe Autier (Head between

March 2006 and January 2007, acting

between January 2007 and July 2007)

epidemiology of childhood cancer, within

several on-going studies The database of

the Automated Childhood Cancer

Information System (ACCIS) has been

explored in a series of articles on survival of

children with cancer, using a novel method

of period survival Looking for causes of

childhood cancer is the objective of

another study, initially limited to Wilms’

tumour Finally, the late effects of

childhood cancer are studied in

collaboration with the team from the

childhood cancer registry of Rhône-Alpes

The expertise in the descriptive epidemiology

of childhood cancer has also contributed to

the international programme My Child

Matters, organised by the UICC and

devoted to improving the understanding and

management of childhood cancer in selected

low-resource countries

The Descriptive Epidemiology

Analysis Team aims to analyse temporal

trends and gather additional descriptive

information about these trends to allow a

better interpretation of the reasons for

temporal changes in incidence and

mortality Thyroid, kidney, bladder and

oesophageal cancers have been studied

with a special emphasis on Europe The

estimation of the burden of cancer is also

an important project for the team, and

regular results for Europe (2004 and 2006)

have already been published The

GLOBOCAN estimates will be updatedwhen the data from CI5 Vol IX arepublished

A secondary goal is to improveaccessibility to and comprehension of thisinformation by the general public Thisteam works on understanding what theraw statistics mean and turning thisinformation into a format that is clear tothe layperson An Internet-basedapplication has been developed by thegroup to present the latest incidence datafrom CI5 Vol IX In collaboration withthe Association of the Nordic CancerRegistries (ANCR), the NORDCAN webapplication has been launched(http://www-dep.iarc.fr/NORDCAN.htm)

It provides access to the most up-to-dateinformation on the incidence, mortalityand prevalence of cancer in the five Nordiccountries This expertise in the datapresentation of epidemiological material to

a large audience will be used to update the

CANCERMondial web site

Another ongoing project of the Group

is on the analysis of temporal–spatialtrends in breast cancer incidence andmortality Since 1985, considerablechanges have taken place in the earlydetection and treatment of breast cancer

Description of incidence or mortalitytrends across a long period of time couldgive us information on how these changes

may have affected the burden of breastcancer Initial analyses and trends have beencalculated in collaboration with theEuropean Cancer Network and thesemethods and analyses will be applied to thesame kind of study of breast cancer in Asia.The Group also set up a WorkingGroup on UV Radiation, which released aposition paper in 2006

Group members have attendeddifferent meetings, including PACT(Program of Action for Cancer Therapy)meetings in Viet Nam organized by theIAEA (International Agency for AtomicEnergy, Vienna); a Symposium on breastcancer, The Lancet Asia Medical Forum,

as well as the 8th Forum for CancerControl Strategy in Seoul, Korea, the 24thAnnual International PapillomavirusConference in Beijing, the SIOP congress(Geneva 2006), and the Frenchparliamentary meeting ‘Alcohol andPrevention’ (Paris 2006)

Since December 2006, DEA hascontributed significantly to the activities ofthe International Association of CancerRegistries (IACR), facilitated by EvaSteliarova-Foucher in the office ofExecutive Secretary of the Association.The IACR activities are described in moredetail in the report of the DEP Group.Data Analysis and Interpretation Group

Biostatistics and Epidemiology Cluster

The DEA Group is grateful to the following for their collaboration in its projects:

Hermann Brenner (Heidelberg, Germany), Volker Arndt (Heidelberg, Germany), Grazia Valsecchi (Milan, Italy), Charles

Stiller (Oxford, UK), Claire Berger (Saint Etienne, France)

Financial Support from the following bodies is gratefully acknowledged:

The Conseil général du Rhône and the Cancéropôle Lyon Auvergne Rhône-Alpes; Agence Française de Sécurité Sanitaire del’Environnement et du Travail (AFSSET), Federal Ministry of Health for the German Federal Government

Publications

Arbyn M, Raifu AO, Autier P, Ferlay J (2007).

Burden of cervical cancer in Europe: estimates

for 2004 Ann Oncol; 18(10):1708-1715.

Arndt V, Kaatsch P, Steliarova-Foucher E,

Peris-Bonet R, Brenner H Up-to-date

moni-toring of childhood cancer long-term survival

in Europe: Central nervous system tumours.

Ann Oncol; 18: 1734–1742, 2007.

Arndt V, Lacour B, Steliarova-Foucher E, Spix

C, Znaor A, Pastore G, Stiller CA, Brenner H

(2007) Up-to-date monitoring of childhood

cancer long-term survival in Europe: Tumours

of the sympathetic nervous system,

retinoblas-toma, renal and bone tumours and soft tissue

sarcomas Ann Oncol; 18: 1722–1733, 2007.

Autier P, Gandini S (2007) Vitamin D

supple-mentation and total mortality: A

meta-analy-sis of randomized controlled trials Ann Oncol;

167:1730-1737.

Autier P, Boniol M, Doré JF (2007) Sunscreen

use and increased duration of intentional sun

exposure: Still a burning issue Int J Cancer;

121:1-5.

Bae J, Gwack J, Park SK, Shin HR, Chang SH,

Yoo KY (2007) Cigarette smoking, alcohol

consumption, tuberculosis and risk of lung

can-cer: the Korean multi-center cancer cohort

study [Korean] J Prev Med Pub

Health;;40(4):321-8

Bosetti C, Garavello W, Levi F, Ferlay J,

Luc-chini F, Bertuccio P, Negri E, La Vecchia C

(2007) Trends in Oesophageal Cancer

Inci-dence and Mortality in Europe Int J Cancer; (in

press).

Bray F, Ferlay J, Devesa SS, McGlynn KA,

Møller H (2006) Interpreting the international

trends in testicular seminoma and

nonsemi-noma incidence Nat Clin Pract Urol;

3(10):532-543.

Brenner H, Steliarova-Foucher E, Arndt V (2007) Up-to-date monitoring of childhood cancer long-term survival in Europe: Method- ology and application to all forms of cancer

combined Submitted Nov 2006 Ann Oncol; 18:

1561–1568.

Brenner H, Coebergh JWW, Parkin DM, Izarzugaza I, Clavel J, Arndt V, Steliarova- Foucher E (2007) Up-to-date monitoring of childhood cancer long-term survival in Europe:

Leukaemias and Lymphomas Ann Oncol; 18:

1569-1577.

Cardis E, Krewski D, Boniol M, Drozdovitch

V, Darby SC, Gilbert ES, Akiba S, Benichou J, Ferlay J, Gandini S, Hill C, Howe G, Kesminiene A, Moser M, Sanchez M, Storm

H, Voisin L, Boyle P (2006) Estimates of the cancer burden in Europe from radioactive fall-

out from the Chernobyl accident Int J Cancer;

Choo SY, Lee SY, Kim CW, Kim SY, Yoon

TH, Shin HR, Moon OR (2007) Educational differences in health care utilization in the last year of life among South Korean cancer pa-

tients J Prev Med Pub Health;40(1):36-44

Ko-rean.

Chung HH, Hwang SY, Jung KW, Won YJ, Shin HR, Kim JW, Lee HP (2007) Gyneco- logic Oncology Committee of Korean Society

of Obstetrics and Gynecology Ovarian cancer

incidence and survival in Korea: 1993-2002 Int

J Gynecol Cancer; 17(3): 595-600.

Clavel J, Steliarova-Foucher E, Berger C, Danon S, Valerianova Z (2006) Hodgkin’s dis- ease incidence and survival in European chil- dren and adolescents (1978-1997): report from

the ACCIS project Eur J Cancer; 42:

2037-2049.

Coebergh JWW, Reedijk AMJ, de Vries E, Martos C, Jakab Z, Steliarova-Foucher E, Kamps WA (2006) Leukaemia incidence and survival in children and adolescents in Europe during 1978-1997 Report from the Automated Childhood Cancer Information System project.

Eur J Cancer; 42: 2019-2036.

de Vries E, Steliarova-Foucher E, Spatz A, germont AMM, Coebergh JWW (2006) Skin cancer incidence and survival in European chil- dren and adolescents (1978-1997): report from

Eg-the ACCIS project Eur J Cancer; 42: 2170-82.

Ferlay J, Autier P, Boniol M, Heanue M, Colombet M, Boyle P (2007) Cancer Inci-

dence and Mortality in Europe, 2006 Ann

Her-HR, Sukvirach S, Thomas JO, Snijders PJ, Munoz N, Meijer CJ (2007) Cervical Infection With Chlamydia trachomatis and Neisseria gonorrhoeae in Women From Ten Areas in

Four Continents: A Cross-Sectional Study Sex

Transm Dis; 34(8): 563-569

Franceschi S, Herrero R, Clifford GM, Snijders

PJ, Arslan A, Anh PT, Bosch FX, Ferreccio C, Hieu NT, Lazcano-Ponce E, Matos E, Molano

M, Qiao YL, Rajkumar R, Ronco G, de jose S, Shin HR, Sukvirach S, Thomas JO, Meijer CJ, Munoz N (2006) Variations in the age-specific curves of human papillomavirus

San-prevalence in women worldwide Int J Cancer;

119(11):2677-84.

Gwack J, Hwang SS, Ko KP, Jun JK, Park SK, Chang SH, Shin HR, Yoo KY (2007) Fasting serum glucose and subsequent liver cancer risk

in a Korean prospective cohort J Prev Med Pub

Health; 40(1):23-28 Korean.

Data Analysis and Interpretation Group Gwack J, Shin A, Kim CS, Ko KP, Kim Y, Jun

JK, Bae J, Park SK, Hong YC, Kang D, Chang

SH, Shin HR, Yoo KY (2006)

CagA-produc-ing Helicobacter pylori and increased risk of

gastric cancer: a nested case-control study in

Korea Br J Cancer; 95(5):639-641.

International Agency for Research on Cancer

(2007) Attributable Causes of Cancer in

France in the year 2000 Report from an IARC

Working Group, Lyon.

Izarzugaza MI, Steliarova-Foucher E, Martos

C, Zivkovic S (2006) Non-Hodgkin

Lym-phomas incidence and survival in European

children and adolescents (1978-1997): report

from the ACCIS project Eur J Cancer; 42:

2050-2063.

Jang SG, Kim IJ, Kang HC, Park HW, Ahn

SA, Yoon HJ, Kim K, Shin HR, Lee JS, Park

JG (2007) GSTT2 promoter polymorphisms

and colorectal cancer risk BMC Cancer;

25;7:16.

Jo H, Jeon YT, Hwang SY, Shin HR, Song YS,

Kang SB, Lee HP, Kim JW (2007) Increasing

trend in the incidence of cervical cancer among

the elderly in Korea: a population-based study

from 1993-2002 Acta Oncol; 46 (6): 852-858

Jun JK, Gwack J, Park SK, Choi YH, Kim Y,

Shin A, Chang SH, Shin HR, Yoo KY (2006).

Fasting serum glucose level and gastric cancer

risk in a nested case-control study [Korean] J

Prev Med Pub Health; 39(6):493-498

Jung KW, Yim SH, Kong HJ, Hwang HY,

Won YJ, Lee JK, Shin HR (2007) Cancer

Sur-vival in Korea 1993-2002: A Population Based

Study JKMS;22(Suppl):S5-10.

Kaatsch P, Steliarova-Foucher E, Crocetti E,

Magnani C, Spix C, Zambon P (2006) Time

trends of cancer incidence in European children

(1978-1997): report from the ACCIS project.

Eur J Cancer; 42: 1961-1971.

Lee JH, Yim SH, Won YJ, Jung KW, Son BO,

Lee HD, Lee ES, Yoo KY, Ahn SH, Shin HR,

and the members of Korean Breast Cancer

So-ciety (KBCS) (2007) Population-based Breast

Cancer Statistics in Korea during 1993-2002;

incidence, mortality, and survival.

JKMS;22(Suppl):S5-10

Lee DH, Liu DY, Jacobs DR Jr, Shin HR, Song

K, Lee IK, Kim B, Hider RC (2006) Common

presence of non-transferrin-bound iron among

patients with type 2 diabetes Diabetes

Care;29(5):1090-1095.

Lim MK, Ju YH, Franceschi S, Oh JK, Kong

HJ, Hwang SS, Park SK, Cho SI, Sohn WM,

Kim DI, Yoo KY, Hong ST, Shin HR (2006).

Clonorchis sinensis infection and increasing

risk of cholangiocarcinoma in the Republic of

Korea Am J Trop Med Hyg;75(1):93-96.

Magnani C, Pastore G, Coebergh JWW, scomi S, Spix C, Steliarova-Foucher E (2006).

Vi-Trends in survival after childhood cancer in

Eu-rope, 1978-97: the ACCIS project Eur J

Can-cer; 42: 1981-2005.

MacCarthy A, Draper GJ, Steliarova-Foucher

E, Kingston JE (2006) Retinoblastoma dence and survival in European children (1978-

inci-1997): report from the ACCIS project Eur J

Cancer; 42: 2092-2102.

Park SK, Sakoda LC, Kang D, Chokkalingam

AP, Lee E, Shin HR, Ahn YO, Shin MH, Lee

CW, Lee DH, Blair A, Devesa SS, Hsing AW (2006) Rising prostate cancer rates in South

Korea Prostate; 66(12):1285-1291.

Pastore G, Znaor A, Spreafico F, Graf N, Pritchard-Jones K, Steliarova-Foucher E (2006) Malignant renal tumours incidence and survival in European children (1978-1997): re-

port from the ACCIS project Eur J Cancer; 42:

2103-2114

Pastore G, Peris-Bonet R, Carli M, García C, Sánchez de Toledo J, Steliarova- Foucher E (2006) Childhood soft tissue sarcomas incidence and survival in European children (1978-97): report from ACCIS proj-

Martínez-ect Eur J Cancer; 42: 2136-2149.

Peris-Bonet R, Martínez-García C, Lacour B, Petrovich S, Giner-Ripoll B, Navajas A, Steliarova-Foucher E (2006) Childhood cen- tral nervous system tumours Incidence and sur- vival in Europe (1978-1997): report from the

ACCIS project Eur J Cancer; 42: 206420-80.

Pineros M, Ferlay J, Murillo R (2006) Cancer incidence estimates at the national and district

levels in Colombia Salud Publica Mex;

48(6):455-465.

Pritchard-Jones K, Kaatsch P, Foucher E, Stiller CA, Coebergh JWW (2006).

Steliarova-Cancer in children and adolescents in Europe:

Developments over 20 years and future

chal-lenges Eur J Cancer; 42:2183-2190.

Sankaranarayanan R and Ferlay J (2006).

Worldwide burden of gynaecological cancer:

the size of the problem Best Pract Res Clin

DH (2007) The comparison of two smoking

biomarkers in various biological samples Clin

Chim Acta;383:180-181

Shen C, Kim J, Lee JK, Bae YM, Choi MH, Oh

JK, Lim MK, Shin HR, Hong ST (2007) lection of Clonorchis sinensis adult worms from infected humans after praziquantel treat-

Col-ment Korean J Parasitol;45(2):149-152.

Shin HR (2006) Epidemiology of Hepatitis C

Virus in Korea Intervirology;49:18-22.

Shin HR, Park SH, Hwang SY, Kim JE, Jung

KW, Won YJ, Hwang SS, Yim SH, Choi KS, Park EC, Park SY, Kim JW, Lee HP (2007) Trends in cervical cancer mortality in Korea 1993-2002: Corrected mortality using national death certification data and national cervical

cancer incidence data IJC; Aug.

Spix C, Pastore G, Sankila R, Stiller CA, liarova-Foucher E (2006) Neuroblastoma inci- dence and survival in European children (1978-1997): report from the ACCIS-project.

Ste-Eur J Cancer; 42: 2081-2091.

Stang A, Schmidt-Pokrzywniak A, Lehnert M, Parkin DM, Ferlay J, Bornfeld N, Marr A, Jöckel KH (2006) Population-based incidence estimates of uveal melanoma in Germany Sup- plementing cancer registry data by case–control

data Eur Journal Cancer Prev, 15:165–170.

Steliarova-Foucher E, Arndt V, Parkin DM, Berrino F, Brenner H (2007) Timely disclosure

of progress in childhood cancer survival by riod analysis in the Automated Childhood

pe-Cancer Information System Ann Oncol; 18:

1554–1560, 2007.

Steliarova-Foucher E (2006) Cancer in the

young: the baseline Eur J Cancer; 42:1697

Steliarova-Foucher E, Kaatsch P, Lacour B, Pompe-Kirn V, Eser S, Miranda A, Danzon A, Ratiu A, Parkin DM (2006) Quality, compara- bility and methods of analysis of data on child- hood cancer in Europe (1978-1997): report from the Automated Childhood Cancer Infor-

mation System project Eur J Cancer; 42:

1915-1951.

Steliarova-Foucher E, Stiller CA, Pukkala E, Lacour B, Plesko I, Parkin DM (2006) Thy- roid cancer incidence and survival among Eu- ropean children and adolescents (1978-1997): Report from the Automated Childhood Cancer

Information System project Eur J Cancer; 42:

2150-2169.

Steliarova-Foucher E, Stiller CA, on behalf of the ACCIS Scientific Committee (2007) The ACCIS (Automated Childhood Cancer Infor-

mation System) Study J Pediatr Hematol Oncol;

29:S1-22.

Biostatistics and Epidemiology Cluster

Stiller CA, Marcos-Gragera R, Ardanaz E,

Pan-nelli F, Almar Marqués E, Cañada Martinez A,

Steliarova-Foucher E (2006) Geographical

pat-terns of childhood cancer incidence in Europe,

1988-1997: Report from the ACCIS project.

Eur J Cancer; 42: 1952-1960.

Stiller CA, Desandes E, Danon SE, Izarzugaza

MI, Ratiu A, Vassileva-Valerianova Z,

Stelia-rova-Foucher E (2006) Cancer incidence and

survival in European adolescents (1978-1997).

Report from the ACCIS project Eur J Cancer;

42: 2006-2018.

Stiller CA, Pritchard J, Steliarova-Foucher E

(2006) Liver cancer in European children:

In-cidence and Survival, 1978-1997 Report from

the ACCIS project Eur J Cancer; 42:

2115-2123.

Stiller CA, Bielack SS, Jundt G,

Steliarova-Foucher E (2006) Bone tumours in European

children and adolescents, 1978-1997 Report

from the ACCIS project Eur J Cancer; 42:

2124-2135.

Sung NY, Choi KS, Park EC, Park K, Lee SY, Lee AK, Choi IJ, Jung KW, Won YJ, Shin HR (2007) Smoking, alcohol and gastric cancer risk

in Korean men: the National Health Insurance

Corporation Study BJC July 17

Vaccarella S, Franceschi S, Herrero R, Munoz

N, Snijders PJ, Clifford GM, Smith JS, cano-Ponce E, Sukvirach S, Shin HR, de San- jose S, Molano M, Matos E, Ferreccio C, Anh

Laz-PT, Thomas JO, Meijer CJ (2006) IARC HPV Prevalence Surveys Study Group Sexual be- havior, condom use, and human papillomavirus:

pooled analysis of the IARC human

papillo-mavirus prevalence surveys Cancer Epidemiol

Biomarkers Prev;15(2):326-333.

Vaccarella S, Herrero R, Dai M, Snijders PJ, Meijer CJ, Thomas JO, Hoang Anh PT, Fer- reccio C, Matos E, Posso H, de Sanjose S, Shin

HR, Sukvirach S, Lazcano-Ponce E, Ronco G, Rajkumar R, Qiao YL, Munoz N, Franceschi S (2006) Reproductive Factors, Oral Contracep- tive Use, and Human Papillomavirus Infection: Pooled Analysis of the IARC HPV Prevalence Surveys Cancer Epidemiol Biomarkers Prev;15(11):2148-2153.

Yoon KA, Park S, Hwangbo B, Shin HD, Cheong HS, Shin HR, Lee JS (2007) Genetic polymorphisms in the Rb-binding zinc finger

gene RIZ and the risk of lung

cancer.Carcino-genesis; 28:1971-1977.

Book chapters

Steliarova-Foucher E, Hery C, Pisani P The 10

My Child Matters countries In: UICC, hood Cancer: Rising to the challenge UICC, Geneva 2006, pp 9-15

Child-The core activity of the Descriptive

Epidemiology Production Group (DEP)

is to support cancer registration all over the

world and to monitor and provide cancer

incidence data as a basis for etiological

research and cancer control policies,

whether local or international The

information on cancer incidence, mortality,

survival and trends quantifies the size of

the burden on cancer incidence, making it

possible to evaluate cancer control actions

taken in that population We collect cancer

incidence statistics through cancer

registries, mainly in low- and

medium-resource countries, to provide data on the

local cancer situation A crucial issue in

these countries is the lack of information

on mortality data, so cancer registries really

are the most reliable source of information

on cancer occurrence Since 1960, IARC

has systematically received data from

population-based cancer registries

worldwide, which is then refined based on

data quality indicators for each cancer

registry The data are subsequently adapted to

make comparisons between the populations

distributed over the five continents

Cancer Incidence in Five Continents, Volume IX

Editorial Board Meetings were held atIARC on 4–6 July 2006, 11–13 Oct 2006,16–19 Jan 2007, 24–26 April 2007 and 3–

4 July 2007, with the active participation

of Drs Maria-Paula Curado, BrendaEdwards, Hans Storm and Hai Rim Shin(see list of collaborators below)

The data produced by the based cancer registries have been convertedinto standardised form and aredisseminated to the scientific community

population-This publication is produced on a 5-year basis, and the current volume is nowavailable through the IARC website Thereference time period was defined to be1998-2002, and in order to allow theeditors to verify some aspects of quality,comparability and completeness, contri-butors were also asked to send data for theyears preceding the reference period

Volume IX is divided into eightchapters: Introduction; Techniques ofregistration; Classification and coding;

Comparability and quality of data:

Histological groups; Processing of data;

Age standardisation, and Tables Theevaluation criteria used to analyse the datasubmitted by the cancer registries werebased on cancer registration data qualityindicators outlined in Cancer Registration,Principles and Methods, IARC ScientificPublication No.95 and the Manual forCancer Registry Personnel, IARCTechnical Report No.10 (Chapter 5)

We received data from 406 populationsfor this volume; we published data oncancer incidence from 300 populations,

225 cancer registries and 60 countries Theproportions of covered cancer registries bycontinent were: Africa 31.3% (5/16);South and Central America 37.9%(11/29); North America 93.1% (54/58);Asia 57.1% (44/77), Europe 83.3%(100/120); Oceania 84.6% (11/13) Theelectronic version of the volume is available

at www-dep.iarc.fr The incidence rates andnumbers as originally published can beaccessed to generate tables and graphs

Descriptive Epidemiology Production Group

Mr Eric Masuyer (until 31 March 2006)

Mr Mathieu Mazuir (from 12 April2007)

Ms Isabelle Savage (from 8 August 2006)

Secretaries

Ms Catherine Bénard (from 14 February to 31 August 2006)

Ms Chantal Déchaux

Ms Evangéline Demourdjian (from 28 Aug 2006 to 27 Aug 2007)

Ms Susan Haver-Legros (until 31 January 2006)

Visiting scientists

Dr Cankut Yakut (from 29 Oct to 30 Nov 2006)

Students

Mr Vincent Benoist(from 7 May to 27 July 2007)

Ms Marilyne Goutagny (from 7 May to 27 July 2007)

Descriptive Epidemiology Production Group (DEP)

CI(5)/ICD(O)-3 Histological Groups

Meeting (16 April 2007)

For comparability purposes, data

present-ed in Cancer Incidence in Five Continents

(CI5) are mainly classified by site using the

International Classification of Diseases

(ICD) In Volumes VIII and IX of CI5,

chapter II (Neoplasms) headings of

ICD10 were the source of the

classification Another axis of interest for

cancer is the histological subtypes, and to

this end the histological codes have been

classified based on the Histological

Classification of Tumours according to the

ICD-O IARC Technical Report No.31,

Histological Groups for Comparative

Studies, was the classification source for

volume VIII of CI5 Since then, ICD-O has

been updated from Revision 2 to Revision 3,

and it has therefore become

necessary to update these histological

groupings for ICD-O3 With this aim in

mind, experts were invited to

participate in a pathology panel, the outcome

of which is detailed in the publication

CanReg Software

During the biennium, new versions of the

CanReg4 software have been developed

and installed in Africa (Botswana, Ghana

and Nigeria), Latin America (Colombia),

Asia (Malaysia, Mongolia, Sri Lanka and

Viet Nam), Europe (France and Albania)

and Oceania (Cook Islands, Fiji and Niue)

Staff were trained during the IARC Annual

Summer School in Cancer Epidemiology

held in Lyon A 5th version of the software

is currently under preparation

IACR/ENCR

DEP provides the facilities for the

administration and secretariat of the

International Association of Cancer

Registries (IACR) and the European

Network of Cancer Registries (ENCR)

IACR (International Association of

Cancer Registries)

Since 1973, IARC has supported the

activities of the non-governmental

International Association of Cancer

Registries (IACR) by hosting its

secretariat During 2006-07, the role of

IACR Executive Secretary was assumed by

Dr Paola Pisani until 30 November 2006,

and by Eva Steliarova-Foucher since then

Technical assistance is also provided byIsabelle Savage and Eric Masuyer Thisteam is responsible for coordinating theactivities of the Association and forpromoting exchange of informationbetween its almost 600 members all overthe world During the biennium, theIACR Secretariat helped to raise funds andorganized two Annual Meetings of theExecutive Board: in Goiania, Brazil, 8-10November 2006, and in Ljubljana,Slovenia, 18-20 September 2007 It alsohosted a satellite meeting for the AfricanRegion at the AORTIC Conference inNovember 2007 Other activities includedmaintenance of the IACR website athttp://www.iacr.com.fr/, the publication ofthe IACR Newsletter, communicationwith associated journals, management ofmembership (applications, fees anddatabase) and IACR fellowships IACRcollaborated with IARC in several projects,namely CI5 Volume IX and thedevelopment of CanReg, the cancer registry software

ENCR (European Network of Cancer Registries)

ENCR Steering Committee meetingswere held at IARC on 17–18 January

2006, 25–26 April 2006, 12–13 September

2006, 30–31 January 2007, 11–12 April

2007 and 28–29 June 2007 The ENCRalso held annual meetings in Palma deMajorca, Spain on 25 May 2006, and inLjubljana, Slovenia, on 21 September

2007 Members of the SteeringCommittee include: Freddie Bray (TheCancer Registry of Norway, Oslo), PascaleGrosclaude (Tarn Cancer Registry, Albi,France), Isabel Izarzugaza (Department ofHealth, Bilbao, Spain), Jean-Michel Lutz(Geneva Tumour Registry and GRELLrepresentative), Henrik Møller (ThamesCancer Registry, London), Hans Storm(Danish Cancer Society and IACRrepresentative) and Laufey Tryggvadottir(Reykjavik Cancer Registry andrepresentative of the Nordic CancerRegistries Association)

A grant application has been ted by the ENCR to the EuropeanCommission through its FP7/ERA-NetProgramme (Work Package on cancer incidence and trends in Europe) It showscomprehensive and systematic analysis of

submit-time trends in cancer incidence and mortality The relevance of this subject isrelated to the prediction of changes in thecancer burden over the time, which may beused to predict future cancer risk andidentify new determinants in cancerincidence

A grant proposal covering a collaboration between ENCR and theUniversity of Bielefeld, Germany on theproject “Monitoring Health Status ofMigrants within Europe: development of indicators” has been submitted to theEuropean Commission The project aims

to identify existing databases withinformation on ethnic origin and compiledefinitions of “migrants” as adopted inthese sources of information In addition,

it aims to assess the consistency ofinformation on migrants, coverage,completeness and quality of data, anddevelop recommendations for a uniformdefinition of the status of migrants for use

in cancer registration Partners in theproject are Prof Alan Krasnick (Denmark)and Prof Mackenbach (Netherlands) DrGeppo Costa (Italy) was also suggested

A programme has also been developed

to update our SQL-based address-listsavailable on the web, and our intranetpages have been revised to better suit theneeds of the users Queries were putforward to build tailored address-lists forcancer registries

ACCIS, ECO, EUNICE, EUROCADET, EUROTIS

ACCIS

Automated Childhood CancerInformation System (ACCIS) is aninternational project, funded initially bythe European Commission and later by

several other institutions (La Ligue contre

le cancer, Comité du Rhône, Canceropôle Lyon, Auvergne, Rhône-Alpes (CLARA), the

Ministry of Health of the FederalGovernment of Germany) jointly withIARC This collaborative project of some

80 population-based cancer registries in 35European countries has risen from theneed for substantial population coveragefor studies of childhood cancer To date,basic data have been accumulated foralmost 140 000 tumours in patientsyounger than 15 years at diagnosis, arisingBiostatistics and Epidemiology Cluster

Descriptive Epidemiology Production Group

from 1172 million person-years, and

became thus the world’s largest childhood

cancer database

The group also participated in the

publication of a special issue of the

European Journal of Cancer in September

2006, providing the reference data for

incidence of and survival from cancer in

children and adolescents in Europe, based

on the analysis of the ACCIS database, as

well as outlook for future epidemiological

and clinical research This work results from

collaboration of 78 cancer registries across

Europe as data providers and 57 co-authors,

including practicing paediatric oncologists

European Cancer Observatory (ECO)

The ECO project is supported by the

Cancéropôle Lyon, Auvergne, Rhône-Alpes

(CLARA), awarded specifically for

supporting the activities of the European

Network of Cancer Registries (ENCR)

This project, outlined in the framework of

the epidemiological platform of Cancéropôle

includes the following major areas of work:

(1) Reinforcement of population-based

cancer registration as the only means of

measuring the cancer burden in Europe

and the basis of etiological studies

(2) Studies of cancer in children that

necessitate international collaboration

(3) Scenarios, meaning modelling of the

cancer burden in a given population,

using available data on incidence,

mortality, survival and prevalence

EUNICE

The main objectives of the EUNICE

project are: (1) to select a core set of

indicators to monitor the cancer burden,

the intensity of screening for breast, cervix

and colorectal cancers, the impact on

incidence and mortality of screening for

breast and cervix cancers, the availability of

radiotherapy facilities by type and patient

access to radiotherapy and cancer drugs in

the EU member states; (2) to compile a

database of the selected indicators for the

European countries, and (3) to describe the

infrastructure required to obtain those

indicators and submit recommendations

for countries where data are missing The

project involves IARC, the German

Cancer Research Centre Department on

Ageing Research in Heidelberg (Prof H

Brenner), the CPO Piemonte in Turin (Dr

A Ponti), the Institute of Public Health,Brussels (Prof M Arbyn), the Institute forStatistical and Epidemiological CancerResearch, Helsinki (Dr N Malila), theInternational Atomic Energy Agency,Vienna (Dr E Rosenblatt) and theKarolinska Institute, Stockholm (Prof N

Wilking and Prof U Ringborg)

EUROCADET

The EUROCADET Project, which aims

to contribute to the battle against cancer

by identifying effective preventivestrategies and making estimations of theeffects of successful implementation ofthese strategies, is coordinated by Dr Jan-Willem Coeberg and ProfessorMackenbach from the Erasmus UniversityMedical Centre, Rotterdam on “TheImpact of Key Determinants on theCurrent and Future Burden of Cancer inEurope” IARC/DEP is a partner in thisproject

EUROTIS

This study, funded by Région Alpes, was dedicated to the analysis ofincidence and mortality trends of thyroidcancer in Europe, with particular emphasis

Rhône-on the histological type in children andadults A Collaborative Research Agree-ment was signed between FRANCIM andIARC/DEP, and Dr Marc Colonna, fromthe Registre des Cancers de l’Isère hastaken responsibility for the work, onbehalf of FRANCIM

Training

(1) Advanced Course on Automated Cancer Registration, Birmingham, 26-27 June 2006

IARC helped in the administrativeorganisation of this IACR-sponsoredcourse organised by Chris Carrigan(National Coordinator for CancerRegistration in England, National CancerAction Team, London) and LorenzoSimonato (University of Padova, Italy) Theother members of the faculty includedRichard Middleton from Queen’s University,Belfast and Wendy Scharber, from BrooklynPark, Minnesota, USA Thirty-nineparticipants from Austria, Ireland, Italy,Spain, Thailand and the United Kingdomattended that course

(2) IARC Summer School in Cancer Epidemiology

As in previous years, our Group activelyparticipated in the cancer registrationmodules of the 2006-07 IARC SummerSchools, providing course coordinators(Paola Pisani in 2006 and Mary Heanue in2007), faculty members and training incancer registration basic principles,methods in data collection, quality controlmeasures, CanReg software data entry,checks and practical exercises

(3) ENCR Course on Cancer Prediction Methods (IARC, 19-21 Sept 2006)

This course was dedicated to the practicalaspects of implementing and interpretingcancer predictions as part of a cancerregistry’s core activities Freddie Bray,Bjørn Møller from the Cancer Registry,Oslo, Tadek Dyba and Timo Hakulinen(Course Coordinator) from the FinnishCancer Registry, and Arduino Verdecchiafrom ISS, Rome were the facultyrepresentatives Twenty-nine participantsfrom Austria, Canada, Denmark, France,Germany, Italy, the Netherlands, Poland,Portugal, Romania, Slovenia, Spain, and theUnited Kingdom participated in the course

(2) Working Group on Data Production in Low- and Medium-Resource Countries (IARC, 25 July 2007)

It was decided to organise this meeting todetermine on what basis the Agency wouldcontinue supporting cancer registration inthe world through its programme ofCollaborative Research Agreements

It was considered that the dataproduced by the registries should be kept

independent from CI5 – IARC is doing

research to serve the Ministries of Health

in different countries, and it should first

bear in mind the cancer control/public

health activities of these respective

countries Cancer registry data should be

seen as an aid to the evaluation of the local

cancer burden and as a tool for cancer

control It was decided that IARC would

set up a Grant Application Fund for

Cancer Registries, to be advertised on the

IARC and IACR websites, with all the

requisites usually required for grant

application purposes The applications will

be reviewed by an official review board

nominated by IARC

Collaboration with the IAEA/PACT

Programme

Dr Mohamed El Baradei, IAEA Director,

received the Nobel Prize in 2003, and

invested the funds in the setting-up of this

Programme of Action for Cancer Therapy

in 2004, which will enable developing

countries to introduce, expand and

improve their cancer care capacity by

integrating radiotherapy into a

comprehensive cancer control programme

that maximizes its therapeutic ness and impact Pilot countries chosen areTanzania, Sri Lanka, Viet Nam, Yemen,Nicaragua and Albania This is a jointeffort of WHO, PACT, IARC, INCTR,NCI, UICC, ACS, Tata and otherinternational partners It should contribute

effective-to the initiation of National CancerControl Plans, increase prevention andearly detection programmes, expandpalliative programmes, improve andexpand radiotherapy services and cancerregistration, and go beyond a government’slifetime IARC’s contribution to thatProgramme covers the setting-up of cancerregistration at each site

IARC already participated in missions

to Albania (2–5 May 2006), Tanzania (29May–2 June 2006), Viet Nam (30 Oct.–2Nov 2006), Yemen (1–5 July 2007), andNicaragua (23–27 July 2007) and in thedevelopment of national cancer controlplans in these countries

Collaboration with the UICC “My Child Matters” Programme

UICC, in collaboration with Aventis, has established a programme

Sanofi-designed to help improve childhood cancermanagement in selected low-resourcecountries A Selection AdvisoryCommittee consists of the representatives

of UICC, St Jude Children's ResearchHospital (TN, USA), the InternationalSociety of Paediatric Oncology (SIOP),the US National Cancer Institute (NCI),the International Agency for Research onCancer (IARC), the InternationalConfederation of Childhood CancerParent Organisations (ICCCPO),Epidaure CRLC Val d'Aurelle-PaulLamarque (France), Groupe Franco-Africain d'Oncologie Pédiatrique, and theInternational Network for CancerTreatment and Research (INCTR) Themost promising 26 projects in 16 countrieswere funded, and the programme has beenwarmly received in the internationalscientific literature and conferences IARC has also contributed to theUICC report and a UICC factsheet onchildhood cancer for distribution to thegeneral public, published in support of the

“My Child Matters” Programme

Biostatistics and Epidemiology Cluster

The DEP Group is grateful to the following for their collaboration in its projects:

Marc Arbyn, Brussels, Belgium; Freddie Bray, Oslo, Norway;

Dan Berney, London, UK; Hermann Brenner, Heidelberg, Germany;

Chris Carrigan, London, UK; Jacqueline Clavel, Paris, France; Jan-Willem Coeberg, Rotterdam, The Netherlands;

Esther de Vries, Rotterdam, The Netherlands; Tadek Dyba, Helsinki, Finland;

Brenda Edwards, Bethesda, MD, USA; Kenneth Fleming, Oxford, UK; April Fritz, Reno, NV, USA;

Anna Gavin, Belfast, Ireland; Pascale Grosclaude, Albi, France; Timo Hakulinen, Helsinki, Finland;

Joe Harford, Bethesda, MD, USA; Guenter Henze, Berlin, Germany; Eric Holowaty, Toronto, Ontario;

Isabel Izarzugaza, San Sebastian, Spain; Peter Kaatsch, Mainz, Germany;

Robert Jakob, Geneva, Switzerland; Lars Age Johannson, Stockholm, Sweden;

Moussa Koulibaly, Conakry, Guinea; Eduardo Laura, Bahia Blanca, Argentina;

Jean-Michel Lutz, Geneva, Switzerland; Angela MacCarthy, Oxford, UK; Corrado Magnani, Turin, Italy;

Nea Malila, Helsinki, Finland; Colin Mathers, Geneva, Switzerland;

Richard Middleton, Belfast, Ireland; Bjørn Møller, Oslo, Norway; Henrik Møller, London, UK;

Guido Pastore, Turin, Italy; Rafael Peris-Bonet, Valencia, Spain; Antonio Ponti, Turin, Italy;

Kathy Pritchard-Jones, London, UK; Maja Primic-Zakelj, Ljubljana, Slovenia;

Ulrik Ringborg, Stockholm, Sweden; Eduardo Rosenblatt, Vienna, Austria; Risto Sankila, Helsinki, Finland;

Wendy Scharber, Brooklyn Park, MN, USA; Hai-Rim Shin, Koyang-si, Republic of Korea;

Lorenzo Simonato, Padua, Italy; Claudia Spix, Mainz, Germany;

Supanee Sriamporn, Ubonratchathani, Thailand; Charles Stiller, Oxford, UK;

Hans Storm, Copenhagen, Denmark; Laufey Tryggvadottir, Reykjavik, Iceland;

Arduino Verdecchia, Rome, Italy; Nils Wilking, Stockholm, Sweden; Tongzhang Zhen, New Haven, CT, USA

Financial support from the following bodies is gratefully acknowledged:

Agence Française de Sécurité Sanitaire de l’ Environnement et du Travail France (EUROTIS)Cancéropôle Lyon, Auvergne, Rhône-Alpes/CLARA, France (ECO, ACCIS)European Commission (ACCIS, EUROCADET, EUROTIS)

German Government (ACCIS)International Union Against Cancer (Childhood Cancer Report)Ligue Nationale contre le Cancer, Comité du Rhône (ACCIS)National Cancer Institute, USA (Cancer registries and CanReg)

Région Rhône-Alpes, France (EUROTIS)

Publications

Bray F, Ferlay J, Devesa SS, McGlynn KA,

Moller H (2006) Interpreting the international

trends in testicular seminoma and

nonseminoma incidence Nat Clin Pract Urol;

3(10):532-543.

Brem R, Cox DG, Chapot B, Moullan N,

Romestaing P, Gerard JP, Pisani P, Hall J

(2006) The XRCC1 -77T->C variant:

haplotypes, breast cancer risk, response to

radiotherapy and the cellular response to DNA

damage Carcinogenesis; 27(12):2469-2474.

Clavel J, Steliarova-Foucher E, Berger C,

Danon S, Valerianova Z (2006) Hodgkin's

disease incidence and survival in European

children and adolescents (1978-1997): Report

from the Automated Cancer Information

System project Eur J Cancer; 42(13):2037-2049

Coebergh JW, Reedijk AM, De Vries E, Martos C, Jakab Z, Steliarova-Foucher E, Kamps WA (2006) Leukaemia incidence and survival in children and adolescents in Europe during 1978-1997 Report from the Automated Childhood Cancer Information System project.

Eur J Cancer; 42(13):2019-2036

De Vries E, Steliarova-Foucher E, Spatz A, Ardanaz E, Eggermont AM, Coebergh JW (2006) Skin cancer incidence and survival in European children and adolescents (1978- 1997) Report from the Automated Childhood

Cancer Information System project Eur J

Cancer; 42(13):2170-2182

Izarzugaza MI, Steliarova-Foucher E, Carmen

MM, Zivkovic S (2006) Non-Hodgkin's lymphoma incidence and survival in European children and adolescents (1978-1997): Report

from the Automated Childhood Cancer

Information System project Eur J Cancer;

42(13):2050-2063

Kaatsch P, Steliarova-Foucher E, Crocetti E, Magnani C, Spix C, Zambon P (2006) Time trends of cancer incidence in European children (1978-1997): Report from the Automated Childhood Cancer Information System project.

Eur J Cancer; 42(13):1961-1971

Maccarthy A, Draper GJ, Steliarova-Foucher

E, Kingston JE (2006) Retinoblastoma incidence and survival in European children (1978-1997) Report from the Automated Childhood Cancer Information System project.

Eur J Cancer; 42(13):2092-2102.

MacKinnon JA, Duncan RC, Huang Y, Lee DJ, Fleming LE, Voti L, Rudolph M, Wilkinson JD.(2007) Detecting an association between Descriptive Epidemiology Production Group

Biostatistics and Epidemiology Cluster

socio-economic status and late stage breast

cancer using spatial analysis and area-based

measures Cancer Epid Biomark

Prev;16:756-762

Magnani C, Pastore G, Coebergh JW, Viscomi

S, Spix C, Steliarova-Foucher E (2006) Trends

in survival after childhood cancer in Europe,

1978-1997: Report from the Automated

Childhood Cancer Information System project

(ACCIS) Eur J Cancer; 42(13):1981-2005.

Pastore G, Peris-Bonet R, Carli M,

Martinez-Garcia C, de Toledo JS, Steliarova-Foucher E

(2006) Childhood soft tissue sarcomas

incidence and survival in European children

(1978-1997): Report from the Automated

Childhood Cancer Information System project.

Eur J Cancer; 42(13):2136-2149

Pastore G, Znaor A, Spreafico F, Graf N,

Pritchard-Jones K, Steliarova-Foucher E

(2006) Malignant renal tumours incidence and

survival in European children (1978-1997):

Report from the Automated Childhood Cancer

Information System project Eur J Cancer;

42(13):2103-2114

Peris-Bonet R, Martinez-Garcia C, Lacour B,

Petrovich S, Giner-Ripoll B, Navajas A,

Steliarova-Foucher E (2006) Childhood central

nervous system tumours - incidence and survival

in Europe (1978-1997): Report from Automated

Childhood Cancer Information System project.

Eur J Cancer; 42(13):2064-2080.

Pisani P, Héry C (2006) The burden of

childhood cancer In: UICC Childhood

Cancer: Rising to the challenge UICC, Geneva,

pp.9-14.

Pisani P, Parkin DM, Ngelangel C, Esteban D,

Gibson L, Munson M, Reyes MG, Laudico A

(2006) Outcome of screening by clinical

examination of the breast in a trial in the

Philippines Int J Cancer; 118(1):149-154

Pisani P, Srivatanakul P, Randerson-Moor J,

Vipasrinimit S, Lalitwongsa S, Unpunyo P,

Bashir S, Bishop DT (2006) GSTM1 and

CYP1A1 polymorphisms, tobacco, air

pollution, and lung cancer: a study in rural

Thailand Cancer Epidemiol Biomarkers Prev;

15(4):667-674.

Pritchard-Jones K, Kaatsch P, Foucher E, Stiller CA, Coebergh JW (2006) Cancer in children and adolescents in Europe:

Steliarova-Developments over 20 years and future

challenges Eur J Cancer; 42(13):2183-2190.

Sankaranarayanan R, Ferlay J (2006).

Worldwide burden of gynaecological cancer:

the size of the problem Best Pract Res Clin

Report from the Automated Childhood Cancer

Information System project Eur J Cancer;

42(13):1972-1980

Spix C, Pastore G, Sankila R, Stiller CA, Steliarova-Foucher E (2006) Neuroblastoma incidence and survival in European children (1978-1997): Report from the Automated Childhood Cancer Information System project.

Eur J Cancer; 42(13):2081-2091

Stang A, Schmidt-Pokrzywniak A, Lehnert

M, Parkin DM, Ferlay J, Bornfeld N, Marr A, Jockel KH (2006) Population-based incidence estimates of uveal melanoma in Germany Supplementing cancer registry data

by case-control data Eur J Cancer Prev;

15(2):165-170

Steliarova-Foucher E Héry C, Pisani P The 10

“My child matters” countries In: UICC Childhood Cancer: Rising to the challenge,

UICC, Geneva, pp.15-30.

Steliarova-Foucher E, Coeberg JW, Kaatsch, P.

Pritchard-Jones K., Stiller C Eds (2006).

Cancer in Children and Adolescents in Europe.

Eur J Cancer, 42(13):1913-2190.

Steliarova-Foucher E, Kaatsch P, Lacour B, Pompe-Kirn V, Eser S, Miranda A, Danzon A, Ratiu A, Parkin DM (2006) Quality,

comparability and methods of analysis of data

on childhood cancer in Europe (1978-1997): Report from the Automated Childhood Cancer

Information System project Eur J Cancer;

42(13):1915-1951

Steliarova-Foucher E, Stiller CA, Pukkala E, Lacour B, Plesko I, Parkin DM (2006) Thyroid cancer incidence and survival among European children and adolescents (1978-1997): Report from the Automated Childhood Cancer

Information System project Eur J Cancer;

System project Eur J Cancer;

42(13):1952-1960.

Stiller CA, Desandes E, Danon SE, Izarzugaza

I, Ratiu A, Vassileva-Valerianova Z, Foucher E (2006) Cancer incidence and survival in European adolescents (1978-1997) Report from the Automated Childhood Cancer

Steliarova-Information System project Eur J Cancer;

42(13):2006-2018.

Stiller CA, Pritchard J, Steliarova-Foucher E Liver cancer in European children: Incidence and survival, 1978-1997 (2006) Report from the Automated Childhood Cancer Information

System project Eur J Cancer;

42(13):2115-2123

Stiller CA, Bielack SS, Jundt G, Foucher E Bone tumours in European children and adolescents, 1978-1997 (2006) Report from the Automated Childhood Cancer

Steliarova-Information System project Eur J Cancer;

42(13):2124-2135.

Information Technology Services Group

The Information Technology Services

Group (ITS) maintains and develops the

Agency’s central computing and electronic

communications services

After the organisational changes and

physical reorganisation of the last

biennium, the Group has put a lot of effort

into improving the network (e.g external

bandwidth, security, mail filtering) and the

management of our servers (e.g user

administration, backups)

A number of improvements have also

been brought to the administration tools,

whether home grown applications or

WHO-HQ provided In this particular

area, the decision approved by the Governing Council in May 2006 to adoptour own Administration ManagementSystem rather than be part of the WHOGSM has led us into a major project incollaboration with the Division ofAdministration and Finance The initialstudy, started in 2006, resulted in SAPbeing chosen as the basis for the newsystem Work began in February 2007 with

a definition of the scope of the project andhas progressed through training withimplementation foreseen for the newbiennium of 2008–2009

The collaboration with GCS towardsthe goal of implementing the new LIMS(Laboratory Information ManagementSystem) has been very successful, and thenew database is now operational

In collaboration with BIO, a meeting

of the European Cancer Mortality Atlasparticipants was organised in May 2006 toreview the material available The text forthe publication is now completed andbeing edited

Information Technology Services Group (ITS)