PREDICTIVE TOXICOLOGY - CHAPTER 2 pps

... THEOCHEM 20 00; 503:17–30. 31. Crivori P, Cruciani G, Carrupt PA, Testa B. Predicting blood– brain barrier permeation from three-dimensional molecular structure. J Med Chem 20 00; 43 :22 04 22 16. 32. Zamora ... electronegativities (KHE) (25 ): KHE ¼ d v À d N 2 ¼ p þ n N 2 Thus, the perturbation term for the calculation of the hydro- gen E-state is: DHI ij ¼ KHE i À KHE j r 2 ij wit...

Ngày tải lên: 11/08/2014, 17:22

... net- work. Nat Genet 20 02; 31:60–63. 82. Rung J, Schlitt T, Brazma A, Freivalds K, Vilo J. Building and analysing genome-wide gene disruption networks. Bioin- formatics 20 02; 18(suppl 2) :S2 02 S210. 83. ... Biotechnol 20 03; 21 : 129 5– 129 7. 80. Laub MT, McAdams HH, Feldblyum T, Fraser CM, Shapiro L. Global analysis of the genetic network controlling a bacter- ial cell cycle. Scien...

Ngày tải lên: 11/08/2014, 17:22

... Actives Number NH 2 –c¼cH– 65 15 3 47 1 NH–C¼N– 9 1 0 8 2 [Cl–]h–4.0A–i [Cl–] 21 2 0 19 3 CH 2 –N–CH 2 29 7 022 4 O–CH¼ 7007 5 N–C¼ 5005 6 O–C¼ 14 1 0 13 7 O ^ –CH 2 –6 0068 Br–CH 2 –5 0059 cH¼cH–c¼cH–cH¼h3–Cli ... Substructure-Based SAR in Toxicology 329 © 20 05 by Taylor & Francis Group, LLC ing human cytochrome P4502D6 (cyp2D6). Other toxicants known to inhibit that...

Ngày tải lên: 11/08/2014, 17:22

... 34:1 320 –1 325 . 8. Klopman G, Wang S. A computer Automated Structure Evaluation (CASE) approach to calculation of partition coefficient. J Comput Chem 1991; 12: 1 025 –10 32. 9. Klopman G. The META-CASETOX ... ASI Ser, Ser 2 1996; 23 :27 –40. 10. Weininger D. SMILES, a chemical language and information system. 1. Introduction to methodology and encoding rules. J Chem Inf Comput Sci 1988;...

Ngày tải lên: 11/08/2014, 17:22

... LLC CHAPTER 2 A Framework for Environmental Toxicology Environmental toxicology can be simplified to the understanding of only three functions. These functions are presented in Figure 2. 1. ... inhibition of the immuno- logical system of an organism — immunological suppression. Immunological sup- pression by xenobiotics could have subtle but important impacts on natural popula- ti...

Ngày tải lên: 10/08/2014, 20:20

... cold sweat stood on the brow of the Grand Pensionary. The Black Tulip ALEXANDRE DUMAS CHAPTER 2 2. The Two Brothers As the fair Rosa, with foreboding doubt, had foretold, so it happened. ... and Cornelius de Witt. "Farewell, and love me. "Cornelius de Witt "August 20 th, 16 72. " John, with tears in his eyes, wiped off a drop of the noble blood which had...

Ngày tải lên: 02/07/2014, 14:20

... and a great surge of fear swept through him - the fear of the wild thing for the trap. It was a token CALL OF THE WILD JACK LONDON CHAPTER 2 II. The Law of Club and Fang Buck's ... husky, long and lean and gaunt, with a battle-scarred face and a single eye which flashed a warning of prowess that commanded respect. He was called Sol-leks, which means the Angry One. Lik...

Ngày tải lên: 02/07/2014, 16:20

... clearing houses, and global funds-transfer systems, the principal payment systems in use today, are covered in separate chapters in this book. Chapter 8 discusses the manage- ment of corporate payment ... may consist of the drawee’s signature alone.” U.C.C. § 3-4 09(a). 2. See Benjamin Geva, The Law of Electronic Funds Transfers, (Matthew Bender, 19 92) , § 1. 02[ 3]. 3. New York Clearin...

Ngày tải lên: 02/07/2014, 16:21