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EVALUATION OF THE IN VIVO EFFICACY OF ONE COSMETIC PRODUCT USING ANTERA 3D AND SELFASSESSMENT IN HEALTHY ASIAN SKIN TYPE FEMALE SUBJECTS REFERENCE OF THE TEST PRODUCT: AcneAid Gel Scar Care (Registration No.1116400029029)

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SPINCONTROL ASIA Co , Ltd 24028 30, Ayothaya Tower, 17th Floor, Ratchadapisek Road, Huaykwang, Huaykwang, Bangkok 10310, THAILAND Version n°00 – 18 May 2022 CONFIDENTIAL STUDY REPORT Ref XX QF01 IV N.

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SPINCONTROL ASIA Co., Ltd

CONFIDENTIAL STUDY REPORT

Ref.: XX-QF01-IV-NE21

EVALUATION OF THE IN VIVO EFFICACY OF ONE COSMETIC PRODUCT USING

ANTERA 3D AND SELF-ASSESSMENT IN HEALTHY ASIAN SKIN TYPE FEMALE

SUBJECTS

REFERENCE OF THE TEST PRODUCT:

Acne-Aid Gel Scar Care (Registration No.11-1-6400029029)

Study Sponsor:

iNova Pharma (Thailand) Co., LTD

98 Sathorn Square Office Tower, 19th Floor, Unit 1901, North Sathorn Rd, Silom, Bangrak,

Bangkok 10500 THAILAND

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1 SITE OF EXPERIMENTATION, PARTICIPANTS

1.1 Site of experimentation

SPINCONTROL ASIA Co., Ltd

240/28-30, Ayothaya Tower, 17th Floor, Ratchadapisek Road,

Huaykwang, Huaykwang, BANGKOK 10310, THAILAND Phone: (+662).274.1714-18 Fax: (+662).274.1721 E-mail: spincontrolasia@spincontrolasia.com

1.2 Study Sponsor

iNova Pharma (Thailand) Co., LTD

98 Sathorn Square Office Tower, 19th Floor, Unit 1901, North Sathorn Rd, Silom, Bangrak, Bangkok 10500

THAILAND

1.3 Study Monitor

Ms Aruna SONGSRIKITIKUL iNova Pharma (Thailand) Co., LTD

Phone: (+66).89.132.2452 Fax: (+662).119.4301 E-mail: A.Songsrikitikul@inovapharma.com

1.4 Investigator

Mr Fabrice PERIN CEO– Ph.D

SPINCONTROL ASIA Co., Ltd

Phone: (+662).274.1714-18 Fax: (+662) 2.74.17.21 E-mail:fabrice@spincontrolasia.com

Date:

Signature:

1.5 Study Coordinator

Ms Kunyanatt CHALOTHORN Pharmacist - M.Sc of Pharmaceutical Technology SPINCONTROL ASIA Co., Ltd

Phone: (+662).274.1714-18 E-mail: kunyanatt@spincontrolasia.com

Date:

Signature:

23-05-2022 23-05-2022

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Table 12b: Results of the self-assessment by the subjects about product efficacy and cosmeticity after

14 days of application

Number of Subjects : 20

EFFICACY AND COSMETICITY OF THE PRODUCT

Acne-Aid Gel Scar Care (Registration

No.11-1-6400029029)

% Favorable

A17 This product helps to brighten dark acne scar 80% 3.35E-04 Yes

A18 This product helps to hydrate the skin 85% 1.02E-04 Yes

A20 In your opinion, this product reduces post acne scars by _%? (Assuming 100% at baseline) 60%: 35% (7 out of 20), 80%: 35% (7 out of 20), 100%: 15% (3 out of

20), No change: 15% (3 out of 20) A21 This product helps to prevent acne scar 80% 3.35E-04 Yes

A22 This product improves my skin appearance 90% 2.14E-05 Yes

A23 This product does not cause any irritation to my skin 100% 3.06E-07 Yes

A24 This product has a fast absorption and does not leave any stickiness on my skin 95% 3.09E-06 Yes

A25 Based on my overall experience, how would I rate my level of satisfaction for this tested product?

Somewhat satisfied: 35% (7 out of 20), Very satisfied: 35% (7 out of 20), Satisfied: 20% (4 out of 20), Neither satisfied nor dissatisfied:

10% (2 out of 20)

Yes: Significant difference in favor of the tested product After 14 days of application

After 14 days of application of the tested product Acne-Aid Gel Scar Care (Registration No.11-1-6400029029), all of the claims asked about the efficacy of the products were significantly

favored opinion by the subjects from this study The percentages of favorable opinion ranged between 75% and 100%

In addition, the second highest percentage of favorable opinion was obtained for the following statement:

o “This product does not cause any irritation to my skin” (100%)

o “This product has a fast absorption and does not leave any stickiness on my skin” (95%)

Based on these results, we can conclude that the tested product Acne-Aid Gel Scar Care (Registration No.11-1-6400029029) was appreciated by the subjects of this study, as seen by the percentages of agreement ranged between 55% and 100%, during the study period on the whole face

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