Monday Morning Continued Elemental Impurities in Pharmaceuticals: Requirements, Applications, Techniques Chair: Nancy Lewen, Bristol-Myers Squibb 9:00 Pilot Study for Using Portable XRF
Trang 12014 Preliminary Technical Oral Program
MONDAY MORNING, NOVEMBER 17
Time Title, Author(s)
American Microchemical Society Benedetti-Pichler Award
Honoring Gene Hall, Rutgers University
Session Chair: Robert Vetricin
9:00 Finger Prick Blood Analysis: The Omega-3 Index, Ken D Stark, University of Waterloo
9:30 Forensic DNA Analysis: The Gold Standard for Criminal Investigation of Biological Evidence, Lawrence
Kobilinsky, John Jay College
10:00 Break
10:20 Doing a Lot with a Little: Ambient Ionization and Microchemistry, Robert B Cody, Jeol USA Inc
10:50 Chemical Microscopy for the 21st Century: Surface-Enhanced Raman Microspectroscopy for the
Ultrasensitive Detection of Organic Colorants, Marco Leona, The Metropolitan Museum of Art
11:20 From Archimedes Palimpsest to Water Analysis: My 35 Years of Instrumental Analytical Chemistry at
Rutgers, Gene S Hall, Rutgers University
New York Section of the Society for Applied Spectroscopy Gold Medal Award
Honoring Larry A Nafie, Syracuse University
Session Chair: Deborah A Peru, Colgate-Palmolive Co.
9:00 Vibrational Optical Activity: An Established Tool for Research and Routine Analytical Applications,
Laurence A Nafie, Syracuse University
9:30 Two-Dimensional Correlation Spectroscopy in Materials Development, Isao Noda, University of
Delaware
10:00 Break
10:20 Electrospun PHA (polyhydroxyalkanoate) Fibers: Influence of Processing on Structure, Bruce Chase,
Liang Gong, Isao Noda, John Rabolt, University of Delaware
10:50 UV Resonance Raman Spectroscopic Studies of Protein Structure and Dynamics, Sanford (Sandy) A
Asher, University of Pittsburgh
Quality Control and Bioanalysis of Protein Therapeutics
Chair: Naidong Weng, Janssen
9:00 Application of UPLC-High Resolution MS in Drug Product Comparability Studies, Pilsoo Kang, Jianmei
Kochling, Yimin Hua, Robert W Donaldson, Genzyme
9:20
Quality-by-Design Method Development of the 2nd Generation Peptide Map Assays for Therapeutic
Proteins, Yimin Hua, Francisca Gbormittah, Alekhya Pochiraju, Qian Guan, Robert W Donaldson,
Jianmei Kochling, Genzyme
9:40 A Novel HILIC Column for the High Speed Analysis of N-Linked Glycans, James Martosella, Oscar
Potter, Jia Liu, Agilent Technologies
10:00 Break
10:20 The Influence of Biocompatible Coating Thickness of Non-porous Polymer Beads on Protein Recoveries
and Resolution, Michael Lu, BioChrom Labs
10:40
Development, Validation and Comparison of a Competitive Ligand Binding and a Functional Cell-Based Assay for Neutralizing Antibody (NAb) Detection, Weifeng Xu, Michael Sank, Jennifer Cummings,
Xuefeng Li, Robert Dodge Renuka Pillutla, Binodh DeSilva, Merck
11:00 Okra Seed Phytochemicals: Potential Treatments for Glycemic Control and Regulators of Enzyme
Cholesterol 7-alpha-Hydroxylase in Bile Acid Biosynthesis, Bishambar Dayal, Rutgers Medical School
Trang 2Monday Morning Continued
Elemental Impurities in Pharmaceuticals: Requirements, Applications, Techniques
Chair: Nancy Lewen, Bristol-Myers Squibb
9:00 Pilot Study for Using Portable XRF for Screening for Elemental Impurities, James Morykin, Bristol-Myers
Squibb
9:30 Determination of Elemental Impurities: A Practical Approach from a Contract Lab, Samina Hussain,
Exova
10:00 Break
10:20 Method Development and Validation for the Quantification of Elemental Impurities in Large and Small
Molecule Drug Substance and Drug Product, Timothy Shelbourn, Eli Lilly
10:50 An Update on General Chapters <232> and <233> and Implementation Timelines, Kahkashan Zaidi,
United States Pharmacopeia
Microscopy and Microanalysis for Cultural Heritage, Part I, organized with the New York Conservation Foundation and New York Microscopical Society
Chair: John Scott, NYCF
9:00 Simple Magnification, Optical Phase Contrast Microscopy, and Desktop SEM-EDS: Characterizing a
Cleaning Agent, John Scott, New York Conservation Foundation
9:30 SEM-EDS and Multi-Instrumental Analysis: Studying the Corrosion of Ag 999 and Ag 925 Inside and
Outside Vitrines, Paula Homem, Universidade do Porto
9:50 Break
10:10
Accessible Microanalysis in Authentication and Attribution: A Case Study, Soraya Alcalá, Hèléne
Fontoira, The Hispanic Society of America, Thiago Assan Piwowazrczyk, Marcelo Myada Redígolo, Interface Research Analysis Solutions
10:40 Scientific Analysis of Pietro da Cortona’s The Triumph of David, Kristen E Watts, Amanda Norbutus,
Anthony Lagalante, Villanova University, Kristin deGhetaldi, University of Delaware
11:00 Morphology of Fungal Stains on Paper Characterized With Multi-Scale and Multi-Sensory Surface
Metrology, Hanna M Szczepanowska, Smithsonian Institution, Brian Renegar, National Institute of
Standards and Technology
Analysis of Textiles and Other Materials
Chair: Sandra Ferris, The Dow Chemical Company
9:00
Investigation of Body Products on Worn Clothing Substrate Found at a Fire Scene Conflicting with Ignitable Liquid Residue Identification by GC/MS, Gina M Guerrera, Brooke W Kammrath, University of
New Haven, Erika Chen, Michael Valetutti, New York City Police Department
9:20 Differentiation of Human, Animal, and Synthetic Hair by ATR FTIR Spectroscopy, Jeremy M Manheim,
Kyle Doty, Greg Mclaughlin, Igor K Lednev, University at Albany
9:40 Quantitation of Dyes in Forensic Fibers Using UHPLC-TOF MS and Building a Dye Database with
AxION EC ID Software, Sharanya Reddy, Joanne Mather, Bonnie Marmor, PerkinElmer
10:00 Break
10:20 Characterization of the Binding Medium Used in Roman Encaustic Paintings on Wall and Wood, Ruben
M Savizky, John L Bove, Pedro Cuni, Jorge Cuni, Brielle Eisen, The Cooper Union
10:40 Structural Characterization of Manmade Fiber Using Fluorescence Microscopy and Image Analysis,
Shailesh P Nagarkar, Prasad Panzade, Aditya Birla Science and Technology Company
11:00 Non-Destructive Testing with Ultrasound and Visual Inspection, an Approach to Historic Buildings, Eloisa
Dezen-Kempter, Gisleiva C S Ferreira, State University of Campinas
11:20 Differentiating Authentic from Counterfeit Drugs by Raman Microscopy, Fran Adar, HORIBA Scientific,
Pauline E Leary, The Graduate Center, City University of New York, John A Reffner, John Jay College
Handheld Vibrational Spectrometers and Imagers: Innovations and Novel Applications
Chair: Heinz W Siesler, University of Duisburg-Essen
9:00 Fit-for-Purpose Miniature NIR Spectroscopy for Solid Dosage Continuous Manufacturing, Krizia Karry,
Rutgers University
9:30 The Next Generation of Long Wavelength Handheld Raman Spectrometers for Raw Material Inspection
and Beyond, Claire Dentinger, Rigaku Raman Technologies
10:00 Break
10:20 Mixture Analysis Using Handheld Raman Spectrometer, Dawn Yang, B&W Tek
10:50 Miniaturized Multi-Spec (UV-NIR, Raman and Hyperspectral) Instruments in Practical In-Situ Analysis,
Fredrick Haibach, BaySpec
Trang 3Monday Morning Continued
Process Analysis and Instrumentation
Chair: Yuwen Wang, Boehringer Ingelheim
9:00 Off-Line and In-Line Monitoring of Mulling Processes, Savitha S Panikar, Suyang Wu, Benjamin J
Glasser, Rohit Ramachandran, Rutgers University
9:20 Achieving Greater Process Understanding Through On-Line Reaction Monitoring, Michael L Hall, Nancy
L Jestel, Eylem Tarkin-Tas, Mark Denniston, Carolyn Degonzague, SABIC
9:40
In-Line PAT Method Development for Flowing Pharmaceutical Blend Homogeneity Monitoring, Fan
Zhang-Plasket, John P Higgins, Cat MacConnell, Mano Ramasamy, Robert F Meyer, Charles E Miller, Jennifer Pai, Merck
10:00 Break
10:20 NIR Analyses in the Field; how to get better Answers, Franklin E Barton, James A de Haseth, Light
Light Solutions Instruments
10:40
High-Throughput Virtual Slit Technology: Benefits for Polymer Extrusion, Yusuf Bismilla, Jeffrey T
Meade, Bradford B Behr, Andrew T Cenko, Brandon DesRoches, Jared Slaa, Arsen R Hajian,
Tornado Spectral Systems
Innovative Practices in Analytical Testing
Chair: Richard B Nguyen, Merial
9:00 Analytical Testing for the Cannabis Industry: A New Era Presents New Opportunities, Christopher J
Hudalla, Nathan M LaCroix, ProVerde Laboratories
9:20 Impact of Method Robustness to the Success of Product Commercialization - Lesson Learned, Xin Bu,
John Castoro, Joel Young, Bristol-Myers Squibb
9:40 Incorporation of Benchtop NMR Spectroscopy into Undergraduate Laboratories: An Active-Learning
Approach, Susanne Riegel, Nanalysis
10:00 Break
10:20 Analytical Pipetting of Serum and Serum-Like Liquids, John T Bradshaw, Richard H Curtis, Rachel
Parshley, Artel Inc
10:40 S.M.A.R.T Laboratory Practices, Julius Neil Buenconsejo, Keppel Seghers Engineering
11:00 Taking the Pain Out of Chromatographic Peak Integration, Peter Bodsky, Shaun Quinn, Thermo Fisher
Scientific
11:20
Innovative Approach to Helium Carrier Gas Conservation in Analytical Gas Chromatography, Lori Dolata,
Edward B McCauley, Massimo Santoro, Paolo Magni, Alexander N Semyonov, Thermo Fisher
Scientific
11:40 Automated, Rapid, Reliable Determination of Dissolved Gases in Water by Static Headspace Gas
Chromatography, Lori Dolata, Andrea Caruso, Richard Jack, Massimo Santoro, Thermo Fisher Scientific
NMR Spectroscopy of Molecules Small and Large: Methods and Applications, Part I
Chair: Bernie O'Hare, Bruker
9:00 Assessing Qualitative and Quantitative NMR Limits in a Drug Metabolism Environment, Gregory Walker,
Pfizer
9:30 Pulsed Field Gradient Nuclear Magnetic Resonance (PFGNMR) Studies of Nanoparticle Surfaces and
their Interactions, Kebede Beshah, Aslin Izmitli, Antony Van Dyk, The Dow Chemical Company
10:00 Break
10:20 High-Throughput Screening of Solid Pharmaceuticals with 35Cl Solid-State NMR, Robert W Schurko,
Michael J Jaroszewicz, Anthony R Sandre, Andrew M Namespetra, Kristopher J Harris, University of Windsor, Adonis Lupulescu, Lucio Frydman, Weizmann Institute
10:40 Strategies to Enhance the Sensitivity and Reduce the Ambiguity of NMR Spectra of Complex Biological
Assemblies, Galia Debelouchina, Princeton University
11:00
Understanding the Behavior of Different Tablet Disintegrants Using High-Resolution FLASH Magnetic
Resonance Imaging, Anuji Abraham, Dolapo Olusanmi, David Good, Denette Murphy, Daniel
McNamara, Venkatramana Rao, Bristol-Myers Squibb, Andrew J Ilott, Alexej Jerschow, New York University
Trang 4MONDAY AFTERNOON, NOVEMBER 17
EAS Award for Outstanding Achievements in the Fields of Analytical Chemistry
Honoring Joseph A Caruso, University of Cincinnati
Sponsored by Bristol-Myers Squibb
Session Chair: William R Heineman, University of Cincinnati
Plenary Lecture and Awards Presentation to Joseph Caruso, University of Cincinnati, immediately follow this session
2:00 New Sources for Ambient Desorption/Ionization Mass Spectrometry, Gary M Hieftje, Jacob T Shelley,
2:30
The Liquid Sampling-Atmospheric Pressure Glow Discharge (LS-APGD) Microplasma: An Example of What I Learned from Joe Caruso - Its More Fun Living (a little) Outside of the Box, R Kenneth Marcus,
Clemson University
3:00 Break
3:20 Plasma Sources Pushing the Limits in Analytical Chemistry, David W Koppenaal, Pacific Northwest
National Laboratory
3:50 Spectroelectrochemistry as a Strategy for Improving Sensor Selectivity, William R Heineman, University
of Cincinnati, Samuel A Bryan, Pacific Northwest National Laboratory
4:30 Presentation of the EAS Award in the Fields of Analytical Chemistry
4:35 From Solution Chemistry to Mass Spectrometry – My Fields of Analytical, Joseph A Caruso, University
of Cincinnati
Development of Pharmaceutical Generics: Analytical Challenges
Chairs: Leonel M Santos, United States Pharmacopeia and Kim Huynh-Ba, Pharmalytik
2:00 Key Issues of Generic Drug Development, Saji Thomas, Par Pharmaceuticals
2:30 Stability Requirements of ANDA Products, Kim Huynh-Ba, Pharmalytik
3:00 Break
3:20 Advances on the Modernization of USP Monographs, Leonel Santos, US Pharmacopeia
3:50 Comparison of Dissolution Profiles Including Bioequivalence, Method Transfer/Validation, and f2, Vivian
Gray, V A Gray Consulting
Microscopy and Microanalysis for Cultural Heritage, Part II, organized with the New York Conservation Foundation and New York Microscopical Society
Chair: Soraya Alcalá, The Hispanic Society of America
2:00 3-D Digital Microscopy and Cultural Heritage: A Successful Marriage, Ilaria Cacciari, Salvatore Siano,
IFAC-CNR
2:30
Pairing 3-D Laser Scanning Confocal Microscopy with Reflectance Transformation Imaging to Gain Insight into the Techniques Used to Create Relief and Contour Lines on Greek Red-Figure Vases, Philip
A Klausmeyer, Paula Artal-Isbrand, Worcester Art Museum
3:00 Break
3:20 Optical Coherence Tomography for the Non-Invasive 3-D Volume Imaging of Cultural Heritage, Haida
Liang, Nottingham Trent University
3:50 Pump-Probe Microscopy Enables Noninvasive, Three-Dimensional Imaging of Artwork, Warren S
Warren, Tana Villafana, Martin Fischer, Duke University
Coblentz 60th Anniversary Session Development of Vibrational Micro Spectroscopy and Imaging, organized
by the Coblentz Society
Chair: James Rydzak, GlaxoSmithKline
2:00 Diffuse Reflections on Chemical Imaging, Neil Lewis, Malvern
2:30 Historical Development of Mid-Infrared Spectroscopy, John Reffner, John Jay College
3:00 Break
3:20 Historical Development of Raman Imaging - the Impact of the Instrumentational Developments on the
Quality of the Results, Fran Adar, J Y Horiba
3:50 Terahertz Spectroscopy: Past, Present and a Very Bright Future, Richard A McKay, Advantest America
Trang 5Monday Afternoon Continued
Electronic Workflow – A New Frontier of Lab Management, organized by ALMA
Chairs: Dennis Swijter, International Flavors and Fragrances and Judy Lin, Bristol-Myers Squibb
2:00 Paper on Glass: A Practical Guide to the Implementation on Electronic Lab Notebook, James
Exarchakis, Colgate-Palmolive Company
2:30 Implementing a Process Intelligence System for Pharmaceutical Development, Edward Keefe, Megerle
Scherholz, Bristol-Myers Squibb
3:00 Break
3:20 The Role of the BIOVIA (Accelrys) Laboratory Execution System (LES) and Inventory Management
System (IM) in a CRO cGMP Environment, Kathy Shanks, PPD
3:50 Electronic Orchestration of Knowledge Creation and Management, Joel Young, Ronald Behling, Larry
Fulton, Bristol-Myers Squibb
Integrating Analytical Chemistry Research into Curriculum
Chair: Dil Ramanathan, Kean University
2:00 Incorporating Research Method Development into the Analytical Lab, Kimberley Frederick, Maryuri
Roca, Lisa Quimby, Skidmore College
2:30 Integrating Teaching and Research: Strategies and Practices for Building a Research-Supportive
Curriculum, Roger S Rowlett, Colgate University
3:00 Break
3:20 Integration of Research into the Curriculum Using XRD and NMR Structural Analysis, Benny Chan, Abby
R O'Connor, The College of New Jersey
3:50 Involving Undergraduate Students in Collaborative Research: The Union College Aerogel Team, Mary
K Carroll, Union College
NMR Spectroscopy of Molecules Small and Large: Methods and Applications, Part II
Chair: David Rovnyak, Bucknell University
2:00 Structure/Function Studies of Obscurin Ig58/59, Nathan T Wright, James Madison University
2:30 Working with Two and Many Dimensions: Non-Uniform Sampling for Sharper Spectra More Quickly and
Principal Component Analysis to Explore Spectral Series, Frank Delaglio, Agilent Technologies
3:00 Break
3:20 Liquid State, High-Resolution 14N-NMR of Symmetrically Substituted Nitrogen-Containing Compounds,
Benjamin Liu, Princeton University
3:40
Noncanonical Polyubiquitin Chains: Insights from Structural and Dynamical Studies , Carlos Castañeda,
Syracuse University, Susan Krueger, National Institute of Standards and Technology, Ashton Cropp, Virginia Commonwealth University, David Fushman, University of Maryland
TUESDAY MORNING, NOVEMBER 18
EAS Award for Outstanding Achievements in Separation Science
Honoring Thomas L Chester, University of Cincinnati
Sponsored by Agilent Technologies
Chair: J David Pinkston, Kellogg Company
9:00 Presentation of the EAS Award for Outstanding Achievements in Separation Science
9:05 Using Complexity To Make Separations Simpler , Thomas L Chester, University of Cincinnati
9:30 Liquid Chromatographic Estimates of Octanol - Water Partitioning: Is there a Rational Stationary Phase
Choice?, John G Dorsey, Florida State University
10:00 Break
10:20
Ultrahigh Performance Supercritical Fluid Chromatography of Lipophilic Compounds with Emphasis on Synthetic and Commercial Biodiesel, Larry T Taylor, Mehdi Ashraf-Khorassani, Virginia Tech, Kenneth
J Fountain, Giorgis Isaac, Waters
10:50 Thinking Outside the Valve: Pressure Control and Other Important Questions in Supercritical Fluid
Chromatography/Mass Spectrometry (SFC/MS), J David Pinkston, Kellogg Company
Trang 6Tuesday Morning Continued
EAS New Faculty Award In NMR Spectroscopy
Honoring Megan Macnaughtan, Louisiana State University
Sponsored by Agilent Technologies
Session Chair: Patrick van der Wel, University of Pittsburgh
9:00 Spherical Nanoparticle Supported Lipid Bilayers for the Study of Membrane Proteins, Fang Tian,
Pennsylvania State University
9:30 Probing Dynamic Protein-Glycosaminoglycan Interactions Using Paramagnetic Ligands, Xu Wang,
Arizona State University
10:00 Break
10:20 NMR Studies of Bacterial Masonry that Provide Protective Barriers, Charles V Rice, University of
Oklahoma
10:50 Presentation of the EAS New Faculty Award in NMR Spectroscopy
10:55 Challenges and Triumphs in Glycoprotein NMR, Megan Macnaughtan, Louisiana State University
The Breath of Inhalation Analytical
Chair: Justin Pennington, Merck
9:00 Solid-State Characterization Techniques for Inhalation Product Development, Matthew Lamm, Merck
9:30 Using Particle and Polymer Properties to Tailor Aerosol Formulations, Christopher Kuehl, Nashwa
El-Gendy, Laird Forrest, Cory Berkland, University of Kansas
10:00 Break
10:20
Making Quantitative Inhalation Analytics Measurements in Real-Time Using Single Particle Aerosol Mass Spectrometry (SPAMS), David P Fergenson, Livermore Instruments, Maria Balaxi, David Kohler, Solvias AG, Anna Susz, Bradley D Morrical, Novartis
10:50 Using Spray Pattern Area as a Surrogate for SAC in Optimizing pMDI Test Methods, Zachary Pitluk,
Proveris Scientific
Detecting Counterfeit Pharmaceuticals
Chair: Matthew Wood, Ocean County Sheriff's Office Forensic Laboratory
9:00 Near Real Time Counterfeit Pharmaceutical Detection Along the Supply Chain, William E Mayo,
Veracity Networks Inc
9:30 Analytical Testing of Counterfeit Drugs in the Field Using Vibrational Spectroscopy and GC/MS, Pauline
Leary, Smiths Detection
10:00 Break
10:20 Paper Test Cards for Presumptive Identification of Falsified and Very Low Quality Pharmaceuticals,
Marya Leiberman, University of Notre Dame
10:50 Analysis of Counterfeit Pharmaceutical Products using Visible and Vibrational Spectroscopies Inside and
Outside of the Laboratory, Adam Lanzarotta, Nicola Ranieri, FDA Forensic Chemistry Center
Microscopy and Microanalysis for Cultural Heritage, Part III, organized with the New York Conservation Foundation and New York Microscopical Society
Chair: John Scott, NYCF
9:00
Jackson Pollock’s Number 1A (1948): Using Spatially Resolved XRF and Multivariate Analysis to
Characterize the Artist Palette and Process, Ana Martins, Jim Coddington, Museum of Modern Art, Donald Dahlberg, Lebanon Valley College, Geert van der Snickt, University of Antwerp, Birgit van Driel, École Polytechnique Fédérale de Lausanne, Joris Dik, Delft University of Technology
9:20
Multiphoton Microscopy: An Efficient and Promising Tool for In Situ Characterization of Historical
Artifacts, Gặl Latour, Laboratory Imagery and Modélisation en Neurobiology et Cancérologie, Laurianne
Robinet, Museum National Natural History, Jean-Philippe Echard, Marie Didier, Musée de la Musique, Marie-Claire Schanne-Klein, Ecole Polytechnique
9:50 Break
10:10
Advances in the Imaging and Microscopy of semiconductor Pigments: From Laser-Based
Time-Resolved Luminescence Imaging to Micro X-Ray Fluorescence Analysis using Synchrotron Radiation ,
Austin Nevin, Sara Bellei, Institute of Nanotechnologies and Photonics, Anna Cesaratto, Valentina Capogrosso, Gianluca Valentini, Daniela Comelli, Politecnico di Milano, Caroline Tokarski, Hervé Vezin, University Lille
10:40
Laser Ablation Surface-Enhanced Raman Microspectroscopy, Pablo Londero, Marco Leona, The
Metropolitan The Metropolitan Museum of Art, Anna Cesaratto, Politecnico di Milano, John R Lombardi, City College on New York
Trang 7Tuesday Morning Continued
LC Productivity Through Particle Change: Size, Type, Shape
Chair: Peter Broske, Agilent Technologies
9:00 Method Development with Zirconia Based Stationary Phases, Clayton McNeff, Daniel Nowlan, Kelly S
Johnson, ZirChrom Separations, Richard Henry, Consultant
9:20 High-Pressure Ion Chromatography: Following the Lead of UHPLC, Peter Bodsky, Frank Hoefler, Maria
Rey, Thermo Fisher Scientific
9:40 Achieving Maximum Kinetic Performance from UHPLC Columns, Richard A Henry, William H
Campbell, David S Bell, Sigma-Aldrich/Supelco
10:00 Break
10:20
Halophase: A Novel Stationary Phase with Tunable Retention Properties through Functionalized
Carboxylate Deposition of Halogenated Small Molecules, Brian A Logue, Michael W Stutelberg,
Venkataiah Mallam, Robert P Oda, Raj K Bhandari, South Dakota State University
10:40
The Use of Elevated Temperature in HPLC Biomolecule Separation to Shorten Analysis Time and
Improve Peak Shape with Wide-Pore, Core-type Silica Columns, Stacy Squillario, Roy Eksteen, Hillel
Brandes, Sigma-Aldrich/Supelco
11:00 Easy Method Transfer and Scalability with Superficially Porous Particles, Anne E Mack, William J Long,
Wu Chen, Xiaoli Wang, Jason Link, Maureen Joseph, Agilent Technologies
11:20 Monolithic Silica’s for “Dirty Sample” HPLC Analysis with Less Sample Preparation, Egidijus
Machtejevas, EMD Millipore
Chemometric and Spectroscopic Applications in Forensics, organized by the Coblentz Society
Chairs: Brandye Smith-Goettler, Merck
9:30 Raman Microspectroscopy and Advanced Statistics for the Analysis of Biological Stains and Gunshot
Residue, Igor K Lednev, Greg McLaughlin, Kyle C Doty, Justin Bueno, University at Albany
10:00 Break
10:20 Chemometrics in Action: Deployment of Handheld Spectroscopic Devices for First Responders,
Suzanne Schreyer, Lin Zhang, Michael Hargreaves, Thermo Fisher Scientific
10:50 Hyperspectral Imaging and its Applications in Forensics Science, Jeffrey Beckstead, ChemImage
Corporation
Detection and Fate of Nanoparticles in Biota
Chair: Jason White, Connecticut Agricultural Experiment Station
9:00 Fate and Effects of Engineered Nanomaterials in Agricultural Systems, Jason White, Joseph Hawthorne,
Roberto De la Torre-Roche, Connecticut Agricultural Experiment Station
9:30
Locating Metal Oxide Nanoparticle Transformation in Plants Using Synchrotron X-Rays, Jorge
Gardea-Torresdey, Jose Hernadez-Viezcas, University of Texas-El Paso, Hiram Castillo-Michel, European Synchrotron Radiation Facility
10:00 Break
10:20
Determination of Carbon Nanotube Fate and Exposure Using a Microwave-Induced Heating Method,
Jacyln Cañas-Carrell, Amanda Parra, Sabrina Deleon, Fahmida Irin, Mohammad Saed, Micah Green, Texas Tech University
10:50
Identification and Avoidance of Potential Artifacts and Misinterpretations in Nanomaterial Ecotoxicity Measurements, Elijah Petersen, Vincent Hackley, Teresa Kirschling, National Institute of Standards and
Technology, Theodore Henry, Heriot-Watt University, Jian Zhao, Baoshan Xing, Stockbridge School of Agricultural, Robert MacCuspie, Florida Polytechnic University, Marina Dobrovolskaia, Leidos
Biomedical Research Inc., Jason White, Connecticut Agricultural Experiment Station
Trang 8Tuesday Morning Continued
Functional Surfaces: Preparation and Analysis
Chair: Robert Opila, University of Delaware
9:00
Silicon Surface Functionalization to Control the Oxidation State of Copper during Metalorganic Chemical
Vapor Deposition of Cu(I) and Cu(II) Precursors, Yichen Duan, Andrew Teplyakov, University of
Delaware
9:20 Mechanism of Electrical Passivation of Silicon Surfaces with Quinhydrone, Meixi Chen, Nicole A
Kotulak, Nikolas J Schreiber, Robert L Opila, University of Delaware
9:40
Electron Beam Induced Reactions of Adsorbed π-Allyl Ruthenium Tricarbonyl Bromide: Towards Design
of Electron Beam Induced Deposition (EBID)-Specific Precursors, Julie A Spencer, Rachel Thorman,
Michael Barclay, D Howard Fairbrother, Johns Hopkins University, Joseph A Brannaka, Lisa McElwee-White, University of Florida, Oddur Ingólfsson, University of Iceland
10:00 Break
10:20 Formation of High-Coverage Nanoparticle Monolayers through Click Chemistry, Mackenzie G Williams,
Yue Liu, Timothy Miller, Andrew Teplyakov, University of Delaware
10:40
Correlation of Carbon Growth on Ru-Capped Multilayer Mirrors Irradiated by Extreme-Ultraviolet Light and Electrons, Michael S Barclay, Nadir S Faradzhev, Howard Fairbrother, Johns Hopkins University,
Shannon B Hill, Thomas B Lucatorto, National Institute of Standards and Technology
11:00 Controlled Synthesis and Optical Studies of ZnO Nanostructures, Zhengxin Li, Jolie Blake, Lars
Gundlach, University of Delaware
Food and Additive Analysis
Chair: Michael Ruberto, Materials Need Consulting
9:00 Detection of Olive Oil Adulteration Using Benchtop NMR Spectroscopy, Susanne Riegel, Nanalysis
9:20
Determination of Perfluorooctanoic Acid (PFOA) from the Surface of Cookware under Simulated Cooking
Conditions Using Accelerated Solvent Extraction (ASE) and LC/MS/MS, Changling Qiu, Douglas Raynie,
South Dakota State University
9:40
HPLC Analysis of a Commercial Whirlpool Hopping Process in the Beer Brewing Industry, Jessica S
Henry, Kelsey A Packard, Elizabeth A Brady, Sterling A Tomellini, University of New Hampshire, Austin D Gregoire, Craft Brew Alliance
10:00 Break
10:20 Development of SERS Methods for Rapid Detection of Multi-Pesticides in Food, Lili He, University of
Massachusetts-Amherst
10:40 Very Large Range Pesticide Screening in Food Using GC Triple Quadrupole MS, Lori Dolata, Massimo
Santoro, Thermo Fisher Scientific
11:00 Analysis of Beer, Wine and their Agricultural Constituents (Hops, Grapes, Grains) for Pesticides Using
QuEChERS Extraction and High-Throughput Sample Preparation, Patricia L Atkins, SPEX CertiPrep
11:20
Vacuum Ultraviolet Detection for the Identification and Quantification of Pesticides by Gas
Chroma-tography, Hui Fan, Doug D Carlton, Jr., Ian Sawicki, Kevin A Schug, University of Texas – Arlington,
Phillip Walsh, Dale Harrison, VUV Analytics
11:40 Development of a Sensitive LC/UV Method to Determine Two Trace Aldehydes in Maltitol, George
Wang, Zhen Wu, Holly M Shackman, Mark S Bolgar, David K Lloyd, Bristol-Myers Squibb
TUESDAY AFTERNOON, NOVEMBER 18
EAS Award For Outstanding Achievements in Chemometrics
Honoring Marcel Maeder, University of New Castle
Sponsored by Eigenvector Research
Session Chair: Paul Gemperline, Eastern Carolina University
2:00 Hard-Modelling - from Titrations to Solving Climate Tribulations, Graeme Puxty, CSIRO
2:30 Hybrid Hard and Soft-Modeling and Local Rank Analysis: Two Relevant Ideas to Describe and Explore
Chemical Systems, Anna de Juan, University of Barcelona
3:00 Break
3:20 Calculation of Feasible Bands for Visualizing the Constraint Effects in Model-Free Methods, Hamid
Abdollahi, Institute for Advanced Studies in Basic Sciences
3:50 Presentation of the EAS Award for Outstanding Achievements in Chemometrics
3:55 Chemometrics: The Balance Between ‘Chemistry’ and ‘Metrics’, Marcel Maeder, University of New
Castle
Trang 9Tuesday Afternoon Continued
Dried Blood Spot (DBS) Analysis and its Alternatives: Recent Advances in Clinical, Forensic and
Pharmaceutical Applications
Chairs: Daniel Norwood, Boehringer Ingelheim and Naiyu Zheng, Bristol-Myers Squibb
2:00 History of DBS and its Development from Clinical to Pharmaceutical Application, Daniel L Norwood,
Boehringer Ingelheim
2:30 Dried Blood Spots - From Newborn Screening to Forensic Science, Donald Chace, Pediatrix Medical
Group
3:00 Break
3:20 Recent Progress in Overcoming Some Obstacles in Implementing Dried Blood Spot Technology in Drug
Development, Qin Ji, Bristol-Myers Squibb
3:50
Automated Bioanalysis of Dried Blood Spots and Dried Plasma Spots Coupled with High Resolution Mass Spectrometry and SRM LC/MS Technologies, Jack Henion, Robert Sturm, Regina Oliveira,
Quintiles Bioanalytical and ADME Labs
Understanding Supercritical Fluid Chromatography and Using It, sponsored by the Chromatography Forum
of Delaware Valley
Chair: Mary Ellen McNally, E.I DuPont de Nemours and Company
2:00 Enhanced-Fluidity Liquid Chromatography (EFLC) for Highly Polar Biologically Relevant Compounds,
Susan Olesik, Martin Beres, Rafael Bennett, Ohio State University
2:30 Recent Advances in SFC Applications, Jennifer Van Anda, Agilent Technologies
3:00 Break
3:20 Effect of Particle Size on the Speed and Resolution of Chiral Separations Using Supercritical Fluid
Chromatography, Mirlinda Biba, Erik L Regalado, Christopher J Welch, Merck, Naijun Wu, Celgene
3:50 The Power of Ultra Performance Convergence Chromatography; Theoretical Considerations and some
Examples of Use, Francois Huby, The Dow Chemical Company
Forensic Toxicology
Chair: Barry K Logan, Center for Forensic Science Research and Education
2:00
Comparison of GCMS, EIA, and LC-QTOF Screening Methods for Novel Psychoactive Substances in Urine Samples, Jill Yeakel, Lehigh Valley Toxicology, Mandi Mohr, Center For Forensic Science
Research and Education, Barry Logan, NMS Labs
2:30 Use of Time-of-Flight (TOF) and Quadrupole Time-of-Flight (QTOF) Methodologies for Detection of
Designer Drugs in Forensic Toxicology Casework, Jared Castellani, South Carolina Law Enforcement
3:00 Break
3:20 Simultaneous Analysis of 22 Anti-Epileptic Drugs in Post-Mortem Blood, Serum and Plasma, Karen
Scott, Arcadia University
3:50 Development and Validation of a Quantitative Method for the Detection of Pyrroldinophenone Designer
Drugs in Blood Using LC-MS/MS, Donna Papsun, NMS Labs
New York Microscopical Society Ernst Abbe Award
Symposium on Atomic Force Microscopy Infrared Spectroscopy, organized with the New York
Conservation Foundation
Honoring Dr Alexandre Dazzi, University of Paris-Sud
Session Chair: John Reffner, John Jay College
2:00 How Photoacoustic and Nanomechanics Combine to Perform IR Spectroscopy at the Nanoscale,
Alexandre Dazzi, University of Paris-Sud
2:30 Extending AFM-Based Infrared Spectroscopy to a Wide Range of Applications, Craig Prater, Anasys
Instruments
3:00 Break
3:20 AFM-IR: Nanoscale IR Spectroscopy for the Materials and Life Sciences, Curtis Marcott, Light Light
Solutions, Craig Prater, Qichi Hu, Michael Lo, Kevin Kjoller, Anasys Instruments
3:50 Tip-Enhanced Infrared Nanospectroscopy via Molecular Expansion Force Detection, Mikhail A Belkin,
Feng Lu, Mingzhou Jin, University of Texas
4:20
NanoIR to Investigate Parchment and its Degradation, Laurianne Robinet, Center of Research for
Conservation, Gặl Latour, Ariane Deniset-Besseau, Alexandre Dazzi, University of Paris-Sud, Marie-Claire Schanne-Klein, Laboratory for Optics and Biosciences
Trang 10Tuesday Afternoon Continued
Novel Applications of Mass Spectrometry to Solve Analytical Challenges
Chair: Fenghe Qiu, Boehringer Ingelheim
2:00
Quantitating Protein Panels And Normalizing Hematocrit From Dried Blood Spots (DBS) Using An Automated SISCAPA® Mass Spectrometry Workflow, Morteza Razavi, Selena S Larkin, Terry W
Pearson, Leigh Anderson, SISCAPA Assay Technologies
2:20
Validated Determination of Dapagliflozin and Qualitative Determination of Its Glucuronide Metabolite in Human Dried Blood Spot: Multiple-Site Pediatric Clinical Experience, Xiaohui Xu, Jane Liu, Jim Shen,
Melanie Pe Benito, Marsha Epstein, Guowen Liu, David Boulton, Pathanjali Kadiyala, Mark E Arnold, Qin C Ji, Bristol-Myers Squibb, Michael Waldron, PPD
2:40 Probing Host-Guest Interaction Using Hydrogen-Deuterium Exchange and Mass Spectrometry, Jui S
Chaugule, Dil Ramanathan, Kean University
3:00 Break
3:20
Advantages and Challenges of Applying LC-MS/MS to Regulated Protein Bioanalysis, Hao Jiang,
Jianing Zeng, Craig A Titsch, Linlin Luo, Dharmesh D Desai, Anne F Aubry, Binodh S DeSilva, Mark
E Arnold, Bristol-Myers Squibb
3:40 Improved LC/MS Method Development for Pain Management Panels, Thomas A Russell, Shimadzu
Scientific Instruments
4:00 Identification of Volatile Organic Compounds in Beer by TurboMatrix Headspace Trap System-Gas
Chromatography-Mass Spectrometry, Hetal Rana, Dil Ramanathan, Kean University
The Role of Analytical Chemistry in Water Quality, sponsored by Thermo Fisher Scientific
Chair: Sut Ahuja, Ahuja Consulting
2:00 TBA, Sut Ahuja, Ahuja Consulting
2:30 Raising Awareness of Water Issues: The Education Connection, the Educational Potential, Mark A
Benvenuto, University of Detroit Mercy
3:00 Break
3:20 Recent Developments in Stationary Phases for Ion Chromatography, Christopher A Pohl, Thermo
Fisher Scientific
4:50 Novel Electrochemical and Reflectance Photometric Techniques for the Measurement of Trace Arsenic
in Water, Abul Hussam, Douglas Mays, Jinsoo Hong, Joan Rozario, George Mason University
4:20 Pharmaceuticals in Environment and Water Quality: The Role of Analytical Chemistry, Hua Yao,
Bristol-Myers Squibb
Surface Spectroscopy and Microscopy
Chair: Andrew Teplyakov, University of Delaware
2:00 Passivation of Semiconductor Surfaces, Robert Opila, University of Delaware
2:30 Interface Analysis of Nano-scale Materials, Leonard Feldman, Rutgers University
3:00 Break
3:20 Assembly and Nanocrystallization in Carbon Nanoparticle Films, Janice Reutt-Robey, University of
Maryland
3:50
Understanding the Electron Stimulated Surface Reactions of Organometallic Complexes to Enable Design of Precursors for Electron Beam Induced Deposition, Howard Fairbrother, Julie Spencer, Mike
Frontiers in Biological NMR Spectroscopy
Chair: Scott Showalter, Pennsylvania State University
2:00 Characterizing the Dynamic Formation of Disease Protein Aggregates using Dark-State Exchange
Saturation Transfer (DEST) NMR, Nicolas L Fawzi, Brown University
2:30 Structure, Dynamics, and Function of Opa60: A Neisserial Beta-Barrel Membrane Protein that Mediates
Host Phagocytosis, Linda Columbus, Alison K Criss, Peter M Kasson, University of Virginia
3:00 Break
3:20 Characterization of the Active Site of Vanadium Chloro-peroxidase by 51V Solid-State NMR
Spectroscopy, Rupal Gupta, Guangjin Hou, Tatyana Polenova, University of Delaware
3:40
13 C-Detect NMR and Mass Spectrometry Applied to Study the Effects of Post-Translational Modifications
on Disordered Proteins, Eric B Gibbs, Debashish Sahu, Scott A Showalter, The Pennsylvania State
University
4:00 Studying Networks of Weak Protein Interactions by NMR, Assen Marintchev, Nabanita Nag, Jielin Yu,
Devika Nadkarni, Boston University School of Medicine, Katherine A Edmonds, Indiana University, Boriana Marintcheva, Bridgewater State University