The principles of toxicology environmental and industrial applications 2nd edition phần 7 pptx

... 64- 17- 5 C 2 H 5 OH 46.1 – 173 173 44 Miscible 1.59 0 .79 Ethyl acetate 141 -78 -6 C 4 H 8 O 2 88.1 –118 171 100 64,000 3 0.89 Ethyl ether 60-29 -7 (C 2 H 5 ) 2 O 74 .1 – 177 94 440 69,000 2.55 0 .71 ... medicine. Ethers as a class are effective anesthetics, and this property increases with the molecular size. The utility of this property is, however, limited by the irritant...

Ngày tải lên: 09/08/2014, 16:20

... involving the interaction between the nervous system and the hormones of the endocrine glands. neurofibril One of the delicate threads running in every direction through the cytoplasm of the body of ... development, and sexual maturation; and effects on the mother concern lactation and acceptance of the offspring. resorption The loss of substance in...

Ngày tải lên: 09/08/2014, 16:20

... 1 General Principles of Toxicology GENERAL PRINCIPLES OF TOXICOLOGY ROBERT C. JAMES, STEPHEN M. ROBERTS, and PHILLIP L. WILLIAMS The intent of this chapter is to provide a concise description of the ... 151 7. 4 Interactions of Industrial Chemical with Other Substances 151 7. 5 General Population Exposure to Environmental Neurotoxicants 152 7. 6 Evaluation of...

Ngày tải lên: 09/08/2014, 16:20

... location of esterases is in the blood (plasma and erythrocytes), and of great concern is the enzyme normally responsible for the hydrolysis of acetylcholine. Blockade of this enzyme is the mode of ... TOXICITY OF THE BLOOD between liver and intestine is also included in the model. These features of the model are choices made by the model developer, and re...

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... hydrophilic substances is reduced. Often the skin of lab animals is covered with plastic wrap to enhance the hydration of the skin and increase the rate of uptake of agents applied to the surface of the skin. For compounds ... RESPONSES OF THE KIDNEY 8 Dermal and Ocular Toxicology: Toxic Effects of the Skin and Eyes DERMAL AND OCULAR TOXICOLOGY WILLIAM...

Ngày tải lên: 09/08/2014, 16:20

... oviductal and uterine motility and immobilization of the cilia lining the oviduct. The pertinence of these observations to human exposures and the observed effects of smoking are not clear. However, the ... mucosal barriers, and the unique activity of 189 Principles of Toxicology: Environmental and Industrial Applications, Second Edition , Edited by P...

Ngày tải lên: 09/08/2014, 16:20

... attached microtubules to the very center of the cell, lining up in the equatorial plane of the mitotic spindle. With still further growth of the spindle, the chromatids in each pair of chromosomes are ... the cell and are deleted by various repair mechanisms. Some, however, remain undetected and are passed to daughter cells. The significance of the mutations va...

Ngày tải lên: 09/08/2014, 16:20

... female mice 57 23 39 156 275 77 .5 Male mice vs. female mice 78 10 23 177 288 88.5 Rats vs. mice 67 32 36 131 266 74 .4 Source: Adapted from Haseman and Huff (19 87) . 13 .7 EMPIRICAL MEASURES OF RELIABILITY ... vs. female rats 74 25 12 181 292 87. 3 Male rats vs. male mice 46 43 36 145 270 70 .7 Male rats vs. female mice 29 33 36 145 273 74 .7 Female rats vs. male mice 46 32...

Ngày tải lên: 09/08/2014, 16:20

... justified by the data, and are they consistent with the current scientific understanding of the test or area of toxicology? • Is the outcome of the reported experiment dependent on the test conditions, ... addition, that is, if they lie above and to the right of the dose-addition line, a synergistic effect can be inferred. On the other hand, responses below th...

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... concerned. The determination of fitness for a given job should be based on the assessment of the health of the worker and on a good knowledge of the job demands and the worksite. The workers ... implement the full measures and intent of the program, it will not work. The worker is the focus of the entire program and is also involved in the process...

Ngày tải lên: 09/08/2014, 16:20