evolution of antimicrobial resistance and serotype distribution of streptococcus pneumoniae isolated from children with invasive and noninvasive pneumococcal diseases in algeria from 2005 to 2012

Evolution of antimicrobial resistance and serotype distribution of Streptococcuspneumoniae isolated from children with invasive and non-invasive pneumococcal diseases in Algeria from 200

Evolution of antimicrobial resistance and serotype distribution of Streptococcus

pneumoniae isolated from children with invasive and non-invasive pneumococcal

diseases in Algeria from 2005 to 2012

Nadjia Ramdani-Bouguessa, Hanifa Ziane, Souad Bekhoucha, Zehor Guechi, Amina

Azzam, Djamila Touati, Malek Naim, Sihame Azrou, Moufida Hamidi, Abdelouahab

Mertani, Abdennour Laraba, Tahar Annane, Salah Kermani, Mohamed Tazir

PII: S2052-2975(15)00030-X

DOI: 10.1016/j.nmni.2015.02.008

Reference: NMNI 29

To appear in: New Microbes and New Infections

Received Date: 19 September 2014

Revised Date: 19 December 2014

Accepted Date: 24 February 2015

Please cite this article as: Ramdani-Bouguessa N, Ziane H, Bekhoucha S, Guechi Z, Azzam A, Touati

D, Naim M, Azrou S, Hamidi M, Mertani A, Laraba A, Annane T, Kermani S, Tazir M, Evolution of

antimicrobial resistance and serotype distribution of Streptococcus pneumoniae isolated from children with invasive and non-invasive pneumococcal diseases in Algeria from 2005 to 2012, New Microbes and New Infections (2015), doi: 10.1016/j.nmni.2015.02.008.

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Bacteremia Meningitis Pleuro- Other IPD Total Otitis LRTI Total Meningitis Pleuro- Bone Otitis LRTI Total Overall

Serotypes pneumonia IPD<5 <5 pneumonia and joint 5 - 16 total

Table 4: Resistance profiles by isolated S pneumoniae serotypes

Antimicrobial 14 19F 6B 23F 5 7F 6A 19A 16F 24A 28F Total

oxa, ery, clin, chl, sxt, tet 1 1

oxa = oxacillin; sxt = cotrimoxazole; tet = tetracyclin; ery = erythromycin; clin = clindamycin; chl = chloramphenicol

Figure 1: Serotype prevalence and pneumococcal vaccine coverage of serotypes isolated

from children ≤5 years with IPD

Figure 2: Resistance to penicillin and cefotaxime of S pneumoniae serotypes isolated from

children ≤5 years I = intermediate resistance; R = resistant

2 1

6 4