Báo cáo y học: "The intelligence in developing systems for molecular biology" potx

... 301.3 Genome Biology 2007, 8:301 Genome Biology 2007, 8:301 Meeting report The intelligence in developing systems for molecular biology S Cenk Sahinalp Address: School of Computing Science, Simon ... sources for visualizing, inferring the topologies of, or understanding the dynamics of networks and subnetworks. Using genotype information, gene expression, protein-protein interac...

Ngày tải lên: 14/08/2014, 17:22

... completed forms were forwarded to the principal investigator on a weekly basis for data entry. Many strategies were used in order to minimize diag- nostic uncertainty in both data collection efforts. ... datasets were of t he nominal type (binary or with multiple categories). Preli- minary analyses consisted of constructing contingency tables where the binary independent grouping variab...

Ngày tải lên: 11/08/2014, 15:22

... even in the absence of proinflammatory cytokines, especially in macrophages [9,148,150]. These viral proteins play a role in the formation of viral reser- voirs in macrophages by activating transcription ... production of cyto- kines [212], viral replication remains very low during the asymptomatic stage of HIV-1 infection. Specific immune responses including Th2 cytokines an d CTLs c...

Ngày tải lên: 12/08/2014, 23:23

... strategy for studying biological systems than as a field of biology. Systems approaches have been very successful in the realms of biochemistry and genetics, especially for genetically tractable ... super-linearly. Put simply, screening 100 times as many genes yields more than 100 times the information; the additional information consists in learning how groups of genes beha...

Ngày tải lên: 09/08/2014, 20:21

... analysis is done, the Galaxy record will eliminate any ambiguity as to which result used which settings. In the long term, the Galaxy history is invaluable if an unforeseen follow-up analysis ... file formats are com- patible and makes analysis accessible, but until systems for analyzing semantic dependencies of this kind are available, Galaxy cannot make analysis fully automatic a...

Ngày tải lên: 09/08/2014, 20:22

... sensitivity of cur- rent analytical pipelines for detecting single nucleotide substitutions (and particularly homozygous substitu- tions), combined wit h the propensity of damaging single nucleotide ... exome sequencing provides sufficient coverage of flanking intron sequence to positively identify potentially damaging, non- coding mutations in the intron sequences immediately flanking ta...

Ngày tải lên: 09/08/2014, 23:20

... each interview was separately analyzed by at least one other researcher to check for reliability of coding. Findings and themes were discussed regularly by an interdisciplinary team comprising ... complexity of managing bipolar disorder for each party. In order to fully realize the benefits of involving relatives in relapse prevention, additional training and support for commun...

Ngày tải lên: 11/08/2014, 16:20

... probability models for early severe sepsis in adult intensive care patients. JAMA 1995, 273:644- 650. 8. Apolone G, D’Amico R, Bertolini G,, Iapichino G, Cattaneo A, De Salvo G, Melotti R: The performance ... customization strategies in the performance of a general severity score. Crit Care Med 1997, 25:2001-2008. 11. Metnitz PG, Valentin A, Vesely H, Alberti C, Lang T, Lenz K, Steltzer...

Ngày tải lên: 12/08/2014, 18:21

... they are in real trouble, and as I mentioned before that covers any phenotypic manifestation that may be underlying the genetic predisposition. So I think that is clearly going to be important in ... in risk stratification. Genetic association studies using single nucleotide polymorphisms or insertion–deletion variants are increasingly in the scientific literature. A MEDLINE search I...

Ngày tải lên: 12/08/2014, 19:22

... they may have underlying diseases but they are dying of infection. When you talk about nosocomial pneumonia, and they have their fifth episode of nosocomial pneumonia, they have had two line infections ... quantify it in any way? [JC] Yes, one of the things that Tony mentioned in passing is that one simple way in which you could do this, which is analogous to the tumors/nodes/metastases...

Ngày tải lên: 12/08/2014, 19:22