effects of intermittent fasting on metabolism in men

Effects of intermittent fasting on animal models Increased resistance to stress after intermittent fasting... recovery,along withimprovementofseveral parametersofMetabolic changes during

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w w w r a m b o r g b r

Fernanda Reis de Azevedoa, ∗, Dimas Ikeokab, Bruno Caramellia

aInterdisciplinary Medicine in Cardiology Unit, Heart Institute (InCor), Medical School, Universidade de São Paulo, São Paulo, SP, Brazil

bSecond Department of Surgery, Post-operative Care Unit, Medical School, Universidade de São Paulo, São Paulo, SP, Brazil

a r t i c l e i n f o

Article history:

Keywords:

Fasting

Obesity

Dyslipidemia

a b s t r a c t

Efeitos do jejum intermitente no metabolismo humano

Palavras-chave:

Jejum

Obesidade

Dislipidemia

r e s u m o

Introduction

Methodology

Pathophysiological basis of obesity and MS

Effects of intermittent fasting on animal models

Increased resistance to stress after intermittent

fasting

recovery,along withimprovementofseveral parametersof

Metabolic changes during fasting in humans

such as GSK-3, which is responsible for the regulation of

Intermittent fasting

Cardiovascular system

Metabolic fuel

Metabolic/

inflammatory

⇑ Fat oxidation Physiological

parameters:

⇓ HR and BP

Decreased inflammatory state Improved

glucose profile ⇓ IL-6,

TNF-α, CRP

⇓ Gl uco se

⇓ In sulin

Pre-infarction:

⇓ Infartion area=

⇓ apoptosis +

Post-infarction:

⇓ Apoptosis

⇓ Myocardial fibrosis

Gene expression in muscle tissue

Cell survival:

⇓ p53 and p38

⇑ Sir 2 and Sirt 1

Improved

^

Lipidic pr ofile:

⇓ TG and ⇑ HDL-c

↓ CHO oxidation

Fig 1 – Potential targets for interventions using intermittent fasting (IF) IF impact in each different pathway of the

organism This is a summary of the different actions of this intervention (IF) within the metabolism demonstrated in all the studies that were used to compose this review CHO, carbohydrate; HR, heart rate; BP, blood pressure; TG, triglycerides; HDL-c, high-density lipoprotein cholesterol; CPR, C-reactive protein; IL-6, interleukine 6.

Grey boxes – Verified in human and animal studies

- - Verified in animal studies only

- Verified in human studies only

⇑ - Increase

⇓ - Decrease.

another important gene responsible for the modulation of

Clinical implications

Ramadan

Protective actions of intermittent fasting in obese individuals

havead libitumand very-low-calorie dieton alternatedays

andad libitumfoodonalternatedays.Thestudyresults

Conclusions

Conflict of interest

r e f e r e n c e s

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