From Helsinki to Istanbul What can the transplant community learn from experience in clinical research

Glassocket al.An epidemic of chronic kidney disease: fact or fiction?Nephrol Dial Transplant2008; 23: 1117–1121.. Familial pure proximal renal tubular acidosis—a clinical and genetic stu

I Editorial Features

EDITORIAL COMMENTS

From Helsinki to Istanbul: What can the transplant

community learn from experience in clinical

research?

Fact or fiction of the epidemic of chronic kidney

disease—let us not squabble about estimated

GFR only, but also focus on albuminuria

P E de Jong and R T Gansevoort

(See related article by R J Glassocket al.An epidemic

of chronic kidney disease: fact or fiction?Nephrol Dial

Transplant2008; 23: 1117–1121.)

(See related article by J Coreshet al.Chronic kidney

disease is common: What do we do next?Nephrol Dial

Transplant2008; 23: 1122–1125.) 1092

Tubulointerstitial nephritis and uveitis syndrome

(TINU): a step forward to understanding an elusive

oculorenal syndrome

H Izzedine

(See related article by L Abedet al.Presence of

autoantibodies against tubular and uveal cells in a patient

with tubulointerstitial nephritis and uveitis (TINU)

syndrome.Nephrol Dial Transplant2008; 23: 1452–1455.) 1095

Periodic paralyses: when channels go wrong

J.-P Lengel ´e, H Belge and O Devuyst

(See related article by I Grgicet al.Hyperkalaemia in a

tetraplegic adolescent due tode novosodium channel

mutation.Nephrol Dial Transplant2008; 23: 1449–1451.) 1098

Proximal RTA: Are all the charts completed yet?

P Gross and C Meye

(See related article by Z Katziret al Familial pure

proximal renal tubular acidosis—a clinical and genetic

study.Nephrol Dial Transplant2008; 23: 1211–1215.) 1101

Pharmacoeconomics in nephrology:

considerations on cost-effectiveness of screening

for albuminuria

M J Postma, C Boersma and R T Gansevoort

(See related article by A J Palmeret al A health

economic analysis of screening and optimal treatment of

nephropathy in patients with type 2 diabetes and

hypertension in the USA.Nephrol Dial Transplant2008;

TRANSLATIONAL NEPHROLOGY

T-cells in angiotensin-II-induced vascular damage

Parvalbumin: a key protein in early distal tubule

NaCl reabsorption

KIDNEY DISEASES BEYOND NEPHROLOGY

Kidney disease in diabetology: lessons from 2007

SPECIAL FEATURE

Quality of care in end-stage renal disease: the

importance of comparing ‘apples with apples’

DEBATE ON THE ‘EPIDEMIC’ OF CHRONIC KIDNEY DISEASE

THE CHALLENGE

An epidemic of chronic kidney disease: fact or

fiction?

R J Glassock and C Winearls

(See related article by P E de Jonget al.Fact or fiction of

the epidemic of chronic kidney disease—let us not

squabble about estimated GFR only, but also focus on

albuminuria.Nephrol Dial Transplant2008; 23:

Chronic kidney disease is common: What do we

do next?

J Coresh, L A Stevens and A S Levey (See related article by P E de Jonget al.Fact or fiction of the epidemic of chronic kidney disease—let us not squabble about estimated GFR only, but also focus on albuminuria.Nephrol Dial Transplant2008; 23:

II Scientific Papers ORIGINAL ARTICLES

EXPERIMENTAL NEPHROLOGY Transforming growth factor-β1 decreases epithelial sodium channel functionality in renal collecting duct cells via a Smad4-dependent pathway

C.-T Chang, C.-C Hung, Y.-C Chen, T.-H Yen, M.-S Wu, C.-W Yang, A Phillips and Y.-C Tian 1126 Evidence for sustained renal hypoxia and

transient hypoxia adaptation in experimental rhabdomyolysis-induced acute kidney injury

C Rosenberger, M Goldfarb, A Shina, S Bachmann,

U Frei, K.-U Eckardt, T Schrader, S Rosen and

A murine model of site-specific renal microvascular endothelial injury and thrombotic microangiopathy

B Hohenstein, A Braun, K U Amann, R J Johnson

Overexpression of PKD2 in the mouse is associated with renal tubulopathy

S Burtey, M Riera, E Ribe, P Pennekamp, E Passage,

R Rance, B Dworniczak and M Font ´es 1157 Cobalt ameliorates renal injury in an obese,

hypertensive type 2 diabetes rat model

S Ohtomo, M Nangaku, Y Izuhara, S Takizawa,

C van Y de Strihou and T Miyata 1166 Fluoxetine effect on kidney water reabsorption

Z P Moyses, F K Nakandakari and A J Magaldi 1173 Treatment with the xanthine oxidase inhibitor

febuxostat lowers uric acid and alleviates systemic and glomerular hypertension in experimental hyperuricaemia

L G S ´anchez-Lozada, E Tapia, V Soto, C

´ Avila-Casado, M Franco, L Zhao and R J Johnson 1179

In vivo effect of the natural antioxidant hydroxytyrosol on cyclosporine nephrotoxicity in rats

G Capasso, C I Di Gennaro, F D Ragione, C Manna,

R Ciarcia, S Florio, A Perna, R M Pollastro, S

Damiano, O Mazzoni, P Galletti and V Zappia 1186 Human mesenchymal stem cells inhibit antibody

production induced in vitro by allostimulation

P Comoli, F Ginevri, R Maccario, M A Avanzini,

M Marconi, A Groff, A Cometa, M Cioni, L Porretti,

W Barberi, F Frassoni and F Locatelli 1196 CLINICAL NEPHROLOGY

A multi-centre evaluation of the RIFLE criteria for early acute kidney injury in critically ill patients

S M Bagshaw, C George, I Dinu and R Bellomo 1203 Familial pure proximal renal tubular acidosis—a

clinical and genetic study

Z Katzir, D Dinour, H Reznik-Wolf, A Nissenkorn and E Holtzman

(See related article by P Grosset al.Proximal RTA: Are all the charts completed yet?Nephrol Dial Transplant

A health economic analysis of screening and

optimal treatment of nephropathy in patients with

type 2 diabetes and hypertension in the USA

A J Palmer, W J Valentine, R Chen, N Mehin,

S Gabriel, B Bregman and R A Rodby

(See related article by M J Postmaet al

Pharmacoeconomics in nephrology: considerations on

cost-effectiveness of screening for albuminuria.Nephrol

Dial Transplant2008; 23: 1103–1106.) 1216

Glomerular endothelium in kidneys with

congenital nephrotic syndrome of the Finnish type

(NPHS1)

A Kaukinen, A.-M Kuusniemi, I Lautenschlager

Comparison between gadolinium and iodine

contrast for percutaneous intervention in

atherosclerotic renal artery stenosis: clinical

outcomes

G C Kane, A W Stanson, D Kalnicka, D W Rosenthal,

C U Lee, S C Textor and V D Garovic 1233

Improved estimation of glomerular filtration rate

by serum cystatin C in preventing contrast

induced nephropathy by N-acetylcysteine or

zinc—preliminary results

M Kimmel, M Butscheid, S Brenner, U Kuhlmann,

Blood pressure measures and risk of chronic

kidney disease in men

E S Schaeffner, T Kurth, T S Bowman, R P Gelber

Methodological issues on the use of urinary

alpha-1-microglobuline in epidemiological studies

L Andersson, B Haraldsson, C Johansson

Chronic kidney disease prevalence in a UK

residential care home population

J L Carter, S E O’Riordan, G L Eaglestone,

Predictors of new-onset decline in kidney function

in a general middle-European population

R P Obermayr, C Temml, M Knechtelsdorfer,

G Gutjahr, J Kletzmayr, S Heiss, A Ponholzer,

S Madersbacher, R Oberbauer and R Klauser-Braun 1265

Correlates of ACE activity in macroalbuminuric

type 2 diabetic patients treated with chronic ACE

inhibition

A Nikzamir, M Nakhjavani, A Esteghamati

Identifying patients with type 2 diabetes at high

risk of microalbuminuria: results of the DEMAND

( Developing Education on Microalbuminuria for

Awareness of reNal and cardiovascular risk in

Diabetes ) Study

M C E Rossi, A Nicolucci, F Pellegrini, M Comaschi,

A Ceriello, D Cucinotta, C Giorda, U Valentini,

Inflammatory markers and the progression of IgA

glomerulonephritis

K Kaartinen, J Syrj ¨anen, I P ¨orsti, M Hurme,

A Harmoinen, A Pasternack, H Huhtala

Mutations in PLCE1 are a major cause of isolated

diffuse mesangial sclerosis (IDMS)

R Gbadegesin, B G Hinkes, B E Hoskins,

C N Vlangos, S F Heeringa, J Liu, C Loirat, F Ozaltin,

S Hashmi, F Ulmer, R Cleper, R Ettenger, C Antignac,

R C Wiggins, M Zenker and F Hildebrandt 1291

The prognosis and pathogenesis of severe lupus

glomerulonephritis

M M Schwartz, S M Korbet and E J Lewis (for the

Mycophenolate mofetil versus cyclophosphamide for inducing remission of ANCA vasculitis with moderate renal involvement

W Hu, C Liu, H Xie, H Chen, Z Liu and L Li 1307 Prolonged conservative treatment for frail elderly

patients with end-stage renal disease: the Verona experience

V De Biase, O Tobaldini, C Boaretti, C Abaterusso,

N Pertica, C Loschiavo, G Trabucco, A Lupo and

DIALYSIS AND TRANSPLANTATION Obesity is not an obstacle for successful autogenous arteriovenous fistula creation in haemodialysis

W Weyde, M Krajewska, W Letachowicz, T Porazko,

E Wa¸torek, M Kusztal, M Banasik, T Gołe¸biowski,

H Bartosik, K Madziarska, D Janczak and M Klinger 1318 Current structure and organization for renal

patient assistance in Italy

S Alloatti, G F M Strippoli, G Buccianti, G Daidone and F P Schena and on behalf of the Italian Society of

Guanidino compounds after creatine supplementation in renal failure patients and their relation to inflammatory status

Y E C Taes, B Marescau, A De Vriese, P P De Deyn,

E Schepers, R Vanholder and J R Delanghe 1330 The outcome of chronic dialysis in infants and

toddlers—advantages and drawbacks of haemodialysis

S Feinstein, C Rinat, R Becker-Cohen, E Ben-Shalom,

Analysis of NO-synthase expression and clinical risk factors in human diabetic nephropathy

B Hohenstein, C P M Hugo, B Hausknecht,

K P Boehmer, R H Riess and R E Schmieder 1346 Acute effects of low and high intravenous doses

of furosemide on myocardial function in anuric haemodialysis patients: a tissue Doppler study

S Y Hayashi, A Seeberger, B Lind, S Gunnes,

A Alvestrand, M M do Nascimento, B Lindholm

Resistance exercise augments the acute anabolic effects of intradialytic oral nutritional

supplementation

K M Majchrzak, L B Pupim, P J Flakoll and T A Ikizler 1362 Diagnostic value of N-terminal pro-B-type

natriuretic peptide (NT-proBNP) for left ventricular dysfunction in patients with chronic kidney disease stage 5 on haemodialysis

S David, P K ¨umpers, V Seidler, F Biertz, H Haller

Calcium and potassium changes during haemodialysis alter ventricular repolarization duration: in vivo and in silico analysis

S Severi, E Grandi, C Pes, F Badiali, F Grandi,

Effects of cinacalcet on gastrointestinal hormone release in patients with secondary

hyperparathyroidism undergoing dialysis

J J D´ıez, J L Miguel, R Codoceo, P Iglesias,

M A Bajo, C S ´anchez, G del Peso, F Gil,

J Martinez-Ara, P G Gancedo and R Selgas 1387 Geriatric comorbidities, such as falls, confer an

independent mortality risk to elderly dialysis patients

M Li, G Tomlinson, G Naglie, W L Cook

Frequency and severity of acute pancreatitis in

chronic dialysis patients

P G Lankisch, B Weber-Dany, P Maisonneuve

Natural killer cell alterations correlate with loss of

renal function and dialysis duration in uraemic

patients

H Vacher-Coponat, C Brunet, L Lyonnet, E Bonnet,

A Loundou, J Sampol, V Moal, B Dussol, P Brunet,

Y Berland, F Dignat-George and P Paul 1406

Patients with complex arrhythmias during and

after haemodialysis suffer from different regimens

of potassium removal

A Santoro, E Mancini, G London, L Mercadal, H Fessy,

B Perrone, L Cagnoli, E Grandi, S Severi and

Glucocorticoid resistance in dialysis patients may

impair the kidney allograft outcome

S R De Antonio, L T S Saber, R S Chriguer

Pre-transplant predictors of cerebrovascular

events after kidney transplantation

S Aull-Watschinger, H Konstantin, D Demetriou,

M Schillinger, A Habicht, W H H ¨orl and

The combined effect of pre-transplant triglyceride

levels and the type of calcineurin inhibitor in

predicting the risk of new onset diabetes after

renal transplantation

E Porrini, P Delgado, A Alvarez, M Cobo, L P ´erez,

J M Gonz ´alez-Posada, L Hortal, R Gallego,

J J Garc´ıa, M Checa, A Morales, E Salido,

Smoking behaviour of patients before and after

renal transplantation

M C Banas, B Banas, J Wolf, U Hoffmann, B Kr ¨uger,

C A B ¨oger, S R Orth and B K Kr ¨amer 1442

III Clinical Reports

BRIEF REPORT

The basic needs of children on haemodialysis in

Turkey

CASE REPORT

Hyperkalaemia in a tetraplegic adolescent due to

de novo sodium channel mutation

I Grgic, H Si, C Depboylu, G U H ¨oglinger, C Busch,

W.-T Heyken, U Kuhlmann, T Maier, R K ¨ohler and

J Hoyer

(See related article by J.-P Lengel ´eet al.Periodic

paralyses: when channels go wrong.Nephrol Dial

Transplant2008; 23: 1098–1101.) 1449

EXCEPTIONAL CASE Presence of autoantibodies against tubular and uveal cells in a patient with tubulointerstitial nephritis and uveitis (TINU) syndrome

L Abed, A Merouani, E Haddad, G Benoit, L L Oligny and H Sartelet

(See related article by H Izzedine Tubulointerstitial nephritis and uveitis syndrome (TINU): a step forward to understanding an elusive oculorenal syndrome.Nephrol Dial Transplant2008; 23: 1095–1097.) 1452

IV Varia LETTERS AND REPLIES Risk factors of the progression of abdominal aortic calcification in patients on chronic haemodialysis

I Shahapuni, N E L Esper, R Opisiv, Z Massy,

G Choukroun, M Garabedian and A Fournier 1456 Reply

Confirming high prevalence of patients with a high risk for obstructive sleep apnoea syndrome after kidney transplantation

M J D´ıaz-Atauri, P Aus´ın, J Sayas, F G Torralba and

Reply

M Z Molnar, I Mucsi and M Novak 1459 Cinacalcet: benefit and cost

Reply

Cinacalcet, fetuin-A and interleukin-6

Reply

An understanding of trace metal physiology as an aid to interpretation of clearance studies by artificial organs

Reply

M D Churchwell, I F Btaiche, D A Pasko and

Think of oxalate when using ascorbate supplementation to optimize iron therapy in dialysis patients

C Canavese, M Marangella and P Stratta 1463 Reply

New strategies in haemodialfiltration (HDF)—-prospective comparative analysis between online mixed HDF and mid-dilution HDF

Reply