1314 production of recombinant adeno associated virus type 2 in insect cells

1314 Production of Recombinant Adeno Associated Virus Type 2 in Insect Cells Molecular Therapy Vol 5, No 5, May 2002, Part 2 of 2 Parts Copyright © The American Society of Gene Therapy S429 ����������[.]

Molecular Therapy Vol 5, No 5, May 2002, Part 2 of 2 Parts

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1311 Non-Invasive Gene T 1 Non-Invasive Gene T 1 Non-Invasive Gene Transfer to Lung for ransfer to Lung for

Systemic Delivery of Therapeutic Proteins

Erin O′Connor,1 Alberto Auricchio,1 Daniel Weiner,1,2 Guang-Ping

Gao,1 Markus Hildinger,1 Lili Wang,1 James M Wilson.1

1 Institute for Human Gene Therapy, The Wistar Institute, Univ of

Pennsylania, Philadelphia, PA, United States; 2 Department of

Pediatrics, University of Pennsylvania, Philadelphia, PA, United

States

1312

1312 A A A Method for Producing Recombinant Method for Producing Recombinant Method for Producing Recombinant AA AA AAV2 V2

V

Vectors with T ectors with T ectors with Targeting Ligands in Specific Capsid argeting Ligands in Specific Capsid

Proteins

Kenneth H Warrington, Jr.,1 Nicholas Muzyczka.1

1 Molecular Genetics and Microbiology and Powell Gene Therapy

Center, University of Florida, Gainesville, Florida, United States

1313 Enhanced T

1313 Enhanced Transduction of Pancreatic Islet Cells ransduction of Pancreatic Islet Cells with T

with Targeted Recombinant argeted Recombinant argeted Recombinant Adeno-Associated V Adeno-Associated V Adeno-Associated Virus irus V

Vectors ectors

Scott A Loiler,1,3,5 Sihong Song,2 Kenneth H Warrington, Jr.,1,5

Anupam Agarwal,4 Matthias Kapturczak,4 Chengwen Li,8 Camillo Ricordi,7 Mark A Atkinson,6 Nicholas Muzyczka,1,5 Terence R Flotte.1,3,5

1 Powell Gene Therapy Center, University of Florida, Gainesville, Florida, United States; 2 Department of Pharmaceutics, University

of Florida, Gainesville, Florida, United States; 3 Department of Pediatrics, University of Florida, Gainesville, Florida, United States; 4 Department of Medicine, University of Florida, Gainesville, Florida, United States; 5 Genetics Institute, University

of Florida, Gainesville, Florida, United States; 6 Department of Pathology, University of Florida, Gainesville, Florida, United States; 7 Diabetes Research Institute, University of Miami, Miami, Florida, United States; 8 Gene Therapy Center, University of North Carolina, Chapel Hill, NC, United States

1314 Production of Recombinant Adeno-Associated V

Virus T irus T irus Type 2 in Insect Cells ype 2 in Insect Cells

Masashi Urabe, Chuantian Ding, Robert M Kotin

1 Lab Biochem Genet., NHLBI/NIH, Bethesda, MD, United States

Molecular Therapy Vol 5, No 5, May 2002, Part 2 of 2 Parts Copyright © The American Society of Gene Therapy

S430

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1315 Neutralizing

1315 Neutralizing Activity Activity Activity Against Different Against Different Against Different AA AA AAV V

Serotypes in Sera from Untreated Humans and in Sera

from Humans T

from Humans Treated with an reated with an reated with an AA AA AAV2 V V2 V V2 Vector ector

Richard Surosky,1 Dorothy Huey-Louie,1 James Allen,1 Shang-Zhen

Zhou,1 Brian Christie,1 Hassibullah Akeefe,1 Ciaran Scallan,1

Sharon Powell,1 Linda Couto,1 Katherine High,2 Mark Kay,3 Alan

McClelland,1 Peter Colosi.1

1 Avigen, Inc., Alameda, CA, United States; 2 Department of

Pediatrics, The Children ′s Hospital of Philadelphia, Philadelphia,

PA, United States; 3 Department of Pediatrics, Stanford University

School of Medicine, Palo Alto, CA, United States

1316 Differential Activation of Innate Immune Responses by Adenovirus and Adeno-Associated Virus V

Vectors ectors

Anne K Zaiss,1 Qiang Liu,1 Gloria P Bowen,1 Norman C W Wong,1

Jeffrey S Bartlett,2 Daniel A Muruve.1

1 Medicine, University of Calgary, Calgary, Alberta, Canada;

2 Pediatrics, Ohio State University, Children ′s Research Institute, Columbus, Ohio, United States

1317 Genetic Predisposition to Autoimmunity Specifically Imparts Immune Responsiveness to T

Transgenes Delivered by Recombinant ransgenes Delivered by Recombinant ransgenes Delivered by Recombinant Adeno- Adeno-Associated Virus

Y Clare Zhang,1 Matthew Powers,1 Clive Wasserfall,1 Todd Brusko,1 Terence Flotte,2 Richard Snyder,3 Mark Potter,3 Marda Scott-Jorgenson,1 Martha Campbell-Thompson,1 James M Crawford,1 Tamir M Ellis,1 Mark A Atkinson.1

1 Department of Pathology, University of Florida, Gainesville, FL, United States; 2 Department of Pediatrics, University of Florida, Gainesville, FL, United States; 3 Vector Core, Powell Gene Therapy Center, University of Florida, Gainesville, FL, United States