1087 synergistic induction of functional angiogenesis and stem cell recruitment by VEGF and angiopoietin 1 gene transfer using AAV vectors

1087 Synergistic Induction of Functional Angiogenesis and Stem Cell Recruitment by VEGF and Angiopoietin 1 Gene Transfer Using AAV Vectors Molecular Therapy Vol 5, No 5, May 2002, Part 2 of 2 Parts Co[.]

Molecular Therapy Vol 5, No 5, May 2002, Part 2 of 2 Parts Copyright © The American Society of Gene Therapy

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1085

1085 AA AA AAV Mediated VEGF Gene T V Mediated VEGF Gene T V Mediated VEGF Gene Transfer Improves the ransfer Improves the

Function of the Ischemic Mouse Heart

Hua Su,1 Shinji Ishizaka,2 Rich Sievers,2 Janice Arakawa-Hoyt,3

William Grossman,2 Yuet-Wai Kan.1,3,4

1 Cardiovascular Research Institute; 2 Cardiovascular Division of

Internal Medicine; 3 Howard Hughes Medical Institute;

4 Department of Laboratory Medicine, University of California, San

Francisco, San Francisco, California, United States

EDD(cm) ESD(cm) FS(%) d-Post d-Ant

AAV-VEGF 0.43±0.02 0.23±0.01 46.0±2.14 0.13±0.01 0.08±0.01

AAV-LacZ 0.44±0.02 0.27±0.01 38.7±1.33 0.12±0.01 0.04±0.02

PBS 0.52±0.03 0.39±0.06 26.2±7.22 0.10±0.01 0.03±0.02

1086 Intracoronary Delivery of Ad5FGF-4 Results in

Undetectable Levels of Systemic FGF-4 Protein

Florence C Paillard,1 Ilona Canestrelli,1 Carol-Gay Yates,1 N Chin

Lai,2 M Dan McKirnan,1 David A Roth,1 John Warner,1 H Kirk

Hammond.2

1 Collateral Therapeutics, Inc., San Diego, CA, United States;

2 Veterans Administration Medical Center, San Diego, CA, United

States

88 898,  

1087 Synergistic Induction of Functional Angiogenesis and Stem Cell Recruitment by VEGF and Angiopoietin-1 Gene T

Angiopoietin-1 Gene Transfer Using ransfer Using ransfer Using AA AA AAV V V V V Vectors ectors

Nikola Arsic,1 Lorena Zentilin,1 Serena Zacchigna,1 Daniela Santoro,1 Giorgio Stanta,2 Alessandro Salvi,3 Gianfranco Sinagra,3

Mauro Giacca.1

1 Molecular Medicine, International Centre for Genetic Engineering and Biotechnology (ICGEB, Trieste, Italy; 2 Istituto di Anatomia Patologica, Universita ′ di Trieste, Italy; 3 Unita ′ di

Cardiologia, Ospedale Maggiore, Trieste, Italy

 

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Molecular Therapy Vol 5, No 5, May 2002, Part 2 of 2 Parts

1088 Muscle Distributon of Plasmid DNA and Related

mRNA Expression Following a Single Intramuscular

Injection of NV1FGF in Dog

Florence Boissière,1 Françoise Finiels,1 Eric Sénéchal,1 Jean Paul

Pasquet,1 Pia Delaère.1

1 Gencell, a division of Aventis Pharma, Vitry sur Seine, France,

Metropolitan

1089 Processed Form of VEGF-D Is the Most Potent Angiogenesis Factor of VEGF Family

Johanna E Markkanen,1 Tuomas T Rissanen,1 Marcin Gruchala,1

Mikko I Kettunen,2 Risto A Kauppinen,2 Marc G Achen,3 Steven A Stacker,3 Kari Alitalo,4 Seppo Ylä-Herttuala.1

1 Molecular Medicine, A I Virtanen Institute, Kuopio University, Kuopio, Finland; 2 National NMR Facility, A.I Virtanen Institute, Kuopio University, Kuopio, Finland; 3 Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Melbourne, Victoria, Australia; 4 Molecular/Cancer Biology Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland

1090 Reversal of Hypercholesterolemia-Induced Impairment of Angiogenesis by FGF-1 Gene Therapy in a Hamster Model of Hindlimb Ischemia

Alexis Caron, Sandrine Michelet, Sylvie Sordello, Claire Saulnier, Bertrand Schwartz, Didier Branellec, Florence Emmanuel